成果/Result
- A novel liposome-polymer hybrid nanoparticles delivering a multi-epitope self-replication DNA vaccine and its preliminary immune evaluation in experimental animals被引量：23收藏
- 作者：Zhao, Zhangting Ma, Xingyuan Zhang, Ruihuan Hu, Fabiao Zhang, Tong Liu, Yuping Han, Myong Hun You, Fang Yang, Yi Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;KIM IL SUNG Univ;Natl Univ Singapore;SinGENE Biotech Pte Ltd
- 来源：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2021
- 关键词：DNA vaccine Liposome-polymer hybrid nanoparticles Delivery Immune evaluation Infectious diseases
- Cascade enzymatic reactions for efficient carbon sequestration被引量：17收藏
- 作者：Xia, Shunxiang Zhao, Xueyan Frigo-Vaz, Benjamin Zheng, Wenyun Kim, Jungbae Wang, Ping
- 机构：Univ Minnesota;Univ Minnesota;E China Univ Sci & Technol;Korea Univ
- 来源：BIORESOURCE TECHNOLOGY 2015
- 关键词：Carbon capture and storage Isocitrate dehydrogenase Aconitase Carbon dioxide Biocatalysis
- Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin被引量：15收藏
- 作者：Liu, Di Guo, Hua Zheng, Wenyun Zhang, Na Wang, Tianwen Wang, Ping Ma, Xingyuan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2016
- 关键词：Heat-labile enterotoxin (LT) A2 domain Cell-penetrating Multi-endocytosis pathway Drugs delivery
- Highly Efficient Folding of Multi-Disulfide ProtEIns in Superoxidizing Escherichia coli Cytoplasm被引量：10收藏
- 作者：Zhang, Wenyao Zheng, Wenyun Mao, Miaowei Yang, Yi
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2014
- 关键词：redox potential disulfide formation oxidative protEIn folding superoxidizing cells
- Multiple targeting strategies achieve novel protEIn drug delivery into proapoptosis lung cancer cells by precisely inhibiting survivin被引量：8收藏
- 作者：Hu, Fabiao Yan, Ting Guo, Wei Liu, Qiuli Han, Myong Hun Liu, Chang Liu, Yuping Zheng, Wenyun You, Fang Yang, Yi Zhang, Wenliang Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;KIM IL SUNG Univ;Natl Univ Singapore;SinGENE Biotech Pte Ltd
- 来源：NANOSCALE 2020
- 关键词：Cancer cells - Tumors - Cell death - Mammals - Diseases - Targeted drug delivery - Biocompatibility - Controlled drug delivery - Recombinant protEIns
- Development of a synthetic library of humanized nanobodies for targeted IL-6 inhibition被引量：6收藏
- 作者：Wang, Lei Dong, Jiayi Wu, Chenlu Yan, Chenyue Bi, Chong Xu, Chengnan Wu, Yiling Zheng, Wenyun Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2024
- 关键词：nanobody humanization stability synthetic library phage display interleukin-6 blocking antibody
- A nanobody-based molecular toolkit for ubiquitin-proteasome system explores the main role of survivin subcellular localization被引量：6收藏
- 作者：Miao, Hui Liu, Chang Ouyang, Hao Zhang, Peiwen Liu, Yuping Zhang, Chen Deng, Changping Fu, Yunhui Niu, Jinping Zheng, Wenyun You, Fang Yang, Yi Ma, Xingyuan
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;Natl Univ Singapore
- 来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2023
- 关键词：survivin subcellular function nanobody targeted TRIM21 apoptosis and cell cycle anti-cancer
- Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment-mediated protEIn nanocages for enhancing cancer biotherapy被引量：5收藏
- 作者：Hu, Fabiao Deng, Changping Zhou, Yiwen Liu, Yuping Zhang, Tong Zhang, Peiwen Zhao, Zhangting Miao, Hui Zheng, Wenyun Zhang, Wenliang Wang, Meiyan Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ North Carolina Greensboro;East China Normal Univ;East China Normal Univ
- 来源：BIOENGINEERING & TRANSLATIONAL MEDICINE 2022
- 关键词：cancer precision therapy ferritin heavy chain nanocages matrix metalloprotEInase-2 survivin transcription and protEIn levels
- Construction and application of a multifunctional CHO cell platform utilizing Cre/lox and Dre/rox site-specific recombination systems被引量：5收藏
