成果/Result
- Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis被引量：155收藏
- 作者：Jiang, Kai Xu, Yue Wang, Dandan Chen, Feng Tu, Zizhuo Qian, Jie Xu, Sheng Xu, Yixiang Hwa, John Li, Jian Shang, Hongcai Xiang, Yaozu
- 机构：Tongji Univ;East China Univ Sci & Technol;Yale Univ;Beijing Univ Chinese Med
- 来源：PROTEIN & CELL 2022
- 关键词：myocardial infarction SGLT2 inhibitors empagliflozin cardioprotection NHE1 autosis
- Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease被引量：75收藏
- 作者：Xu, Yi-xiang Wang, Huan Li, Xiao-kang Dong, Sheng-nan Liu, Wen-wen Gong, Qi Wang, Tian-duan-yi Tang, Yun Zhu, Jin Li, Jian Zhang, Hai-yan Mao, Fei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
- 关键词：Multifunctional agents AChE inhibitors MAO-B inhibitors Metal chelating agents Alzheimer's disease
- Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease被引量：57收藏
- 作者：Mao, Fei Wang, Huan Ni, Wei Zheng, Xinyu Wang, Manjiong Bao, Keting Ling, Dazheng Li, Xiaokang Xu, Yixiang Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2018
- 关键词：Alzheimer's disease drug repositioning dual-target inhibitor AChE inhibition PDE5 inhibition
- Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain被引量：43收藏
- 作者：Gong, Jing Du, Fang Qian, Zhong Ming Luo, Qian Qian Sheng, Yuan Yung, Wing-ho Xu, Yan Xin Ke, Ya
- 机构：E China Univ Sci & Technol;Chinese Univ Hong Kong;Fudan Univ
- 来源：FREE RADICAL BIOLOGY AND MEDICINE 2016
- 关键词：Hepcidin brain iron Reactive oxygen species (ROS) Cortex Hippocampus Striatum Substantia nigra Iron-overloaded rat
- Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents被引量：41收藏
- 作者：Xu, Yixiang Zhang, Jian Wang, Huan Mao, Fei Bao, Keting Liu, Wenwen Zhu, Jin Li, Xiaokang Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2019
- 关键词：Alzheimer's disease multifunctional agents AChE inhibitors MAO-B inhibitors metal chelating agents
- Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation被引量：39收藏
- 作者：Li, Xiaokang Wang, Huan Xu, Yixiang Liu, Wenwen Gong, Qi Wang, Wei Qiu, Xiaoxia Zhu, Jin Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2017
- 关键词：Alzheimer's disease depression multitarget-directed ligand ChE inhibition 5-HT1A agonist 5-HT reuptake inhibition
- Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis被引量：35收藏
- 作者：Kai Jiang Yue Xu Dandan Wang Feng Chen Zizhuo Tu Jie Qian Sheng Xu Yixiang Xu John Hwa Jian Li Hongcai Shang Yaozu Xiang
- 机构：Shanghai East Hospital;State Key Laboratory of Bioreactor Engineering;Section of Cardiovascular Medicine;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing
- 来源：蛋白质与细胞（英文版） 2022
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- Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses被引量：29收藏
- 作者：Zhou, Xiaoyu Zhao, Cheng Xu, Haiyan Xu, Yixiang Zhan, Li Wang, Pei He, Jingyi Lu, Taotao Gu, Yueling Yang, Yan Xu, Chanjuan Chen, Yiyang Liu, Yuxuan Zeng, Yue Tian, Fuyun Chen, Qian Xie, Xin Liu, Jianfeng Hu, Hailan Li, Jian Zheng, Yueming Guo, Jiangtao Gao, Zhaobing
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;Zhejiang Univ;Zhejiang Univ;Nanjing Univ Chinese Med
- 来源：NATURE CHEMICAL BIOLOGY 2024
- Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment被引量：25收藏
