成果/Result
- Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway被引量：35收藏
- 作者：Wei, Jinlian Chen, Xin Li, Yongyun Li, Ruoxi Bao, Keting Liao, Liang Xie, Yuqing Yang, Tiannuo Zhu, Jin Mao, Fei Ni, Shuaishuai Jia, Renbing Xu, Xiaofang Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Univ Tradit Chinese Med;Dali Univ;Tongji Univ
- 来源：ACTA PHARMACEUTICA SINICA B 2022
- 关键词：Conjunctival melanoma Cucurbitacin B Activity-based protein profiling G2 M cell cycle GRP78 FOXM1 KIF20A Rare tumor
- Photocatalytic C-Si Bond Formations Using Pentacoordinate Silylsilicates as Silyl Radical Precursors: Synthetic Tricks Using Old Reagents被引量：22收藏
- 作者：Zhao, Yumo Wan, Yi Yuan, Qiyang Wei, Jinlian Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2023
- Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo被引量：19收藏
- 作者：Chen, Xin Yang, Xi Mao, Fei Wei, Jinlian Xu, Yixiang Li, Baoli Zhu, Jin Ni, Shuaishuai Jia, Lijun Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Dali Univ;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021
- 关键词：Neddylation cullin1-Nedd8 Benzimidazole-derived inhibitor Anticancer
- Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway被引量：14收藏
- 作者：Bao, Keting Li, Yongyun Wei, Jinlian Li, Ruoxi Yang, Jie Shi, Jiahao Li, Baoli Zhu, Jin Mao, Fei Jia, Renbing Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Dali Univ;East China Univ Sci & Technol
- 来源：CELL DEATH & DISEASE 2021
- Trilogy of drug repurposing for developing cancer and chemotherapy-induced heart failure co-therapy agent被引量：8收藏
- 作者：Chen, Xin Mu, Xianggang Ding, Lele Wang, Xi Mao, Fei Wei, Jinlian Liu, Qian Xu, Yixiang Ni, Shuaishuai Jia, Lijun Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Jinan Univ
- 来源：ACTA PHARMACEUTICA SINICA B 2024
- 关键词：Anticancer Heart failure Complication Drug repurposing Bi-functional drug
- Drug repurposing of propafenone to discover novel anti-tumor agents by impairing homologous recombination to delay DNA damage recovery of rare disease conjunctival melanoma被引量：5收藏
- 作者：Wei, Jinlian Li, Yongyun Li, Ruoxi Chen, Xin Yang, Tiannuo Liao, Liang Xie, Yuqing Zhu, Jin Mao, Fei Jia, Renbing Xu, Xiaofang Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Dali Univ;Tongji Univ;Hainan Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2023
- 关键词：Conjunctival melanoma Propafenone Homologous recombination DNA damage MRE11-RAD50-NBS1 complex
- Discovery of N-Trifluoromethylated Noscapines as Novel and Potent Agents for the Treatment of Glioblastoma被引量：4收藏
- 作者：Cui, Guangwei Fan, Yuhang Yang, Yue Ma, Yiwen Deng, Haiyang Wang, Pan Zhu, Yuxin Li, Jian Wei, Jinlian Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2024
- Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R Ca2+-PIK3CA pathway-被引量：3收藏
- 作者：Song, Lingyi Wu, Huiwen Sun, Xiao Liu, Xiaohu Ling, Xianwu Ni, Wei Li, Lijuan Liu, Beibei Wei, Jinlian Li, Xiaokang Li, Jian Wang, Yudong Mao, Fei
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shihezi Univ;Hainan Univ;Shanghai Municipal Key Clin Specialty
- 来源：ISCIENCE 2025
- Structural simplification and ester bond flipping lead to bis-benzodioxole derivatives as potential hypolipidemic and hepatoprotective agent被引量：3收藏
- 作者：Xie, Yundong Wang, Siyao Sun, Mengfei Pang, Yan Liu, Jiping Shi, Yongheng Xu, Xinya Wei, Peifeng Wei, Jinlian He, Shipeng
- 机构：Shaanxi Univ Chinese Med;Shaanxi Adm Tradit Chinese Med;Shaanxi Univ Tradit Chinese Med;East China Univ Sci & Technol;Shanghai Univ
