成果/Result
- Developing a Computational Framework To Advance Bioprocess Scale-Up被引量：87收藏
- 作者：Wang, Guan Haringa, Cees Noorman, Henk Chu, Ju Zhuang, Yingping
- 机构：East China Univ Sci & Technol ECUST;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：TRENDS IN BIOTECHNOLOGY 2020
- 关键词：Metabolism
- Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses被引量：81收藏
- 作者：Wang, Guan Tang, Wenjun Xia, Jianye Chu, Ju Noorman, Henk van Gulik, Walter M.
- 机构： State Key Laboratory of Bioreactor Engineering; DSM Biotechnology Center; Department of Biotechnology
- 来源：Engineering in Life Sciences 2020
- 关键词：Metabolism - Mass transfer - Mixing - Metabolic engineering - Batch data processing - Kinetics - Carbon dioxide
- A 9-pool metabolic structured kinetic model describing days to seconds dynamics of growth and product formation by Penicillium chrysogenum被引量：45收藏
- 作者：Tang, Wenjun Deshmukh, Amit T. Haringa, Cees Wang, Guan van Gulik, Walter van Winden, Wouter Reuss, Matthias Heijnen, Joseph J. Xia, Jianye Chu, Ju Noorman, Henk J.
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol;Univ Stuttgart
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2017
- 关键词：structured model black box model feast-famine kinetics Penicillium chrysogenum
- Effect of temperature and surfactant on biomass growth and higher-alcohol production during syngas fermentation by Clostridium carboxidivorans P7被引量：40收藏
- 作者：Shen, Shaohuang Wang, Guan Zhang, Ming Tang, Yin Gu, Yang Jiang, Weihong Wang, Yonghong Zhuang, Yingping
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIORESOURCES AND BIOPROCESSING 2020
- 关键词：Clostridium carboxidivorans P7 Higher alcohol Two-step temperature culture Surfactant Comparative transcriptome
- Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains被引量：40收藏
- 作者：Xia, Jianye Wang, Guan Fan, Meng Chen, Min Wang, Zeyu Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF CHEMICAL ENGINEERING 2021
- 关键词：Fermentation Scale-up Bioreactors Gas-liquid flow Kinetics
- Develop Dynamic Hybrid Modeling of Fuel Ethanol Fermentation Process by Integrating Biomass Concentration XGBoost Model and Kinetic Parameters Artificial Neural Network Model into Mechanism Model被引量：22收藏
- 作者：Li, Xinzhe Dong, Yufeng Chang, Lu Chen, Lifan Wang, Guan Zhuang, Yingping Yan, Xuefeng
- 机构： Key Laboratory of Smart Manufacturing in Energy Chemical Process; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2022
- 关键词：Biomass - Ethanol - Fermentation - Forecasting - Fuels - Glucose - Kinetic parameters - Process control
- Coupled metabolic-hydrodynamic modeling enabling rational scale-up of industrial bioprocesses被引量：21收藏
- 作者：Wang, Guan Haringa, Cees Tang, Wenjun Noorman, Henk Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：East China Univ Sci & Technol;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2020
- 关键词：CFD Euler-Langrange metabolic model metabolomics population heterogenEIty scale down
- A dynamic model-based preparation of uniformly-13C-labeled internal standards facilitates quantitative metabolomics analysis of Penicillium chrysogenum被引量：20收藏
- 作者：Wang, Guan Chu, Ju Zhuang, Yingping van Gulik, Walter Noorman, Henk
- 机构：East China Univ Sci & Technol;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2019
- 关键词：Dynamic Fed-batch model Isotope dilution mass spectrometry (IDMS) Perturbation Metabolomics Penicillium chrysogenum
- Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels被引量：18收藏
- 作者：Wang, Guan Wu, Baofeng Zhao, Junfei Haringa, Cees Xia, Jianye Chu, Ju Zhuang, Yingping Zhang, Siliang Heijnen, Joseph J. van Gulik, Walter Deshmukh, Amit T. Noorman, Henk J.
