成果/Result
- Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and the physicochemical and biological properties被引量：62收藏
- 作者：Wu, Hao Deng, Zhaizhu Zhou, Bijian Qi, Minghui Hong, Minghuang Ren, Guobin
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2019
- 关键词：Ibuprofen Ionic liquids Molecular interaction Skin permeability Cytotoxicity
- Development of a gliclazide ionic liquid and its mesoporous silica particles: An effective formulation strategy to improve oral absorption properties被引量：58收藏
- 作者：Zhou, Bijian Teng, Dan Li, Jinghui Zhang, Yanhong Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Shanghai Key Laboratory of New Drug Design; State Key Laboratory of Bioreactor Engineering
- 来源：RSC Advances 2022
- 关键词：Silica - Targeted drug delivery - Molecules - Controlled drug delivery - Encapsulation - Solubility - Positive ions - Mesoporous materials - Physicochemical properties - Supersaturation
- Insight into the effect of cocrystal polymorphism / stoichiomorphism on thermodynamic and photoluminescence properties: a case study被引量：45收藏
- 作者：Han, Xianyang Yin, Yu Zhu, Fan Yao, Yichen Hong, Minghuang Qi, Minghui Zhu, Bin Ren, Guobin
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2025
- 关键词：Crystal structure - Fluorescence - Fluorescence spectroscopy - Optical properties - Phase transitions - Photoluminescence - Polymorphism - Single crystals - Thermoanalysis - X ray diffraction
- Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point被引量：40收藏
- 作者：Yao, Yi-Chen Jin, Zhe Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology
- 来源：Crystal Growth and Design 2024
- 关键词：Melting point - Single crystals - Surface analysis - Thermoanalysis
- Drug-Drug Cocrystals Provide Significant Improvements of Drug Properties in Treatment with Progesterone被引量：37收藏
- 作者：Guo, Chunyang Zhang, Qi Zhu, Bingqing Zhang, Zaiyong Ma, Xiaoyu Dai, Wenjuan Gong, Xiaoyi Ren, Guobin Mei, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2020
- 关键词：Pelletizing - Solubility - Stability - Differential scanning calorimetry
- Solid-State Characterization and Insight into Transformations and Stability of Apatinib Mesylate Solvates被引量：32收藏
- 作者：Zhu, Bin Zhang, Qi Ren, Guobin Mei, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2017
- 关键词：Differential scanning calorimetry - Single crystals - Thermogravimetric analysis - Quality control
- Ionic liquid form of donepezil: Preparation, characterization and formulation development被引量：31收藏
- 作者：Wu, Hao Fang, Fang Zheng, Lulu Ji, Weijie Qi, Minghui Hong, Minghuang Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2020
- 关键词：Ionic liquids AlzhEImer's disease Donepezil Drug-in-adhesive patch Skin permeability
- Slow-Release Drug-Drug Cocrystals of Oxaliplatin with Flavonoids: Delaying Hydrolysis and Reducing Toxicity被引量：31收藏
- 作者：Yin, He-Mei Wu, Nan Zhou, Bi-Jian Hong, Ming-Huang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Cancer cells - Controlled drug delivery - Fourier transform infrared spectroscopy - Dissolution - Targeted drug delivery - Cells - Flavonoids - X ray diffraction - Hydrogen bonds - Thermoanalysis - Toxicity - Cytology
- Toward Understanding the Effect of Solvent Evaporation on the Morphology of PLGA Microspheres by Double Emulsion Method被引量：29收藏
- 作者：Si, Wei Yang, Qingqing Zong, Yuan Ren, Guobin Zhao, Ling Hong, Minghuang Xin, Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2021
- 关键词：Emulsification - Evaporation - Morphology - Microspheres - Diffusion
- Stable Cocrystals and Salts of the Antineoplastic Drug Apatinib with Improved Solubility in Aqueous Solution被引量：29收藏
- 作者：Zhu, Bin Wang, Jian-Rong Zhang, Qi Li, Meiqi Guo, Chunyang Ren, Guobin Mei, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2018
