成果/Result
- A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and Apoptosis被引量：153收藏
- 作者：Chen, Zhuo Liang, Xin Zhang, Huanying Xie, Hua Liu, Jianwen Xu, Yufang Zhu, Weiping Wang, Yi Wang, Xin Tan, Shaoying Kuang, Dong Qian, Xuhong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2010
- MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling被引量：153收藏
- 作者：Xu, Ke Chen, Guo Li, Xiaobo Wu, Xiaoqin Chang, Zhijie Xu, Jianhua Zhu, Yu Yin, Peihao Liang, Xin Dong, Lei
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;Emory Univ;Tianjin Inst Pharmaceut Res;Anhui Med Univ
- 来源：SCIENTIFIC REPORTS 2017
- Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop被引量：138收藏
- 作者：Xu, Ke Zhan, Yueping Yuan, Zeting Qiu, Yanyan Wang, Haijing Fan, Guohua Wang, Jie Li, Wei Cao, Yijun Shen, Xian Zhang, Jun Liang, Xin Yin, Peihao
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;Anhui Med Univ;Univ Iowa
- 来源：MOLECULAR THERAPY 2019
- MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2被引量：124收藏
- 作者：Zhou, Lin Liang, Xin Zhang, Lingling Yang, Liyan Nagao, Norio Wu, Hongkun Liu, Chang Lin, Shengchao Cai, Guoxiang Liu, Jianwen
- 机构：Second Mil Med Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Prefectural Univ Hiroshima;Fudan Univ
- 来源：ONCOTARGET 2016
- 关键词：miR-27a-3p apoptosis BTG2 gastric cancer cell proliferation
- miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2被引量：104收藏
- 作者：Li, Qingguo Liang, Xin Wang, Yuwei Meng, Xianke Xu, Ye Cai, Sanjun Wang, Zhimin Liu, Jianwen Cai, Guoxiang
- 机构：Fudan Univ;Fudan Univ;E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Natl Human Genome Ctr
- 来源：SCIENTIFIC REPORTS 2016
- miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells被引量：85收藏
- 作者：Xu, Ke Liang, Xin Cui, Daling Wu, Yixin Shi, Weibin Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Hamamatsu Univ Sch Med;Shanghai Jiao Tong Univ
- 来源：MOLECULAR CARCINOGENESIS 2013
- 关键词：colorectal carcinoma multidrug-resistance microRNA Bcl-2 microRNA array
- Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy被引量：83收藏
- 作者：Zheng, Yuanhong Yin, Guifang Le, Vanminh Zhang, Anle Chen, Siyu Liang, Xin Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 2016
- 关键词：DAMPs Immunogenic apoptosis Antitumor vaccination Hypericin CD47
- Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop被引量：79收藏
- 作者：Lei, Kecheng Liang, Xin Gao, Yuwei Xu, Baixue Xu, Yichun Li, Yueqi Tao, Yiwen Shi, Weibin Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Guangzhou Med Univ;Shanghai Jiao Tong Univ
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2017
- 关键词：Gastric cancer lnc-ATB miR-141-3p TGF-beta
- EpCAM Aptamer-Functionalized Cationic Liposome-Based Nanoparticles Loaded with miR-139-5p for Targeted Therapy in Colorectal Cancer被引量：74收藏
- 作者：Zhao, Yuyu Xu, Jiajun Van Minh Le Gong, Qianyi Li, Shaoyu Gao, Feng Ni, Lei Liu, Jianwen Liang, Xin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Natl Inst Med Mat;Xinjiang Med Univ
- 来源：MOLECULAR PHARMACEUTICS 2019
- 关键词：nanoparticle CRC targeted therapy miR-139-5p
- Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis被引量：70收藏
- 作者：Xu, Wen Song, Changfeng Wang, Xiaotong Li, Yueqi Bai, Xue Liang, Xin Wu, Jingjing Liu, Jianwen
- 机构：East China Univ Sci & Technol;Shanghai Key Lab New Drug Design;Shanghai Univ TCM
- 来源：AGING-US 2021
- 关键词：triple-negative breast cancer microRNA 155-5p cetuximab apoptosis pyroptosis
- miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2被引量：69收藏
- 作者：Xu, Ke Liang, Xin Shen, Ke Cui, Daling Zheng, Yuanhong Xu, Jianhua Fan, Zhongze Qiu, Yanyan Li, Qi Ni, Lei Liu, Jianwen
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：BIOCHEMICAL JOURNAL 2012
