成果/Result
- Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs被引量：90收藏
- 作者：Mao, Fei Ni, Wei Xu, Xiang Wang, Hui Wang, Jing Ji, Min Li, Jian
- 机构：E China Univ Sci & Technol
- 来源：MOLECULES 2016
- 关键词：drug-like property chemical structure-related criteria ring system functional group the heavy atoms proportion drug design
- Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents被引量：83收藏
- 作者：Li, Xiaokang Wang, Huan Lu, Zhengyu Zheng, Xinyu Ni, Wei Zhu, Jin Fu, Yan Lian, Fulin Zhang, Naixia Li, Jian Zhang, Haiyan Mao, Fei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease被引量：75收藏
- 作者：Xu, Yi-xiang Wang, Huan Li, Xiao-kang Dong, Sheng-nan Liu, Wen-wen Gong, Qi Wang, Tian-duan-yi Tang, Yun Zhu, Jin Li, Jian Zhang, Hai-yan Mao, Fei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
- 关键词：Multifunctional agents AChE inhibitors MAO-B inhibitors Metal chelating agents Alzheimer's disease
- Development of the First Generation of Disulfide-Based Subtype Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors被引量：71收藏
- 作者：Liu, Yifu Xie, Zuoquan Zhao, Dan Zhu, Jin Mao, Fei Tang, Shuai Xu, Hui Luo, Cheng Geng, Meiyu Huang, Min Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2017
- Tacrine-propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer's disease被引量：62收藏
- 作者：Mao, Fei Li, Jianheng Wei, Hui Huang, Ling Li, Xingshu
- 机构：Sun Yat Sen Univ;E China Univ Sci & Technol;Guangdong Pharmaceut Univ
- 来源：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2015
- 关键词：Alzheimer's disease cholinesterase inhibitor hepatotoxicity neurotoxicity
- Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease被引量：57收藏
- 作者：Mao, Fei Wang, Huan Ni, Wei Zheng, Xinyu Wang, Manjiong Bao, Keting Ling, Dazheng Li, Xiaokang Xu, Yixiang Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2018
- 关键词：Alzheimer's disease drug repositioning dual-target inhibitor AChE inhibition PDE5 inhibition
- Curcumin-based polarity fluorescent probes: Design strategy and biological applications被引量：41收藏
- 作者：Hu, Linghao Shi, Donglei Li, Xinming Zhu, Jin Mao, Fei Li, Xiaokang Xia, Conglong Jiang, Bei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ
- 来源：DYES AND PIGMENTS 2020
- 关键词：Curcumin Polarity-specificity Polarity fluorescent probe Lysosome Live-cell imaging Design strategy
- Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents被引量：41收藏
- 作者：Xu, Yixiang Zhang, Jian Wang, Huan Mao, Fei Bao, Keting Liu, Wenwen Zhu, Jin Li, Xiaokang Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2019
- 关键词：Alzheimer's disease multifunctional agents AChE inhibitors MAO-B inhibitors metal chelating agents
- Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation被引量：39收藏
- 作者：Li, Xiaokang Wang, Huan Xu, Yixiang Liu, Wenwen Gong, Qi Wang, Wei Qiu, Xiaoxia Zhu, Jin Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2017
- 关键词：Alzheimer's disease depression multitarget-directed ligand ChE inhibition 5-HT1A agonist 5-HT reuptake inhibition
- Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat被引量：38收藏
- 作者：Li, Ruoxi Ling, Dazheng Tang, Tongke Huang, Zhenghui Wang, Manjiong Ding, Yan Liu, Taiping Wei, Hanwen Xu, Wenyue Mao, Fei Zhu, Jin Li, Xiaokang Jiang, Lubin Li, Jian
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci;ShanghaiTech Univ;Army Med Univ;Dali Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2021
- Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway被引量：35收藏
- 作者：Wei, Jinlian Chen, Xin Li, Yongyun Li, Ruoxi Bao, Keting Liao, Liang Xie, Yuqing Yang, Tiannuo Zhu, Jin Mao, Fei Ni, Shuaishuai Jia, Renbing Xu, Xiaofang Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Univ Tradit Chinese Med;Dali Univ;Tongji Univ
- 来源：ACTA PHARMACEUTICA SINICA B 2022
