成果/Result
- Combined 13C-assisted metabolomics and metabolic flux analysis reveals the impacts of glutamate on the central metabolism of high β-galactosidase-producing Pichia pastoris被引量：45收藏
- 作者：Liu, Ping Huang, Mingzhi Guo, Menglei Qian, Jiangchao Lin, Weilu Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresources and Bioprocessing 2016
- 关键词：Gene expression - Physiology - Recombinant proteins - Yeast
- Impacts of high β-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via 13C metabolic flux analysis被引量：31收藏
- 作者：Nie, Yongsheng Huang, Mingzhi Lu, Junjie Qian, Jiangchao Lin, Weilu Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2014
- 关键词：P. pastoris C-13 metabolic flux analysis Central metabolism Heterologous protein expression
- Pre-analysis of multi-batch bioprocesses data with finite mixture models in the reduced feature subspace被引量：20收藏
- 作者：Lin, Weilu Martin, Elaine Montague, Gary
- 机构： State Key Laboratory of Bioreactor Engineering; School of Chemical Engineering and Advanced Materials
- 来源：IFAC Proceedings Volumes (IFAC-PapersOnline) 2010
- 关键词：Maximum principle - Fisher information matrix - Discriminant analysis - Gaussian distribution
- Prediction intervals of an alternative formulation of partial least squares algorithm被引量：15收藏
- 作者：Lin, Weilu Martin, Elaine
- 机构： State Key Laboratory of Bioreactor Engineering; School of Chemical Engineering and Advanced Materials
- 来源：2011 International Symposium on Advanced Control of Industrial Processes, ADCONIP 2011 2011
- 关键词：Inverse problems - Iterative methods - Forecasting - Least squares approximations
- Comprehensive reconstruction and evaluation of Pichia pastoris genome-scale metabolic model that accounts for 1243 ORFs被引量：12收藏
- 作者：Ye, Rui Huang, Mingzhi Lu, Hongzhong Qian, Jiangchao Lin, Weilu Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2017
- 关键词：Genome-scale metabolic model Pichia pastoris Multi-omics beta-Galactosidase
- Changes in Oxygen Availability during Glucose-Limited Chemostat Cultivations of Penicillium chrysogenum Lead to Rapid Metabolite, Flux and Productivity Responses被引量：6收藏
- 作者：Yang, Qi Lin, Wenli Xu, Jiawei Guo, Nan Zhao, Jiachen Wang, Gaoya Wang, Yongbo Chu, Ju Wang, Guan
- 机构：East China Univ Sci & Technol ECUST
- 来源：METABOLITES 2022
- 关键词：dissolved oxygen industrial metabolomics penicillin Penicillium chrysogenum scale-down
- On estimation of multivariate prediction regions in partial least squares regression被引量：5收藏
- 作者：Lin, Weilu Zhuang, Yingping Zhang, Siliang Martin, Elaine
- 机构：East China Univ Sci Technol;Newcastle Univ
- 来源：JOURNAL OF CHEMOMETRICS 2013
- 关键词：multivariate prediction region partial least squares Jacobian matrix local linearization
- Optimization of the n-propanol concentration and feedback control strategy with electronic nose in erythromycin fermentation processes被引量：5收藏
- 作者：Zhao, Hong-Tu Pang, Kun-Yun Lin, Wei-Lu Wang, Ze-Jian Gao, Da-Qi Guo, Mei-Jin Zhuang, Ying-Ping
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：PROCESS BIOCHEMISTRY 2016
- 关键词：Erythromycin Fermentation On-line n-propanol monitoring Electronic nose Feedback control
- Variable selection in partial least squares with the weighted variable contribution to the first singular value of the covariance matrix被引量：5收藏
- 作者：Lin, Weilu Hang, Haifeng Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol
- 来源：CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS 2018
- 关键词：Informative variables Interval variable selection Partial least squares Variable contribution Maximal singular value Spectroscopy
- 中红外在线监测技术在黑曲霉发酵过程中的应用被引量：5收藏
- 作者：史梦菲 林伟璐 赵伟 杭海峰 储炬 庄英萍
- 机构：华东理工大学;山东福洋生物科技有限公司
- 来源：《食品科技》 2017
- 关键词：中红外 偏最小二乘法 衰减全反射 在线监测 黑曲霉发酵
- 摘要：利用傅里叶变换中红外光谱结合衰减全反射(FT-MIR-ATR)分析技术,经全因子设计的标准液图谱通过偏最小二乘法(Partial least squares,PLS)建立模型,获得快速、在线监测黑曲霉发酵过程中葡萄糖和葡...
