成果/Result
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- Negatively charged phospholipids accelerate the membrane fusion activity of the plant-specific insert domain of an aspartic protease被引量：53收藏
- 作者：Zhao, Xiaoli Ma, Xiaomin Dupius, John H. Qi, Ruxi Tian, Jenny Chen, Jiaxin Ou, Xiuyuan Qian, Zhaohui Liang, Dehai Wang, Peiyi Yada, Rickey Y. Wang, Shenlin
- 机构： College of chemistry and molecular engineering; State Key Laboratory of Bioreactor Engineering; Cryo-EM center; Food Nutrition and Health Program; MOH Key Laboratory
- 来源：Journal of Biological Chemistry 2022
- 关键词：Phospholipids - Plants (botany) - Nuclear magnetic resonance spectroscopy - Cell membranes - Liposomes
- A random fractional 13C labeling strategy for P. pastoris expressed eukaryotic membrane proteins for solid-state NMR studies被引量：44收藏
- 作者：Sang, Meihui Fan, Zejun Ren, Qiongqiong Liu, Jing Zhao, Shaokai Wang, Shenlin
- 机构： State Key Laboratory of Bioreactor Engineering; College of Chemistry and Chemical Engineering
- 来源：Magnetic Resonance Letters 2025
- 关键词：Biological membranes - Cost effectiveness - Light polarization - Nuclear magnetic resonance spectroscopy - Proteins - Sanitary sewers - Sodium compounds - Spectral resolution
- Characterizing Y224 conformational flexibility in FtmOx1-catalysis using 19F NMR spectroscopy被引量：36收藏
- 作者：Wang, Xinye Yang, Lingyun Wang, Shenlin Wang, Jun Li, Kelin Naowarojna, Nathchar Ju, Yi Ye, Ke Han, Yuchen Yan, Wupeng Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构： State Key Laboratory of Bioreactor Engineering; iHuman Institute; School of Life Sciences and Biotechnology; Department of Chemistry; Program of Chemistry
- 来源：Catalysis Science and Technology 2024
- 关键词：Biosynthesis - Complexation - Conformations - Nuclear magnetic resonance spectroscopy
- Development of Antibacterial Peptides with Membrane Disruption and Folate Pathway Inhibitory Activities against Methicillin-Resistant Staphylococcus aureus被引量：18收藏
- 作者：Li, Chunlei Zhou, Ziyi Wang, Weitao Zhao, Yanqiu Yin, Xin Meng, Yiwei Zhao, Peipei Wang, Mengmeng Liu, Xueting Wang, Xinye Wang, Shenlin Ren, Biao Zhang, Lixin Xia, Xuekui
- 机构：Qilu Univ Technol;Shandong Univ;Sichuan Univ;Sichuan Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2024
- Advances in the structural characterization of complexes of therapeutic antibodies with PD-1 or PD-L1被引量：14收藏
- 作者：Jiang, Mengzhen Liu, Man Liu, Guodi Ma, Jiawen Zhang, Lixin Wang, Shenlin
- 机构：East China Univ Sci & Technol
- 来源：MABS 2023
- 关键词：Antibody structure antibody-antigen interactions PD-1
- Access to Axially Chiral Biaryl Benzylamines via Ancestral Enzyme-Enabled Reductive Amination Desymmetrization被引量：11收藏
- 作者：Zheng, Wen-Qing Zhu, Xin-Xin Zhu, Zheng Yang, Tairan Zheng, Lifen Pan, Rui Wang, Shenlin Zhang, Lixin Chen, Qi Xu, Jian-He Xie, Yongtao Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2025
- 关键词：biocatalysis desymmetrization reductive amination ancestral imine reductase axially chiral biaryl benzylamine
- A rapid nucleic acid detection platform based on phosphorothioate-DNA and sulfur binding domain被引量：9收藏
- 作者：Shuai, Yuting Ju, Yi Li, Yuanhang Ma, Dini Jiang, Lan Zhang, Jingyu Tan, Gao-Yi Liu, Xueting Wang, Shenlin Zhang, Lixin Liu, Guang
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Shanghai Jiao Tong Univ