- 作者：Liu, Wenwen Wang, Huan Li, Xiaokang Xu, Yixiang Zhang, Jian Wang, Wei Gong, Qi Qiu, Xiaoxia Zhu, Jin Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2018
- 关键词：Depression Cognitive impairment Multitarget-directed ligand 5-HT1A agonist 5-HT reuptake inhibition ChE inhibition
- Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease被引量：24收藏
- 作者：Li, Xiaokang Lu, Jian Xu, Yixiang Wang, Jiaying Qiu, Xiaoxia Fan, Lei Li, Baoli Liu, Wenwen Mao, Fei Zhu, Jin Shen, Xu Li, Jian
- 机构：East China Univ Sci & Technol;Nanjing Univ Chinese Med;Chinese Acad Sci
- 来源：ACTA PHARMACEUTICA SINICA B 2020
- 关键词：Alzheimer's disease Autophagy Nitazoxanide beta-amyloid Tau protein
- Effects of aspirin on expression of iron transport and storage proteins in BV-2 microglial cells被引量：21收藏
- 作者：Xu, Yan Xin Du, Fang Jiang, Li Rong Gong, Jing Zhou, Yu-Fu Luo, Qian Qian Qian, Zhong Ming Ke, Ya
- 机构：East China Univ Sci & Technol;Fudan Univ;Chinese Univ Hong Kong
- 来源：NEUROCHEMISTRY INTERNATIONAL 2015
- 关键词：Aspirin (acetylsalicylic acid, ASA) Iron metabolism Inflammation and lipopolysaccharides (LPS) Transferrin receptor 1 (TfR1) Ferroportin 1 (Fpn1) Tumor necrosis factor-alpha lpha (TNF-alpha) Interleukin-6 (IL-6) Hepcidin
- Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction被引量：21收藏
- 作者：Huang, Yunyuan Xu, Yixiang Song, Rongrong Ni, Shuaishuai Liu, Jiaqi Xu, Yanhong Ren, Yanliang Rao, Li Wang, Yingjie Wei, Lin Feng, Lingling Su, Chen Peng, Chao Li, Jian Wan, Jian
- 机构：Cent China Normal Univ;East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Shenzhen Bay Lab;Natl Facil Prot Sci Shanghai
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2020
- Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents被引量：21收藏
- 作者：Hu, Linghao Feng, Hongxuan Zhang, Hongguang Yu, Songda Zhao, Qinyuan Wang, Wei Bao, Fengxia Ding, Xun Hu, Jiajing Wang, Manjiong Xu, Yixiang Wu, Zengrui Li, Xiaokang Tang, Yun Mao, Fei Chen, Xiaoyan Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2020
- Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo被引量：20收藏
- 作者：Ni, Shuaishuai Wei, Hanwen Li, Baoli Chen, Feifei Liu, Yifu Chen, Wenhua Xu, Yixiang Qiu, Xiaoxia Li, Xiaokang Lu, Yanli Liu, Wenwen Hu, Linhao Lin, Dazheng Wang, Manjiong Zheng, Xinyu Mao, Fei Zhu, Jin Lan, Lefu. Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2017
- Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift被引量：20收藏
- 作者：Li, Xinming Shi, Donglei Song, Yihe Xu, Yixiang Gao, Ying Qiu, Wenjing Chen, Xin Li, Xiaokang Huang, Yunyuan Feng, Yanjun Li, Baoli Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;East China Univ Sci & Technol;Dali Univ;Tongji Univ
- 来源：CHINESE CHEMICAL LETTERS 2022
- 关键词：Heart failure Monoamine oxidase A Oxidative stress Fluorescent probe Far-red emission Diagnosis
- Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo被引量：19收藏
- 作者：Chen, Xin Yang, Xi Mao, Fei Wei, Jinlian Xu, Yixiang Li, Baoli Zhu, Jin Ni, Shuaishuai Jia, Lijun Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Dali Univ;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021
- 关键词：Neddylation cullin1-Nedd8 Benzimidazole-derived inhibitor Anticancer
- Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes被引量：18收藏
