成果/Result
- Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat被引量：38收藏
- 作者：Li, Ruoxi Ling, Dazheng Tang, Tongke Huang, Zhenghui Wang, Manjiong Ding, Yan Liu, Taiping Wei, Hanwen Xu, Wenyue Mao, Fei Zhu, Jin Li, Xiaokang Jiang, Lubin Li, Jian
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci;ShanghaiTech Univ;Army Med Univ;Dali Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2021
- Drug repositioning by prediction of drug's anatomical therapeutic chemical code via network-based inference approaches被引量：37收藏
- 作者：Peng, Yayuan Wang, Manjiong Xu, Yixiang Wu, Zengrui Wang, Jiye Zhang, Chao Liu, Guixia Li, Weihua Li, Jian Tang, Yun
- 机构：East China Univ Sci & Technol
- 来源：BRIEFINGS IN BIOINFORMATICS 2021
- 关键词：anatomical therapeutic chemical code drug repositioning network-based inference
- Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety被引量：28收藏
- 作者：Wang, Manjiong Tang, Tongke Li, Ruoxi Huang, Zhenghui Ling, Dazheng Zheng, Lulu Ding, Yan Liu, Taiping Xu, Wenyue Zhu, Feng Min, Hui Boonhok, Rachasak Mao, Fei Zhu, Jin Li, Xiaokang Jiang, Lubin Li, Jian
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci;ShanghaiTech Univ;Army Med Univ;Univ S Florida
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2022
- Chlorpromazine Sensitizes Progestin-Resistant Endometrial Cancer Cells to MPA by Upregulating PRB被引量：25收藏
- 作者：Cui, Yunxia Wu, Huiwen Yang, Linlin Huang, Ting Li, Jian Gong, Xiaodi Li, Lijuan Sun, Xiao Mao, Fei Wang, Yudong
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Dali Univ;East China Univ Sci & Technol;Shanghai Municipal Key Clin Specialty
- 来源：FRONTIERS IN ONCOLOGY 2021
- 关键词：endometrial cancer chlorpromazine medroxyprogesterone acetate anticancer activity sequential treatment
- Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift被引量：20收藏
- 作者：Li, Xinming Shi, Donglei Song, Yihe Xu, Yixiang Gao, Ying Qiu, Wenjing Chen, Xin Li, Xiaokang Huang, Yunyuan Feng, Yanjun Li, Baoli Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;East China Univ Sci & Technol;Dali Univ;Tongji Univ
- 来源：CHINESE CHEMICAL LETTERS 2022
- 关键词：Heart failure Monoamine oxidase A Oxidative stress Fluorescent probe Far-red emission Diagnosis
- Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo被引量：19收藏
- 作者：Chen, Xin Yang, Xi Mao, Fei Wei, Jinlian Xu, Yixiang Li, Baoli Zhu, Jin Ni, Shuaishuai Jia, Lijun Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Dali Univ;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021
- 关键词：Neddylation cullin1-Nedd8 Benzimidazole-derived inhibitor Anticancer
- A rapid-response near-infrared fluorescent probe with a large Stokes shift for senescence-associated β-galactosidase activity detection and imaging of senescent cells被引量：19收藏
- 作者：Qiu, Wenjing Li, Xiaokang Shi, Donglei Li, Xinming Gao, Ying Li, Jinwen Mao, Fei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2020
- 关键词：Senescence-associated beta-galactosidase NIR fluorescent probe Aging Senescent cells Living-cell imaging
- Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway被引量：14收藏
- 作者：Bao, Keting Li, Yongyun Wei, Jinlian Li, Ruoxi Yang, Jie Shi, Jiahao Li, Baoli Zhu, Jin Mao, Fei Jia, Renbing Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Dali Univ;East China Univ Sci & Technol
- 来源：CELL DEATH & DISEASE 2021
- Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents被引量：13收藏
- 作者：Li, Ruoxi Ling, Dazheng Tang, Tongke Huang, Zhenghui Wang, Manjiong Mao, Fei Zhu, Jin Jiang, Lubin Li, Jian Li, Xiaokang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Dali Univ;East China Univ Sci & Technol;ShanghaiTech Univ
- 来源：CHINESE CHEMICAL LETTERS 2021
- 关键词：Malaria PfHDAC inhibitor Drug repurposing Epigenetic modulator Erythrocytic therapy
- A senolytic strategy integrating multiple technologies delays aging被引量：1收藏
- 作者：Guo, Yuan Li, Jian
- 机构：Northwest Univ;East China Univ Sci & Technol
- 来源：NATURE AGING 2023
