成果/Result
- Enzymatic Cleavage and Subsequent Facile Intramolecular Transcyclization for in Situ Fluorescence Detection of γ-Glutamyltranspetidase Activities被引量：78收藏
- 作者：Tong, Hongjuan Zheng, Yongjun Zhou, Li Li, Xiangmin Qian, Rui Wang, Rui Zhao, Jianhong Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ New Mexico
- 来源：ANALYTICAL CHEMISTRY 2016
- 关键词：Cancer cells - Cells - Diseases - Diagnosis - Cytology - Fluorescence spectroscopy - Probes - Enzymes - Product design
- 本芴醇的合成工艺改进被引量：14收藏
- 作者：Yang, Kang Zheng, Qun Wu, Weiting Chen, Xuxiang Zhao, Jianhong
- 机构： Engineering Research Center of Pharmaceutical Process Chemistry
- 来源：[1] Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China 2024
- Catalyst-Free ?-Alkylation-?-Hydroxylation of Oxindole with Alcohols被引量：9收藏
- 作者：Wu, Siwei Song, Wei Zhu, Runyu Hu, Jingwen Zhao, Lin Li, Zheyao Yu, Xinhong Xia, Chengcai Zhao, Jianhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Taishan Med Univ
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2022
- 关键词：Catalysts - Hydroxylation - Transition metals
- A ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system被引量：8收藏
- 作者：Guo, Ying Ji, Si-Zhe Chen, Cheng Liu, Hong-Wei Zhao, Jian-Hong Zheng, Yu-Lin Ji, Ya-Fei
- 机构：E China Univ Sci & Technol;Shanghai Ocean Univ;Shanghai New Asia Pharmaceut Co Ltd
- 来源：RESEARCH ON CHEMICAL INTERMEDIATES 2015
- 关键词：Cu-catalysis Unactivated aryl bromides Methoxylation Aryl methyl ethers Recovery of pure MeOH
- Highly Efficient and Practical Synthesis of the Key Intermediate of Telmisartan被引量：7收藏
- 作者：Zhao, Jianhong Xiong, Yicheng Yang, Wu-Lin Yang, Fan Jin, Yu
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2021
- 关键词：Telmisartan practical synthesis 1,7 '-dimethyl-2 '-propyl-2,5 '-bi(1H-benzimidazole) Duff reaction benzimidazole
- A practical ligand-free copper(I) bromide-catalyzed fluoroalkoxylation of unactivated aryl bromides被引量：5收藏
- 作者：Guo, Ying Li, Yu-Dao Chen, Cheng Zhao, Jian-Hong Liu, Hong-Wei Liao, Dao-Hua Ji, Ya-Fei
- 机构：E China Univ Sci & Technol
- 来源：RESEARCH ON CHEMICAL INTERMEDIATES 2016
- 关键词：Fluoroalkoxylation Ligand-free catalysis Unactivated aryl bromides Copper(I) bromide Aryl fluoroalkyl ethers
- High atomic utilization conversion of ethers into furancarbaldehydes via an ether oxidation iminium-ion activation cascade strategy被引量：1收藏
- 作者：Li, Zheyao Ma, Chunmei Zhao, Lin Lin, Zhongren Hu, Yang Zhao, Jianhong Yu, Xinhong
- 机构：East China Univ Sci & Technol; East China Univ Sci & Technol
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2023
- 关键词：Chemical activation - Ions - Oxidation - Synthesis (chemical)
- 已上市MEK抑制剂合成路线综述被引量：1收藏
- 作者：李瑞鹏 赵建宏 夏广新 谢建树 邓卫平
- 机构：华东理工大学药学院;上海医药集团股份有限公司中央研究院
- 来源：《中国医药工业杂志》 2021
- 关键词：抗肿瘤药 丝裂原活化的细胞外信号调节激酶(MEK) 抑制剂 曲美替尼 考比替尼 司美替尼 比美替尼 合成
- 摘要：丝裂原活化的细胞外信号调节激酶(MEK)抑制剂是重要的抗肿瘤药物,目前已上市4个产品,分别是曲美替尼、考比替尼、司美替尼和比美替尼。本文简要介绍了这4种药物,并对已报道的合成路线进行综述。
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- Unconventional Synthetic Process of Fasudil Hydrochloride: Costly Homopiperazine Was Avoided被引量：1收藏
- 作者：Zhao, Jianhong Wang, Dingding Yang, Wu-Lin Niu, Jinming Wu, Weiting
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2022
- 关键词：fasudil hydrochloride homopiperazine one-pot process practical synthesis
- 阿贝西利的合成研究进展被引量：1收藏
- 作者：李瑞鹏 夏广新 赵建宏 谢建树 邓卫平
- 机构：华东理工大学药学院;上海医药集团股份有限公司中央研究院
- 来源：《中国医药工业杂志》 2021
- 关键词：阿贝西利 抗乳腺癌 合成 综述
- 摘要：阿贝西利是经FDA批准上市的新型细胞周期蛋白依赖性激酶4/6(CDK4/6)抑制剂,临床用于治疗晚期或转移性乳腺癌。本文分别对阿贝西利及其重要中间体的合成方法进行了总结和概括,并对各路线进行了简要评述。
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- Pd-Catalyzed Asymmetric Reactions Involving β-Hydride Elimination被引量：0收藏
- 作者：Chen, Ziqi Zheng, Qizhi Zhang, Ruinan Fang, Chao Zhang, Pei-Chao Chai, Xiaoyun Zhao, Qingjie Luo, Wenjun Zhao, Jianhong Xu, Bing Zhang, Zhan-Ming Zhang, Junliang
- 机构：Naval Med Univ;Fudan Univ;East China Univ Sci & Technol;Gannan Normal Univ;Fudan Zhangjiang Inst
- 来源：ACS CATALYSIS 2026
- 关键词：beta-H elimination palladium catalysis asymmetric catalysis enantioselectivity axial chirality inherent chirality central chirality
- Development of a Robust, Efficient, and Scalable Process for the Synthesis of Bisacodyl被引量：0收藏
- 作者：Bian, Wentao Chen, Jiamin Duan, Kongling Shen, Qilei Zhao, Jianhong
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2026
- 关键词：bisacodyl scalable synthesis high regioselectivity operational simplicity single protecting group
- A Novel, Practical, and Efficient Synthetic Process for Chiral 10-Aza-isoergoline Scaffold of the Antipsychotic Candidate IHCH7041被引量：0收藏
- 作者：Li, Ruipeng Bian, Wentao Xie, Jianshu Xia, Guangxin Zhao, Jianhong
- 机构：East China Univ Sci & Technol;Shanghai Pharmaceut Holding Co Ltd
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2026
- 关键词：10-aza-isoergoline antipsychotic candidate process development chiral resolution
- 托法替尼中间体的合成工艺改进被引量：0收藏
- 作者：朱俊 孙缜 张耀华 喻婕 赵建宏
- 机构：华东理工大学药学院;上海医药集团股份有限公司
- 来源：《中国医药工业杂志》 2024
- 关键词：JAK抑制剂 托法替尼 中间体 4-氯-7H-吡咯并[2 3-d]嘧啶 工艺改进
- 摘要：以丙二腈为起始原料,与溴代乙醛缩二乙醇(2)发生α-烷基化反应,后经硫脲环合、脱保护、环合、酸化、脱除巯基、Sandmeyer氯代等反应,得到托法替尼中间体,4-氯-7H-吡咯并[2,3-d]嘧啶(1),总收率49%(以...
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