- 作者：Xu, Yi-xiang Huang, Yun-yuan Song, Rong-rong Ren, Yan-liang Chen, Xin Zhang, Chao Mao, Fei Li, Xiao-kang Zhu, Jin Ni, Shuai-shuai Wan, Jian Li, Jian
- 机构：East China Univ Sci & Technol;Cent China Normal Univ;Shanghai Univ Tradit Chinese Med
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
- 关键词：Diabetes FBPase Disulfiram Covalent inhibitors Drug repurposing
- Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression被引量：15收藏
- 作者：Zhang, Chao Wang, Lan Xu, Yixiang Huang, Yunyuan Huang, Junyang Zhu, Jin Wang, Wei Li, Wangsheng Sun, Annan Li, Xiaokang Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Dali Univ;Tongji Univ;Hainan Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
- 关键词：Alzheimer's disease Depression Multi-target-directed ligands RAGE (Receptor for advanced glycation end products) SERT (Serotonin transporter)
- Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus被引量：13收藏
- 作者：Ni, Shuaishuai Li, Baoli Chen, Feifei Wei, Hanwen Mao, Fei Liu, Yifu Xu, Yixiang Qiu, Xiaoxi Li, Xiaokang Liu, Wenwen Hu, Linghao Ling, Dazheng Wang, Manjiong Zheng, Xinyu Zhu, Jin Lan, Lefu Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACS MEDICINAL CHEMISTRY LETTERS 2018
- 关键词：Virulence factor pigment multidrug resistant MRSA CrtN inhibitor
- Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria被引量：13收藏
- 作者：Xu, Yixiang Zhang, Chao Jiang, Kai Yang, Xinchun Chen, Feng Cheng, Zhiyang Zhao, Jinlong Cheng, Jiaxing Li, Xiaokang Chen, Xin Zhou, Luoyifan Duan, Hao Huang, Yunyuan Xiang, Yaozu Li, Jian
- 机构：East China Univ Sci & Technol;Tongji Univ;East China Univ Sci & Technol;Cent China Normal Univ;Dali Univ
- 来源：ACTA PHARMACEUTICA SINICA B 2023
- The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression被引量：13收藏
- 作者：Li, Xiaokang Li, Jinwen Huang, Yunyuan Gong, Qi Fu, Yan Xu, Yixiang Huang, Junyang You, Haolan Zhang, Dong Zhang, Dan Mao, Fei Zhu, Jin Wang, Huan Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Dali Univ;Tongji Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
- 关键词：Alzheimer's disease Depression Comorbidity Multi-target-directed ligands
- N-Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction被引量：10收藏
- 作者：Wen, Wuqiang Cao, Hongxuan Xu, Yixiang Ren, Yanliang Rao, Li Shao, Xubo Chen, Han Wu, Lixia Liu, Jiaqi Su, Chen Peng, Chao Huang, Yunyuan Wan, Jian
- 机构：Cent China Normal Univ;East China Univ Sci & Technol;Zhangjiang Lab
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2022
- Trilogy of drug repurposing for developing cancer and chemotherapy-induced heart failure co-therapy agent被引量：8收藏
- 作者：Chen, Xin Mu, Xianggang Ding, Lele Wang, Xi Mao, Fei Wei, Jinlian Liu, Qian Xu, Yixiang Ni, Shuaishuai Jia, Lijun Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Jinan Univ
- 来源：ACTA PHARMACEUTICA SINICA B 2024
- 关键词：Anticancer Heart failure Complication Drug repurposing Bi-functional drug
- Structure Optimization of Natural Product Catalpol to Obtain Novel and Potent Analogs against Heart Failure被引量：6收藏
- 作者：Liu, Hanfang Guo, Xiaobo Yang, Jin Xia, Conglong Yao, Yue Li, Xiao Liu, Xiaoyang Yang, Junqi Li, Xiaokang Xu, Yixiang Li, Jian Wang, Manjiong
- 机构：East China Univ Sci & Technol;Dali Univ;Shihezi Univ;Hainan Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2025