- 关键词：colorectal carcinoma microRNA (miRNA) microRNA array multidrug resistance (MDR) multictrug resistance-associated protein 2 (MRP-2)
- MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17被引量：65收藏
- 作者：Xu, Ke Liang, Xin Shen, Ke Sun, Liyun Cui, Daling Zhao, Yuxia Tian, Jianhui Ni, Lei Liu, Jianwen
- 机构：Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：EXPERIMENTAL CELL RESEARCH 2012
- 关键词：Colorectal carcinoma Multidrug-resistance (MDR) MiR-222 ADAM-17 TGF-alpha EGFR
- Targeted deletion of miR-139-5p activates MAPK, NF-B and STAT3 signaling and promotes intestinal inflammation and colorectal cancer被引量：57收藏
- 作者：Zou, Fangyuan Mao, Rurong Yang, Liyan Lin, Shengchao Lei, Kecheng Zheng, Yuanhong Ding, Yue Zhang, Peng Cai, Guoxiang Liang, Xin Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：FEBS JOURNAL 2016
- 关键词：acute colitis apoptosis colitis-associated colorectal cancer miR-139-5p proliferation
- Therapeutic Effect of Puerarin on Non-Alcoholic Rat Fatty Liver by Improving Leptin Signal Transduction through JAK2/STAT3 Pathways被引量：54收藏
- 作者：Zheng, Peiyong Ji, Guang Ma, Zansong Liu, Tao Xin, Lianjun Wu, Hongzhong Liang, Xin Liu, Jianwen
- 机构：Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol
- 来源：AMERICAN JOURNAL OF CHINESE MEDICINE 2009
- 关键词：Puerarin Non alcoholic Fatty Disease Leptin Leptin Resistance P-JAK2/P-STAT3
- miR-503-5p confers drug resistance by targeting PUMA in colorectal被引量：53收藏
- 作者：Xu, Ke Chen, Guo Qiu, Yanyan Yuan, Zeting Li, Hongchang Yuan, Xia Sun, Jian Xu, Jianhua Liang, Xin Yin, Peihao
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Med;Emory Univ;Emory Univ;Shanghai Univ Tradit Chinese Med
- 来源：ONCOTARGET 2017
- 关键词：colorectal carcinoma multidrug-resistance miR-503-5p PUMA p53
- Targeting CD133 reverses drug-resistance via the AKT/NF-κB/MDR1 pathway in colorectal cancer被引量：51收藏
- 作者：Yuan, Zeting Liang, Xin Zhan, Yueping Wang, Ziyuan Xu, Jian Qiu, Yanyan Wang, Jie Cao, Yijun Le, Van-Minh Ly, Hai-Trieu Xu, Jianhua Li, Wei Yin, Peihao Xu, Ke
- 机构：Shanghai Univ Tradit Chinese Med;Anhui Med Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med
- 来源：BRITISH JOURNAL OF CANCER 2020
- Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemosensitization towards oxaliplatin through inducing pro-death autophagy被引量：49收藏
- 作者：Lin, Shengchao Yang, Liyan Shi, Haiyang Du, Wenpei Qi, Yingxue Qiu, Cen Liang, Xin Shi, Weibin Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2017
- 关键词：Endoplasmic reticulum (ER) Photodynamic therapy (PDT) Autophagic cell death Chemo-sensitization
- A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications被引量：49收藏
- 作者：He, Haihong Xia, Yang Qi, Yingxue Wang, Hong-Yin Wang, Zhuang Bao, Jianming Zhang, Ziqian Wu, Fu-Gen Wang, Haolu Chen, Daijie Yang, Dahai Liang, Xiaowen Chen, Jinquan Zhou, Shengmin Liang, Xin Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;Univ Queensland;East China Normal Univ;Shanghai Jiao Tong Univ;Southeast Univ
- 来源：BIOCONJUGATE CHEMISTRY 2018
- PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing被引量：45收藏
- 作者：Liang, Xin Chen, Weixia Shi, Haiyang Gu, Xiangyu Li, Yueqi Qi, Yingxue Xu, Ke Zhao, Aiguang Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med
- 来源：CELL DEATH & DISEASE 2018
- Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway被引量：44收藏
- 作者：Fang, Kai Zhan, Yueping Zhu, Ruiqiu Wang, Yuqian Wu, Chengqi Sun, Min Qiu, Yanyan Yuan, Zeting Liang, Xin Yin, Peihao Xu, Ke
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF TRANSLATIONAL MEDICINE 2021
- 关键词：Angiogenesis Bufalin Colorectal cancer STAT3 Tumour microenvironment
- Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism被引量：43收藏