- 作者：Zhang, Chen Chang, Feng Miao, Hui Fu, Yunhui Tong, Xikui Feng, Yu Zheng, Wenyun Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2023
- 关键词：CHO Cre/lox Dre/rox CRISPR/Cas9 site-specific recombination hotspot production stability
- Design and evaluation of ionically crosslinked multifunctional ELP-SA composite hydrogels for 3D cell culture被引量：2收藏
- 作者：Chen, Yiying Wang, Yangmin Li, Yuxi Chen, Xingyang Zheng, Wenyun Wang, Tianwen Jia, Hao Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Anhui Polytech Univ;Shanghai Jiao Tong Univ
- 来源：REGENERATIVE BIOMATERIALS 2025
- 关键词：elastin-like polypeptide sodium alginate composite hydrogel 3D cell culture
- Screening and construction of nanobodies against human CD93 using phage libraries and study of thEIr antiangiogenic effects被引量：2收藏
- 作者：Miao, Hui Wu, Yiling Ouyang, Hao Zhang, Peiwen Zheng, Wenyun Ma, Xingyuan
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol
- 来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2024
- 关键词：CD93 nanobody phage display angiogenesis vascular permeability
- A Novel Method for Efficient Preparation of Mucosal Adjuvant Escherichia coli Heat-Labile Enterotoxin Mutant (LTm) by Artificially Assisted Self-Assembly In Vitro被引量：1收藏
- 作者：Liu, Di Zhang, Na Zheng, Wenyun Guo, Hua Wang, Xiaoli Wang, Tianwen Wang, Ping Ma, Xingyuan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2016
- 关键词：Heat-labile enterotoxin (LT) Mucosal adjuvant In vitro preparation Artificially assisted self-assembly
- Development of ZmT-PEG hydrogels through Michael addition reaction and protEIn self-assembly for 3D cell culture被引量：1收藏
- 作者：Fu, Yunhui Zhou, Yiwen Chen, Yiying Zhang, Zhedan Zhang, Chen Deng, Changping Tong, Xikui Zheng, Wenyun Wang, Meiyan Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Dahua Hosp Xuhui Dist;East China Univ Sci & Technol;Shanghai Univ
- 来源：BIOMATERIALS SCIENCE 2024
- 关键词：Animal cell culture - Batch cell culture - Gelation
- TGF-β1 fused to elastin-like polypeptides nanoparticles with kartogenin loading for mesenchymal stem cell directed cartilage differentiation and promoting in vivo repair被引量：1收藏
- 作者：Fu, Yunhui Li, Yuxi Wu, Chenlu Chen, Yiying Zhang, Chen Tong, Xikui Wang, Yangmin Shen, Yue Zheng, Wenyun Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2026
- 关键词：Cartilage - Cell culture - Elastin - Hyaluronic acid - Hydrogels - Nanoparticles - Pathology - Repair - Transmission electron microscopy
- Construction of a Synthetic Shark-Derived Nanobody Library with Conserved CDR3 Tryptophan and Its Application in Screening Antibodies Targeting Urinary Tumor Biomarkers被引量：0收藏
- 作者：Shen, Yue Li, Shipo Han, Bo Yin, Xuanwei Yan, Chenyue Wu, Lihua Cheng, Shiyang Zheng, Wenyun Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS BIOMATERIALS SCIENCE & ENGINEERING 2026
- 关键词：shark-derived nanobody synthetic library urinary tumor biomarker Hyal-1 PSA EN2
- Modulation of Gut Microbiota by ProtEIn-Oligosaccharide Maillard-Reaction-Derived Probiotic Microcapsules被引量：0收藏
- 作者：Zhang, Hongxing Shen, Yue Huang, Wanting Fang, Xinyi Wang, Yanlin Ma, Xingyuan Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanxi Anjianda Breeding Co Ltd
- 来源：FOOD BIOENGINEERING 2025
- 关键词：gut microbiota in vitro fermentation Maillard reaction microcapsule synbiotic
- The key technologies and main challenges for the engineering production of animal cell meat cultured in bioreactors被引量：0收藏
- 作者：Wang, Yangmin Tong, Xikui Niu, Jinping Chen, Xinyang Zheng, Wenyun Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FOOD PRODUCTION PROCESSING AND NUTRITION 2025
- 关键词：Cultured meat Animal cell reactor Key technologies Main challenges
