成果/Result
- leSensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zbrafish被引量：61收藏
- 作者：Yang, Dahai Zheng, Xin Chen, Shouwen Wang, Zhuang Xu, Wenting Tan, Jinchao Hu, Tianjian Hou, Mingyu Wang, Wenhui Gu, Zhaoyan Wang, Qiyao Zhang, Ruilin Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin;Shanghai Collaborat Innovat Ctr Biomfg;Fudan Univ
- 来源：NATURE COMMUNICATIONS 2018
- Evaluation of Microalgae as Immunostimulants and Recombinant Vaccines for Diseases Prevention and Control in Aquaculture被引量：58收藏
- 作者：Ma, Ke Bao, Qiuwen Wu, Yue Chen, Siwei Zhao, Shuxin Wu, Haizhen Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2020
- 关键词：aquaculture industry microalgae immunostimulant oral vaccine polymicrobial infections
- Dysregulated hemolysin liberates bacteria outer membrane vesicles for cytosolic lipopolysaccharide sensing被引量：52收藏
- 作者：Chen, Shouwen Yang, Dahai Wen, Ying Jiang, Zhiwei Zhang, Lingzhi Jiang, Jiatiao Chen, Yaozhen Hu, Tianjian Wang, Qiyao Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Univ Michigan;Univ Michigan;Xijing Hosp
- 来源：PLOS PATHOGENS 2018
- Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota被引量：50收藏
- 作者：Ma, Ke Chen, Siwei Wu, Yue Ma, Yiting Qiao, Haochen Fan, Jianhua Wu, Haizhen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2022
- 关键词：Microalgae Zebrafish Growth performance Immune status Gut microbiota
- Zebrafish gasdermin E cleavage-engaged pyroptosis by inflammatory and apoptotic caspases被引量：32收藏
- 作者：Chen, Hao Wu, Xiaomin Gu, Zhaoyan Chen, Shouwen Zhou, Xiangshan Zhang, Yuanxing Liu, Qin Wang, Zhuang Yang, Dahai
- 机构：East China Univ Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2021
- 关键词：Zebrafish Gsdme Pyroptosis Inflammatory caspases Apoptotic caspases
- caspase-mediated LPS sensing and pyroptosis signaling in Hydra被引量：31收藏
- 作者：Chen, Shouwen Li, Shuxin Chen, Hao Gong, Yuxin Yang, Dahai Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai
- 来源：SCIENCE ADVANCES 2023
- 关键词：Network security
- Dual function of a turbot inflammatory caspase in mediating both canonical and non-canonical inflammasome activation被引量：28收藏
- 作者：Chen, Shouwen Jin, Peng Chen, Hao Wu, Di Li, Shuxin Zhang, Yuanxing Liu, Qin Yang, Dahai
- 机构：East China Univ Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2021
- 关键词：Turbot Inflammatory caspase Cytosolic LPS receptor NLRP3 inflammasome GSDME Pyroptosis Antibacterial activity
- Mesenchymal Stromal Cells Directly Promote Inflammation by canonical NLRP3 and Non-canonical caspase-11 Inflammasomes被引量：25收藏
- 作者：Chen, Yaozhen Qin, Xiangyang An, Qunxing Yi, Jing Feng, Fan Yin, Dandan An, Ning Liu, Zheng Weng, Lihong Chen, Shouwen Hu, Xingbin Yin, Wen
- 机构：Fourth Mil Med Univ;Fourth Mil Med Univ;Fourth Mil Med Univ;Fourth Mil Med Univ;Fourth Mil Med Univ
- 来源：EBIOMEDICINE 2018
- 关键词：Mesenchymal stromal cells Inflammasome NLRP3 caspase-11 Pyroptosis
- Scophthalmus maximus interleukin-1β limits Edwardsiella piSCIcida colonization in vivo被引量：18收藏
- 作者：Chen, Shouwen Ma, Xin Wu, Di Yang, Dahai Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin
- 来源：FISH & SHELLFISH IMMUNOLOGY 2019
- 关键词：Scophthabnus maximus Interleukin-1 beta Edwardsiella piSCIcida Bacterial colonization
- Dysregulated haemolysin promotes bacterial outer membrane vesicles-induced pyroptotic-like cell death in zebrafish被引量：16收藏
