成果/Result
- Metaproteomics: A strategy to study the taxonomy and functionality of the gut microbiota被引量：63收藏
- 作者：Wang, Yuqiu Zhou, Yanting Xiao, Xiao Zheng, Jing Zhou, Hu
- 机构：Chinese Acad Sci;Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF PROTEOMICS 2020
- 关键词：Metaproteomics Gut microbiota Metagenomics Metatranscriptomics Metabolomics Multi-omics
- Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs被引量：53收藏
- 作者：Feng, Ying Liu, Siyuan Mo, Qiqin Liu, Pengpeng Xiao, Xiao Ma, Hanhui
- 机构：East China Univ Sci & Technol;ShanghaiTech Univ;Univ Massachusetts
- 来源：PROTEIN & CELL 2023
- Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism被引量：17收藏
- 作者：Wang, Yuqiu Yang, Chen Hu, Hanyang Chen, Chen Yan, Mengdi Ling, Feixiang Wang, Kathy Cheng Wang, Xintao Deng, Zhe Zhou, Xinyue Zhang, Feixu Lin, Sen Du, Zengmin Zhao, Kai Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;NYU;Army Med Univ
- 来源：MOLECULAR THERAPY NUCLEIC ACIDS 2022
- Quantitative proteomic analysis uncovers inhibition of melanin synthesis by silk fibroin via MITF/tyrosinase axis in B16 melanoma cells被引量：15收藏
- 作者：Wang, Yuqiu Duan, Tianbi Hong, Minhua Zhou, Yanting Huang, Hui Xiao, Xiao Zheng, Jing Zhou, Hu Lu, Zhi
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Inoherb Co Ltd;East China Univ Sci & Technol;Univ Chinese Acad Sci
- 来源：LIFE SCIENCES 2021
- 关键词：Silk fibroin Quantitative proteomics Melanin Microphthalmia-associated transcription factor Tyrosinase
- Repeated Systemic Dosing of Adeno-Associated Virus Vectors in Immunocompetent Mice After Blockade of T Cell Costimulatory Pathways被引量：13收藏
- 作者：Zhong, Chen Jiang, Wei Wang, Yefan Sun, Junjiang Wu, Xia Zhuang, Yingping Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ N Carolina;Univ N Carolina
- 来源：HUMAN GENE THERAPY 2022
- 关键词：CTLA4-Ig CD40-Ig AAV multiple systemic administration immune tolerance
- Construction of the Isocopalane Skeleton: Application of a Desulfinylative 1,7-Hydrogen Atom Transfer Strategy被引量：12收藏
- 作者：Xiao, Xiong Xu, ZhongYu Zeng, Qian-Ding Chen, Xi-Bo Ji, Wen-Hao Han, Ying Wu, PeiYing Ren, Jiangmeng Zeng, Bu-Bing
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Shanghai Univ Tradit Chinese Med;Yangzhou Univ
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2015
- 关键词：hydrogen transfer natural products persulfates synthons terpenoids
- A Translational Study of TNF-Alpha Antagonists as an Adjunctive Therapy for Preventing Hemophilic Arthropathy被引量：11收藏
- 作者：Zhang, Feixu Xu, Mengyang Yang, Qin Hua, Baolai Xia, Binglan Lin, Zhenyang Xiao, Xiao Monahan, Paul E. Sun, Junjiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Yangzhou Univ;Univ N Carolina;Univ N Carolina
- 来源：JOURNAL OF CLINICAL MEDICINE 2020
- 关键词：hemophilia hemarthrosis hemophilic arthropathy TNF alpha anti-TNF alpha
- Treatment of experimental autoimmune encephalomyelitis using AAV gene therapy by blocking T cell costimulatory pathways被引量：9收藏
- 作者：Zhong, Chen Chen, Zifeng Xia, Yong Wu, Jun Zhang, Feixu Cheng, Cheng Wu, Xia Zhuang, Yingping Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ N Carolina
- 来源：MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT 2022
- Exploring the Potential Feasibility of Intra-articular Adeno-Associated Virus-Mediated Gene Therapy for Hemophilia Arthropathy被引量：8收藏
- 作者：Zhang, Feixu Yan, Xiaobo Li, Min Hua, Baolai Xiao, Xiao Monahan, Paul E. Sun, Junjiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Yangzhou Univ;Univ N Carolina;Univ N Carolina
- 来源：HUMAN GENE THERAPY 2020
- 关键词：hemophilia arthropathy intraarticular recombinant human factor VIII adeno-associated virus neutralizing antibody
- A Facile Diethylene Glycol Reduction Method for the Synthesis of Ultrafine Pd/C Electrocatalyst with High Electrocatalytic Activity for Methanol Oxidation被引量：8收藏
- 作者：Zhai, Y. N. He, S. Xiao, X. Wu, Z. Q. Li, S. N. Lee, J. M.