- 关键词：Infrared spectroscopy - Single crystals - Solubility - X ray diffraction - Cell proliferation - Drug delivery - Endothelial cells - Amino acids - Differential scanning calorimetry
- Resurrecting the 'Disappearing Polymorph' of Rotigotine via Conformational Landscape Engineering被引量：25收藏
- 作者：Yi, Dongxu Qi, Minghui Xu, Shaohong Qi, Yonghua Xia, Ran Wu, Hao Ren, Guobin
- 机构： School of Pharmacy; School of Pharmacy; Children's Hospital Affiliated to Zhengzhou University; Henan Children’ s Hospital Zhengzhou Children’s Hospital; Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2025
- 关键词：Boltzmann equation - Conformations - Crystallization kinetics - Drug products - Engineering research - Molecular biology - Molecular physics - Polymorphism - Potential energy
- Cocrystals of Oxymatrine: Reducing Hygroscopicity and Affecting the Dissolution Rate被引量：25收藏
- 作者：Qi, Ming-Hui Li, Heng Zhu, Bin Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Dissolution - Hydrogen bonds - Metabolism
- Polymorphs and Hydrates of Apatinib Mesylate: Insight into the Crystal Structures, Properties, and Phase Transformations被引量：22收藏
- 作者：Zhu, Bin Wang, Jian-Rong Ren, Guobin Mei, Xuefeng
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2016
- 关键词：Differential scanning calorimetry - Single crystals - Thermogravimetric analysis - Hydrates - Phase transitions - Fourier transform infrared spectroscopy - X ray diffraction
- Estimating Thermodynamic Stability Relationship of Polymorphs of Sofosbuvir被引量：22收藏
- 作者：Qi, Ming-Hui Hong, Ming-Huang Liu, Yan Wang, En-Fu Ren, Fu-Zheng Ren, Guo-Bin
- 机构：E China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2015
- 关键词：Solubility - Thermoanalysis - X ray powder diffraction - Free energy - Melting
- Study of Crystal Structures, Properties, and Form Transformations among a Polymorph, Hydrates, and Solvates of Apatinib被引量：22收藏
- 作者：Zhu, Bin Fang, Xiaoxue Zhang, Qi Mei, Xuefeng Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：CRYSTAL GROWTH & DESIGN 2019
- 关键词：Differential scanning calorimetry - X ray diffraction - Cell proliferation - Hydration - Endothelial cells - Thermogravimetric analysis - Amino acids - Single crystals
- Strategy for Efficient Discovery of Cocrystals via a Network-Based Recommendation Model被引量：22收藏
- 作者：Zheng, Lulu Zhu, Bin Wu, Zengrui Fang, Xiaoxue Hong, Minghuang Liu, Guixia Li, Weihua Ren, Guobin Tang, Yun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2020
- Cocrystals of Lenvatinib with Sulfamerazine and Salicylic Acid: Crystal Structure, Equilibrium Solubility, Stability Study, and Anti-Hepatoma Activity被引量：20收藏
- 作者：Hong, Minghuang Li, Shijia Ji, Weijie Qi, Ming-Hui Ren, Guo-bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Surface analysis - Crystal structure - Nuclear magnetic resonance spectroscopy - Salicylic acid - Differential scanning calorimetry - Amino acids - Fourier transform infrared spectroscopy - Thermogravimetric analysis - Hydrogen bonds - Drug delivery - Spectrometers - X ray diffraction
- Insight into the Formation of Cocrystals of Flavonoids and 4,4′-Vinylenedipyridine: Heteromolecular Hydrogen Bonds, Molar Ratio, and Structural Analysis被引量：19收藏
- 作者：Zhang, Yanhong Zhu, Bin Ji, Wei-Jie Guo, Chun-Yang Hong, Minghuang Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Hydrogen bonds - Single crystals - Molar ratio
- Analysis of the dissolution behavior and solubility of Rotigotine form II in different mono-solvents被引量：16收藏
- 作者：Yi, Dongxu Dong, Yuhang Wang, Qinglin Wu, Juan Qi, Minghui Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2023
