成果/Result
- Ectopic Osteogenesis of Macroscopic Tissue Constructs Assembled from Human Mesenchymal Stem Cell-Laden Microcarriers through In Vitro Perfusion Culture被引量：148收藏
- 作者：Chen, Maiqin Zhou, Min Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：PLOS ONE 2014
- Fine Tuning Micellar Core-Forming Block of Poly(ethylene glycol)-block-poly(ε-caprolactone) Amphiphilic Copolymers Based on Chemical Modification for the Solubilization and Delivery of Doxorubicin被引量：135收藏
- 作者：Yan, Jinliang Ye, Zhaoyang Chen, Min Liu, Zhanzhan Xiao, Yan Zhang, Yan Zhou, Yan Tan, Wensong Lang, Meidong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMACROMOLECULES 2011
- Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes被引量：107收藏
- 作者：Shi, Xiao-Lei Gao, Yimeng Yan, Yupeng Ma, Hucheng Sun, Lulu Huang, Pengyu Ni, Xuan Zhang, Ludi Zhao, Xin Ren, Haozhen Hu, Dan Zhou, Yan Tian, Feng Ji, Yuan Cheng, Xin Pan, Guoyu Ding, Yi-Tao Hui, Lijian
- 机构：Nanjing Univ;Chinese Acad Sci;ShanghaiTech Univ;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：CELL RESEARCH 2016
- 关键词：acute liver failure functional hepatocytes bioartificial liver
- A modular approach to the engineering of a centimeter-sized bone tissue construct with human amniotic mesenchymal stem cells-laden microcarriers被引量：94收藏
- 作者：Chen, Maiqin Wang, Xiu Ye, Zhaoyang Zhang, Yan Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2011
- 关键词：Tissue engineering Modular approach Microcarriers Macrotissue Mesenchymal stem cells Osteogenic differentiation
- Antihypertensive Effects, Molecular Docking Study, and Isothermal Titration Calorimetry Assay of Angiotensin I-Converting Enzyme Inhibitory Peptides from Chlorella vulgaris被引量：87收藏
- 作者：Xie, Jingli Chen, Xujun Wu, Junjie Zhang, Yanyan Zhou, Yan Zhang, Lujia Tang, Ya-Jie Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Hubei Univ Technol;Shanghai Business Sch;SCICB
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2018
- 关键词：Chlorella vulgaris ACE inhibitory peptides anti hypertensive activity molecular docking isothermal titration calorimetry
- Myocardial regeneration: Roles of stem cells and hydrogels被引量：75收藏
- 作者：Ye, Zhaoyang Zhou, Yan Cai, Haibo Tan, Wensong
- 机构：E China Univ Sci & Technol
- 来源：ADVANCED DRUG DELIVERY REVIEWS 2011
- 关键词：Myocardial regeneration Cell therapy Tissue engineering Stem cells Hydrogels
- A combinatorial variation in surface chemistry and pore size of three-dimensional porous poly(ε-caprolactone) scaffolds modulates the behaviors of mesenchymal stem cells被引量：62收藏
- 作者：Zhao, Yingdi Tan, Ke Zhou, Yan Ye, Zhaoyang Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2016
- 关键词：Tissue engineering Mesenchymal stem cells Three-dimensional porous scaffolds Surface chemistry Pore size
- In Situ Forming and Reversibly Cross-Linkable Hydrogels Based on Copolypept(o)ides and Polysaccharides被引量：58收藏
- 作者：Tong, Yanping Wang, Zhaochuang Xiao, Yan Liu, Wei Pan, Jinghao Zhou, Yan Lang, Meidong
- 机构： Key Laboratory for Ultrafine Materials of Ministry of Education; State Key Laboratory of Bioreactor Engineering
- 来源：ACS Applied Bio Materials 2019
- 关键词：Amides - Amino acids - Drug delivery - Cell culture - Scaffolds (biology) - Ring opening polymerization - Biocompatibility - Biomechanics - Esters - Cell engineering - Gelation - Sodium alginate
- Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I被引量：58收藏
- 作者：Zhang, Ludi Shao, Yanjiao Li, Lu Tian, Feng Cen, Jin Chen, Xiaotao Hu, Dan Zhou, Yan Xie, Weifen Zheng, Yunwen Ji, Yuan Liu, Mingyao Li, Dali Hui, Lijian
- 机构：Chinese Acad Sci;East China Normal Univ;East China Normal Univ;Fudan Univ;East China Univ Sci & Technol
- 来源：SCIENTIFIC REPORTS 2016
- Synthesis, characterization, fluorescence labeling and cellular internalization of novel amine-functionalized poly(ethylene glycol)-block- poly(Ε-caprolactone) amphiphilic block copolymers被引量：54收藏
- 作者：Yan, Jinliang Ye, Zhaoyang Luo, Houyong Chen, Min Zhou, Yan Tan, Wensong Xiao, Yan Zhang, Yan Lang, Meidong
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials of Ministry of Education
- 来源：Polymer Chemistry 2011