- 来源：MEDICINAL CHEMISTRY RESEARCH 2024
- 关键词：Bis-benzodioxole derivatives Hypolipidemia Antioxidant Anti-inflammation Hepatoprotection
- Molecular hybridization method for obtaining paeonol-based fibrate derivatives with potent lipid-lowering and hepatoprotective activity被引量：1收藏
- 作者：Quan, Lina Guo, Ying Wang, Siyao Sun, Mengfei Pang, Yan Cui, Chunli Wang, Jinrui Wei, Jinlian Wei, Peifeng Xie, Yundong
- 机构：Shaanxi Univ Chinese Med;Northwest Univ;East China Univ Sci & Technol;Shaanxi Univ Tradit Chinese Med
- 来源：MEDICINAL CHEMISTRY RESEARCH 2024
- 关键词：Paeonol-based fibrate derivatives Hypolipidemia Hepatoprotection PPAR-alpha HMG-CoA
- Drug Repurposing of ACT001 to Discover Novel Promising Sulfide Prodrugs with Improved Safety and Potent Activity for Neutrophil-Mediated Antifungal Immunotherapy被引量：1收藏
- 作者：Lu, Xiangran Wang, Rongrong Yu, Yao Wei, Jinlian Xu, Yixiang Zhou, Luoyifan Mao, Fei Li, Jian Li, Xiaokang Jia, Xinming
- 机构：Tongji Univ;East China Univ Sci & Technol;Dali Univ;Hainan Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2024
- Design, synthesis and anti-GBM activities of amide-modified Curcumol derivatives被引量：1收藏
- 作者：Hu, Shiqi Fan, Yuhang Zhao, Yumo Gao, Zhengyang Lu, Jie Li, Jian Wei, Jinlian Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2025
- 关键词：Curcumol Amide-modification Anti-GBM activity BBB permeability
- PyfSeTs as a novel and photosensitive reagent for green light-induced arene C-H selenenylation: a versatile strategy for the synthesis of aryl selenides被引量：0收藏
- 作者：Shi, Haoliang Qu, Huorong Wang, Xinyan Wei, Jinlian Wu, Shanchao Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Naval Med Univ
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2026
- 关键词：Aromatic hydrocarbons - Drug discovery - Drug products - Molecular oxygen - Reagents - Redox reactions - Selenium compounds
- Discovery of tetrahydrothiazolopyridine-incorporated curcumol derivatives as novel and highly potent anti-cancer agents被引量：0收藏
- 作者：Guo, Shixun Fan, Yuhang Li, Wei Lu, Kailin Wang, Qiang Meng, Chong Tong, Yuxuan Li, Jian Wei, Jinlian Zhang, Yongqiang
- 机构：East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2026
- 可见光/路易斯碱协同催化的三氟甲基取代烯烃脱氟硅化反应研究被引量：0收藏
- 作者：朱佳洁 万义 袁启洋 魏金莲 张永强
- 机构：华东理工大学药学院
- 来源：《有机化学》 2023
- 关键词：可见光催化 路易斯碱催化 硅硼烷 三氟甲基取代烯烃 偕二氟烯丙基硅合成
- 摘要：以三氟甲基取代烯烃为底物,使用硅硼烷为硅自由基供体,开发了一项可见光/路易斯碱协同催化的脱氟硅化反应新技术,实现了多样性偕二氟烯丙基硅砌块的绿色高效合成.新反应以奎宁环为路易斯碱催化剂,通过其对硅硼键的辅助活化促进硅自由...
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- Discovery of Hirsutellones as Nucleolin-Targeting Natural Macrocycles for Triple-Negative Breast Cancer Treatment被引量：0收藏
- 作者：Gong, Lizhi Yang, Jin Guo, Jiacheng Gao, Zhen Gao, Ning Wu, Yuzhen Xiong, Pengyu Xin, Xiujuan Li, Baoli Li, Jian Wei, Jinlian An, Faliang
- 机构：East China Univ Sci & Technol;Bohai Rim Adv Res Inst Drug Discovery;Hainan Univ;East China Univ Sci & Technol;Shihezi Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2026
- Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies被引量：0收藏
- 作者：Liao, Liang Wang, Qiang Gao, Zhengyang Liu, Jiayao Tong, Yuxuan Chen, Xin Zhu, Jin Li, Jian Wei, Jinlian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shihezi Univ;Hainan Univ
- 来源：ACTA PHARMACEUTICA SINICA B 2026
- 关键词：CRBN Fluorescence polarization Rifamycin O Novel ligand Hematopoietic malignancies IKZF1/3 Molecular glue Proteasomal degradation