- 机构：ECUST;Delft Univ Technol;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2018
- 关键词：degeneration glucose transport power input redox energy metabolism scale down
- Leveraging and manufacturing in vitro multicellular spheroid-based tumor cell model as a preclinical tool for translating dysregulated tumor metabolism into clinical targets and biomarkers被引量：17收藏
- 作者：Wang, Tong Wang, Lin Wang, Guan Zhuang, Yingping
- 机构：East China Univ Sci & Technol ECUST
- 来源：BIORESOURCES AND BIOPROCESSING 2020
- 关键词：Multicellular tumor spheroids In vitro models Tumor metabolism Preclinical evaluation Cancer therapy Precision medicine
- Dynamic hybrid modeling of fuel ethanol fermentation process by integrating biomass concentration XGBoost model and kinetic parameter artificial neural network model into mechanism model被引量：16收藏
- 作者：Li, Xinzhe Dong, Yufeng Chang, Lu Chen, Lifan Wang, Guan Zhuang, Yingping Yan, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;POB 293
- 来源：RENEWABLE ENERGY 2023
- 关键词：Fuel ethanol fermentation process Hybrid model Mechanism model Extreme gradient boosting Artificial neural network
- A data enhancement method based on generative adversarial network for small sample-size with soft sensor application被引量：14收藏
- 作者：Zhang, Zhongyi Wang, Xueting Wang, Guan Jiang, Qingchao Yan, Xuefeng Zhuang, Yingping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：COMPUTERS & CHEMICAL ENGINEERING 2024
- 关键词：Small sample-size Generating adversarial network Soft sensor Process modeling
- Understanding the effect of temperature downshift on CHO cell growth, antibody titer and product quality by intracellular metabolite profiling and in vivo monitoring of redox state被引量：14收藏
- 作者：Zhu, Ziyu Chen, Xiaoqian Li, Wenhao Zhuang, Yingping Zhao, Yuzheng Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;East China Univ Sci & Technol;Chinese Acad Med Sci;East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY PROGRESS 2023
- 关键词：antibody CHO cell culture intracellular sensor metabolomics NAD(+)/NADH ratio NADPH redox state temperature downshift
- Harnessing microbial metabolomics for industrial applications被引量：13收藏
- 作者：Zhao, Jiachen Wang, Guan Chu, Ju Zhuang, Yingping
- 机构：ECUST
- 来源：WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2020
- 关键词：Industrial fermentation Metabolomics Metabolic engineering Process optimization System biology Synthetic biology
- Quantitative metabolomics and metabolic flux analysis reveal impact of altered trehalose metabolism on metabolic phenotypes of Penicillium chrysogenum in aerobic glucose-limited chemostats被引量：13收藏
- 作者：Wang, Guan Zhao, Junfei Wang, Xinxin Wang, Tong Zhuang, Yingping Chu, Ju Zhang, Siliang Noorman, Henk J.
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2019
- 关键词：Chemostat Genome-scale metabolic model Metabolomics Penicillium chrysogenum Trehalose metabolism Metabolic flux analysis
- Comparative Fluxome and Metabolome Analysis of Formate as an Auxiliary Substrate for Penicillin Production in Glucose-Limited Cultivation of Penicillium chrysogenum被引量：12收藏
- 作者：Wang, Guan Wang, Xinxin Wang, Tong van Gulik, Walter Noorman, Henk J. Zhuang, Yingping Chu, Ju Zhang, Siliang
- 机构：ECUST;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOTECHNOLOGY JOURNAL 2019
- 关键词：auxiliary substrates chemostat metabolomics penicillin Penicillium chrysogenum
- Neural networks-based hybrid beneficial variable selection and modeling for soft sensing被引量：11收藏
- 作者：Zhang, Zhongyi Jiang, Qingchao Wang, Guan Pan, Chunjian Cao, Zhixing Yan, Xuefeng Zhuang, Yingping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Univ Elect Power
- 来源：CONTROL ENGINEERING PRACTICE 2023
- 关键词：Deep neural network Variable selection Soft sensing Process modeling
- Application of a silica gel prolonged-release system for methanol in the production of biodiesel被引量：11收藏
- 作者：Luo, Yu Wang, Gang Ma, Yushu Wei, Dongzhi
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 2006
- 关键词：biodiesel lipase prolonged release silica gel
- A systematic evaluation of quenching and extraction procedures for quantitative metabolome profiling of HeLa carcinoma cell under 2D and 3D cell culture conditions被引量：10收藏
- 作者：Wang, Tong Wang, Xueting Zhuang, Yingping Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol;East China Univ Sci & Technol ECUST
- 来源：BIOTECHNOLOGY JOURNAL 2023
