成果/Result
- Organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions被引量：140收藏
- 作者：Zhang, Shi-Lei Xie, He-Xin Zhu, Jin Li, Hao Zhang, Xin-Shuai Li, Jian Wang, Wei
- 机构：Chinese Acad Sci;Univ New Mexico;E China Univ Sci & Technol
- 来源：NATURE COMMUNICATIONS 2011
- A Direct Amine-Palladium Acetate Cocatalyzed Saegusa Oxidation Reaction of Unmodified Aldehydes to α,β-Unsaturated Aldehydes被引量：85收藏
- 作者：Zhu, Jin Liu, Jie Ma, Ruoqun Xie, Hexin Li, Jian Jiang, Hualiang Wang, Wei
- 机构：E China Univ Sci & Technol;Univ New Mexico;Chinese Acad Sci
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2009
- 关键词：aminocatalysis organocatalysis Saegusa reaction alpha,beta-unsaturated aldehydes
- Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents被引量：83收藏
- 作者：Li, Xiaokang Wang, Huan Lu, Zhengyu Zheng, Xinyu Ni, Wei Zhu, Jin Fu, Yan Lian, Fulin Zhang, Naixia Li, Jian Zhang, Haiyan Mao, Fei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Discovering Potent Small Molecule Inhibitors of Cyclophilin A Using de Novo Drug Design Approach被引量：82收藏
- 作者：Ni, Shuaishuai Yuan, Yaxia Huang, Jin Mao, Xiaona Lv, Maosheng Zhu, Jin Shen, Xu Pei, Jianfeng Lai, Luhua Jiang, Hualiang Li, Jian
- 机构：Peking Univ;Peking Univ;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2009
- Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease被引量：75收藏
- 作者：Xu, Yi-xiang Wang, Huan Li, Xiao-kang Dong, Sheng-nan Liu, Wen-wen Gong, Qi Wang, Tian-duan-yi Tang, Yun Zhu, Jin Li, Jian Zhang, Hai-yan Mao, Fei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
- 关键词：Multifunctional agents AChE inhibitors MAO-B inhibitors Metal chelating agents Alzheimer's disease
- Development of the First Generation of Disulfide-Based Subtype Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors被引量：71收藏
- 作者：Liu, Yifu Xie, Zuoquan Zhao, Dan Zhu, Jin Mao, Fei Tang, Shuai Xu, Hui Luo, Cheng Geng, Meiyu Huang, Min Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2017
- A Strategy Enabling Enantioselective Direct Conjugate Addition of Inert Aryl Methane Nucleophiles to Enals with a Chiral Amine Catalyst under Mild Conditions被引量：67收藏
- 作者：Li, Tengfei Zhu, Jin Wu, Deyan Li, Xiangmin Wang, Sinan Li, Hao Li, Jian Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2013
- 关键词：aryl methane enals iminium catalysis Michael addition organocatalysis
- Identification of Novel Falcipain-2 Inhibitors as Potential Antimalarial Agents through Structure-Based Virtual Screening被引量：65收藏
- 作者：Li, Honglin Huang, Jin Chen, Lili Liu, Xiaofeng Chen, Tong Zhu, Jin Lu, Weiqiang Shen, Xu Li, Jian Hilgenfeld, Rolf Jiang, Hualiang
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Med Univ Lubeck
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2009
- Discovery of Novel Small Molecule Inhibitors of Dengue Viral NS2B-NS3 Protease Using Virtual Screening and Scaffold Hopping被引量：64收藏
- 作者：Deng, Jing Li, Ning Liu, Hongchuan Zuo, Zhili Liew, Oi Wah Xu, Weijun Chen, Gang Tong, Xiankun Tang, Wei Zhu, Jin Zuo, Jianping Jiang, Hualiang Yang, Cai-Guang Li, Jian Zhu, Weiliang
- 机构：Chinese Acad Sci;E China Univ Sci & Technol;Singapore Polytech;Natl Univ Singapore
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2012
- Discovery and Optimization of 1,3,4-Trisubstituted-pyrazolone Derivatives as Novel, Potent, and Nonsteroidal Farnesoid X Receptor (FXR) Selective Antagonists被引量：64收藏
- 作者：Huang, Huang Yu, Ying Gao, Zhenting Zhang, Yong Li, Chenjing Xu, Xing Jin, Hui Yan, Wenzhong Ma, Ruoqun Zhu, Jin Shen, Xu Jiang, Hualiang Chen, Lili Li, Jian
- 机构：Chinese Acad Sci;E China Univ Sci & Technol;Zunyi Med Coll
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2012
- Direct Oxidation of β-Aryl Substituted Aldehydes to α,β-Unsaturated Aldehydes Promoted by an o-Anisidine-Pd(OAc)2 Co-catalyst被引量：64收藏
