成果/Result
- Total Synthesis and Stereochemical Assignment of Delavatine A: Rh-Catalyzed Asymmetric Hydrogenation of Indene-Type Tetrasubstituted Olefins and Kinetic Resolution through Pd Catalyzed Triflamide-Directed C-H Olefination被引量：77收藏
- 作者：Zhang, Zhongyin Wang, Jinxin Li, Jian Yang, Fan Liu, Guodu Tang, Wenjun He, Weiwei Fu, Jian-Jun Shen, Yun-Heng Li, Ang Zhang, Wei-Dong
- 机构：East China Univ Sci & Technol;Second Mil Med Univ;Chinese Acad Sci
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2017
- 关键词：Synthesis (chemical) - Cell culture - Kinetics - Olefins - Reaction intermediates - Stereochemistry - Palladium compounds - Polycyclic aromatic hydrocarbons - Catalysis - Hydrogenation - Sulfur compounds
- (-) and (+)-Merrilliaquinone, a pair of new quinone enantiomers from Illicium merrillianum and thEIr distinctive effect on human hepatoma and hepatic cells被引量：16收藏
- 作者：Tian, Xinhui Li, Li Pei, Jinpeng Yue, Rongcai Fang, Xin Zhang, Jianping He, Weiwei Shan, Lei Shen, Yunheng Zhang, Weidong
- 机构：Second Mil Med Univ;Chinese Acad Med Sci;Peking Union Med Coll;E China Univ Sci & Technol;Shanghai Inst Pharmaceut Ind
- 来源：RSC ADVANCES 2015
- 关键词：Chirality - Enantiomers - Spectroscopic analysis - Cell culture - Quantum theory - Mitochondria - Cell death - Cell membranes
- Celastrol as a tool for the study of the biological events of metabolic diseases被引量：14收藏
- 作者：Lan, Gongcai Zhang, Jie Ye, Wenbo Yang, Fan Li, Ang He, Weiwei Zhang, Wei-Dong
- 机构：Guangdong Pharmaceut Univ;East China Univ Sci & Technol;Chinese Acad Sci;Second Mil Med Univ;Jiangxi Qingfeng Pharmaceut Co Ltd
- 来源：SCIENCE CHINA-CHEMISTRY 2019
- 关键词：celastrol obesity type 2 diabetes endoplasmic reticulum stress inflammation
- Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi被引量：13收藏
- 作者：Zhang, Zhongyin Yang, Fan Fu, Jian-Jun Shen, Yun-Heng He, Weiwei Zhang, Wei-Dong
- 机构：Second Mil Med Univ;East China Univ Sci & Technol
- 来源：RSC ADVANCES 2016
- 关键词：Bioactivity - Drug products - Metabolites - Cell culture - Spectroscopic analysis
- Worm Generator: A System for High-Throughput in Vivo Screening被引量：8收藏
- 作者：Yang, Anqi Lin, Xiang Liu, Zijian Duan, Xin Yuan, Yurou Zhang, Jiaxuan Liang, Qilin Ji, Xianglin Sun, Nannan Yu, Huajun He, Weiwei Zhu, Lili Xu, Bingzhe Lin, Xudong
- 机构：Sun Yat sen Univ;City Univ Hong Kong;Guangdong Med Univ;East China Univ Sci & Technol
- 来源：NANO LETTERS 2023
- 关键词：triboelectric nanogenerator microfluidics Caenorhabditis elegans high-throughput drug screening
- Identification and Mechanistic Studies of a Cell Cycle Regulator JP18 from a Library of Synthetic Indole Terpenoid Mimics被引量：5收藏
- 作者：Pei, Jinpeng Zhou, Shupeng Yang, Fan Sun, Yu Li, Ang Zhang, Wei-Dong He, Weiwei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Second Mil Med Univ
- 来源：CHEMISTRY-AN ASIAN JOURNAL 2016
- 关键词：CDK/cyclin complexes cell cycle arrest hybrid structures indoles terpenoids
- Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A被引量：4收藏
- 作者：Peng, Yan Zhang, Yumeng Fang, Ruan Jiang, Hao Lan, Gongcai Xu, Zhou Liu, Yajie Nie, Zhaoyang Ren, Lu Wang, Fengcan Zhang, Shou-De Ma, Yuyong Yang, Peng Ge, Hong-Hua Zhang, Wei-Dong Luo, Cheng Li, Ang He, Weiwei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci;Zhengzhou Univ;Zhengzhou Univ
- 来源：ADVANCED SCIENCE 2024
- 关键词：Cdh1 CENP-A regulation colchicine-binding site inhibitor indole terpenoid target identification
