成果/Result
- Novel Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives被引量：54收藏
- 作者：Xu, Minghao Zhu, Junsheng Diao, Yanyan Zhou, Hongchang Ren, Xiaoli Sun, Deheng Huang, Jin Han, Dongmei Zhao, Zhenjiang Zhu, Lili Xu, Yufang Li, Honglin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Huzhou Teachers Coll;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2013
- Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase被引量：47收藏
- 作者：Zhu, Junsheng Han, Le Diao, Yanyan Ren, Xiaoli Xu, Minghao Xu, Liuxin Li, Shiliang Li, Qiang Dong, Dong Huang, Jin Liu, Xiaofeng Zhao, Zhenjiang Wang, Rui Zhu, Lili Xu, Yufang Qian, Xuhong Li, Honglin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2015
- Discovery of Diverse Human Dihydroorotate Dehydrogenase Inhibitors as Immunosuppressive Agents by Structure-Based Virtual Screening被引量：41收藏
- 作者：Diao, Yanyan Lu, Weiqiang Jin, Huangtao Zhu, Junsheng Han, Le Xu, Minghao Gao, Rui Shen, Xu Zhao, Zhenjiang Liu, Xiaofeng Xu, Yufang Huang, Jin Li, Honglin
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2012
- Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery被引量：40收藏
- 作者：Diao, Yanyan Liu, Dandan Ge, Huan Zhang, Rongrong Jiang, Kexin Bao, Runhui Zhu, Xiaoqian Bi, Hongjie Liao, Wenjie Chen, Ziqi Zhang, Kai Wang, Rui Zhu, Lili Zhao, Zhenjiang Hu, Qiaoyu Li, Honglin
- 机构：East China Univ Sci & Technol;East China Normal Univ;Lingang Lab
- 来源：NATURE COMMUNICATIONS 2023
- Fast and effective identification of the bioactive compounds and their targets from medicinal plants via computational chemical biology approach被引量：31收藏
- 作者：Zhang, Shoude Lu, Weiqiang Liu, Xiaofeng Diao, Yanyan Bai, Fang Wang, Liyan Shan, Lei Huang, Jin Li, Honglin Zhang, Weidong
- 机构：Second Mil Med Univ;Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：MEDCHEMCOMM 2011
- New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein被引量：29收藏
- 作者：Liu, Xiujie Huang, Xiaoli Lin, Wanhua Wang, Dongye Diao, Yanyan Li, Honglin Hui, Xiaoyan Wang, Yu Xu, Aimin Wu, Donghai Ke, Ding
- 机构：Chinese Acad Sci;Chinese Acad Sci;Chinese Acad Sci;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2011
- 关键词：alpha-FABP inhibitor Aromatic substituted pyrazoles Inflammatory response Inflammation related diseases
- Lanostane Triterpenoids from the Stems of Schisandra glaucescens被引量：26收藏
- 作者：Zou, Juan Yang, Li-Bin Jiang, Jing Diao, Yan-Yan Li, Xiao-Nian Huang, Jin Yang, Jian-Hong Li, Hong-Lin Xiao, Wei-Lie Du, Xue Shang, Shan-Zhai Pu, Jian-Xin Sun, Han-Dong
- 机构：Chinese Acad Sci;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：PLANTA MEDICA 2012
- 关键词：lanostane triterpenoids Schisandraceae Schisandra glaucescens FXR
- Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity被引量：24收藏
- 作者：Li, Shiliang Luan, Guoqin Ren, Xiaoli Song, Wenlin Xu, Liuxin Xu, Minghao Zhu, Junsheng Dong, Dong Diao, Yanyan Liu, Xiaofeng Zhu, Lili Wang, Rui Zhao, Zhenjiang Xu, Yufang Li, Honglin
- 机构：E China Univ Sci & Technol
- 来源：SCIENTIFIC REPORTS 2015
- Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity被引量：23收藏
- 作者：Zou, Juan Jiang, Jing Diao, Yan-Yan Yang, Li-Bin Huang, Jin Li, Hong-Lin Du, Xue Xiao, Wei-Lie Pu, Jian-Xin Sun, Han-Dong
- 机构：Chinese Acad Sci;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：FITOTERAPIA 2012
- 关键词：Schisandra glaucescens Schisandraceae Cycloartane triterpenoid FXR agonistic and antagonistic effects
- MacFrag: segmenting large-scale molecules to obtain diverse fragments with high qualities被引量：22收藏
- 作者：Diao, Yanyan Hu, Feng Shen, Zihao Li, Honglin
- 机构：East China Univ Sci & Technol;East China Normal Univ;Lingang Lab
- 来源：BIOINFORMATICS 2023
- Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors被引量：20收藏
- 作者：Dou, Dou Wang, Jie Qiao, Yunjin Wumaier, Gulinuer Sha, Wenjie Li, Wenjie Mei, Wenyi Yang, Tingyuan Zhang, Chen He, Huan Wang, Caolin Chu, Linna Sun, Baihui Su, Rongrong Ma, Xiangyu Gong, Mengdie Xie, Lijuan Jiang, Wenzhe Diao, Yanyan Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Xu, Yufang Li, Shengqing Li, Honglin
