成果/Result
- Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and the physicochemical and biological properties被引量：62收藏
- 作者：Wu, Hao Deng, Zhaizhu Zhou, Bijian Qi, Minghui Hong, Minghuang Ren, Guobin
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2019
- 关键词：Ibuprofen Ionic liquids Molecular interaction Skin permeability Cytotoxicity
- Development of a gliclazide ionic liquid and its mesoporous silica particles: An effective formulation strategy to improve oral absorption properties被引量：58收藏
- 作者：Zhou, Bijian Teng, Dan Li, Jinghui Zhang, Yanhong Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Shanghai Key Laboratory of New Drug Design; State Key Laboratory of Bioreactor Engineering
- 来源：RSC Advances 2022
- 关键词：Silica - Targeted drug delivery - Molecules - Controlled drug delivery - Encapsulation - Solubility - Positive ions - Mesoporous materials - Physicochemical properties - Supersaturation
- Insight into the effect of cocrystal polymorphism / stoichiomorphism on thermodynamic and photoluminescence properties: a case study被引量：45收藏
- 作者：Han, Xianyang Yin, Yu Zhu, Fan Yao, Yichen Hong, Minghuang Qi, Minghui Zhu, Bin Ren, Guobin
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2025
- 关键词：Crystal structure - Fluorescence - Fluorescence spectroscopy - Optical properties - Phase transitions - Photoluminescence - Polymorphism - Single crystals - Thermoanalysis - X ray diffraction
- Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point被引量：40收藏
- 作者：Yao, Yi-Chen Jin, Zhe Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology
- 来源：Crystal Growth and Design 2024
- 关键词：Melting point - Single crystals - Surface analysis - Thermoanalysis
- Drug-Drug Cocrystals Provide Significant Improvements of Drug Properties in Treatment with Progesterone被引量：37收藏
- 作者：Guo, Chunyang Zhang, Qi Zhu, Bingqing Zhang, Zaiyong Ma, Xiaoyu Dai, Wenjuan Gong, Xiaoyi Ren, Guobin Mei, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2020
- 关键词：Pelletizing - Solubility - Stability - Differential scanning calorimetry
- Solid-State Characterization and Insight into Transformations and Stability of Apatinib Mesylate Solvates被引量：32收藏
- 作者：Zhu, Bin Zhang, Qi Ren, Guobin Mei, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2017
- 关键词：Differential scanning calorimetry - Single crystals - Thermogravimetric analysis - Quality control
- Ionic liquid form of donepezil: Preparation, characterization and formulation development被引量：31收藏
- 作者：Wu, Hao Fang, Fang Zheng, Lulu Ji, Weijie Qi, Minghui Hong, Minghuang Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2020
- 关键词：Ionic liquids Alzheimer's disease Donepezil Drug-in-adhesive patch Skin permeability
- Slow-Release Drug-Drug Cocrystals of Oxaliplatin with Flavonoids: Delaying Hydrolysis and Reducing Toxicity被引量：31收藏
- 作者：Yin, He-Mei Wu, Nan Zhou, Bi-Jian Hong, Ming-Huang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Cancer cells - Controlled drug delivery - Fourier transform infrared spectroscopy - Dissolution - Targeted drug delivery - Cells - Flavonoids - X ray diffraction - Hydrogen bonds - Thermoanalysis - Toxicity - Cytology
- Stable Cocrystals and Salts of the Antineoplastic Drug Apatinib with Improved Solubility in Aqueous Solution被引量：29收藏
- 作者：Zhu, Bin Wang, Jian-Rong Zhang, Qi Li, Meiqi Guo, Chunyang Ren, Guobin Mei, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2018
- 关键词：Infrared spectroscopy - Single crystals - Solubility - X ray diffraction - Cell proliferation - Drug delivery - Endothelial cells - Amino acids - Differential scanning calorimetry
- Toward Understanding the Effect of Solvent Evaporation on the Morphology of PLGA Microspheres by Double Emulsion Method被引量：29收藏