- 关键词：Conjunctival melanoma Cucurbitacin B Activity-based protein profiling G2 M cell cycle GRP78 FOXM1 KIF20A Rare tumor
- Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells被引量：35收藏
- 作者：Wu, Deng-wei Mao, Fei Ye, Yan Li, Jian Xu, Chuan-lian Luo, Xiao-min Chen, Jing Shen, Xu
- 机构：Zhejiang Sci Tech Univ;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACTA PHARMACOLOGICA SINICA 2015
- 关键词：Dengue virus antiviral drug NS2B/NS3 protease policresulen molecular docking molecular modeling
- Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice被引量：33收藏
- 作者：Fan, Lei Qiu, Xiao-xia Zhu, Zhi-yuan Lv, Jian-lu Lu, Jian Mao, Fei Zhu, Jin Wang, Jia-ying Guan, Xiao-wei Chen, Jing Ren, Jin Ye, Ji-ming Zhao, Yong-hua Li, Jian Shen, Xu
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;East China Univ Sci & Technol;Nanjing Univ Chinese Med;RMIT Univ
- 来源：ACTA PHARMACOLOGICA SINICA 2019
- 关键词：Alzheimer's disease nitazoxanide autophagy inflammation APP/PS1 transgenic mice
- Discovery of New Imidazole Derivatives Containing the 2,4-Dienone Motif with Broad-Spectrum Antifungal and Antibacterial Activity被引量：32收藏
- 作者：Liu, Chunliu Shi, Ce Mao, Fei Xu, Yong Liu, Jinyan Wei, Bing Zhu, Jin Xiang, Mingjie Li, Jian
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Humanwell Healthcare Grp Co Ltd
- 来源：MOLECULES 2014
- 关键词：imidazole 2,4-dienone broad-spectrum antifungal antibacterial
- Melting Point Distribution Analysis of Globally Approved and Discontinued Drugs: A Research for Improving the Chance of Success of Drug Design and Discovery被引量：32收藏
- 作者：Mao, Fei Kong, Qingya Ni, Wei Xu, Xiang Ling, Dazheng Lu, Zhengyu Li, Jian
- 机构：East China Univ Sci & Technol
- 来源：CHEMISTRYOPEN 2016
- 关键词：approved drugs discontinued drugs drug design and discovery drug-like properties Lipinskis rule of five melting point distribution
- Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety被引量：28收藏
- 作者：Wang, Manjiong Tang, Tongke Li, Ruoxi Huang, Zhenghui Ling, Dazheng Zheng, Lulu Ding, Yan Liu, Taiping Xu, Wenyue Zhu, Feng Min, Hui Boonhok, Rachasak Mao, Fei Zhu, Jin Li, Xiaokang Jiang, Lubin Li, Jian
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci;ShanghaiTech Univ;Army Med Univ;Univ S Florida
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2022
- Chlorpromazine Sensitizes Progestin-Resistant Endometrial Cancer Cells to MPA by Upregulating PRB被引量：25收藏
- 作者：Cui, Yunxia Wu, Huiwen Yang, Linlin Huang, Ting Li, Jian Gong, Xiaodi Li, Lijuan Sun, Xiao Mao, Fei Wang, Yudong
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Dali Univ;East China Univ Sci & Technol;Shanghai Municipal Key Clin Specialty
- 来源：FRONTIERS IN ONCOLOGY 2021
- 关键词：endometrial cancer chlorpromazine medroxyprogesterone acetate anticancer activity sequential treatment
- Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity被引量：25收藏
- 作者：Li, Baoli Ni, Shuaishuai Mao, Fei Chen, Feifei Liu, Yifu Wei, Hanwen Chen, Wenhua Zhu, Jin Lan, Lefu Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2018
- Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment被引量：25收藏
- 作者：Liu, Wenwen Wang, Huan Li, Xiaokang Xu, Yixiang Zhang, Jian Wang, Wei Gong, Qi Qiu, Xiaoxia Zhu, Jin Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2018
- 关键词：Depression Cognitive impairment Multitarget-directed ligand 5-HT1A agonist 5-HT reuptake inhibition ChE inhibition
- Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)被引量：24收藏
- 作者：Ni, Wei Wang, Huan Li, Xiaokang Zheng, Xinyu Wang, Manjiong Zhang, Jian Gong, Qi Ling, Dazheng Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2018
- 关键词：Multifunctional agents AChE inhibitors PDE5 inhibitors Alzheimer's disease
- Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease被引量：24收藏
- 作者：Li, Xiaokang Lu, Jian Xu, Yixiang Wang, Jiaying Qiu, Xiaoxia Fan, Lei Li, Baoli Liu, Wenwen Mao, Fei Zhu, Jin Shen, Xu Li, Jian
- 机构：East China Univ Sci & Technol;Nanjing Univ Chinese Med;Chinese Acad Sci
- 来源：ACTA PHARMACEUTICA SINICA B 2020
- 关键词：Alzheimer's disease Autophagy Nitazoxanide beta-amyloid Tau protein
- Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents被引量：21收藏
- 作者：Hu, Linghao Feng, Hongxuan Zhang, Hongguang Yu, Songda Zhao, Qinyuan Wang, Wei Bao, Fengxia Ding, Xun Hu, Jiajing Wang, Manjiong Xu, Yixiang Wu, Zengrui Li, Xiaokang Tang, Yun Mao, Fei Chen, Xiaoyan Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2020
- Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H被引量：21收藏
- 作者：Xiao, Qiang Dong, Ningning Yao, Xue Wu, Dang Lu, Yanli Mao, Fei Zhu, Jin Li, Jian Huang, Jin Chen, Aifang Huang, Lu Wang, Xuehai Yang, Guangxiao He, Guangyuan Xu, Yong Lu, Weiqiang
- 机构：Huazhong Univ Sci & Technol;E China Univ Sci & Technol;Hubei Biopharmaceut Ind Technol Inst Inc;E China Normal Univ
- 来源：SCIENTIFIC REPORTS 2016
- Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells被引量：21收藏
- 作者：Ni, Shuaishuai Liu, Qian Chen, Xin Ding, Lele Cai, Lili Mao, Fei Shi, Donglei Hoffman, Robert M. Li, Jian Jia, Lijun
- 机构：Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;Univ Calif San Diego
- 来源：SIGNAL TRANSDUCTION AND TARGETED THERAPY 2022
- Targeting GRP75 with a Chlorpromazine Derivative Inhibits Endometrial Cancer Progression Through GRP75-IP3R-Ca2+-AMPK Axis被引量：20收藏
- 作者：Wang, Qi Li, Lijuan Gao, Xiaoyan Zhang, Chunxue Xu, Chen Song, Lingyi Li, Jian Sun, Xiao Mao, Fei Wang, Yudong
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：ADVANCED SCIENCE 2024
- 关键词：chlorpromazine endometrial cancer GRP75 MAM
- Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo被引量：20收藏
- 作者：Ni, Shuaishuai Wei, Hanwen Li, Baoli Chen, Feifei Liu, Yifu Chen, Wenhua Xu, Yixiang Qiu, Xiaoxia Li, Xiaokang Lu, Yanli Liu, Wenwen Hu, Linhao Lin, Dazheng Wang, Manjiong Zheng, Xinyu Mao, Fei Zhu, Jin Lan, Lefu. Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2017
- Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo被引量：19收藏
- 作者：Chen, Xin Yang, Xi Mao, Fei Wei, Jinlian Xu, Yixiang Li, Baoli Zhu, Jin Ni, Shuaishuai Jia, Lijun Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Dali Univ;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021
- 关键词：Neddylation cullin1-Nedd8 Benzimidazole-derived inhibitor Anticancer
- A rapid-response near-infrared fluorescent probe with a large Stokes shift for senescence-associated β-galactosidase activity detection and imaging of senescent cells被引量：19收藏
- 作者：Qiu, Wenjing Li, Xiaokang Shi, Donglei Li, Xinming Gao, Ying Li, Jinwen Mao, Fei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2020
- 关键词：Senescence-associated beta-galactosidase NIR fluorescent probe Aging Senescent cells Living-cell imaging
- Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely被引量：19收藏
- 作者：Chen, Wenhua Huang, Zhenghui Wang, Wanyan Mao, Fei Guan, Longfei Tang, Yun Jiang, Hualiang Li, Jian Huang, Jin Jiang, Lubin Zhu, Jin
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2017
- 关键词：Antimalarial drug Plasmodium falciparum FP-2 PfDHFR Dual inhibitor
- Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes被引量：18收藏
- 作者：Xu, Yi-xiang Huang, Yun-yuan Song, Rong-rong Ren, Yan-liang Chen, Xin Zhang, Chao Mao, Fei Li, Xiao-kang Zhu, Jin Ni, Shuai-shuai Wan, Jian Li, Jian
- 机构：East China Univ Sci & Technol;Cent China Normal Univ;Shanghai Univ Tradit Chinese Med
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
- 关键词：Diabetes FBPase Disulfiram Covalent inhibitors Drug repurposing
