成果/Result
- Chitooligosaccharides display anti-tumor effects against human cervical cancer cells via the apoptotic and autophagic pathways被引量：57收藏
- 作者：Zhao, Mengyao Gu, Liming Li, Yun Chen, Shumin You, Jiangshan Fan, Liqiang Wang, Yudong Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;SCICBT
- 来源：CARBOHYDRATE POLYMERS 2019
- 关键词：Chitooligosaccharides Enzyme-membrane coupling reactor Apoptosis ROS production Autophagy
- Insights into the nanofiltration separation mechanism of monosaccharides by molecular dynamics simulation被引量：49收藏
- 作者：Yao, Lei Qin, Zhen Chen, Qiming Zhao, Mengyao Zhao, Hefei Ahmad, Waheed Fan, Liqiang Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol SC;Univ Nebraska
- 来源：SEPARATION AND PURIFICATION TECHNOLOGY 2018
- 关键词：Monosaccharide Nanofiltration Molecular dynamics simulation Diffusion coefficient Interaction energy
- Absorption Characteristics of Chitobiose and Chitopentaose in the Human Intestinal Cell Line Caco-2 and Everted Gut Sacs被引量：37收藏
- 作者：Chen, Ping Zhao, Mengyao Chen, Qiming Fang, Liqiang Gao, Feng Zhao, Liming
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;SCICBT
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2019
- 关键词：chitooligosaccharide everted gut sac model intestinal absorption Caco-2 cell model glucose transporter 2 (GLUT2)
- The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice被引量：33收藏
- 作者：Zhao, Mengyao Deng, Linlin Lu, Xiaoxuan Fan, Liqiang Zhu, Yang Zhao, Liming
- 机构：East China Univ Sci & Technol;Wageningen Univ & Res
- 来源：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 2022
- 关键词：Acrylamide Oxidative stress Neurotoxicity Neurotransmission impairment Neuroinflammation NLRP3 inflammasome
- Detection of the 5-hydroxymethylfurfural content in roasted coffee using machine learning based on near-infrared spectroscopy被引量：28收藏
- 作者：Xie, Chuanqi Wang, Changyan Zhao, Mengyao Zhou, Weidong
- 机构：Zhejiang Acad Agr Sci;East China Univ Sci & Technol
- 来源：FOOD CHEMISTRY 2023
- 关键词：NIR spectroscopy Roasted coffee 5-hydroxymethylfurfural Machine learning Content prediction
- Modulation of tryptophan metabolism via AHR-IL22 pathway mediates the alleviation of DSS-induced colitis by chitooligosaccharides with different degrees of polymerization被引量：21收藏
- 作者：Wang, Yu Ji, Xiaoguo Zhao, Mengyao Li, Juan Yin, Hao Jin, Jiayang Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Changzheng Hosp;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI;Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met
- 来源：CARBOHYDRATE POLYMERS 2023
- 关键词：Colitis IDO1 AHR-IL-22 Tryptophan metabolism Chitooligosaccharides
- CD36 and DGAT2 facilitate the lipid-lowering effect of chitooligosaccharides via fatty acid intake and triglyceride synthesis signaling被引量：19收藏
- 作者：Shen, Xin Liang, Xinyi Ji, Xiaoguo You, Jiangshan Zhuang, Xinye Song, Yudong Yin, Hao Zhao, Mengyao Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Changzheng Hosp;Shanghai Collaborat Innovat Ctr Biomfg Technol SC
- 来源：FOOD & FUNCTION 2021
- 关键词：Biosynthesis - Cholesterol - ProtEIns - Mammals
- Acrylamide induces neurotoxicity in zebrafish (Danio rerio) via NLRP3-mediated pyroptosis被引量：17收藏
- 作者：Zhang, Boya Zhao, Mengyao Ji, Xiaoguo Xia, Quanming Jiang, Lihua Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI;Shanghai Changzheng Hosp;East China Univ Sci & Technol
- 来源：SCIENCE OF THE TOTAL ENVIRONMENT 2023
- 关键词：Acrylamide Zebrafish Neurotoxicity Pyroptosis NLRP3 inflammasome Caspy -based pathways
- Enhanced Low Molecular WEIght Poly-γ-Glutamic Acid Production in Recombinant Bacillus subtilis 1A751 with Zinc Ion被引量：15收藏
- 作者：Jiang, Sijing Fan, Liqiang Zhao, Mengyao Qiu, Yongjun Zhao, Liming
- 机构：East China Univ Sci & Technol;SCICBT
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2019
- 关键词：Recombinant Bacillus subtilis Low molecular wEIght Poly-gamma-glutamic acid (gamma-PGA) Poly-gamma-glutamic acid synthase pgsBCAE center dot Zn2+
- Construction of chitooligosaccharide-based nanoparticles of pH/redox cascade responsive for co-loading cyclosporin A and AZD9291被引量：15收藏
- 作者：Chen, Shumin Ji, Xiaoguo Zhao, Mengyao Jin, Jiayang Zhang, Haiping Zhao, Liming
- 机构：East China Univ Sci & Technol;Tongji Univ;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI;East China Univ Sci & Technol
- 来源：CARBOHYDRATE POLYMERS 2022