- 作者：Liu, Jie Zhu, Jin Jiang, Hualiang Wang, Wei Li, Jian
- 机构：E China Univ Sci & Technol;Univ New Mexico;Chinese Acad Sci
- 来源：CHEMISTRY-AN ASIAN JOURNAL 2009
- 关键词：aldehydes anisidine organocatalysis palladium Saegusa reaction
- Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections被引量：48收藏
- 作者：Wang, Youxin Chen, Feifei Di, Hongxia Xu, Yong Xiao, Qiang Wang, Xuehai Wei, Hanwen Lu, Yanli Zhang, Lingling Zhu, Jin Sheng, Chunquan Lan, Lefu Li, Jian
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Hubei Biopharmaceut Ind Technol Inst Inc;Humanwell Healthcare Grp Co Ltd;Second Mil Med Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Design and Synthesis of Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases?被引量：46收藏
- 作者：Deng, Jing Feng, Enguang Ma, Sheng Zhang, Yan Liu, Xiaofeng Li, Honglin Huang, Huang Zhu, Jin Zhu, Weiliang Shen, Xu Miao, Liyan Liu, Hong Jiang, Hualiang Li, Jian
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Soochow Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2011
- Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions被引量：44收藏
- 作者：Ma, Ruoqun Zhu, Jin Liu, Jie Chen, Lili Shen, Xu Jiang, Hualiang Li, Jian
- 机构：Chinese Acad Sci;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：MOLECULES 2010
- 关键词：microwave-assisted reactions one-pot pyrazolones
- A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1被引量：44收藏
- 作者：Huang, Zhenghui Li, Ruoxi Tang, Tongke Ling, Dazheng Wang, Manjiong Xu, Dandan Sun, Maoxin Zheng, Lulu Zhu, Feng Min, Hui Boonhok, Rachasak Ding, Yan Wen, Yuhao Chen, Yicong Li, Xiaokang Chen, Yuxi Liu, Taiping Han, Jiping Miao, Jun Fang, Qiang Cao, Yaming Tang, Yun Cui, Jie Xu, Wenyue Cui, Liwang Zhu, Jin Wong, Gary Li, Jian Jiang, Lubin
- 机构：Univ Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol;ShanghaiTech Univ;Bengbu Med Coll
- 来源：CELL DISCOVERY 2020
- Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent被引量：43收藏
- 作者：Huang, Huang Lu, Weiqiang Li, Xi Cong, Xiaoli Ma, Hongmei Liu, Xiaofeng Zhang, Yu Che, Peng Ma, Ruoqun Li, Honglin Shen, Xu Jiang, Hualiang Huang, Jin Zhu, Jin
- 机构：E China Univ Sci & Technol;Minsheng Pharma;Chinese Acad Sci
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2012
- 关键词：Falcipain-2 Dihydrofolate reductase Dual inhibitor Antimalarial drug SAR Molecular docking
- Curcumin-based polarity fluorescent probes: Design strategy and biological applications被引量：41收藏
- 作者：Hu, Linghao Shi, Donglei Li, Xinming Zhu, Jin Mao, Fei Li, Xiaokang Xia, Conglong Jiang, Bei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ
- 来源：DYES AND PIGMENTS 2020
- 关键词：Curcumin Polarity-specificity Polarity fluorescent probe Lysosome Live-cell imaging Design strategy
- Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents被引量：41收藏
- 作者：Xu, Yixiang Zhang, Jian Wang, Huan Mao, Fei Bao, Keting Liu, Wenwen Zhu, Jin Li, Xiaokang Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2019
- 关键词：Alzheimer's disease multifunctional agents AChE inhibitors MAO-B inhibitors metal chelating agents
- Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation被引量：39收藏
- 作者：Li, Xiaokang Wang, Huan Xu, Yixiang Liu, Wenwen Gong, Qi Wang, Wei Qiu, Xiaoxia Zhu, Jin Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：ACS CHEMICAL NEUROSCIENCE 2017
- 关键词：Alzheimer's disease depression multitarget-directed ligand ChE inhibition 5-HT1A agonist 5-HT reuptake inhibition
- Pd-catalyzed cascade Heck-Saegusa: direct synthesis of enals from aryl iodides and allyl alcohol被引量：38收藏
- 作者：Liu, Jie Zhu, Jin Jiang, Hualiang Wang, Wei Li, Jian
- 机构：E China Univ Sci & Technol;Univ New Mexico;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2010
- Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat被引量：38收藏
- 作者：Li, Ruoxi Ling, Dazheng Tang, Tongke Huang, Zhenghui Wang, Manjiong Ding, Yan Liu, Taiping Wei, Hanwen Xu, Wenyue Mao, Fei Zhu, Jin Li, Xiaokang Jiang, Lubin Li, Jian
