成果/Result
- Secondary Amine Pendant β-Peptide Polymers Displaying Potent Antibacterial Activity and Promising Therapeutic Potential in Treating MRSA-Induced Wound Infections and Keratitis被引量：124收藏
- 作者：Qian, Yuxin Deng, Shuai Cong, Zihao Zhang, Haodong Lu, Ziyi Shao, Ning Bhatti, Sonia Abid Zhou, Cong Cheng, Jiagao Gellman, Samuel H. Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Wisconsin
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2022
- 关键词：Amines - Antibiotics - Cytotoxicity - Amino acids - Functional polymers
- Insights into pesticide toxicity against aquatic organism: QSTR models on Daphnia Magna被引量：53收藏
- 作者：He, Lujue Xiao, Keya Zhou, Cong Li, Guanglong Yang, Hongbin Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 2019
- 关键词：Pesticide Aquatic toxicity Daphnia magna Quantitative structure toxicity relationship (QSTR) Machine learning
- Rational Exploration of Novel SDHI Fungicide through an Amide-?-ketonitrile Bioisosteric Replacement Strategy被引量：42收藏
- 作者：Zhou, Cong Sun, Xujuan Fu, Wen Li, Zhong Cheng, Jiagao Maienfisch, Peter
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2023
- 关键词：?-ketonitriles succinate dehydrogenase inhibitors fungicidal activity bioisosteric replacement molecular docking 3D-QSAR
- Silicon-Containing Complex II Acaricides-Design, Synthesis, and Pharmacological Optimization被引量：30收藏
- 作者：Zhou, Cong Wang, Xin Quan, Xiaocao Cheng, Jiagao Li, Zhong Maienfisch, Peter
- 机构：East China Univ Sci & Technol;CreInSol MCB
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022
- 关键词：carbon-silicon bioisosteric replacements silicon-containing drugs and pesticides complex II acaricides cyflumetofen structure-activity relationship mode of action computational modeling
- Reversible Regulation of Succinate Dehydrogenase by Tools of Photopharmacology被引量：28收藏
- 作者：Fu, Wen Shao, Zhongli Sun, Xujuan Zhou, Cong Xu, Zhiping Zhang, Yang Cheng, Jiagao Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022
- 关键词：regulation SDH photochromic ligands azobenzene optical control
- Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement被引量：28收藏
- 作者：Zhou, Cong Cheng, Jiagao Beadle, Ryan Earley, Fergus G. Li, Zhong Maienfish, Peter
- 机构：East China Univ Sci & Technol;Syngenta Crop Protect AG;Syngenta Crop Protect AG;Univ York
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2020
- 关键词：Discovery of Sila-Cyflumetofen Beta-ketonitrile acaricide Carbon-silicon bioisosteric replacement Succinate ubiquinone oxidoreductase Homology model Spider mite SQR inhibition
- Anthranilic Diamides Containing Monofluoroalkene Amide Linkers as Potential Insect RyR Activators: Design, Synthesis, Bio-evaluation, and Computational Study被引量：23收藏
- 作者：Yang, Guantian Zhou, Cong Wang, Yutong Li, Yuxin Gu, Yucheng Li, Zhong Cheng, Jiagao Xu, Xiaoyong
- 机构：East China Univ Sci & Technol;Nankai Univ;Syngenta
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2023
- 关键词：anthranilic diamides ryanodine receptor insecticidal activity acrylamide monofluoroalkene
- 3D-QSAR model-oriented optimization of Pyrazole β-Ketonitrile derivatives with diphenyl ether moiety as novel potent succinate dehydrogenase inhibitors被引量：16收藏
- 作者：Cheng, Liangliang Zhou, Cong Yuan, Qinglong Zhang, Letian Shao, Xusheng Xu, Xiaoyong Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol
- 来源：PEST MANAGEMENT SCIENCE 2024
- 关键词：succinate dehydrogenase inhibitors beta-Ketonitriles fungicide diphenyl ether pesticide molecular design
- Design, synthesis and insecticidal evaluation of phthalic diamide analogs containing maleic diamide structures被引量：14收藏
- 作者：Pang, Xiwen Han, Li Zhou, Cong Xu, Xiaoyong Li, Zhong
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：ADVANCED AGROCHEM 2022
- 关键词：Keywords Diamide insecticide Insecticidal activity Maleic diamide Scaffold hopping Olefin