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
- 关键词：4-Anilinoquinazoline Non-small cell lung cancer (NSCLC) Epidermal growth factor receptor (EGFR) Kinase inhibitor Anti-proliferative activity
- PTID: an integrated web resource and computational tool for agrochemical discovery被引量：20收藏
- 作者：Gong, Jiayu Liu, Xiaofeng Cao, Xianwen Diao, Yanyan Gao, Daqi Li, Honglin Qian, Xuhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOINFORMATICS 2013
- RETRACTED: Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins (Retracted Article)被引量：20收藏
- 作者：Zhang, Shoude Yin, Jun Li, Xia Zhang, Jigang Yue, Rongcai Diao, Yanyan Li, Honglin Wang, Hui Shan, Lei Zhang, Weidong
- 机构：Second Mil Med Univ;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：BMC CANCER 2014
- 关键词：Bcl-2 Jacarelhyperol A Apoptosis Hypericum japonicum Thunb.ex Murray Leukemia
- Discovery of natural estrogen receptor modulators with structure-based virtual screening被引量：20收藏
- 作者：Cao, Xianwen Jiang, Jing Zhang, Shoude Zhu, Lili Zou, Juan Diao, Yanyan Xiao, Weilie Shan, Lei Sun, Handong Zhang, Weidong Huang, Jin Li, Honglin
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ;Chinese Acad Sci;Second Mil Med Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2013
- 关键词：Molecular docking Natural product Estrogen receptor Virtual screening
- Synthesis, Design, and Structure-Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase被引量：15收藏
- 作者：Xu, Le Li, Wenjie Diao, Yanyan Sun, Hongxia Li, Honglin Zhu, Lili Zhou, Hongchang Zhao, Zhenjiang
- 机构：East China Univ Sci & Technol;Huzhou Teachers Coll
- 来源：MOLECULES 2018
- 关键词：P. falciparum PfDHODH pyrimidone antimalarial agents
- Design, synthesis and structure-activity relationship study of aminopyridine derivatives as novel inhibitors of Janus kinase 2被引量：14收藏
- 作者：Wang, Wanqi Diao, Yanyan Li, Wenjie Luo, Yating Yang, Tingyuan Zhao, Yuyu Qi, TianTian Xu, Fangling Ma, Xiangyu Ge, Huan Liang, Yingfan Zhao, Zhenjiang Liang, Xin Wang, Rui Zhu, Lili Li, Honglin Xu, Yufang
- 机构：East China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2019
- 关键词：JAK2 Rheumatoid arthritis Crizotinib Molecular docking
- Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening被引量：13收藏
- 作者：Diao, Yanyan Jiang, Jing Zhang, Shoude Li, Shiliang Shan, Lei Huang, Jin Zhang, Weidong Li, Honglin
- 机构：East China Univ Sci & Technol;Second Mil Med Univ
- 来源：FRONTIERS IN CHEMISTRY 2018
- 关键词：FXR antagonist virtual screening molecular docking similarity searching natural product
- Discovery of Pteridine-7(8H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK)被引量：10收藏
- 作者：Dou, Dou Diao, Yanyan Sha, Wenjie Su, Rongrong Tong, Linjiang Li, Wenjie Leng, Limin Xie, Lijuan Yu, Zhixiao Song, Haoming Shen, Zihao Zhu, Lili Zhao, Zhenjiang Xie, Hua Chen, Zhuo Li, Honglin Xu, Yufang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2022
- A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton被引量：10收藏
- 作者：Zhang, Jin Zhou, Jing Ren, Xiaomei Diao, Yanyan Li, Honglin Jiang, Hualiang Ding, Ke Pei, Duanqing
- 机构：Chinese Acad Sci;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：INVESTIGATIONAL NEW DRUGS 2012
- 关键词：D181 Receptor tyrosine kinase G1/M arrest Tubulin polymerization
- Discovery and optimization of 2-aminopyridine derivatives as novel and selective JAK2 inhibitors被引量：10收藏
- 作者：Ma, Xiangyu Diao, Yanyan Ge, Huan Xu, Fangling Zhu, Lili Zhao, Zhenjiang Li, Honglin
- 机构：East China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2020
- 关键词：JAK2 Selectivity SBDD SAR
- Discovery of pyrrolo[1,2-a]quinoxalin-4(5H)-one derivatives as novel non-covalent Bruton's tyrosine kinase (BTK) inhibitors被引量：7收藏
- 作者：Su, Rongrong Diao, Yanyan Sha, Wenjie Dou, Dou Yu, Zhixiao Leng, Limin Zhao, Zhenjiang Chen, Zhuo Li, Honglin Xu, Yufang
- 机构：East China Univ Sci & Technol
- 来源：BIOORGANIC CHEMISTRY 2022
- 关键词：Noncovalent BTK inhibitor B cell malignancy Autoimmune disorder Tyrosine kinase inhibitor Scaffold hopping