- 关键词：3D tumor spheroids extraction HeLa isotope dilution mass spectrometry metabolomics quenching sample preparation
- Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model被引量：9收藏
- 作者：Wang, Lin Wang, Xueting Wang, Tong Zhuang, Yingping Wang, Guan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2021
- 关键词：Drug resistance mechanism HeLa carcinoma cells Multicellular tumor spheroid Multi-omics analysis Preclinical evaluation Tumor metabolism
- Semi-supervised soft sensor method for fermentation processes based on physical monotonicity and variational autoencoders被引量：9收藏
- 作者：Cheng, Xinyue Yu, Zhenhua Wang, Guan Jiang, Qingchao Cao, Zhixing
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE 2024
- 关键词：Soft sensor Variational autoencoder Fermentation process Semi-supervised learning
- A machine learning-based approach for improving plasmid DNA production in Escherichia coli fed-batch fermentations被引量：7收藏
- 作者：Xu, Zhixian Zhu, Xiaofeng Mohsin, Ali Guo, Jianfei Zhuang, Yingping Chu, Ju Guo, Meijin Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY JOURNAL 2024
- 关键词：Escherichia coli heating rate machine learning multi-parameter correlation analysis plasmid fermentation
- Data-Augmented Deep Learning Algorithm for Accurate Control of Bioethanol Fermentation Using an Online Raman Analyzer被引量：6收藏
- 作者：Ji, Kaidi Yu, Xiaofei Chen, Lifan Wang, Yongbo Guo, Zhiqiang Chen, Biao Li, Qingyang Li, Zhen Zhang, Hu Wang, Guan Zhuang, Yingping Ruan, Yinlan
- 机构：Guilin Univ Elect Technol;Chinese Acad Sci;Guilin Univ Elect Technol;Guilin Univ Elect Technol;Guilin Univ Elect Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2025
- 关键词：data augmentation deep learning feedback control fermentation raman analyzer
- Enhanced variational autoencoder with continual learning capability for multimode process monitoring被引量：6收藏
- 作者：Yu, Zhenhua Wang, Guan Jiang, Qingchao Yan, Xuefeng Cao, Zhixing
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CONTROL ENGINEERING PRACTICE 2025
- 关键词：Multimode process monitoring Mode segmentation Continual learning Catastrophic forgetting
- Multiple feature fusion transformer for modeling penicillin fermentation process with unequal sampling intervals被引量：5收藏
- 作者：Sun, Yifei Yan, Xuefeng Jiang, Qingchao Wang, Guan Zhuang, Yingping Wang, Xueting
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2023
- 关键词：Multiple feature fusion Unequal sampling intervals Time series prediction Transformer Penicillin fermentation process
- Mutual information and attention-based variable selection for soft sensing of industrial processes被引量：4收藏
- 作者：Yu, Zhenhua Wang, Guan Yan, Xuefeng Jiang, Qingchao Cao, Zhixing
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF PROCESS CONTROL 2025
- 关键词：Soft sensing Variable selection Attention mechanisms Process modeling
- Overexpression of SLC2A1, ALDOC, and PFKFB4 in the glycolysis pathway drives strong drug resistance in 3D HeLa tumor cell spheroids被引量：2收藏
- 作者：Wang, Tong Wang, Xueting Zheng, Xuli Guo, Zhongfang Mohsin, Ali Zhuang, Yingping Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY JOURNAL 2024
- 关键词：ALDOC, drug resistance mechanism, HeLa cells, multicellular tumor spheroid
- Physiological Response of Penicillium chrysogenum to Mimicked Local and Global Perturbations of Substrate and Dissolved Oxygen Gradients at Industrial-Scale被引量：2收藏
- 作者：Chen, Yining Haringa, Cees Wang, Zejian Zhuang, Yingping Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;Delft Univ Technol;East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2025
- 关键词：dissolved oxygen gradients industrial-scale fermentation metabolomics Penicillium chrysogenum scale-down substrate gradients
- An industrial perspective on metabolic responses of Penicillium chrysogenum to periodic dissolved oxygen feast-famine cycles in a scale-down system被引量：2收藏
- 作者：Wang, Xueting Yang, Qi Haringa, Cees Wang, Zejian Chu, Ju Zhuang, Yingping Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;Delft Univ Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2024
- 关键词：dissolved oxygen flux analysis industrial metabolomics Penicillium chrysogenum scale down
- Process fault root cause diagnosis through state evolution mapping based on temporal unit shapelets被引量：0收藏
- 作者：Yu, Zhenhua Wang, Guan Jiang, Qingchao Yan, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF CHEMICAL ENGINEERING 2025
- 关键词：Root cause diagnosis Neural networks Shapelet Fermentation Bioprocess