- Discovery of Potential Neonicotinoid Insecticides by an Artificial Intelligence Generative Model and Structure-Based Virtual Screening被引量：13收藏
- 作者：Kong, Yijin Zhou, Cong Tan, Du Xu, Xiaoyong Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：neonicotinoid insecticides generative model transfer learning virtual screening moleculardynamics simulations
- Synthesis and activity-detection of photoswitchable ligands with fipronil to insect被引量：10收藏
- 作者：Hou, Qing-Qing Huang, Qiu-Tang Xu, Qi Zhou, Cong Du, Yao-Yao Ji, Yun-Fan Xu, Zhi-Ping Cheng, Jia-Gao Zhao, Chun-Qing Li, Zhong Shao, Xu-Sheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Nanjing Agr Univ
- 来源：PEST MANAGEMENT SCIENCE 2023
- 关键词：azobenzene dithienylethene fipronil GABA receptor photopharmacology mosquito
- Design, Synthesis, and Insecticidal Evaluation of N-Pyridylpyrazole Amide Derivatives Containing 4,5-Dihydroisoxazole Amide as Potential Ryanodine Receptor Activators被引量：10收藏
- 作者：Pang, Xiwen Han, Li Zhou, Cong Li, Yuxin Xu, Xiaoyong Shao, Xusheng Li, Zhong
- 机构：East China Univ Sci & Technol;Nankai Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2023
- 关键词：anthranilic diamides 4,5-dihydroisoxazol insecticidal activity ryanodine receptor
- Diamides conformationally restricted with central amino acid: Design, synthesis, and biological activities被引量：10收藏
- 作者：Chen, Rui-Jia Zhou, Cong Dong, Le-Feng Feng, Ting-Ting Wang, Gang-Ao Wang, Jun-Jie Gu, Yu-Cheng Xu, Zhi-Ping Cheng, Jia-Gao Shao, Xu-Sheng Xu, Xiao-Yong Li, Zhong
- 机构：East China Univ Sci & Technol;Syngenta
- 来源：JOURNAL OF HETEROCYCLIC CHEMISTRY 2022
- Insights into the synergistic mechanism of target resistance: A case study of N. lugens RDL-GABA receptors and fipronil被引量：7收藏
- 作者：Li, Ting Zhou, Cong Zheng, Nan Yang, Hongbin Kuang, Guanglin Shao, Xusheng Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOPHYSICAL CHEMISTRY 2020
- 关键词：Resistance RDL-GABA receptor Fipronil Molecular dynamics simulation Homology modelling
- Computational Modeling Oriented Substructure Splicing Application in the Identification of Thiazolidine Derivatives as Potential Low Honeybee Toxic Neonicotinoids被引量：6收藏
- 作者：Zhou, Cong Kong, Yijin Zhang, Huihui Zhai, Na Li, Zhong Qian, Xuhong Liu, Zewen Cheng, Jiagao
- 机构：East China Univ Sci & Technol;Nanjing Agr Univ;East China Normal Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：neonicotinoid insecticides thiazolidine derivatives insecticidal activity bee toxicity acetylcholinebinding protein
- Discovery of Novel Nicotinamide Derivatives by a Two-Step Strategy of Azo-Incorporating and Bioisosteric Replacement被引量：5收藏
- 作者：Ru, Yifan Fu, Wen Guo, Sifan Li, Xiaoyan Zhou, Cong Xu, Zhiping Cheng, Jiagao Li, Zhong Shao, Xusheng
- 机构：East China Univ Sci & Technol;Yantai Inst China Agr Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024
- 关键词：nicotinamide azo-incorporating bioisostericreplacement fungicidal spectrum SDH
- Novel Acaricidal Silico-Containing Pyrazolyl Acrylonitrile Derivatives Identified through Rational Carbon-Silicon Bioisosteric Replacement Strategy被引量：5收藏
- 作者：Zhou, Cong Li, Zhong Qian, Xuhong Cheng, Jiagao Maienfisch, Peter
- 机构：East China Univ Sci & Technol;East China Normal Univ;CreInSol MCB
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2023
- 关键词：carbon-siliconbioisosteric replacement pyrazolylacrylonitrile acaricides cyenopyrafen cyetpyrafen complex II binding site structure activity relationship computational modeling
- 吡唑并嘧啶衍生物的设计、合成、杀虫活性及其与γ -氨基丁酸受体的结合模式被引量：4收藏
- 作者：栗广龙 江卓媛 周聪 须志平 李忠 程家高
- 机构：华东理工大学药学院
- 来源：《农药学学报》 2021
- 关键词：吡唑并嘧啶 氟虫腈 骨架跃迁 杀虫活性 γ-氨基丁酸受体 结合模式
- 摘要：基于氟虫腈低能构象进行骨架跃迁,设计、合成了25个未见文献报道的苯基吡唑并嘧啶胺和苯基吡唑并嘧啶酮类化合物,所有化合物的结构均通过核磁共振氢谱(^(1)H NMR)、碳谱(^(13)C NMR)及高分辨质谱(HRMS)确...