- 作者：Lin, Shengchao Lei, Kecheng Du, Wenpei Yang, Liyan Shi, Haiyang Gao, Yuwei Yin, Peihao Liang, Xin Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med
- 来源：INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2016
- 关键词：Photodynamic therapy (PDT) Hypericin Oxaliplatin Nucleotide excision repair (NER) Glutathione Glutathione S-transferase (GST)
- MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells被引量：40收藏
- 作者：Xu, Ke Shen, Ke Liang, Xin Li, Yueqi Nagao, Norio Li, Jiyu Liu, Jianwen Yin, Peihao
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;East China Univ Sci & Technol;Prefectural Univ Hiroshima
- 来源：ONCOTARGET 2016
- 关键词：colorectal cancer miR-139-5p NOTCH1 drug resistance
- MiR-212-3p inhibits LPS-induced inflammatory response through targeting HMGB1 in murine macrophages被引量：39收藏
- 作者：Chen, Weiwei Ma, Xiaoying Zhang, Peng Li, Qifeng Liang, Xin Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：EXPERIMENTAL CELL RESEARCH 2017
- 关键词：MiR-212-3p HMGB1 Inflammatory response MAPKs
- Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways被引量：39收藏
- 作者：Wang, Xiaotong Gong, Qianyi Song, Changfeng Fang, Jiaping Yang, Yun Liang, Xin Huang, Xuan Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Jiaxing Univ;Nat Med & Hlth Food Res & Technol Innovat Team Ji;Jiaxing Key Lab Oncol Photodynam Therapy & Target
- 来源：TOXICOLOGY AND APPLIED PHARMACOLOGY 2021
- 关键词：Photodynamic therapy (PDT) Berberine Cisplatin Melanoma cancer ROS
- IL-8/CXCR2 mediates tropism of human bone marrow-derived mesenchymal stem cells toward CD133+/CD44+Colon cancer stem cells被引量：36收藏
- 作者：Ma, Xiaoying Chen, Jingyun Liu, Jiajun Xu, Baixue Liang, Xinyu Yang, Xiaotong Feng, Yun Liang, Xin Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF CELLULAR PHYSIOLOGY 2021
- 关键词：colon cancer stem cell CXCR2 inhibitor IL-8 peptide inhibitor mesenchymal stem cell stemness tropism
- The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling被引量：36收藏
- 作者：Mao, Rurong Zou, Fangyuan Yang, Liyan Lin, Shengchao Li, Yueqi Ma, Mingxing Yin, Peihao Liang, Xin Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med
- 来源：INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2015
- 关键词：Transgenic murine model CAC MiR-139-5p beta-Catenin IGF-1R
- Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion被引量：34收藏
- 作者：Xu, Ke Liang, Xin Gao, Feng Zhong, Jianjiang Liu, Jianwen
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：PROCESS BIOCHEMISTRY 2010
- 关键词：Ganoderic acid T Metastasis Invasion MMPs NF-kappa B
- Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction被引量：33收藏
- 作者：Qi, Yingxue Chen, Wenchun Liang, Xinyu Xu, Ke Gu, Xiangyu Wu, Fengying Fan, Xuemei Ren, Shengxiang Liu, Junling Zhang, Jun Li, Renhao Liu, Jianwen Liang, Xin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Emory Univ;Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med
- 来源：JOURNAL OF HEMATOLOGY & ONCOLOGY 2018
- 关键词：GPIb alpha vWF Platelets Antibody Metastasis
- 3B, a novel photosensitizer, inhibits glycolysis and inflammation via miR-155-5p and breaks the JAK/STAT3/SOCS1 feedback loop in human breast cancer cells被引量：30收藏
- 作者：Lei, Kecheng Du, Wenpei Lin, Shengchao Yang, Liyan Xu, Yichun Gao, Yuwei Xu, Baixue Tan, Shaoying Xu, Yufang Qian, Xuhong Liang, Xin Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2016
- 关键词：PDT miR-155 Glycolysis Inflammation
- Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5-fluorouracil in gastric cancer cells被引量：29收藏
- 作者：Liang, Xin Shi, Haiyang Yang, Liyan Qiu, Cen Lin, Shengchao Qi, Yingxue Li, Jiyu Zhao, Aiguang Liu, Jianwen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Tongji Univ;Shanghai Univ Tradit Chinese Med
- 来源：BRITISH JOURNAL OF CANCER 2017
- 关键词：PTBP3 apoptosis cell cycle arrest 5-FU gastric cancer
