成果/Result
- A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and Apoptosis被引量：153收藏
- 作者：Chen, Zhuo Liang, Xin Zhang, Huanying Xie, Hua Liu, Jianwen Xu, Yufang Zhu, Weiping Wang, Yi Wang, Xin Tan, Shaoying Kuang, Dong Qian, Xuhong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2010
- Design and development of novel EGFR inhibitors spanning all subgroups of EGFR mutations in non-small cell lung cancer被引量：70收藏
- 作者：Wang, Caolin Cen, Yiting Zhang, Manzhan Tang, Jiahong Yan, Zitong Xie, Lijuan Sun, Deheng Zhou, Wei Wang, Jie Yu, Panpan Yuan, Zhen Wang, Junyi Hu, Zeyan Yang, Tingyuan Sha, Wenjie Li, Shiliang Zhao, Zhenjiang Xu, Yufang Chen, Zhuo Li, Honglin
- 机构： School of Pharmacy; Innovation Center for AI and Drug Discovery
- 来源：Innovation 2026
- 关键词：Binding sites - Biological organs - Design for testability - Diagnosis - Lung cancer - Medical applications - Metabolism - Structural optimization
- Light-Driven Intramolecular C-N Cross-Coupling via a Long-Lived Photoactive Photoisomer Complex被引量：60收藏
- 作者：Jing, Dong Lu, Cong Chen, Zhuo Jin, Songyang Xie, Lijuan Meng, Ziyi Su, Zhishan Zheng, Ke
- 机构：Sichuan Univ;East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2019
- 关键词：cross-coupling heterocycles photochemistry reaction mechanisms synthetic methods
- Self-Assembly of a Monochromophore-Based Polymer Enables Unprecedented Ratiometric Tracing of Hypoxia被引量：60收藏
- 作者：Wang, Shuwen Gu, Kaizhi Guo, Zhiqian Yan, Chenxu Yang, Tingyuan Chen, Zhuo Tian, He Zhu, Wei-Hong
- 机构：Shanghai Key Lab Funct Mat Chem Key Lab Adv Mat &;E China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED MATERIALS 2019
- 关键词：clustering-triggered emission hypoxia sensing monochromophore-based polymers NIR ratiometric mode self-assembly
- Oxo-heterocyclic fused naphthalimides as antitumor agents: Synthesis and biological evaluation被引量：54收藏
- 作者：Tan, Shaoying Yin, Hong Chen, Zhuo Qian, Xuhong Xu, Yufang
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2013
- 关键词：Oxo-heterocyclic Naphthalimides Antitumor agents Topo I Topo II DNA intercalation
- Rationally Designed Multitarget Anticancer Agents被引量：50收藏
- 作者：Chen, Zhuo Han, Le Xu, Minghao Xu, Yufang Qian, Xuhong
- 机构：E China Univ Sci & Technol
- 来源：CURRENT MEDICINAL CHEMISTRY 2013
- 关键词：Multitarget tumor pharmacophore combination quinazoline naphthalimide chemotherapy
- Naphthalimides and analogues as antitumor agents: A review on molecular design, bioactivity and mechanism of action被引量：46收藏
- 作者：Chen, Zhuo Xu, Yufang Qian, Xuhong
- 机构：East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2018
- 关键词：Naphthalimides Antitumor Structure activity relationship Drug design strategy Mechanism of action
- Highly Selective Fluorescent Turn-On Probe for Protein Thiols in Biotin Receptor-Positive Cancer Cells被引量：38收藏
- 作者：Sun, Qian Sun, Deheng Song, Lun Chen, Zhuo Chen, Zhaoyang Zhang, Weibing Qian, Junhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：ANALYTICAL CHEMISTRY 2016
- 关键词：Lanthanum compounds - Body fluids - Coenzymes - Fluorescence imaging - Cytology - Cancer cells - Diseases
- Acenaphtho[1,2-b]pyrrole-Based Selective Fibroblast Growth Factor Receptors 1 (FGFR1) Inhibitors: Design, Synthesis, and Biological Activity被引量：35收藏
- 作者：Chen, Zhuo Wang, Xin Zhu, Weiping Cao, Xianwen Tong, Linjiang Li, Honglin Xie, Hua Xu, Yufang Tan, Shaoying Kuang, Dong Ding, Jian Qian, Xuhong
- 机构：Chinese Acad Sci;E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2011
- Antiproliferative and apoptosis-inducing activities of novel naphthalimide-cyclam conjugates through dual topoisomerase (topo) I/II inhibition被引量：31收藏
- 作者：Tan, Shaoying Sun, Deheng Lyu, Jiankun Sun, Xiao Wu, Fangshu Li, Qiang Yang, Yiqi Liu, Jianxu Wang, Xin Chen, Zhuo Li, Honglin Qian, Xuhong Xu, Yufang
- 机构：E China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2015