- Identification of Guaifenesin-Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation被引量：4收藏
- 作者：Huang, Yunyuan Xu, Haiyan Wang, Pei Gu, Rurong Li, Xiaokang Xu, Yixiang Wang, Jiqun Qiao, Sicong Shi, Donglei Gao, Zhaobing Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Dali Univ;Tongji Univ;Hainan Univ
- 来源：ACS CHEMICAL NEUROSCIENCE 2022
- 关键词：epilepsy combination drug anticonvulsant activity synergistic mechanism guaifenesin andrographolide
- Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria被引量：3收藏
- 作者：Yixiang Xu Chao Zhang Kai Jiang Xinchun Yang Feng Chen Zhiyang Cheng Jinlong Zhao Jiaxing Cheng Xiaokang Li Xin Chen Luoyifan Zhou Hao Duan Yunyuan Huang Yaozu Xiang Jian Li
- 机构：State Key Laboratory of Bioreactor Engineering;Shanghai East Hospital;East China University of Science and Technology-Tengbai Pharmaceutical Innovative Drugs Joint Research Institute;Hubei Key Laboratory of Genetic Regulation and Integrative Biology;Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan
- 来源：药学学报（英文版） 2023
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- Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer’s disease被引量：2收藏
- 作者：Xiaokang Li Jian Lu Yixiang Xu Jiaying Wang Xiaoxia Qiu Lei Fan Baoli Li Wenwen Liu Fei Mao Jin Zhu Xu Shen Jian Li
- 机构：State Key Laboratory of Bioreactor Engineering;School of Medicine and Life Sciences;Center for Drug Safety Evaluation and Research
- 来源：药学学报（英文版） 2020
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- Veronica anagallis-aquatica L. iridoid glycosides alleviate heart failure via metabolites homoveratrumic acid and 2-hydroxy-3,4-dimethoxybenzoic acid mediated by the gut microbiota被引量：2收藏
- 作者：Wang, Manjiong Guo, Xiaobo Liu, Hanfang Li, Xiao Yao, Yue Fu, Qing Jin, Yu Ni, Shuaishuai Li, Xiaokang Xiao, Chaojiang Jiang, Bei Xia, Conglong Li, Jian Xu, Yixiang
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Dali Univ;Dali Univ;Shihezi Univ
- 来源：ACTA PHARMACEUTICA SINICA B 2025
- 关键词：Iridoid glycosides Heart failure Gut microbiota Metabolite Homoveratrumic acid 2-Hydroxy-3,4-dimethoxybenzoic acid Cardiac hypertrophy HDAC2 HDAC2
- Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift被引量：1收藏
- 作者：Xinming Li Donglei Shi Yihe Song Yixiang Xu Ying Gao Wenjing Qiu Xin Chen Xiaokang Li Yunyuan Huang Yanjun Feng Baoli Li Yuan Guo Jian Li
- 机构：State Key Laboratory of Bioreactor Engineering;Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education;Frontiers Science Center for Materiobiology and Dynamic Chemistry;College of Pharmacy and Chemistry;Clinical Medicine Scientific and Technical Innovation Center
- 来源：中国化学快报（英文版） 2022
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- Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid-Onset Antidepressant Agent in Mice被引量：1收藏
- 作者：Wang, Sisi Zhou, Xiaoyu Li, Mengdan Zhang, Chao Xu, Haiyan He, Jingyi Zhan, Li Gu, Yueling Gu, Hao Tu, Tianyu Liu, Hanfang Lu, Taotao Zheng, Yueming Li, Jian Gao, Zhaobing Xu, Yixiang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Henan Univ;Hainan Univ;Shihezi Univ
- 来源：ADVANCED SCIENCE 2026
- 关键词：depression Kir4.1 inhibitors rapid-onset (S)-ketamine structural repurposing