- 下载全文在线阅读
- On structural identifiability analysis of the cascaded linear dynamic systems in isotopically non-stationary 13C labelling experiments被引量：3收藏
- 作者：Lin, Weilu Wang, Zejian Huang, Mingzhi Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol
- 来源：MATHEMATICAL BIOSCIENCES 2018
- 关键词：Isotopically non-stationary 13C labelling experiments Structural identifiability Taylor series expansion Non-stationary cumomer balance equations
- Evaluate the number of clusters in finite mixture models with the penalized histogram difference criterion被引量：1收藏
- 作者：Lin, Weilu Wang, Yonghong Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF PROCESS CONTROL 2013
- 关键词：Finite mixture models Penalized histogram difference criterion Gaussian mixtures Information criteria EM algorithm
- Modelling steady state intercellular isotopic distributions with isotopomer decomposition units被引量：1收藏
- 作者：Lin, Weilu Huang, Mingzhi Wang, Zejian Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci Technol
- 来源：COMPUTERS & CHEMICAL ENGINEERING 2019
- 关键词：Isotopomer decomposition unit Steady state isotope labeling experiments Isotopomer labeling systems Cascaded linear systems
- Combined ^(13)C-assisted metabolomics and metabolic flux analysis reveals the impacts of glutamate on the central metabolism of highβ-galactosidase-producing Pichia pastoris被引量：1收藏
- 作者：Ping Liu Mingzhi Huang Menglei Guo Jiangchao Qian Weilu Lin Ju Chu Yingping Zhuang Siliang Zhang
- 机构：State Key Laboratory of Bioreactor Engineering
- 来源：生物资源与生物加工(英文) 2016
- 下载全文在线阅读
- Nonstationary 13C metabolic flux analysis reveals cryptic phenylacetic acid catabolism in glucose-limited Penicillium chrysogenum chemostat cultures被引量：0收藏
- 作者：Zhao, Jiachen Lin, Wenli Yang, Jing Wang, Gaoya Wang, Yongbo Chang, Mengyuan Wang, Xueting Muawiya, Muhammad Alkali Wang, Zejian Zhuang, Yingping Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;Chinese Acad Sci
- 来源：BIORESOURCE TECHNOLOGY 2026
- 关键词：Overflow control Feedback control Penicillin PAA degradation Metabolomics Isotope tracing
- On stability analysis of cascaded linear time varying systems in dynamic isotope experiments被引量：0收藏
- 作者：Lin, Weilu Wang, Zejian Huang, Mingzhi Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol
- 来源：AICHE JOURNAL 2020
- 关键词：dynamic cumomer balance equations dynamic isotope experiments metabolic nonsteady state stability analysis
- Comprehensive reconstruction and evaluation of Pichia pastoris genome-scale metabolic model that accounts for 1243 ORFs被引量：0收藏
- 作者：Rui Ye Mingzhi Huang Hongzhong Lu Jiangchao Qian Weilu Lin Ju Chu Yingping Zhuang Siliang Zhang
- 机构：State Key Laboratory of Bioreactor Engineering
- 来源：生物资源与生物加工(英文) 2017
- 下载全文在线阅读
- Combined C-assisted metabolomics and metabolic flux analysis reveals the impacts of glutamate on the central metabolism of high β-galactosidase-producing .被引量：0收藏
- 作者：Liu, Ping Huang, Mingzhi Guo, Menglei Qian, Jiangchao Lin, Weilu Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：State Key Laboratory of Bioreactor Engineering
- 来源：Bioresources and bioprocessing 2016
- 关键词：13C metabolic flux analysis Glutamate Metabolomics P. pastoris Recombinant protein expression