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- Identification of potential novel insect TRPV channel modulators by homology modeling, binding mode analysis, virtual screening studies and chemical optimization被引量：3收藏
- 作者：Li, Xiaoyang Zhou, Cong He, Lujue Xu, Zhiping Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol
- 来源：NEW JOURNAL OF CHEMISTRY 2024
- 关键词：Binding energy - Binding sites - Modulators - Pyridine - Scaffolds
- Discovery of Novel Neonicotinoids with Conjugated Diene Enabled by Cascade Allylation/Isomerization Synthetic Methodology被引量：3收藏
- 作者：Zhang, Dongxu Zhou, Cong Qi, Suzhen Zhang, Huihui Shao, Xusheng Xu, Xiaoyong Cheng, Jiagao Liu, Zewen Li, Zhong Yang, Wu-Lin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Agr Sci;Nanjing Agr Univ
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2025
- 关键词：neonicotinoid insecticides insect resistance bee toxicity conjugated system insecticidal activity cascade reaction
- Design, Synthesis, Insecticidal Evaluation and Modeling Studies on 1,4,6,7-tetrahydropyrazolo[3,4-d][1,3]oxazine Derivatives: An Application of Scaffold Hopping Strategy on Fipronil被引量：2收藏
- 作者：Li, Guanglong Zhou, Cong Zhu, Chengchun He, Lujue Li, Xiaoyang Xu, Zhiping Xu, Xiaoyong Shao, Xusheng Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：LETTERS IN DRUG DESIGN & DISCOVERY 2019
- 关键词：Scaffold hopping fipronil low energy conformation insecticidal activity molecular modeling GABA receptors
- Novel Synthetic Method and Insecticidal Evaluation of CF3-Containing Polycyclic Neonicotinoid Derivatives被引量：2收藏
- 作者：Zeng, Xiaoqin Zhou, Cong Xu, Qian Shao, Xusheng Xu, Xiaoyong Cheng, Jiagao Yang, Wu-Lin Li, Zhong
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2025
- 关键词：neonicotinoid insecticides insecticidal activity trifluoromethyl group annulation reaction molecular docking
- Discovery of Novel Pyrazole β-Ketonitrile Derivatives as Broad Spectrum SDHI Fungicides by Introducing a Flexible Motif被引量：2收藏
- 作者：Cheng, Liangliang Wang, Hanting Zhou, Cong Qin, Jiawei Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2025
- 关键词：fungicide succinate dehydrogenase inhibitors beta-ketonitriles molecular docking molecularflexibility
- N-Difluoromethylthiophthalimide Reagents for Modular Synthesis of Diversified α-Difluoromethylthiolated Ketones被引量：2收藏
- 作者：Liang, Junqing Fu, Wen Dong, Lefeng Zhou, Cong Yuan, Qinglong Chang, Wenning Yang, Wu-Lin Xu, Xiaoyong Shao, Xusheng Li, Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2023
- Design, Synthesis, and Insecticidal Activity of 3-(6-Methyltriazinone)-3,4-dihydrobenzo[b][1,5]diazin-2(1H)-ones: Conformationally Restricted Pymetrozine Analogues被引量：2收藏
- 作者：Li, Xiaoyang Zhou, Cong Yang, Wulin Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol
- 来源：CHEMISTRYSELECT 2024
- 关键词：Conformational restriction Molecular docking Pymetrozine Ring-closure TRPV channel
- Hit to lead optimization of carbothioate derivatives as novel succinate dehydrogenase inhibitors using a multistep virtual screening approach被引量：2收藏
- 作者：Zhou, Cong Wang, Cong Sun, Xujuan Cheng, Liangliang Shao, Xusheng Xu, Zhiping Xu, Xiaoyong Li, Zhong Qian, Xuhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol;East China Normal Univ;East China Univ Sci & Technol
- 来源：PEST MANAGEMENT SCIENCE 2025
- 关键词：fungicide succinate dehydrogenase inhibitors virtual screening carbothioates lead optimization
- Novel Insecticidal Benzo[4,5]imidazo[1,2-b]pyrazole Derivatives Idenatified Through Ring-Closure Scaffold Hopping on Fipronil被引量：1收藏
- 作者：Zhou, Cong Li, Guanglong Wang, Sihui Li, Zhong Qian, Xuhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol;East China Normal Univ
- 来源：CHEMISTRY & BIODIVERSITY 2025
- 关键词：Scaffold hopping Fipronil Insecticidal activity GABARs Binding mode
- Binding differences of fluxapyroxad with succinate dehydrogenase across species: insights from in silico simulations被引量：1收藏
- 作者：Zhai, Na Zhou, Cong Cheng, Liangliang Xu, Xiaoyong Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PEST MANAGEMENT SCIENCE 2025
- 关键词：succinate dehydrogenase fluxapyroxad receptor structure prediction binding mode molecular dynamics binding free energy
- Novel Insecticidal Pyridylhydrazono Derivatives Identified via Scaffold Hopping and Conformation Regulation Strategies被引量：1收藏
- 作者：Li, Xiaoyang Zhou, Cong Yang, Wulin Li, Zhong Cheng, Jiagao
- 机构：East China Univ Sci & Technol
- 来源：CHEMISTRY & BIODIVERSITY 2024
- 关键词：Pymeteozine Scaffold hopping Molecular docking Conformation regulation Potential energy surface scanning
- Convenient access to L-3,4,5-trioxygenated phenylalanine compounds from L-tyrosine被引量：1收藏
- 作者：Zhou, Shengfeng Zhou, Chen Lu, Qian Liu, Xintong Yuan, Jie Yu, Xinhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：TETRAHEDRON 2020
- 关键词：Trioxygenated phenylalanine L-tyrosine Bishydroxylation Trabectedin