- 关键词：Naphthalimide-cyclam conjugates Antitumor agents Topoisomerase I Topoisomerase II DNA intercalation Apoptosis
- Discovery and Rational Design of Pteridin-7(8H)-one-Based Inhibitors Targeting FMS-like Tyrosine Kinase 3 (FLT3) and Its Mutants被引量：27收藏
- 作者：Sun, Deheng Yang, Yu Lyu, Jiankun Zhou, Wei Song, Wenlin Zhao, Zhenjiang Chen, Zhuo Xu, Yufang Li, Honglin
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation被引量：24收藏
- 作者：Su, Zhicheng Yang, Tingyuan Wang, Jie Lai, Mengzhen Tong, Linjiang Wumaier, Gulinuer Chen, Zhuo Li, Shengqing Li, Honglin Xie, Hua Zhao, Zhenjiang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Fudan Univ;Fudan Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2020
- 关键词：EGFR NSCLC C797S
- Novel carbazole aminoalcohols as inhibitors of β-hematin formation: Antiplasmodial and antischistosomal activities被引量：24收藏
- 作者：Wang, Weisi Li, Qiang Wei, Yufen Xue, Jian Sun, Xiao Yu, Yang Chen, Zhuo Li, Shizhu Duan, Liping
- 机构：Chinese Minist Hlth;Zhejiang Univ;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE 2017
- 关键词：Carbazole aminoalcohols Plasmodium falciparum Schistosoma japonicum Antiplasmodials Antischistosomals Hematin
- C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis被引量：24收藏
- 作者：Chen, Zhuo Tong, Lin-jiang Tang, Bai-you Liu, Hong-yan Wang, Xin Zhang, Tao Cao, Xian-wen Chen, Yi Li, Hong-lin Qian, Xu-hong Xu, Yu-fang Xie, Hua Ding, Jian
- 机构：Chinese Acad Sci;East China Univ Sci & Technol
- 来源：ACTA PHARMACOLOGICA SINICA 2019
- 关键词：C11 FGFR1 inhibitor antitumor breast cancer metastasis angiogenesis
- Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation被引量：23收藏
- 作者：Hao, Yongjia Wang, Xia Zhang, Tao Sun, Deheng Tong, Yi Xu, Yuqiong Chen, Haiyang Tong, Linjiang Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Ding, Jian Xie, Hua Xu, Yufang Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs)被引量：22收藏
- 作者：Wang, Xin Chen, Zhuo Tong, Linjiang Tan, Shaoying Zhou, Wei Peng, Ting Han, Kun Ding, Jian Xie, Hua Xu, Yufang
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2013
- 关键词：Angiogenesis Multitarget Naphthalimide Topoisomerase II Tyrosine kinase
- Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors被引量：20收藏
- 作者：Dou, Dou Wang, Jie Qiao, Yunjin Wumaier, Gulinuer Sha, Wenjie Li, Wenjie Mei, Wenyi Yang, Tingyuan Zhang, Chen He, Huan Wang, Caolin Chu, Linna Sun, Baihui Su, Rongrong Ma, Xiangyu Gong, Mengdie Xie, Lijuan Jiang, Wenzhe Diao, Yanyan Zhu, Lili Zhao, Zhenjiang Chen, Zhuo Xu, Yufang Li, Shengqing Li, Honglin
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
- 关键词：4-Anilinoquinazoline Non-small cell lung cancer (NSCLC) Epidermal growth factor receptor (EGFR) Kinase inhibitor Anti-proliferative activity
- Carbazole Aminoalcohols Induce Antiproliferation and Apoptosis of Human Tumor Cells by Inhibiting Topoisomerase I被引量：20收藏
- 作者：Wang, Weisi Sun, Xiao Sun, Deheng Li, Shizhu Yu, Yang Yang, Tingyuan Yao, Junmin Chen, Zhuo Duan, Liping
- 机构：Chinese Minist Hlth;East China Univ Sci & Technol;Zhejiang Univ
- 来源：CHEMMEDCHEM 2016
- 关键词：antitumor agents apoptosis carbazole aminoalcohols cell-cycle arrest topoisomerase
- Novel metal complexes of naphthalimide-cyclam conjugates as potential multi-target receptor tyrosine kinase (RTK) inhibitors: Synthesis and biological evaluation被引量：20收藏
- 作者：Tan, Shaoying Han, Kun Li, Qiang Tong, Linjiang Yang, Yiqi Chen, Zhuo Xie, Hua Ding, Jian Qian, Xuhong Xu, Yufang
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2014
- 关键词：Metal complexes Naphthalimide Cyclam RTK inhibitors Antiproliferation Antiangiogenesis
- Toxicity of a molluscicide candidate PPU07 against Oncomelania hupensis (Gredler, 1881) and local fish in field evaluation被引量：16收藏
