成果/Result
- Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference被引量：626收藏
- 作者：Cheng, Feixiong Liu, Chuang Jiang, Jing Lu, Weiqiang Li, Weihua Liu, Guixia Zhou, Weixing Huang, Jin Tang, Yun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：PLOS COMPUTATIONAL BIOLOGY 2012
- 关键词：Cell culture - Complex networks - Computation theory - Drug interactions - Tensors
- Target identification among known drugs by deep learning from heterogeneous networks被引量：244收藏
- 作者：Zeng, Xiangxiang Zhu, Siyi Lu, Weiqiang Liu, Zehui Huang, Jin Zhou, Yadi Fang, Jiansong Huang, Yin Guo, Huimin Li, Lang Trapp, Bruce D. Nussinov, Ruth Eng, Charis Loscalzo, Joseph Cheng, Feixiong
- 机构：Hunan Univ;Xiamen Univ;East China Normal Univ;East China Normal Univ;East China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2020
- 关键词：Network embeddings - Deep learning - Genome
- Assembly of a Highly Stable Luminescent Zn5 Cluster and Application to Bio-Imaging被引量：99收藏
- 作者：Zeng, Ming-Hua Yin, Zheng Liu, Ze-Hui Xu, Hai-Bing Feng, Ying-Chun Hu, Yue-Qiao Chang, Li-Xian Zhang, Yue-Xing Huang, Jin Kurmoo, Mohamedally
- 机构：Guangxi Normal Univ;Hubei Univ;Shaanxi Univ Sci & Technol;East China Univ Sci & Technol;Univ Strasbourg
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2016
- 关键词：3d-metal coordination cluster bio-imaging fluorescence probes pH sensitivity Zn clusters
- Binding of oxo-Cu2 clusters to ferric ion-binding protEIn A from NEIsseria gonorrhoeae: A structural insight被引量：63收藏
- 作者：Chen, Weijing Ye, Danrong Wang, Hongfei Lin, Dechang Huang, Jin Sun, Hongzhe Zhong, Weiqing
- 机构： School of Pharmacy; Institute of Opto-Electronics; School of Pharmacy; Department of Chemistry
- 来源：Metallomics 2013
- 关键词：Copper compounds - Iron - Biological systems - Crystal structure - Amino acids - ProtEIns
- Identification of Essential Sensitive Regions of the Aerolysin Nanopore for Single Oligonucleotide Analysis被引量：61收藏
- 作者：Wang, Ya-Qian Li, Meng-Yin Qiu, Hu Cao, Chan Wang, Ming-Bo Wu, Xue-Yuan Huang, Jin Ying, Yi-Lun Long, Yi-Tao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Nanjing Univ Aeronaut & Astronaut;East China Univ Sci & Technol
- 来源：ANALYTICAL CHEMISTRY 2018
- 关键词：Molecular dynamics - Amino acids - Electrostatics - NuclEIc acids - Oligonucleotides - Bioinformatics
- Rationally Designed Sensing Selectivity and Sensitivity of an Aerolysin Nanopore via Site-Directed Mutagenesis被引量：58收藏
- 作者：Wang, Ya-Qian Cao, Chan Ying, Yi-Lun Li, Shuang Wang, Ming-Bo Huang, Jin Long, Yi-Tao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS SENSORS 2018
- 关键词：selectivity sensitivity single molecule aerolysin nanosensor
- Development of a new colorimetric assay for lipoxygenase activity被引量：48收藏
- 作者：Lu, Weiqiang Zhao, Xue Xu, Zhongyu Dong, Ningning Zou, Shien Shen, Xu Huang, Jin
- 机构：E China Univ Sci & Technol;Fudan Univ
- 来源：ANALYTICAL BIOCHEMISTRY 2013
- 关键词：Lipoxygenase Colorimetric assay Ferrithiocyanate Lipid hydroperoxides Inhibitors