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci;ShanghaiTech Univ;Army Med Univ;Dali Univ
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2021
- Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway被引量：35收藏
- 作者：Wei, Jinlian Chen, Xin Li, Yongyun Li, Ruoxi Bao, Keting Liao, Liang Xie, Yuqing Yang, Tiannuo Zhu, Jin Mao, Fei Ni, Shuaishuai Jia, Renbing Xu, Xiaofang Li, Jian
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Univ Tradit Chinese Med;Dali Univ;Tongji Univ
- 来源：ACTA PHARMACEUTICA SINICA B 2022
- 关键词：Conjunctival melanoma Cucurbitacin B Activity-based protein profiling G2 M cell cycle GRP78 FOXM1 KIF20A Rare tumor
- Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice被引量：33收藏
- 作者：Fan, Lei Qiu, Xiao-xia Zhu, Zhi-yuan Lv, Jian-lu Lu, Jian Mao, Fei Zhu, Jin Wang, Jia-ying Guan, Xiao-wei Chen, Jing Ren, Jin Ye, Ji-ming Zhao, Yong-hua Li, Jian Shen, Xu
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;East China Univ Sci & Technol;Nanjing Univ Chinese Med;RMIT Univ
- 来源：ACTA PHARMACOLOGICA SINICA 2019
- 关键词：Alzheimer's disease nitazoxanide autophagy inflammation APP/PS1 transgenic mice
- Discovery of New Imidazole Derivatives Containing the 2,4-Dienone Motif with Broad-Spectrum Antifungal and Antibacterial Activity被引量：32收藏
- 作者：Liu, Chunliu Shi, Ce Mao, Fei Xu, Yong Liu, Jinyan Wei, Bing Zhu, Jin Xiang, Mingjie Li, Jian
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Humanwell Healthcare Grp Co Ltd
- 来源：MOLECULES 2014
- 关键词：imidazole 2,4-dienone broad-spectrum antifungal antibacterial
- Synthesis, Structure-Activity Relationship, and Pharmacophore Modeling Studies of Pyrazole-3-Carbohydrazone Derivatives as Dipeptidyl Peptidase IV Inhibitors被引量：30收藏
- 作者：Wu, Deyan Jin, Fangfang Lu, Weiqiang Zhu, Jin Li, Cui Wang, Wei Tang, Yun Jiang, Hualiang Huang, Jin Liu, Guixia Li, Jian
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：CHEMICAL BIOLOGY & DRUG DESIGN 2012
- 关键词：dipeptidyl peptidase IV inhibitors molecular docking pharmacophore modeling synthesis
- Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety被引量：28收藏
- 作者：Wang, Manjiong Tang, Tongke Li, Ruoxi Huang, Zhenghui Ling, Dazheng Zheng, Lulu Ding, Yan Liu, Taiping Xu, Wenyue Zhu, Feng Min, Hui Boonhok, Rachasak Mao, Fei Zhu, Jin Li, Xiaokang Jiang, Lubin Li, Jian
- 机构：East China Univ Sci & Technol;Univ Chinese Acad Sci;ShanghaiTech Univ;Army Med Univ;Univ S Florida
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2022
- Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN)被引量：26收藏
- 作者：Wang, Youxin Di, Hongxia Chen, Feifei Xu, Yong Xiao, Qiang Wang, Xuehai Wei, Hanwen Lu, Yanli Zhang, Lingling Zhu, Jin Lan, Lefu Li, Jian
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Hubei Biopharmaceut Ind Technol Inst Inc;Humanwell Healthcare Grp Co Ltd
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly被引量：26收藏
- 作者：Liu, Yanqing Zhou, Enkun Yu, Kunqian Zhu, Jin Zhang, Yu Xie, Xin Li, Jian Jiang, Hualiang
- 机构：Chinese Acad Sci;E China Univ Sci & Technol;Southwest Univ;Chinese Acad Sci
- 来源：MOLECULES 2008
- 关键词：CCR5 antagonist fragment assembly HIV-1 molecular modeling
- Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity被引量：25收藏
- 作者：Li, Baoli Ni, Shuaishuai Mao, Fei Chen, Feifei Liu, Yifu Wei, Hanwen Chen, Wenhua Zhu, Jin Lan, Lefu Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2018
- Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment被引量：25收藏
- 作者：Liu, Wenwen Wang, Huan Li, Xiaokang Xu, Yixiang Zhang, Jian Wang, Wei Gong, Qi Qiu, Xiaoxia Zhu, Jin Mao, Fei Zhang, Haiyan Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2018
- 关键词：Depression Cognitive impairment Multitarget-directed ligand 5-HT1A agonist 5-HT reuptake inhibition ChE inhibition
