成果/Result
- Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply被引量：82收藏
- 作者：Wang, Qin Quan, Shu Xiao, Han
- 机构：Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Terpenoid Mevalonate pathway 2-C-Methyl-D-erythritol 4-phosphate (MEP) Isopentenyl diphosphate (IPP) Dimethylallyl diphosphate (DMAPP) Biosynthesis
- Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding protEIns被引量：60收藏
- 作者：Liu, Renmei Yang, Jing Yao, Jing Zhao, Zhou He, Wei Su, Ni Zhang, Zeyi Zhang, Chenxia Zhang, Zhuo Cai, Haibo Zhu, Linyong Zhao, Yuzheng Quan, Shu Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE BIOTECHNOLOGY 2022
- 关键词：ProtEIns - Cell culture
- Selection and screening strategies in directed evolution to improve protEIn stability被引量：27收藏
- 作者：Ren, Chang Wen, Xin Mencius, Jun Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Directed evolution ProtEIn folding ProtEIn stability Cell surface display Cell-free display Reporter protEIn Stability biosensor
- Fluorogenic sensing of amorphous aggregates, amyloid fibers, and chaperone activity via a near-infrared aggregation-induced emission-active probe被引量：20收藏
- 作者：He, Wei Yang, Yuanyuan Qian, Yuhui Chen, Zhuoyi Zheng, Yongxin Zhao, Wenping Yan, Chenxu Guo, Zhiqian Quan, Shu
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：AGGREGATE 2024
- 关键词：aggregation-induced emission fluorescence molecular chaperone protEIn aggregation
- Conversion of the molecular chaperone Spy into a novel fusion tag to enhance recombinant protEIn expression被引量：20收藏
- 作者：Ruan, Alessandro Ren, Chang Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2020
- 关键词：ProtEIn expression Fusion tag Molecular chaperone Spy
- Exploring microbial degradation of polyamide 4 in soils: UnvEIling degradation mechanisms, pathways, and the contribution of strain NR4被引量：16收藏
- 作者：Wang, Li Zhang, Ziwei Zhang, Di Qiu, Yongjun Wang, Yibing Quan, Shu Zhao, Liming
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI;East China Univ Sci & Technol
- 来源：JOURNAL OF CLEANER PRODUCTION 2023
- 关键词：Polyamide 4 Biodegradation Soil Enrichment and acclimation PA4 degrading mechanism
- Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes被引量：12收藏
- 作者：Zheng, Yongxin Huang, Yinping Mencius, Jun Li, Yanjing Zhao, Lijie Luo, Wanting Chen, Yong Quan, Shu
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;ShanghaiTech Univ
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2021
- 关键词：Alkylation - Enzymes - Kinetics - Amino acids - Gene expression - Catalysis - Molecular dynamics - Peptides
- Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering被引量：9收藏
- 作者：Shang, Yue-Peng Chen, Qi Li, Ai-Tao Quan, Shu Xu, Jian-He Yu, Hui-Lei
- 机构：East China Univ Sci & Technol;Hubei Univ
- 来源：JOURNAL OF BIOTECHNOLOGY 2020
- 关键词：Haloketone reductase Substrate inhibition ProtEIn engineering X-ray crystal structure Asymmetric reduction
- Increased surface charge in the protEIn chaperone Spy enhances its anti-aggregation activity被引量：7收藏
- 作者：He, Wei Zhang, Jiayin Sachsenhauser, Veronika Wang, Lili Bardwell, James C. A. Quan, Shu
- 机构：East China Univ Sci & Technol;Univ Michigan
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2020
- 关键词：molecular chaperone Spy protEIn engineering protEIn aggregation electrostatic interaction hydrophobic interaction kinetics protEIn folding conformational change chaperone-substrate interaction
- Chaperone-substrate interactions monitored via a robust TEM-1 β-lactamase fragment complementation assay被引量：5收藏
- 作者：Bai, Ling He, Wei Li, Tianpeng Yang, Cuiting Zhuang, Yingping Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2017
- 关键词：Cell envelope Chaperone ProtEIn fragment complementation assay ProtEIn-protEIn interaction Stress TEM-1 beta-lactamase
- FADS-Based Directed Evolution of a Robust Bst DNA Polymerase Adapting High-Temperature Loop-Mediated Isothermal Amplification (HT-LAMP)被引量：4收藏
- 作者：Li, Xiao Tang, Qiongwei Jiang, Jingjie Shang, Yuepeng Lu, Zelin Chen, Mingli He, Jiajia Liu, Feng Zhu, Sisi Zhang, Zengping Han, Hui Yu, Xixi Li, Qiuxian Xiu, Yuansong Yang, Yuhong Gui, Ping Wang, Xuefeng Lu, Feng Jing, Wei Xu, Langping Lin, Yanna Wang, Xinglong Quan, Shu Liu, Xiang Yin, Huancai Ma, Fuqiang
- 机构：Chinese Acad Sci;Yeasen Biotechnol Shanghai Co Ltd;Molefuture Biotechnol Shanghai Co Ltd;Shandong Lab Adv Biomat & Med Devices Weihai;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2025
- 关键词：FADS Bst DNA polymerase HT-LAMP strand displacement index hydrophobic blade
- Sensing Cellular Damages Induced by Food Safety Hazards Using Bacterial Stress-Responsive Biosensors被引量：0收藏
- 作者：Li, Ruiqi Lou, Manzhuan He, Wei Quan, Shu
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Chinese Acad Sci
- 来源：BIOSENSORS-BASEL 2025
- 关键词：whole-cell biosensor cellular damage detection food safety hazards stress-responsive biosensors
- Artificial Intelligence-Powered Construction of a Microbial Optimal Growth Temperature Database and Its Impact on Enzyme Optimal Temperature Prediction被引量：0收藏
- 作者：Wang, Xiaotao Zong, Yuwei Zhou, Xuanjie Xu, Li He, Wei Quan, Shu
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF PHYSICAL CHEMISTRY B 2024
- 关键词：Catalysis - Database systems - Forecasting - Growth temperature
- Correction to: Chaperone–substrate interactions monitored via a robust TEM-1 β-lactamase fragment complementation assay (Biotechnology Letters, (2017), 39, 8, (1191-1199), 10.1007/s10529-017-2347-9)被引量：-1收藏
- 作者：Bai, Ling He, Wei Li, Tianpeng Yang, Cuiting Zhuang, Yingping Quan, Shu
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology Letters 2020
