成果/Result
- Real-time viable-cell mass monitoring in high-cell-density fed-batch glutathione fermentation by Saccharomyces cerevisiae T65 in industrial complex medium被引量：35收藏
- 作者：Xiong, Zhi-Qiang Guo, Mei-Jin Guo, Yuan-Xin Chu, Ju Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOSCIENCE AND BIOENGINEERING 2008
- 关键词：on-line viable-cell mass monitoring capacitance complex medium glutathione production high-cell-density culture Saccharomyces cerevisiae
- High-Throughput System for Screening of cephalosporin C High-Yield Strain by 48-Deep-Well Microtiter Plates被引量：30收藏
- 作者：Tan, Jun Chu, Ju Hao, Yuyou Guo, Yuanxin Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2013
- 关键词：cephalosporin C High-throughput screening High-throughput bioactivity assay 48-deep MTP Mixture culture
- RQ feedback control for simultaneous improvement of GSH yield and GSH content in Saccharomyces cerevisiae T65被引量：21收藏
- 作者：Xiong, Zhi-Qiang Guo, Mei-Jin Guo, Yuan-Xin Chu, Ju Zhuang, Ying-Ping Wang, Nam Sun Zhang, Si-Liang
- 机构：E China Univ Sci & Technol;Univ Maryland
- 来源：ENZYME AND MICROBIAL TECHNOLOGY 2010
- 关键词：Reduced glutathione Saccharomyces cerevisiae Respiratory quotient Feedback control Fed-batch phase Oxygen uptake rate carbon dioxide evolution rate
- Efficient extraction of intracellular reduced glutathione from fermentation broth of Saccharomyces cerevisiae by ethanol被引量：20收藏
- 作者：Xiong, Zhi-Qiang Guo, Mei-Jin Guo, Yuan-Xin Chu, Ju Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：E China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2009
- 关键词：Reduced glutathione Full factorial designs Saccharomyces cerevisiae Ethanol extraction
- Computational Fluid Dynamics Modeling of an Inverted Frusto-conical Shaking Bioreactor for Mammalian cell Suspension Culture被引量：11收藏
- 作者：Hang, Haifeng Guo, Yuanxin Liu, Jian Bai, Li Xia, Jianye Guo, Meijin Hui, Matthew
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2011
- 关键词：inverted frusto-conical shaking bioreactor mammalian cell suspension culture mixing time volumetric oxygen transfer coefficient computational fluid dynamics simulation
- Artificial intelligence-guided fermentation process regulation reveals metabolic rewiring in gentamicin C1a overproduction被引量：10收藏
- 作者：Xu, Feng Su, Lihuan Wang, Yuan Gao, Hao Hu, Kaihao Ben, Rong Guo, Yuanxin Li, Xu Chu, Ju Tian, Xiwei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2025
- 关键词：Fermentation optimization Artificial neural network Multi-sensor monitoring Genetic algorithm Metabolic flux analysis
- Engineering the methyltransferase through inactivation of the genK and genL leads to a significant increase of gentamicin C1a production in an industrial strain of Micromonospora echinospora 49-92S被引量：10收藏
- 作者：Xu, Feng Zhang, Xinyu Liu, Ling Ke, Xiang Wu, Jie Guo, Yuanxin Tian, Xiwei Chu, Ju
- 机构：East China Univ Sci & Technol
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2022
- 关键词：Micromonospora echinospora Gentamicin C1a Methyltransferase GenK-genL Metabolic flux analysis
- High-throughput screening strategy used for enhanced production of pigment by Monascus purpureus D39-4被引量：7收藏
- 作者：Tan, Jun Chu, Ju Shi, Wenjuan Lin, Cheng Guo, Yuanxin Zhuang, Yingping Zhang, Siliang Imanaka, Tadayuki
- 机构：E China Univ Sci & Technol
- 来源：FOOD SCIENCE AND BIOTECHNOLOGY 2012
- 关键词：Monascus Box-Behnken design response surface methodology medium optimization high-throughput screening
- Optimization and validation of an extraction method and HPAEC-PAD for determination of residual sugar composition in L-lactic acid industrial fermentation broth with a high salt content被引量：5收藏
- 作者：Lv, Xiangyun Guo, Yuanxin Zhuang, Yingping Wang, Yonghong
- 机构：E China Univ Sci & Technol;Shanghai Inst Biomfg Technol;Collaborat Innovat Ctr
- 来源：ANALYTICAL METHODS 2015
- 关键词：calcium - Ion exchange - Extraction - Ion chromatography - Fermentation - Starch - Ions - Sodium hydroxide
- Oxygen uptake rate (OUR) guided nitrogen control strategy for improving nemadectin production by Streptomyces cyaneogriseus ssp. noncyanogenus被引量：2收藏
- 作者：Song, Xiaoqing Zhang, Zishu Yu, Junxiong Zhang, Yun Xue, Jiayun Guo, Yuanxin Liang, Jianguang Ren, Min Ling, Qingyun Mohsin, Ali Qian, Jiangchao Wang, Zejian Wang, Yonghong
- 机构：East China Univ Sci & Technol;Changshu Inst Technol;Jiangsu Weiling Pharmaceut Co Ltd
- 来源：PROCESS BIOCHEMISTRY 2025
- 关键词：Nemadectin S. cyaneogriseus On-line parameters Real-time monitoring Fed-batch fermentation
- Systematic engineering of Micromonospora echinospora cell factory for gentamicin C1a overproduction被引量：1收藏
- 作者：Xu, Feng Gao, Hao Ben, Rong Hu, Kaihao Wang, Yuan Mohsin, Ali Guo, Yuanxin Li, Xu Hang, Haifeng Chu, Ju Tian, Xiwei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：TRENDS IN BIOTECHNOLOGY 2026
- 关键词：Antibiotics - Biochemistry - Biosynthesis - Genes - Metabolism - Optimization
- Artificial intelligence-driven dynamic regulation for high-efficiency gentamicin C1a production被引量：0收藏
- 作者：Xu, Feng Wang, Yuan Gao, Hao Hu, Kaihao Ben, Rong Mohsin, Ali Guo, Yuanxin Li, Xu Wu, Hui Hang, Haifeng Chu, Ju Tian, Xiwei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：GREEN CHEMISTRY 2025
- Artificial intelligence-driven dynamic regulation for high-efficiency gentamicin C1a production (vol 27 , pg13436 , 2025 )被引量：0收藏
- 作者：Xu, Feng Wang, Yuan Gao, Hao Hu, Kaihao Ben, Rong Mohsin, Ali Guo, Yuanxin Li, Xu Wu, Hui Hang, Haifeng Chu, Ju Tian, Xiwei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：GREEN CHEMISTRY 2026
- Enhancing cephalosporin C Biosynthesis through a 2A Peptide-Based Multigene Coexpression System被引量：0收藏
- 作者：Chen, Zhen Li, Yifan Wei, Xiaorong Hong, Wei Guo, Yuanxin Hang, Haifeng Chu, Ju Tian, Xiwei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS SYNTHETIC BIOLOGY 2025
- 关键词：Acremonium chrysogenum CPC 2A peptide multigene coexpression