- 作者：Wen, Ying Chen, Shouwen Jiang, Zhiwei Wang, Zhuang Tan, Jinchao Hu, Tianjian Wang, Qiyao Zhou, Xiangshan Zhang, Yuanxing Liu, Qin Yang, Dahai
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg;Shanghai Engn Res Ctr Marine Cultured Anim Vaccin
- 来源：CELLULAR MICROBIOLOGY 2019
- 关键词：bacterial outer membrane vesicles Edwardsiella piSCIcida haemolysin pyroptotic-like cell death zebrafish intestinal infection
- Dysregulation of Cytosolic c-di-GMP in Edwardsiella piSCIcida Promotes Cellular Non-canonical Ferroptosis被引量：13收藏
- 作者：Wen, Ying Wang, Ying Chen, Shouwen Zhou, Xiangshan Zhang, Yuanxing Yang, Dahai Nunez, Gabriel Liu, Qin
- 机构：East China Univ Sci & Technol;Univ Michigan;Univ Michigan;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Shanghai Engn Res Ctr Maricultured Anim Vaccines
- 来源：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2022
- 关键词：Edwardsiella piSCIcida c-di-GMP accumulation non-canonical ferroptosis bacterial virulence pathogen infection
- Red blood cells undergo lytic programmed cell death involving NLRP3被引量：11收藏
- 作者：Chen, Yaozhen Chen, Shouwen Liu, Zhixin Wang, Yafen An, Ning Chen, Yutong Peng, Yihao Liu, Zheng Liu, Qin Hu, Xingbin
- 机构：Fourth Mil Med Univ;East China Univ Sci & Technol;Chinese Univ Hong Kong
- 来源：CELL 2025
- Hydra gasdermin-gated pyroptosis signalling regulates tissue regeneration被引量：5收藏
- 作者：Chen, Shouwen Gong, Yuxin Li, Shuxin Yang, Dahai Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Shanghai Engn Res Ctr Marine Cultured Anim Vaccine
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2023
- 关键词：Gasdermin Pyroptosis Wnt Mitochondrial ROS Regeneration
- Cleavage of gasdermin by apoptotic caspases triggers pyroptosis restricting bacterial colonization in Hydra被引量：0收藏
- 作者：Li, Shuxin Lin, Xiuqing Zhang, Yuanxing Liu, Qin Chen, Shouwen
- 机构：East China Univ Sci & Technol;Southern Marine Sci & Engn Guangdong Lab Zhuhai;Shanghai Engn Res Ctr Marine Cultured Anim Vaccine
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2024
- 关键词：Gasdermin GSDME Evolution Recognition motif Hydra
- Identification of stable reference genes in plasma astrocyte-derived exosomal mRNA for RT-qPCR analysis in Alzheimer's disease被引量：0收藏
- 作者：Guo, Guigui Qu, Yiwen Wang, Qiyao Xiao, Zhihua Liu, Qin Zeng, Xianfeng Chen, Shouwen
- 机构：East China Univ Sci & Technol;Shanghai OPM Biosci Co Ltd;Yanan Univ;Northwest Univ
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2026
- 关键词：Reference gene RT-qPCR Astrocyte-derived exosome mRNA Alzheimer's disease
- Complement-coupled erythrocyte platform for rapid enrichment of candidate NLRP3 modulators被引量：0收藏
- 作者：Shi, Lijia Liu, Wenjing Xie, Xueman Zhang, Yuanxing Liu, Qin Chen, Shouwen
- 机构：East China Univ Sci & Technol
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2026
- 关键词：Complement-mediated hemolysis High-throughput drug discovery NLRP3 Phenotypic screening Spectosis
- Porcine plasma-derived extracellular vesicles orchestrate multi-target neuroimmune reconfiguration to alleviate Alzheimer's disease pathology in a 5×FAD mouse model被引量：0收藏
- 作者：Lu, Xiaoyang Jiang, Yiling Lin, Xiuqing Zhang, Yuanxing Liu, Qin Chen, Shouwen
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF NEUROINFLAMMATION 2026
- 关键词：Alzheimer's disease Small extracellular vesicles Porcine plasma Microglia Reactive astrocyte Neuroinflammation Cross-species therapy