- Design, synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors被引量：7收藏
- 作者：Liu, Dandan Ge, Huan Xu, Fangling Xu, Yufang Liu, Wenjun Li, Honglin Zhu, Lili Diao, Yanyan Zhao, Zhenjiang
- 机构：East China Univ Sci & Technol;Jiangzhong Pharmaceut Co Ltd
- 来源：CHINESE CHEMICAL LETTERS 2022
- 关键词：JAK2 Selectivity Inhibitors Cancer Structure-activity relationships
- Efficacy of WWQ-131, a highly selective JAK2 inhibitor, in mouse models of myeloproliferative neoplasms被引量：7收藏
- 作者：Ge, Huan Wang, Caolin Tian, Chaoquan Diao, Yanyan Wang, Wanqi Ma, Xiangyu Zhang, Jian Li, Honglin Zhao, Zhenjiang Zhu, Lili
- 机构：East China Univ Sci & Technol;East China Normal Univ
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2022
- 关键词：Selective JAK2 inhibitor JAK2 signaling pathway Myeloproliferative neoplasms WWQ-131
- Design, synthesis, and biological evaluation of diphenyl ether substituted quinazolin-4-amine derivatives as potent EGFRL858R/T790M/C797S inhibitors被引量：6收藏
- 作者：Dou, Dou Zhang, Xingsen Wang, Jie Wumaier, Gulinuer Qiao, Yunjin Xie, Lijuan Jiang, Wenzhe Sha, Wenjie Li, Wenjie Mei, Wenyi Zhang, Chen He, Huan Wang, Caolin Wu, Lingkang Diao, Yanyan Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Xu, Yufang Li, Shengqing Li, Honglin
- 机构：East China Univ Sci & Technol;Hebei Agr Univ;Fudan Univ;East China Normal Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2024
- 关键词：NSCLC EGFR C797S mutation Resistance 4-Anilinoquinazoline
- Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors被引量：6收藏
- 作者：Diao, Yanyan Fang, Xiaoyu Song, Peiran Lai, Mengzhen Tong, Linjiang Hao, Yongjia Dou, Dou Liu, Yingqiang Ding, Jian Zhao, Zhenjiang Xie, Hua Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;ShanghaiTech Univ;Nanchang Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2019
- 关键词：Bruton's tyrosine kinase B-cell malignancies Potent inhibitors Structure-activity relationship Cellular activities
- Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2被引量：5收藏
- 作者：Li, Wenjie Mei, Wenyi Jiang, Hewei Wang, Jie Li, Xiaoli Quan, Lina Diao, Yanyan Ma, Yanni Fan, Sisi Xie, Zhuwei Gong, Mengdie Zhu, Huan Bi, Dewen Zhang, Feng Ma, Lei Zhang, Jian Gao, Yufeng Paschalidis, Aris Lin, Honghuang Liu, Fangfang Liu, Kangdong Ye, Mingliang Zhao, Zhenjiang Duan, Yajun Chen, Zhuo Xu, Yufang Xiao, Weilie Tao, Shengce Zhu, Lili Li, Honglin
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Yunnan Univ;Yunnan Univ;Chinese Acad Sci
- 来源：SCIENCE CHINA-LIFE SCIENCES 2025
- 关键词：pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition
- Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors被引量：5收藏
- 作者：Chen, Haiyang Song, Peiran Diao, Yanyan Hao, Yongjia Dou, Dou Wang, Wanqi Fang, Xiaoyu Wang, Yanling Zhao, Zhenjiang Ding, Jian Li, Honglin Xie, Hua Xu, Yufang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;ShanghaiTech Univ
- 来源：MEDCHEMCOMM 2018
- Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors被引量：4收藏
- 作者：Lai, Meng-zhen Song, Pei-ran Dou, Dou Diao, Yan-yan Tong, Lin-jiang Zhang, Tao Xie, Hua Li, Hong-lin Ding, Jian
- 机构：Nanchang Univ;Chinese Acad Sci;ShanghaiTech Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol
- 来源：ACTA PHARMACOLOGICA SINICA 2020
- 关键词：B cell receptor Bruton's tyrosine kinase ibrutinib small-molecule inhibitor B cell malignancies
- Discovery of pyrido[3,4-b]indol-1-one derivatives as novel non-covalent Bruton's tyrosine kinase (BTK) inhibitors被引量：4收藏
- 作者：Dou, Dou Sha, Wenjie Diao, Yanyan Su, Rongrong Qiao, Yunjin Yu, Zhixiao Zhao, Zhenjiang Li, Honglin Chen, Zhuo Xu, Yufang
- 机构：East China Univ Sci & Technol
- 来源：BIOORGANIC CHEMISTRY 2022
- 关键词：BTK Inhibitors Non-covalent inhibitors Scaffold hopping Structure-activity relationship
- Biological evaluation of quinoline derivatives as inhibitors of human dihydroorotate dehydrogenase被引量：3收藏
- 作者：Wang, Jiawei Diao, Yanyan Zhu, Junsheng Li, Shiliang Zhao, Zhenjiang Li, Honglin Zhu, Lili
- 机构：E China Univ Sci & Technol
- 来源：MEDCHEMCOMM 2016