- 机构：Shaanxi Normal Univ;East China Univ Sci & Technol;Nanyang Technol Univ
- 来源：FUEL CELLS 2016
- 关键词：Diethylene Glycol Reduction Dispersion Electrocatalysis Methanol Oxidation Reaction Pd Nanoparticles
- Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models被引量：6收藏
- 作者：Zhou, Kaiyi Yuan, Meng Sun, Jiabao Zhang, Feixu Li, Xinting Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：GENE THERAPY 2025
- CuI-catalyzed intramolecular cyclization of 3-(2-aminophenyl)-2-bromoacrylate: synthesis of 2-carboxyindoles被引量：6收藏
- 作者：Xiao, Xiong Chen, Tian-Qi Ren, Jiangmeng Chen, Wei-Dong Zeng, Bu-Bing
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：TETRAHEDRON LETTERS 2014
- 关键词：Indoles CuI-catalyzed Intramolecular coupling 2-Bromo-3-phenylacrylate
- Integrated proteome and phosphoproteome analysis of interscapular brown adipose and subcutaneous white adipose tissues upon high fat diet feeding in mouse被引量：6收藏
- 作者：Wang, Yuqiu Li, Junmin Lu, Dayun Meng, Qian Song, Nixue Zhou, Hu Xiao, Xiao Sun, Liming Zhu, Hongwen
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Fudan Univ;Univ Chinese Acad Sci
- 来源：JOURNAL OF PROTEOMICS 2022
- 关键词：Brown adipose tissue Subcutaneous white adipose tissue High fat diet Proteomics Phosphoproteomics Metabolism
- Concise synthesis of (+)-subersic acid from (-)-Sclareol被引量：5收藏
- 作者：Wang, Peiqiang Li, Jue Yu, Chen-Lin Xiao, Xiong Wu, Pei-Ying Zeng, Bu-Bing
- 机构：E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Chinese Acad Sci
- 来源：TETRAHEDRON 2015
- 关键词：(+)-Subersic acid [3,3]-Claisen rearrangement Mitsunobu reaction (-)-Sclareol
- Hippocampus-targeted BDNF gene therapy to rescue cognitive impairments of Alzheimer's disease in multiple mouse models被引量：3收藏
- 作者：Tang, Siqi Luo, Wenshu Wu, Shihao Yuan, Meng Wen, Jiashuo Zhong, Guoshen Shen, Leshan Jiang, Wei Cheng, Cheng Wu, Xia Xiao, Xiao
- 机构：East China Univ Sci & Technol;Belief Biomed Inc;Yunnan Univ;East China Univ Sci & Technol
- 来源：GENES & DISEASES 2026
- 关键词：AAVT42 Alzheime's disease Brain-derived neurotrophic factor Cognitive impairment Hippocampal RNA sequencing
- Systemic effect of FHL1 on neuromuscular junction and myotube formation via insulin-like growth factor and myostatin signaling pathways被引量：3收藏
- 作者：Wu, Jiamei Zhao, Kai Du, Zengmin Chen, Ying Zhang, Feixu Jiang, Wei Zheng, Jing Wu, Xia Shen, Chengyong Xiao, Xiao
- 机构：East China Univ Sci & Technol;Zhejiang Univ
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2021
- Prevalence of neutralizing antibodies against AAV8, AAV9, and AAV843 in a Chinese population被引量：3收藏
- 作者：Xu, Jingjing Zhang, Jingyu Xin, Lei Yang, Chen Zhang, Feixu Tang, Siqi Yao, Jie Wang, Hui Ning, Qinjie Yan, Mendi Li, Min Wu, Jiamei Chen, Ying Zhong, Chen Zhou, Kaiyi Du, Zengmin Jiang, Wei Wu, Xia Yang, Youjun Sun, Junjiang Xiao, Xiao Zheng, Jing
- 机构：East China Univ Sci & Technol;Harbin Med Univ
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 2019
- 关键词：Neutralizing antibodies adeno-associated virus prevalence gene therapy
- Methyl Group in Isocopalane Derivative Showed an Unusual Negative 1H NMR Chemical Shift被引量：2收藏
- 作者：Xiao, Xiong Chen, Tianqi Zhang, Fengfeng Cheng, Jiagao Wu, Peiying Ren, Jiangmeng Zeng, Bubing
