成果/Result
- Tumor-derived exosomes induce immunosuppressive macrophages to foster intrahepatic cholangiocarcinoma progression被引量：92收藏
- 作者：Luo, Chubin Xin, Haoyang Zhou, Zhengjun Hu, Zhiqiang Sun, Rongqi Yao, Na Sun, Qiman Borjigin, Uyunbilig Wu, Xia Fan, Jia Huang, Xiaowu Zhou, Shaolai Zhou, Jian
- 机构：Fudan Univ;Fudan Univ;Inner Mongolia Univ;East China Univ Sci & Technol;Fudan Univ
- 来源：HEPATOLOGY 2022
- Repeated Systemic Dosing of Adeno-Associated Virus Vectors in Immunocompetent Mice After Blockade of T Cell Costimulatory Pathways被引量：13收藏
- 作者：Zhong, Chen Jiang, Wei Wang, Yefan Sun, Junjiang Wu, Xia Zhuang, Yingping Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ N Carolina;Univ N Carolina
- 来源：HUMAN GENE THERAPY 2022
- 关键词：CTLA4-Ig CD40-Ig AAV multiple systemic administration immune tolerance
- Dynamic changes of histone acetylation and methylation in bovine oocytes, zygotes, and preimplantation embryos被引量：12收藏
- 作者：Wu, Xia Hu, Shuxiang Wang, Lingling Li, Yan Yu, Haiquan
- 机构：East China Univ Sci & Technol;Inner Mongolia Univ
- 来源：JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION 2020
- 关键词：fertilization histone acetylation histone methylation oocyte meiosis preimplantation development
- Treatment of experimental autoimmune encephalomyelitis using AAV gene therapy by blocking T cell costimulatory pathways被引量：9收藏
- 作者：Zhong, Chen Chen, Zifeng Xia, Yong Wu, Jun Zhang, Feixu Cheng, Cheng Wu, Xia Zhuang, Yingping Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ N Carolina
- 来源：MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT 2022
- Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models被引量：6收藏
- 作者：Zhou, Kaiyi Yuan, Meng Sun, Jiabao Zhang, Feixu Li, Xinting Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：GENE THERAPY 2025
- In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer被引量：5收藏
- 作者：Tao, Deyou Liang, Junqing Pan, Yihong Zhou, Yanting Feng, Ying Zhang, Lin Xu, Jingjing Wang, Hui He, Ping Yao, Jie Zhao, Yang Ning, Qinjie Wang, Wen Jiang, Wei Zheng, Jing Wu, Xia
- 机构：Taizhou Enze Med Grp;Inner Mongolia Med Univ;Gynecol Taizhou Enze Med Ctr Grp Enze Hosp;East China Univ Sci & Technol
- 来源：JOURNAL OF BREAST CANCER 2019
- 关键词：Breast neoplasms Disease progression LAPTM4B protein human MCF-7 cells
- Prevention of Portal-Tract Fibrosis in Zfyve19-/- Mouse Model with Adeno-Associated Virus Vector Delivering ZFYVE19被引量：4收藏
- 作者：Zhang, Yanan Tang, Dingyue Wang, Li Yang, Jing Wu, Xia Xiao, Xiao Wang, Jian-She
- 机构：Fudan Univ;Fudan Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Key Lab Birth Defect
- 来源：HUMAN GENE THERAPY 2023
- 关键词：AAV gene therapy mouse model portal-tract fibrosis ZFYVE19
- Hippocampus-targeted BDNF gene therapy to rescue cognitive impairments of Alzheimer's disease in multiple mouse models被引量：3收藏
- 作者：Tang, Siqi Luo, Wenshu Wu, Shihao Yuan, Meng Wen, Jiashuo Zhong, Guoshen Shen, Leshan Jiang, Wei Cheng, Cheng Wu, Xia Xiao, Xiao
- 机构：East China Univ Sci & Technol;Belief Biomed Inc;Yunnan Univ;East China Univ Sci & Technol