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2023
- 关键词：Phosphorothioate Sulfur binding domain Nucleic acid detection
- Mechanisms of antimicrobial peptides as characterized by solid-state NMR被引量：7收藏
- 作者：Han, Rong Wang, Shenlin
- 机构：Peking Univ;Peking Univ;East China Univ Sci & Technol;Beijing Natl Lab Mol Sci
- 来源：MAGNETIC RESONANCE LETTERS 2022
- 关键词：Antimicrobial peptides (AMP) Solid-state NMR (SSNMR) Sample preparation Antimicrobial mechanisms Whole -cell NMR
- Assisting and accelerating NMR assignment with restrained structure prediction被引量：5收藏
- 作者：Liu, Sirui Chu, Haotian Xie, Yuhao Wu, Fangming Mu, Fangjing Wei, Jiachen Ni, Ningxi Wang, Chenghao Zhang, Jun Chen, Mengyun Li, Junbin Yu, Fan Fu, Hui Wang, Shenlin Tian, Changlin Wang, Zidong Gao, Yi Qin
- 机构：Changping Lab;Huawei Technol Co Ltd;Chinese Acad Sci;Peking Univ;East China Univ Sci & Technol ECUST
- 来源：COMMUNICATIONS BIOLOGY 2025
- Dynamics of base pairs with low stability in RNA by solid-state nuclear magnetic resonance exchange spectroscopy被引量：4收藏
- 作者：Zhao, Sha Li, Xinming Wen, Ziyang Zou, Mengbing Yu, Ge Liu, Xiangyang Mao, Jiafei Zhang, Lixin Xue, Yi Fu, Riqiang Wang, Shenlin
- 机构：Peking Univ;East China Univ Sci & Technol;Tsinghua Univ;Goethe Univ Frankfurt;Goethe Univ Frankfurt
- 来源：ISCIENCE 2022
- Advances in the Structure of GGGGCC Repeat RNA Sequence and Its Interaction with Small Molecules and Protein Partners被引量：3收藏
- 作者：Liu, Xiaole Zhao, Xinyue He, Jinhan Wang, Sishi Shen, Xinfei Liu, Qingfeng Wang, Shenlin
- 机构：East China Univ Sci & Technol;Peking Univ
- 来源：MOLECULES 2023
- 关键词：amyotrophic lateral sclerosis frontotemporal dementia C9orf72 GGGGCC G4
- Advances in solid-state NMR methods for studying RNA structures and dynamics被引量：2收藏
- 作者：He, Jinhan Liu, Xiaole Wang, Shenlin
- 机构：East China Univ Sci & Technol
- 来源：MAGNETIC RESONANCE LETTERS 2025
- 关键词：Solid-state NMR RNA Structure Dynamics Pulse sequences
- Characterizing Y224 conformational flexibility in FtmOx1-catalysis using 19F NMR spectroscopy被引量：2收藏
- 作者：Wang, Xinye Yang, Lingyun Wang, Shenlin Wang, Jun Li, Kelin Naowarojna, Nathchar Ju, Yi Ye, Ke Han, Yuchen Yan, Wupeng Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构：East China Univ Sci & Technol;ShanghaiTech Univ;Shanghai Jiao Tong Univ;Boston Univ;Sakon Nakhon Rajabhat Univ
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2025
- A strategy for producing isotopically labeled peptides with antimicrobial activity or with short in vivo lifetime in Escherichia coli被引量：1收藏
- 作者：Ren, Qiongqiong Fan, Zejun Han, Rong Sang, Meihui Ma, Changxing Zhao, Xiaoli Wang, Shenlin
- 机构：East China Univ Sci & Technol;Peking Univ;Peking Univ;Shandong Polytech
- 来源：PEPTIDE SCIENCE 2024
- 关键词：antimicrobial peptide fusion expression system fusion peptide isotope labeling NMR
- Mechanisms of antimicrobial peptides as characterized by solid-state NMR被引量：1收藏
- 作者：Rong Han Shenlin Wang
- 机构：College of Chemistry and Molecular Engineering and Beijing NMR Center;State Key Laboratory of Bioreactor Engineering;Beijing National Laboratory for Molecular Science
- 来源：磁共振快报（英文） 2022
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- The Intrinsic Disordered N-Terminus of Nucleocapsid Protein of SARS-CoV-2 Is Critical in DNA Aptamer Binding被引量：0收藏