- 作者：Si, Wei Yang, Qingqing Zong, Yuan Ren, Guobin Zhao, Ling Hong, Minghuang Xin, Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2021
- 关键词：Emulsification - Evaporation - Morphology - Microspheres - Diffusion
- Development of gliclazide ionic liquid and the transdermal patches: An effective and noninvasive sustained release formulation to achieve hypoglycemic effects被引量：27收藏
- 作者：Zhou, Bijian Liu, Siyuan Yin, Hemei Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2021
- 关键词：Diabetes mellitus Gliclazide Ionic liquid Transdermal drug delivery Hypoglycemic effect
- Resurrecting the 'Disappearing Polymorph' of Rotigotine via Conformational Landscape Engineering被引量：25收藏
- 作者：Yi, Dongxu Qi, Minghui Xu, Shaohong Qi, Yonghua Xia, Ran Wu, Hao Ren, Guobin
- 机构： School of Pharmacy; School of Pharmacy; Children's Hospital Affiliated to Zhengzhou University; Henan Children’ s Hospital Zhengzhou Children’s Hospital; Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2025
- 关键词：Boltzmann equation - Conformations - Crystallization kinetics - Drug products - Engineering research - Molecular biology - Molecular physics - Polymorphism - Potential energy
- Cocrystals of Oxymatrine: Reducing Hygroscopicity and Affecting the Dissolution Rate被引量：25收藏
- 作者：Qi, Ming-Hui Li, Heng Zhu, Bin Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Dissolution - Hydrogen bonds - Metabolism
- Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy被引量：23收藏
- 作者：Chen, Wenhua Guo, Ne Qi, Minghui Dai, Haiying Hong, Minghuang Guan, Longfei Huan, Xiajuan Song, Shanshan He, Jinxue Wang, Yingqing Xi, Yong Yang, Xinying Shen, Yanyan Su, Yi Sun, Yiming Gao, Yinglei Chen, Yi Ding, Jian Tang, Yun Ren, Guobin Miao, Zehong Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Univ Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017
- 关键词：Antitumor drug BRCA1/2 PARP inhibitors Molecular docking
- 面向生物医药新工科方向的生物工程一流本科专业建设探索与实践被引量：23收藏
- 作者：王启要 高淑红 白云鹏 任国宾 庄英萍 宋恭华
- 机构：华东理工大学生物工程学院;华东理工大学药学院
- 来源：《生物工程学报》 2022
- 关键词：生物医药新工科 三位一体 三全育人 课程体系
- 摘要：《“健康中国2030”规划纲要》将生物医药列为重点规划发展领域,上海也将生物医药列为重要新兴支柱产业。生物医药产业的快速发展对人才需求提出了更高要求。华东理工大学生物工程学院秉承交叉融合、互惠发展、传承创新的思路,将生物...
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- Study of Crystal Structures, Properties, and Form Transformations among a Polymorph, Hydrates, and Solvates of Apatinib被引量：22收藏
- 作者：Zhu, Bin Fang, Xiaoxue Zhang, Qi Mei, Xuefeng Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2019
- 关键词：Differential scanning calorimetry - X ray diffraction - Cell proliferation - Hydration - Endothelial cells - Thermogravimetric analysis - Amino acids - Single crystals
- Strategy for Efficient Discovery of Cocrystals via a Network-Based Recommendation Model被引量：22收藏
- 作者：Zheng, Lulu Zhu, Bin Wu, Zengrui Fang, Xiaoxue Hong, Minghuang Liu, Guixia Li, Weihua Ren, Guobin Tang, Yun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2020
- Estimating Thermodynamic Stability Relationship of Polymorphs of Sofosbuvir被引量：22收藏
- 作者：Qi, Ming-Hui Hong, Ming-Huang Liu, Yan Wang, En-Fu Ren, Fu-Zheng Ren, Guo-Bin
- 机构：E China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2015
- 关键词：Solubility - Thermoanalysis - X ray powder diffraction - Free energy - Melting
- Polymorphs and Hydrates of Apatinib Mesylate: Insight into the Crystal Structures, Properties, and Phase Transformations被引量：22收藏
- 作者：Zhu, Bin Wang, Jian-Rong Ren, Guobin Mei, Xuefeng
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2016
- 关键词：Differential scanning calorimetry - Single crystals - Thermogravimetric analysis - Hydrates - Phase transitions - Fourier transform infrared spectroscopy - X ray diffraction