- 关键词：Chitooligosaccharides Drug delivery system AZD9291 Cyclosporin A Nanoparticles
- Prediction of acrylamide content in potato chips using near-infrared spectroscopy被引量：14收藏
- 作者：Xie, Chuanqi Wang, Changyan Zhao, Mengyao Zhao, Liming
- 机构：East China Univ Sci & Technol;Zhejiang Acad Agr Sci;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI
- 来源：SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 2023
- 关键词：NIR spectroscopy Potato chips Acrylamide Prediction effective wavenumbers
- Chitopentaose inhibits hepatocellular carcinoma by inducing mitochondrial mediated apoptosis and suppressing protective autophagy被引量：7收藏
- 作者：Zhu, Chunfeng Zhao, Mengyao Fan, Liqiang Cao, Xuni Xia, Quanming Zhou, Jiachun Yin, Hao Zhao, Liming
- 机构：East China Univ Sci & Technol;Shandong Univ Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol SC;Shanghai Changzheng Hosp
- 来源：BIORESOURCES AND BIOPROCESSING 2021
- 关键词：Chitooligosaccharides Singular DP HCC Apoptosis Autophagy
- effect of chitooligosaccharides with a specific degree of polymerization on multiple targets in T2DM mice被引量：7收藏
- 作者：You, Jiangshan Zhao, Mengyao Chen, Shumin Jiang, Lihua Gao, Shuhong Yin, Hao Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Changzheng Hosp;Shanghai Collaborat Innovat Ctr Biomfg Technol SC
- 来源：BIORESOURCES AND BIOPROCESSING 2022
- 关键词：Chitooligosaccharides Diabetes mellitus Insulin resistance Hypoglycemic effect
- Inhibitory effect of chitooligosaccharides on retinol metabolism and bioavailability in mice被引量：3收藏
- 作者：Li, Wei Zhao, Mengyao Qin, Zhen Chen, Qiming Fan, Liqiang Zhou, Jiachun Zhao, Liming
- 机构：East China Univ Sci & Technol;SCICBT;Huizhou Long Dragon Biotechnol Co Ltd
- 来源：JOURNAL OF FOOD BIOCHEMISTRY 2019
- 关键词：chemical interaction chitooligosaccharides retinol retinol bioavailability retinol metabolism
- Chitobiose exhibited a lipid-lowering effect in ob/ob-/- mice via butyric acid enrolled liver-gut crosstalk被引量：3收藏
- 作者：Zhuang, Xinye Zhao, Mengyao Ji, Xiaoguo Yang, Sihan Yin, Hao Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Changzheng Hosp;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI
- 来源：BIORESOURCES AND BIOPROCESSING 2023
- 关键词：Chitobiose Butyric acid Non-alcoholic fatty liver disease Lipid beta-oxidation Liver-gut axis signaling
- The Preventative effect of Chitooligosaccharides against Chronic Alcoholic Liver Disease by Regulating Alcohol Metabolism, Fatty Acid Metabolism, and Intestinal Barrier Damage被引量：1收藏
- 作者：Li, Yuan Zou, Jiaqi Yin, Hao Zhao, Mengyao Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Changzheng Hosp;Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met
- 来源：JOURNAL OF FOOD BIOCHEMISTRY 2024
- 关键词：Cytology - Diseases - Fatty acids - Mammals - ProtEIns
- Desulfovibrio-Hydrogen Sulfide Mediates Capsaicin-Induced Oxidative Stress and Gut Inflammation via TXNIP/NLRP3 Pathway被引量：0收藏
- 作者：Zhu, Liangliang Feng, Xiangru Lu, Xiaoxuan Han, Geng Zou, Jiaqi Dong, Zhaoyang Luo, Ting Jin, Jiayang Zhao, Mengyao Ji, Xiaoguo Zhao, Liming
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：FOOD BIOENGINEERING 2026
- 关键词：capsaicin Desulfovibrio Faecalibacterium prausnitzii gut inflammation hydrogen sulfide
- Long-term capsaicin intake and gut inflammation: microbial alterations, metabolic mechanisms, and intervention effects被引量：0收藏
- 作者：Zhu, Liangliang Chen, Yijia Jin, Jiayang Zhao, Mengyao Ran, Jingfang Yin, Hao Ji, Xiaoguo Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Chang Zheng Hosp;East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI
- 来源：FOOD RESEARCH INTERNATIONAL 2026
- 关键词：Capsaicin Metabolomics Vanillate decarboxylase Caco-2 cell Human microbiota-associated animal
- Computer-Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism被引量：0收藏
- 作者：Jing, Rui Deng, Shanshan Zhao, Mengyao Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI
- 来源：FOOD BIOENGINEERING 2026
- 关键词：functional oligosaccharides lipid metabolism modulation molecular simulation NAFLD oligosaccharide structure
- 壳寡糖对体外诱导的非酒精性脂肪肝细胞模型的降脂机理研究被引量：0收藏
- 作者：沈欣 赵梦瑶 邱勇隽 夏泉鸣 赵黎明
- 机构：华东理工大学生物工程学院
- 来源：《食品科学技术学报》 2020
- 关键词：壳寡糖 非酒精性脂肪肝 细胞模型 降脂机理 CD36 DGAT2
- 摘要：为探讨壳寡糖在体外对肝脂质积累的抑制效果及潜在作用机制,选用油酸钠诱导HepG2细胞建立非酒精性脂肪肝细胞模型,通过油红O染色及各试剂盒检测胞内总脂质积累、甘油三酯、总胆固醇、高低密度脂蛋白胆固醇及游离脂肪酸的含量,实时...
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