- 作者：Lu, Hongye Ma, Jiawen Ma, Xiaomin Wu, Yuanpeng Sun, Xuan Ma, Changxing Li, Xiaoxian Xu, Zhiyong Lu, Pengxi Luo, Zhaofeng Zhang, Liyun Zhang, Lixin Wang, Shenlin
- 机构：East China Univ Sci & Technol;Sun Yan Sen Univ;Shanghai Jiao Tong Univ;Univ Sci & Technol China;Nankai Univ
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2026
- 关键词：nucleocapsid protein (N protein) DNA aptamer A48 protein-nucleic acid interaction intrinsically disordered region (IDR) SARS-CoV-2 NMR
- Production of isotope-labeled nanobody KN035 in Pichia pastoris yields native-like conformation and PD-L1 binding activity comparable to KN035 expressed in mammalian cells被引量：0收藏
- 作者：Ren, Piaoran Jiang, Mengzhen Wang, Shenlin
- 机构：East China Univ Sci & Technol
- 来源：MAGNETIC RESONANCE LETTERS 2026
- 关键词：Pichia pastoris Nanobody Isotope labeling Nuclear magnetic resonance Protein expression
- DNA硫修饰结合蛋白识别序列的表征与拓展促进新型核酸检测技术发展被引量：0收藏
- 作者：帅玉婷 许安安 李甲乙 韩照晰 马蒂尼 段海容 王馨叶 蒋岚 张敬宇 谭高翼 刘雪婷 赵一雷 童垚俊 王申林 贺新义 邓子新 刘光 张立新
- 机构：East China Univ Sci & Technol ECUST;Shanghai Jiao Tong Univ
- 来源：《Science Bulletin》 2023
- 关键词：核酸检测技术 限制性核酸内切酶 SBD 序列模式 识别序列 防御系统 硫原子 抗氧化应激
- 摘要：DNA硫修饰是一种DNA磷酸骨架上的非桥接氧原子被硫原子所取代的修饰,属于原核生物表观遗传标志物之一,它对细菌防御系统、抗氧化应激和基因调控等生命过程具有重要影响.DNA硫修饰可以被硫修饰依赖限制性核酸内切酶的硫结合域S...
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- Recent advances in solid-state nuclear magnetic resonance studies on membrane fusion proteins被引量：0收藏
- 作者：Zheng, Lifen Wang, Shenlin
- 机构：East China Univ Sci & Technol
- 来源：FEBS JOURNAL 2025
- 关键词：enveloped virus membrane fusion membrane fusion protein saposin-like proteins family solid-state NMR
- Characterization of Base-pairing of RNA in RNA Gels Formed by Nucleotide Repeat Expansion by Proton-detected Solid-state NMR被引量：0收藏
- 作者：Sha Zhao Ziyang Wen Mengbing Zou Shenlin Wang
- 机构：College of Chemistry and Molecular Engineering;Beijing NMR Center;Beijing National Laboratory for Molecular Sciences;State Key Laboratory of Bioreactor Engineering
- 来源：[1]College of Chemistry and Molecular Engineering,Peking University;[2]Beijing NMR Center,Peking University;[3]Beijing National Laboratory for Molecular Sciences;[4]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology 2021
- A random fractional ^(13)C labeling strategy for P.pastoris expressed eukaryotic membrane proteins for solid-state NMR studies被引量：0收藏
- 作者：Meihui Sang Zejun Fan Qiongqiong Ren Jing Liu Shaokai Zhao Shenlin Wang
- 机构：State Key Laboratory of Bioreactor Engineering;College of Chemistry and Chemical Engineering
- 来源：磁共振快报(英文) 2026
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- A random fractional 13 C labeling strategy for P. pastoris expressed eukaryotic membrane proteins for solid-state NMR studies被引量：0收藏
- 作者：Sang, Meihui Fan, Zejun Ren, Qiongqiong Liu, Jing Zhao, Shaokai Wang, Shenlin
- 机构：East China Univ Sci & Technol;Peking Univ
- 来源：MAGNETIC RESONANCE LETTERS 2026
- 关键词：Solid-state NMR Sparse 13 C labeling Eukaryotic membrane proteins P. pastoris expression system
- Advances in solid-state NMR methods for studying RNA structures and dynamics被引量：0收藏
- 作者：Jinhan He Xiaole Liu Shenlin Wang
- 机构：State Key Laboratory of Bioreactor Engineering
- 来源：磁共振快报(英文) 2025
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