- Cocrystals of Lenvatinib with Sulfamerazine and Salicylic Acid: Crystal Structure, Equilibrium Solubility, Stability Study, and Anti-Hepatoma Activity被引量：20收藏
- 作者：Hong, Minghuang Li, Shijia Ji, Weijie Qi, Ming-Hui Ren, Guo-bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Surface analysis - Crystal structure - Nuclear magnetic resonance spectroscopy - Salicylic acid - Differential scanning calorimetry - Amino acids - Fourier transform infrared spectroscopy - Thermogravimetric analysis - Hydrogen bonds - Drug delivery - Spectrometers - X ray diffraction
- Insight into the Formation of Cocrystals of Flavonoids and 4,4′-Vinylenedipyridine: Heteromolecular Hydrogen Bonds, Molar Ratio, and Structural Analysis被引量：19收藏
- 作者：Zhang, Yanhong Zhu, Bin Ji, Wei-Jie Guo, Chun-Yang Hong, Minghuang Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Hydrogen bonds - Single crystals - Molar ratio
- Enhancing the solubility of natural compound xanthotoxin by modulating stability via cocrystallization engineering被引量：19收藏
- 作者：Chen, Jin-Yao Wu, Hao Guo, Chun-Yang Zhu, Bin Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Dali Univ
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2019
- 关键词：Xanthotoxin Cocrystals Crystal structure Solubility Stability
- Investigating molecular interactions of high-loaded glipizide-HPMCAS microparticles by integrated experimental and modeling techniques被引量：17收藏
- 作者：Li, Qiang Zhao, Qianqian Jing, Qiufang Ma, Xiaosi Chen, Ning Ren, Guobin Ouyang, Defang Ren, Fuzheng
- 机构：East China Univ Sci & Technol;Univ Macau
- 来源：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2019
- 关键词：Glipizide Hydroxypropyl methylcellulose acetate succinate (HPMCAS) Molecular interaction Molecular dynamics simulation
- Cocrystals of flavonoids with 4,4′-ethylenebispyridine: Crystal structures analysis, dissolution behavior, and anti-tumor activity被引量：16收藏
- 作者：Zhang, Yanhong Yang, Rui Yin, He-Mei Zhou, Bijian Hong, Minghuang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2022
- 关键词：Tumors - Cancer cells - Single crystals - Dissolution
- Analysis of the dissolution behavior and solubility of Rotigotine form II in different mono-solvents被引量：16收藏
- 作者：Yi, Dongxu Dong, Yuhang Wang, Qinglin Wu, Juan Qi, Minghui Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2023
- 关键词：Rotigotine Hirshfeld surface Solubility Correlation Molecular simulation
- Influence of Temperature, Solvents, and Excipients on Crystal Transformation of Agomelatine被引量：16收藏
- 作者：Liu, Yan Gao, Huiru Xu, Hao Ren, Fuzheng Ren, Guobin
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2016
- 关键词：Temperature
- Strategy to Tune the Performance of Two Drug Components: Drug-Drug Cocrystals of Lobaplatin with Flavonoids被引量：15收藏
- 作者：Yin, He-Mei Xie, Jun-Yi Jiang, Jun-Yi Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2022
- 关键词：Dissolution - Solubility
- Three solid forms of chlorantraniliprole: Structure, characterization, and phase transformation被引量：14收藏
- 作者：Du, Dan Liu, Peng-Jian Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2018
- 关键词：Chlorantraniliprole Solid forms Solvates Crystal structure Phase transformation
- Solubility correlation and thermodynamic analysis of two forms of Metaxalone in different pure solvents被引量：14收藏
- 作者：Hong, Minghuang Wu, Shiwang Qi, Minghui Ren, Guobin
- 机构：E China Univ Sci & Technol
- 来源：FLUID PHASE EQUILIBRIA 2016
- 关键词：Solubility Thermodynamic models Endothermic Entropy driven Nonspontaneous
- Solvent-Mediated Polymorphic Transformation of Famoxadone from Form II to Form I in Several Mixed Solvent Systems被引量：14收藏
- 作者：Du, Dan Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol
- 来源：CRYSTALS 2019
- 关键词：famoxadone solvent-mediated polymorphic transformation hydrogen-bond-acceptance ability