- wSDTNBI: a novel network-based inference method for virtual screening被引量：36收藏
- 作者：Wu, Zengrui Ma, Hui Liu, Zehui Zheng, Lulu Yu, Zhuohang Cao, Shuying Fang, Wenqing Wu, Lili Li, Weihua Liu, Guixia Huang, Jin Tang, Yun
- 机构：East China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2022
- 关键词：Carboxylic acids - Crystal structure - Tensors
- Tracking the multiple-step formation of an iron(III) complex and its application in photodynamic therapy for breast cancer被引量：23收藏
- 作者：Zhu, Zhong-Hong Hu, Qian Pan, Hui-Ling Zhang, Yuexing Xu, Haibing Kurmoo, Mohamedally Huang, Jin Zeng, Ming-Hua
- 机构：Guangxi Normal Univ;Hubei Univ;East China Univ Sci & Technol;Univ Strasbourg
- 来源：SCIENCE CHINA-CHEMISTRY 2019
- 关键词：tandem formation iron(III) complex DFT calculation photodynamic therapy breast cancer
- Identification of Inhibitors against p90 Ribosomal S6 Kinase 2 (RSK2) through Structure-Based Virtual Screening with the Inhibitor-Constrained Refined Homology Model被引量：20收藏
- 作者：Li, Shiliang Zhou, Yi Lu, Weiqiang Zhong, Ye Song, Wenlong Liu, Kangdong Huang, Jin Zhao, Zhenjiang Xu, Yufang Liu, Xiaofeng Li, Honglin
- 机构：E China Univ Sci & Technol;Zhengzhou Univ
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2011
- 关键词：Virtual reality - Crystal structure - Digital libraries - Amino acids - Binding sites - Diseases
- Recent advances in the anti-aging effects of natural polysaccharides: Sources, structural characterization, action mechanisms and structure-activity relationships被引量：14收藏
- 作者：Teng, Hao Xiao, Huanhuan Li, Xueying Huang, Jin Zhang, Bin Zeng, Minghua
- 机构：Guangxi Normal Univ;Guilin Tourism Univ;Hefei Univ Technol;East China Univ Sci & Technol
- 来源：TRENDS IN FOOD SCIENCE & TECHNOLOGY 2025
- 关键词：Polysaccharides Anti-aging effect Sources Structural characterization Mechanisms Structure-activity relationships
- A fluorimetric assay for human reticulocyte 15-lipoxygenase-1 activity被引量：4收藏
- 作者：Lu, Weiqiang Zhao, Xue Zou, Shien Huang, Jin
- 机构：E China Univ Sci & Technol;Fudan Univ
- 来源：ANALYTICAL BIOCHEMISTRY 2012
- 关键词：15-Lipoxygenase-1 Inhibitor Fluorimetric assay Dihydrorhodamine 123
- 基于遗传编码荧光探针的精氨酸实时监测新技术被引量：0收藏
- 作者：李婷 黄瑾 张卓 赵玉政
- 机构：华东理工大学药学院;中国医学科学院细胞代谢监测成像新技术创新单元
- 来源：《科学通报》 2025
- 关键词：尿素 瓜氨酸 精氨酸 一氧化氮 代谢 鸟氨酸
- 摘要：精氨酸是氨基酸中的“多面手”,除了作为蛋白质和多肽的组成部分外,精氨酸可代谢产生尿素、鸟氨酸、瓜氨酸、一氧化氮、肌酸、胍丁胺等重要分子,在调节人体氮代谢稳态、心血管生理活动、免疫反应、生长繁殖等重要过程中发挥着关键作用[...
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- A Domino-Synthesized Dicoordinate Copper(I) Bis-imidazopyridine Complex Triggering Cuproptosis/Ferroptosis for Enhanced Cancer Immunotherapy被引量：0收藏
- 作者：Tian, Ning Ju, Haoyu Liu, Yu Huang, Jinmei Luan, Zhenggang Hou, Qifeng Chen, Qing Zhang, Bin Huang, Jin Zeng, Ming- Hua
- 机构：Guangxi Normal Univ;East China Univ Sci & Technol;Guangxi Univ Chinese Med;Shantou Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2026
- 关键词：copper complex cuproptosis domino reaction ferroptosis immunogenic cell death
