成果/Result
- The yeast peroxisome: A dynamic storage depot and subcellular factory for squalene overproduction被引量：194收藏
- 作者：Liu, Guo-Song Li, Tian Zhou, Wei Jiang, Min Tao, Xin-Yi Liu, Min Zhao, Ming Ren, Yu-Hong Gao, Bei Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：METABOLIC ENGINEERING 2020
- 关键词：Synthetic biology Saccharomyces cerevisiae Peroxisome Storage depot Subcellular factory Terpene
- Metabolic Engineering of Saccharomyces cerevisiae To Overproduce Squalene被引量：71收藏
- 作者：Li, Tian Liu, Guo-Song Zhou, Wei Jiang, Min Ren, Yu-Hong Tao, Xin-Yi Liu, Min Zhao, Ming Wang, Feng-Qing Gao, Bei Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2020
- 关键词：Saccharomyces cerevisiae metabolic engineering squalene overproduction ethanol carbon source utilization
- Significantly Enhanced Production of Patchoulol in Metabolically Engineered Saccharomyces cerevisiae被引量：53收藏
- 作者：Ma, Bin Liu, Min Li, Zhen-Hai Tao, Xinyi Wei, Dong-Zhi Wang, Feng-Qing
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2019
- 关键词：patchoulol sesquiterpene metabolic engineering Saccharomyces cerevisiae terpenoids
- Metabolic engineering of Pichia pastoris for the production of dammarenediol-II被引量：51收藏
- 作者：Liu, Xin-Bin Liu, Min Tao, Xin-Yi Zhang, Zhong-Xi Wang, Feng-Qing Wei, Dong-Zhi
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2015
- 关键词：Dammarenediol-II Metabolic engineering Pichia pastoris Ginsenosides 2,3-Oxidosqualene
- Engineering Saccharomyces cerevisiae for Hyperproduction of β-Amyrin by Mitigating the Inhibition Effect of Squalene on β-Amyrin Synthase被引量：35收藏
- 作者：Du, Meng-Meng Zhu, Zhan-Tao Zhang, Ge-Ge Zhao, Yun-Qiu Gao, Bei Tao, Xin-Yi Liu, Min Ren, Yu-Hong Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022
- 关键词：beta-amyrin squalene inhibition peroxisome compartmentalization competition pathway Saccharomyces cerevisiae
- Engineered 3-ketosteroid 9a-hydroxylases in Mycobacterium neoaurum: An efficient platform for production of steroid drugs被引量：30收藏
- 作者：Liu, Hao-Hao Xu, Li-Qin Yao, Kang Xiong, Liang-Bin Tao, Xin-Yi Liu, Min Wang, Feng-Qing Wei, Dong-Zhi
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Applied and Environmental Microbiology 2018
- 关键词：Metabolic engineering - Lipids - Alcohols - Metabolism
- Increasing L-homoserine production in Escherichia coli by engineering the central metabolic pathways被引量：25收藏
- 作者：Liu, Min Lou, Jiali Gu, Jiali Lyu, Xiao-Mei Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol;Huzhou Univ;Nanyang Technol Univ
- 来源：JOURNAL OF BIOTECHNOLOGY 2020
- 关键词：L-Homoserine Central metabolic pathways Metabolic engineering Escherichia coli
- Integrated Transcriptome and Proteome Studies Reveal the Underlying Mechanisms for Sterol Catabolism and Steroid Production in Mycobacterium neoaurum被引量：24收藏
- 作者：Liu, Min Xiong, Liang-Bin Tao, Xinyi Liu, Qing-Hai Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2018
- 关键词：sterol catabolism transcriptome proteome Mycobacterium
- Design and evaluation of a phospholipase D based drug delivery strategy of novel phosphatidyl-prodrug被引量：22收藏
- 作者：Tao, Xinyi Jia, Ning Cheng, Nenghui Ren, Yuhong Cao, Xuni Liu, Min Wei, Dongzhi Wang, Feng-Qing
- 机构：East China Univ Sci & Technol
- 来源：BIOMATERIALS 2017
- 关键词：Phosphatidyl-prodrug Phospholipase D Doxorubicin Triggered release Reverse multidrug resistance
- Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin被引量：17收藏