- 作者：Chen, Zhuo Wang, Weisi Yao, Junmin Li, Shizhu Zhang, Xia Hu, Hehua Liu, Xiong Luo, Binrong Liu, Yuhua Xu, Huiyong Duan, Liping
- 机构：East China Univ Sci & Technol;Chinese Minist Hlth;Jianglin Inst Schistosomiasis Control;Dali Inst Schistosomiasis Control;Jiangsu Acad Agr Sci
- 来源：CHEMOSPHERE 2019
- 关键词：Molluscicide Oncomelania hupensis Schistosoma japonicum Fish toxicity PPU07
- Novel seven-membered ring-fused naphthalimide derivatives with potentials for cancer theranostics被引量：15收藏
- 作者：Yang, Yonghui Shi, Xiayu Chen, Zhuo Xu, Yufang Qian, Xuhong Zhu, Weiping
- 机构：East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2023
- 关键词：Seven -membered ring Antitumor activity High fluorescent quantum yield Theranostics
- Discovery of a novel family of polycyclic aromatic molecules with unique reactivity and members valuable for fluorescent sensing and medicinal chemistry被引量：14收藏
- 作者：Xiao, Yi Liu, Fengyu Chen, Zhuo Zhu, Weipin Xu, Yufang Qian, Xuhong
- 机构：Dalian Univ Technol;E China Univ Sci & Technol
- 来源：CHEMICAL COMMUNICATIONS 2015
- Discrimination between streptavidin and avidin with fluorescent affinity-based probes被引量：14收藏
- 作者：Sun, Qian Tian, Haiyu Qu, Haoran Sun, Deheng Chen, Zhuo Duan, Liping Zhang, Weibing Qian, Junhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Ctr Dis Control & Prevent
- 来源：ANALYST 2015
- Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agents被引量：13收藏
- 作者：Song, Wenlin Li, Shiliang Tong, Yi Wang, Jiawei Quan, Lina Chen, Zhuo Zhao, Zhenjiang Xu, Yufang Zhu, Lili Qian, Xuhong Li, Honglin
- 机构：East China Univ Sci & Technol
- 来源：MEDCHEMCOMM 2016
- Synthesis and Biological Evaluation of Carbazole Aminoalcohols as Antitumor Agents被引量：13收藏
- 作者：Chen, Zhuo Yang, Tingyuan Wang, Weisi Yao, Junmin Han, Shaomin Tao, Yi Wang, Rui Duan, Liping
- 机构：East China Univ Sci & Technol;Chinese Minist Hlth;Xinjiang Med Univ;Qinghai Prov Peoples Hosp
- 来源：CHEMISTRYSELECT 2018
- 关键词：Apoptosis Bcl-2 Carbazole aminoalcohols Topoisomerase I (topo I)
- 7-b, a novel amonafide analogue, cause growth inhibition and apoptosis in Raji cells via a ROS-mediated mitochondrial pathway被引量：12收藏
- 作者：Lin, Bing Chen, Zhuo Xu, Yufang Zhang, Huanying Liu, Jianwen Qian, Xuhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：LEUKEMIA RESEARCH 2011
- 关键词：7-b Cell cycle Apoptosis Reactive oxygen species Mitochondrial membrane potential p21
- Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design被引量：11收藏
- 作者：He, Huan Zhang, Xingsen Wang, Jie Liu, Qi Zhang, LeiHao Chen, Lu Yuan, Yuan Zhao, Zhenjiang Li, Honglin Chen, Zhuo
- 机构：East China Normal Univ;East China Univ Sci & Technol;Lingang Lab
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2024
- The discovery of novel small molecule allosteric activators of aldehyde dehydrogenase 2被引量：11收藏
- 作者：Tian, Wei Guo, Jiapeng Zhang, Qingsen Fang, Shaoyu Zhou, Ruolan Hu, Jian Wang, Mingping Zhang, Yuefan Guo, Jin-Min Chen, Zhuo Zhu, Ju Zheng, Canhui
- 机构：Second Mil Med Univ;Gen Hosp Cent Theater Commond;Shanghai Univ;960 Hosp Joint Logist Support Force;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021
- 关键词：Aldehyde dehydrogenase 2 Allosteric activators Inactive Asian variant Virtual screening Structural optimization Ischemic stroke
- Discovery of Pteridine-7(8H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK)被引量：10收藏
- 作者：Dou, Dou Diao, Yanyan Sha, Wenjie Su, Rongrong Tong, Linjiang Li, Wenjie Leng, Limin Xie, Lijuan Yu, Zhixiao Song, Haoming Shen, Zihao Zhu, Lili Zhao, Zhenjiang Xie, Hua Chen, Zhuo Li, Honglin Xu, Yufang
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2022
- Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors被引量：9收藏
- 作者：Hao, Yongjia Lyu, Jiankun Qu, Rong Sun, Deheng Zhao, Zhenjiang Chen, Zhuo Ding, Jian Xie, Hua Xu, Yufang Li, Honglin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：SCIENTIFIC REPORTS 2017