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Shanghai Univ Tradit Chinese Med
- 来源：CHINESE JOURNAL OF CHEMISTRY 2015
- 关键词：shielding effect diterpenoid dihydropyrazole negative chemical shift computational study
- Sildenafil increases AAV9 transduction after a systemic administration and enhances AAV9-dystrophin therapeutic effect in mdx mice被引量：1收藏
- 作者：Zhou, Kaiyi Yuan, Meng Sun, Jiabao Zhang, Feixu Zong, Xiaoying Li, Zhanao Tang, Dingyue Zhou, Lichen Zheng, Jing Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Gen Hosp Western Theater Command PLA;Belief BioMed;Univ N Carolina
- 来源：GENE THERAPY 2024
- Activated factor X delivered by adeno-associated virus significantly inhibited bleeding and alleviated hemophilic synovitis in hemophilic mice被引量：1收藏
- 作者：Zhang, Feixu Zhou, Xinyue Hua, Baolai He, Xinyi Li, Zhanao Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Capital Med Univ
- 来源：GENE THERAPY 2024
- The local density of H3K9me3 dictates the stability of HP1a condensates-mediated genomic interactions被引量：1收藏
- 作者：Feng, Ying Guo, Li Yang, Chen Zheng, Hui Xiao, Xiao Ma, Hanhui
- 机构：East China Univ Sci & Technol;ShanghaiTech Univ;ShanghaiTech Univ
- 来源：JOURNAL OF GENETICS AND GENOMICS 2023
- 关键词：H3K9me3 HP1 alpha Chromatin dynamics Genomic interaction Epigenetic perturbation
- Naive haemophilia mice displayed different pattern of cytokine profiles of cytokine profiles changes might be associated with subclinical bleeding被引量：0收藏
- 作者：Zhang, Feixu Zong, Xiaoying Zhou, Xinyue Sun, Shuming Xiao, Xiao Sun, Junjiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ North Carolina;Univ North Carolina;Univ North Carolina
- 来源：BLOOD COAGULATION & FIBRINOLYSIS 2021
- 关键词：cytokine haemophilia prothrombin fragment 1+2 subclinical bleeding
- Prophylaxis CTLA4-ig reduces anti-AAV neutralizing antibodies in AAV gene therapy for hemophilia被引量：0收藏
- 作者：Yu, Dandan Xu, Bingqi Liu, Wei Xue, Feng Chen, Yunfei Liu, Xiaofan Ju, Mankai Ting, Sun Dai, Xinyue Dong, Huan Gu, Wenjing Yang, Renchi Xiao, Xiao Wu, Xia Pei, Xiaolei Zhang, Lei
- 机构：Chinese Acad Med Sci;East China Univ Sci & Technol
- 来源：BLOOD 2025
- Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs (vol 14, pg 304, 2023)被引量：0收藏
- 作者：Feng, Ying Liu, Siyuan Mo, Qiqin Liu, Pengpeng Xiao, Xiao Ma, Hanhui
- 机构：ShanghaiTech Univ;East China Univ Sci & Technol;Univ Massachusetts
- 来源：PROTEIN & CELL 2024
- Synthesis of Typical Isocopalane Diterpenes: ent-Spongian-16-one, ent-Isoagatholactone, and Anisodorin 5被引量：0收藏
- 作者：Rena, Jiangmeng Zhao, Pu Xiao, Xiong Chen, Tianqi Zeng, Bu-Bing
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：SYNTHESIS-STUTTGART 2016
- 关键词：terpenoids total synthesis anisodorin 5 spongianone isoagatholactone
- Novel AAV843 Vector-Mediated Gene Replacement Therapy Rescues Primary Hyperoxaluria Type I in Mice被引量：0收藏
- 作者：Zhang, Jingjia Yin, Ye Ji, Baowei Sun, Manqing Jiang, Yuanyan Wu, Xiaohui Xiao, Xiao Shen, Qian Wu, Xia Xu, Hong
- 机构：Fudan Univ;Shanghai Kidney Dev & Pediat Kidney Dis Res Ctr;Fudan Univ;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CELLS 2026
- 关键词：primary hyperoxaluria type I gene replacement therapy AAV843 kidney injury
