成果/Result
- Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors被引量：20收藏
- 作者：Dou, Dou Wang, Jie Qiao, Yunjin Wumaier, Gulinuer Sha, Wenjie Li, Wenjie Mei, Wenyi Yang, Tingyuan Zhang, Chen He, Huan Wang, Caolin Chu, Linna Sun, Baihui Su, Rongrong Ma, Xiangyu Gong, Mengdie Xie, Lijuan Jiang, Wenzhe Diao, Yanyan Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Xu, Yufang Li, Shengqing Li, Honglin
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
- 关键词：4-Anilinoquinazoline Non-small cell lung cancer (NSCLC) Epidermal growth factor receptor (EGFR) Kinase inhibitor Anti-proliferative activity
- Anti-metastatic effect and mechanisms of Wenshen Zhuanggu Formula in human breast cancer cells被引量：17收藏
- 作者：Han, Xiang-hui Wang, Chun-li Xie, Yan Ma, Jiang Zhang, Xiao-hui Hu, Qian-wen Lin, Ge Liu, Sheng Lu, Jin-gen
- 机构：Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Chinese Univ Hong Kong
- 来源：JOURNAL OF ETHNOPHARMACOLOGY 2015
- 关键词：Wenshen Zhuanggu Formula Traditional Chinese medicine Mesenchymal stem cells Breast cancer Metastases
- Discovery of novel 4-arylamino-quinazoline derivatives as EGFRL858R/T790M inhibitors with the potential to inhibit the non-small cell lung cancers被引量：14收藏
- 作者：Gan, Wenhui Wang, Caolin Pan, Qingshan Li, Yuzhen Guo, Yuping Fan, Dang Peng, Yuting Rao, Zixuan Xu, Shan Zheng, Pengwu Zhu, Wufu
- 机构：Jiangxi Sci & Technol Normal Univ;East China Univ Sci & Technol;Jiangxi Sci & Technol Normal Univ
- 来源：BIOORGANIC CHEMISTRY 2022
- 关键词：Quinazoline derivatives NSCLC EGFRL(858R/T790M) EGFR inhibitors
- Efficacy of WWQ-131, a highly selective JAK2 inhibitor, in mouse models of myeloproliferative neoplasms被引量：7收藏
- 作者：Ge, Huan Wang, Caolin Tian, Chaoquan Diao, Yanyan Wang, Wanqi Ma, Xiangyu Zhang, Jian Li, Honglin Zhao, Zhenjiang Zhu, Lili
- 机构：East China Univ Sci & Technol;East China Normal Univ
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2022
- 关键词：Selective JAK2 inhibitor JAK2 signaling pathway Myeloproliferative neoplasms WWQ-131
- Rational design and synthesis of 2,4-dichloro-6-methyl pyrimidine derivatives as potential selective EGFRT790M/L858R inhibitors for the treatment of non-small cell lung cancer被引量：6收藏
- 作者：Duan, Lei Chu, Cilong Huang, Xiaoling Yao, Huizhi Wen, Jie Chen, Rui Wang, Caolin Tu, Yuanbiao Lv, Qiaoli Pan, Qingshan Xu, Shan
- 机构：Jiangxi Sci & Technol Normal Univ;East China Univ Sci & Technol;Jangxi Univ Tradit Chinese Med;Jiangxi Canc Hosp;Jiangxi Sci & Technol Normal Univ
- 来源：ARCHIV DER PHARMAZIE 2024
- 关键词：docking EGFR T790M/L858R mutation NSCLC patient-derived xenograft
- Exploration of potential mechanism of Rougan formula against hepatic fibrosis by network analysis and experimental assessment被引量：6收藏
- 作者：Wang, Wenyi Zhang, Yu Jiang, Yue Wang, Yujie Zhu, Junfeng Wang, Chunli Han, Xianghui Wang, Jianyi
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med
- 来源：JOURNAL OF ETHNOPHARMACOLOGY 2023
- 关键词：Rougan formula Hepatic fibrosis Network pharmacology Hepatic stellate cell Pharmacological mechanism
- Design, synthesis, and biological evaluation of diphenyl ether substituted quinazolin-4-amine derivatives as potent EGFRL858R/T790M/C797S inhibitors被引量：6收藏
- 作者：Dou, Dou Zhang, Xingsen Wang, Jie Wumaier, Gulinuer Qiao, Yunjin Xie, Lijuan Jiang, Wenzhe Sha, Wenjie Li, Wenjie Mei, Wenyi Zhang, Chen He, Huan Wang, Caolin Wu, Lingkang Diao, Yanyan Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Xu, Yufang Li, Shengqing Li, Honglin
- 机构：East China Univ Sci & Technol;Hebei Agr Univ;Fudan Univ;East China Normal Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2024
- 关键词：NSCLC EGFR C797S mutation Resistance 4-Anilinoquinazoline
- Extraction optimisation and compositional characterisation of total flavonoids from the Chinese herb tulip: a natural source of antioxidants and anti-inflammatory agents被引量：3收藏
- 作者：Ye, Jiafeng Cao, Jiamin Chen, Xian Ma, Jingjing Li, Yangchen Gao, Xia Zhang, Yurui Wang, Chunli
- 机构：East China Univ Sci & Technol;Eneplus Biotech Co Ltd
- 来源：NATURAL PRODUCT RESEARCH 2024
- 关键词：Chinese herb tulip total flavonoids ultrasonic-assisted extraction (UAE) UPLC-Q exactive plus orbitrap MS antioxidant anti-inflammatory
- Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms被引量：2收藏
- 作者：Wang, Caolin Chen, Ziqi Wang, Siyu Wang, Jie Yu, Panpan Huang, Chulu Wu, Yunpeng Zhao, Zhenjiang Mei, Wenyi Li, Honglin Zhu, Lili
- 机构：East China Univ Sci & Technol;Lingang Lab;East China Normal Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2025
- Discovery of novel CSF1R inhibitor for triple-negative breast cancer (TNBC) treatment through TAMs reprogramming被引量：0收藏
- 作者：Sha, Wenjie Yan, Zitong Wu, Yunpeng Wang, Caolin Cen, Yiting Du, Husheng Yu, Panpan Chang, Longfeng Pang, Xuelian Chen, Ziqi Li, Shiliang Zhao, Zhenjiang Jiang, Hualiang Li, Honglin Chen, Zhuo
- 机构：East China Univ Sci & Technol;East China Normal Univ;Chinese Acad Sci;Meilong Rd 130
- 来源：BIOCHEMICAL PHARMACOLOGY 2026
- 关键词：CSF1R Kinase inhibitor TAMs Antitumor Tumor microenvironment TNBC