- 作者：Sun, Bing-Yao Sui, Hua-Lu Liu, Zi-Wei Tao, Xin-Yi Gao, Bei Zhao, Ming Ma, Yu-Shu Zhao, Jian Liu, Min Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2022
- 关键词：Flavin-containing monooxygenase Indirubin Loop region Substrate tunnel Structure-guided enzyme engineering Microbial synthesis
- Production of sesquiterpene patchoulol in mitochondrion-engineered Saccharomyces cerevisiae被引量：16收藏
- 作者：Tao, Xin-Yi Lin, Yang-Chen Wang, Feng-Qing Liu, Qing-Hai Ma, Yu-Shu Liu, Min Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2022
- 关键词：Patchoulol Mitochondria compartmentation S cerevisiae Metabolic engineering Sesquiterpene
- Metabolic Adaptation of Mycobacterium neoaurum ATCC 25795 in the Catabolism of Sterols for Producing Important Steroid Intermediates被引量：15收藏
- 作者：Liu, Min Xiong, Liang-Bin Tao, Xinyi Liu, Qing-Hai Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2018
- 关键词：sterol catabolism mycobacteria cell envelope steroids efflux pumps
- CRISPR-Cas12a assisted precise genome editing of Mycolicibacterium neoaurum被引量：13收藏
- 作者：Liu, Ke Gao, Yang Zhen-Hai Li Liu, Min Feng-Qing Wang Dong-Zhi Wei
- 机构：East China Univ Sci & Technol
- 来源：NEW BIOTECHNOLOGY 2022
- 关键词：CRISPR-Cas12a Genome editing Mycolicibacterium neoaurum NHEJ Gene integration
- Immediate, multiplexed and sequential genome engineering facilitated by CRISPR/Cas9 in Saccharomyces cerevisiae被引量：9收藏
- 作者：Li, Zhen-Hai Meng, Hao Ma, Bin Tao, Xinyi Liu, Min Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol;Hunan Norchem Pharmaceut Co Ltd
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2020
- 关键词：Saccharomyces cerevisiae CRISPR Cas9 Gene targeting Cell factory
- Cpf1-assisted efficient genomic integration of in vivo assembled DNA parts in Saccharomyces cerevisiae被引量：8收藏
- 作者：Li, Zhen-Hai Liu, Min Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2018
- 关键词：CRISPR-Cpf1 Saccharomyces cerevisiae Genomic integration
- Single nucleotide polymorphism analysis for the production of valuable steroid intermediates in Mycobacterium neoaurum被引量：2收藏
- 作者：Liu, Min Zhu, Zhan-Tao Tao, Xin-Yi Wang, Feng-Qing Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2016
- 关键词：Deep sequencing Mycobacterium neoaurum RNA sequencing Single nucleotide polymorphism Sterol transformation Steroid Transcriptome
- Preparation and purification of novel phosphatidyl prodrug and performance modulation of phosphatidyl nanoprodrug被引量：2收藏
- 作者：Niu, Rui Zhang, PeiLei Wang, Feng-Qing Liu, Min Liu, QingHai Jia, Ning Yang, ShengLi Tao, XinYi Wei, DongZhi
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Phosphatidyl prodrug Purification Gradient elution Silica gel column chromatography PEGylation RGD modification
- Rational engineering of Corynebacterium glutamicum for L-Glutamine biosynthesis被引量：0收藏
- 作者：Lin, Ying-Tong Chai, Meng Liu, Qing-Hai Ma, Yu-Shu Tao, Xin-Yi Liu, Min Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2026
- 关键词：L-Glutamine Metabolic engineering RBS engineering SRNA interference Growth-responsive promoter
- Metabolic engineering of Escherichia coli for efficient production of O-succinyl-L-homoserine被引量：0收藏
- 作者：Liu, Longmei Gu, Jieyun Lyu, Xiaomei Gu, JiaLi Liu, Qinghai Ma, Yu-Shu Tao, Xin-Yi Liu, Min Wei, Dong-Zhi
- 机构：East China Univ Sci & Technol;Jiangnan Univ;Huzhou Univ
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2026
- 关键词：O-Succinyl-L-homoserine Escherichia coli Self-regulating promoter Metabolic engineering Flagellar system
