成果/Result
- Shikonin is a novel and selectiveIMPDH2inhibitor that target triple-negative breast cancer被引量：41收藏
- 作者：Wang, Wanyan Wu, Yu Chen, Si Liu, Xi He, Jiacheng Wang, Shuyi Lu, Weiqiang Tang, Yong Huang, Jin
- 机构：East China Univ Sci & Technol;East China Normal Univ;East China Normal Univ;Guangxi Med Univ
- 来源：PHYTOTHERAPY RESEARCH 2021
- 关键词：guanine nucleotides IMPDH2 natural product shikonin triple-negative breast cancer
- Design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-Alzheimer agents被引量：26收藏
- 作者：Yang, Gui-Xiang Ge, Song-Lan Wu, Yan Huang, Jin Li, Shi-Liang Wang, Rui Ma, Lei
- 机构：East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
- 关键词：Sarsasapogenin derivatives Alzheimer's disease Antioxidation Antiinflammation Structure-activity relationship Beta-amyloid
- A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer被引量：10收藏
- 作者：Liu, Xi Hu, Qian Wang, Wanyan Ma, Hui Pu, Jiaqian Cui, Jiayan Gong, Ting Wu, Yu Lu, Weiqiang Huang, Jin
- 机构：East China Univ Sci & Technol;East China Normal Univ;East China Normal Univ
- 来源：BIOCHEMICAL PHARMACOLOGY 2021
- 关键词：Estrogen receptor alpha Breast cancer GLPCA Celastrol Gambogic acid
- Synthesis and biological evaluation of 3-carbamate smilagenin derivatives as potential neuroprotective agents被引量：6收藏
- 作者：Zhang, Cong Wu, Yan Li, Jie Yang, Gui-Xiang Su, Lin Huang, Yan Wang, Rui Ma, Lei
- 机构：East China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2019
- 关键词：Smilagenin derivatives Alzheimer's disease Oxidative stress Neuroprotective activity
- Solubility Measurement and Dynamic Simulation Analysis of the Brivaracetam Form A in 12 Pure Solvents被引量：3收藏
- 作者：Wu, Yue Shao, Jia-Hui Zhu, Bin Hong, Minghuang Ren, Guo-Bin Qi, Ming-Hui
- 机构：Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL AND ENGINEERING DATA 2025
- 关键词：Hydrogen bonds - Molecular dynamics - Solubility
- Exploring New Solid Forms of Antirheumatic Drug Hydroxychloroquine: Novel Salts with Sustained-Release Performance被引量：1收藏
- 作者：Ji, Wei-Jie Wu, Yue Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL RESEARCH AND TECHNOLOGY 2024
- 关键词：hydroxychloroquine hygroscopicity salification sustained-release