- 关键词：Rotigotine Hirshfeld surface Solubility Correlation Molecular simulation
- Influence of Temperature, Solvents, and Excipients on Crystal Transformation of Agomelatine被引量：16收藏
- 作者：Liu, Yan Gao, Huiru Xu, Hao Ren, Fuzheng Ren, Guobin
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2016
- 关键词：Temperature
- Cocrystals of flavonoids with 4,4′-ethylenebispyridine: Crystal structures analysis, dissolution behavior, and anti-tumor activity被引量：16收藏
- 作者：Zhang, Yanhong Yang, Rui Yin, He-Mei Zhou, Bijian Hong, Minghuang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2022
- 关键词：Tumors - Cancer cells - Single crystals - Dissolution
- Strategy to Tune the Performance of Two Drug Components: Drug-Drug Cocrystals of Lobaplatin with Flavonoids被引量：15收藏
- 作者：Yin, He-Mei Xie, Jun-Yi Jiang, Jun-Yi Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2022
- 关键词：Dissolution - Solubility
- Solubility correlation and thermodynamic analysis of two forms of Metaxalone in different pure solvents被引量：14收藏
- 作者：Hong, Minghuang Wu, Shiwang Qi, Minghui Ren, Guobin
- 机构：E China Univ Sci & Technol
- 来源：FLUID PHASE EQUILIBRIA 2016
- 关键词：Solubility Thermodynamic models Endothermic Entropy driven Nonspontaneous
- Three solid forms of chlorantraniliprole: Structure, characterization, and phase transformation被引量：14收藏
- 作者：Du, Dan Liu, Peng-Jian Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2018
- 关键词：Chlorantraniliprole Solid forms Solvates Crystal structure Phase transformation
- Solubility of Agomelatine Crystal Form I and Form II in Pure Solvents and (Isopropanol + Water) Mixtures被引量：12收藏
- 作者：Liu, Yan Gao, Huiru Ren, Fuzheng Ren, Guobin
- 机构： Laboratory of Pharmaceutical Crystal Engineering and Technology
- 来源：Journal of Chemical and Engineering Data 2015
- 关键词：Solvents - Binary mixtures
- Study of Cycloxaprid Co-crystals: Characterization, Theory Calculation, Solubility, and Stability被引量：12收藏
- 作者：Li, Mengnan Wang, Jinling Xu, Xiaoyong Ren, Guobin Zhu, Bin Hong, Minghuang Li, Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2022
- 关键词：Chemical stability - Differential scanning calorimetry - Fourier transform infrared spectroscopy - Molecular orbitals - Nuclear magnetic resonance spectroscopy - Single crystals - Thermogravimetric analysis - X ray diffraction
- SMINBR: An Integrated Network and Chemoinformatics Tool Specialized for Prediction of Two-Component Crystal Formation被引量：11收藏
- 作者：Zheng, Lulu Zhu, Bin Wu, Zengrui Liang, Fang Hong, Minghuang Liu, Guixia Li, Weihua Ren, Guobin Tang, Yun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2021
- 关键词：Molecular interactions - Molecular structure - Crystals - Physicochemical properties
- Modified rivaroxaban microparticles for solid state properties improvement based on drug-protEIn/polymer supramolecular interactions被引量：11收藏
- 作者：Chen, Ning Di, Peiwen Ning, Shangqi Jiang, Wenjun Jing, Qiufang Ren, Guobin Liu, Yan Tang, Yun Xu, Zhongyu Liu, Guixia Ren, Fuzheng
- 机构：East China Univ Sci & Technol
- 来源：POWDER TECHNOLOGY 2019
- 关键词：Bottom-up Dissolution Molecular docking Rivaroxaban Supramolecular interactions
- Preparation and characterization of several azoxystrobin channel solvates被引量：11收藏
- 作者：Du, Dan Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2019
- 关键词：Azoxystrobin Channel solvates Isostructurality Hirshfeld surface Pseudopolymorph Solvent-replacement method Porosity
- Structure properties of scoparone: Polymorphs and cocrystals被引量：10收藏
- 作者：Chen, Jin-yao Wang, Xiao-yu Hong, Ming-huang Yi, Dong-xu Qi, Ming-hui Ren, Guo-bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2019
- 关键词：Scoparone Polymorphs Cocrystals Crystal structure Powder dissolution study