- 来源：GENES & DISEASES 2026
- 关键词：AAVT42 Alzheime's disease Brain-derived neurotrophic factor Cognitive impairment Hippocampal RNA sequencing
- Prevalence of neutralizing antibodies against AAV8, AAV9, and AAV843 in a Chinese population被引量：3收藏
- 作者：Xu, Jingjing Zhang, Jingyu Xin, Lei Yang, Chen Zhang, Feixu Tang, Siqi Yao, Jie Wang, Hui Ning, Qinjie Yan, Mendi Li, Min Wu, Jiamei Chen, Ying Zhong, Chen Zhou, Kaiyi Du, Zengmin Jiang, Wei Wu, Xia Yang, Youjun Sun, Junjiang Xiao, Xiao Zheng, Jing
- 机构：East China Univ Sci & Technol;Harbin Med Univ
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 2019
- 关键词：Neutralizing antibodies adeno-associated virus prevalence gene therapy
- Systemic effect of FHL1 on neuromuscular junction and myotube formation via insulin-like growth factor and myostatin signaling pathways被引量：3收藏
- 作者：Wu, Jiamei Zhao, Kai Du, Zengmin Chen, Ying Zhang, Feixu Jiang, Wei Zheng, Jing Wu, Xia Shen, Chengyong Xiao, Xiao
- 机构：East China Univ Sci & Technol;Zhejiang Univ
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2021
- Sildenafil increases AAV9 transduction after a systemic administration and enhances AAV9-dystrophin therapeutic effect in mdx mice被引量：1收藏
- 作者：Zhou, Kaiyi Yuan, Meng Sun, Jiabao Zhang, Feixu Zong, Xiaoying Li, Zhanao Tang, Dingyue Zhou, Lichen Zheng, Jing Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Gen Hosp Western Theater Command PLA;Belief BioMed;Univ N Carolina
- 来源：GENE THERAPY 2024
- Activated factor X delivered by adeno-associated virus significantly inhibited bleeding and alleviated hemophilic synovitis in hemophilic mice被引量：1收藏
- 作者：Zhang, Feixu Zhou, Xinyue Hua, Baolai He, Xinyi Li, Zhanao Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Capital Med Univ
- 来源：GENE THERAPY 2024
- Safety and Efficacy of Dalnacogene Ponparvovec (BBM-H901) in Moderate to Severe Adult Hemophilia B Participants: Long Term Follow-Up Data in an Early Phase Pilot Study被引量：0收藏
- 作者：Xue, Feng Zhang, Lei Xiao, Xiao Wu, Xia Sun, Yujie
- 机构：Chinese Acad Med Sci;Ctr Diag & Treatment Thrombosis & Hemostasis;Belief Med Technol Shanghai Co Ltd;East China Univ Sci & Technol;Takeda China Int Trading Co
- 来源：HAEMOPHILIA 2026
- 关键词：BBM-H901 gene therapy Hemophilia B
- Novel AAV843 Vector-Mediated Gene Replacement Therapy Rescues Primary Hyperoxaluria Type I in Mice被引量：0收藏
- 作者：Zhang, Jingjia Yin, Ye Ji, Baowei Sun, Manqing Jiang, Yuanyan Wu, Xiaohui Xiao, Xiao Shen, Qian Wu, Xia Xu, Hong
- 机构：Fudan Univ;Shanghai Kidney Dev & Pediat Kidney Dis Res Ctr;Fudan Univ;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CELLS 2026
- 关键词：primary hyperoxaluria type I gene replacement therapy AAV843 kidney injury
- Prophylaxis CTLA4-ig reduces anti-AAV neutralizing antibodies in AAV gene therapy for hemophilia被引量：0收藏
- 作者：Yu, Dandan Xu, Bingqi Liu, Wei Xue, Feng Chen, Yunfei Liu, Xiaofan Ju, Mankai Ting, Sun Dai, Xinyue Dong, Huan Gu, Wenjing Yang, Renchi Xiao, Xiao Wu, Xia Pei, Xiaolei Zhang, Lei
- 机构：Chinese Acad Med Sci;East China Univ Sci & Technol
- 来源：BLOOD 2025