- 关键词：Drug delivery - Medical applications - Proteins - Fluorophores - Particle size - Ring opening polymerization - Critical micelle concentration - Hyaluronic acid - Polyols - Esters - Ethylene glycol - Organic acids - Block copolymers - Cell culture - Solutions - Ethylene - Fluorescence microscopy - Polyethylene glycols - Polyethylene oxides
- Three-Dimensional and Serum-Free Culture in Fixed-Bed Bioreactor Enhance Exosome Production by Affecting the Cytoskeleton被引量：52收藏
- 作者：Zhou, Yan Huo, Chuanfu Zhao, Yuanyuan Song, Meng Guo, Yuzhe Li, Shihao Tan, Wensong
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Key Laboratory of Multiphase Materials Chemical Engineering
- 来源：SSRN 2024
- 关键词：Bioconversion - Cell culture - Microfiltration - Plastic bottles - Proteins - Stem cells
- Preparation and characterization of antibacterial polyvinyl alcohol/chitosan sponge and potential applied for wound dressing被引量：51收藏
- 作者：Fan, Yao Lu, Qiaohui Liang, Wencheng Wang, Youchang Zhou, Yan Lang, Meidong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：EUROPEAN POLYMER JOURNAL 2021
- 关键词：PVA DMAEMA Chitosan Wound dressing Antibacterial
- Fine tuning micellar core-forming block of poly(ethylene glycol)- block -poly(Ε-caprolactone) amphiphilic copolymers based on chemical modification for the solubilization and delivery of doxorubicin被引量：50收藏
- 作者：Yan, Jinliang Ye, Zhaoyang Chen, Min Liu, Zhanzhan Xiao, Yan Zhang, Yan Zhou, Yan Tan, Wensong Lang, Meidong
- 机构： Key Laboratory for Ultrafine Materials of Ministry of Education; State Key Laboratory of Bioreactor Engineering
- 来源：Biomacromolecules 2011
- 关键词：Chemical modification - Esterification - Polyethylene glycols - Solutions - Controlled drug delivery - Critical micelle concentration - Motion Picture Experts Group standards - Esters - Ethylene glycol - Polyethylene oxides - Polyols - Lactic acid - Ring opening polymerization - Solubility - Targeted drug delivery - Block copolymers - Fluorescence spectroscopy
- The effect of gap junction-mediated transfer of miR-200b on osteogenesis and angiogenesis in a co-culture of MSCs and HUVECs被引量：49收藏
- 作者：Fan, Xiaoting Teng, Yi Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF CELL SCIENCE 2018
- 关键词：Pre-vascularized bone Mesenchymal stem cell Endothelial cell Gap junction miR-200b
- Pendant small functional groups on poly(Ε-caprolactone) substrate modulate adhesion, proliferation and differentiation of human mesenchymal stem cells被引量：45收藏
- 作者：Chen, Min Zhang, Yi Zhou, Yan Zhang, Yan Lang, Meidong Ye, Zhaoyang Tan, Wen-Song
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials of Ministry of Education
- 来源：Colloids and Surfaces B: Biointerfaces 2015
- 关键词：Tissue regeneration - Tissue - Adhesion - Scaffolds (biology) - Biomaterials - Cell culture - Cell engineering - Surface chemistry
- Microfluidic Regulation of Porous Poly(L-Lactide-Co-Ε-Caprolactone) Microcarrier to Refine Myoblast Differentiation Potential被引量：42收藏
- 作者：Wang, Zining Wang, Lu Song, Meng An, Chenjing Li, Yijing Zhou, Yan Cen, Lian
- 机构： Shanghai Key Laboratory of Multiphase Materials Chemical Engineering; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2024
- 关键词：Cytology - Gene expression - Macrophages - Microspheres - Muscle
- 体外扩增过程中人骨髓间充质干细胞的增殖与分化规律被引量：42收藏
- 作者：胡静波 周燕 蒋丹丹 谭文松
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《细胞与分子免疫学杂志》 2006
- 关键词：骨髓间充质干细胞 成骨 成软骨 成脂肪
- 摘要：目的系统考察体外扩增过程中人骨髓间充质干细胞(MSC)的增殖与分化规律,为MSC在组织修复以及细胞治疗中的应用提供参考。方法以全骨髓贴壁法分离成人肋骨骨髓MSC,在相同条件下分别考察各代细胞形态、生长、表面标记、细胞周期...
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- A multifunctional green antibacterial rapid hemostasis composite wound dressing for wound healing被引量：42收藏
- 作者：Liang, Wencheng Lu, Qiaohui Yu, Fan Zhang, Junyong Xiao, Chuang Dou, Xiaoming Zhou, Yan Mo, Xiumei Li, Jun Lang, Meidong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Donghua Univ;Tongji Univ
- 来源：BIOMATERIALS SCIENCE 2021
- Lycopene production in recombinant strains of Escherichia coli is improved by knockout of the central carbon metabolism gene coding for glucose-6-phosphate dehydrogenase被引量：41收藏
- 作者：Zhou, Yan Nambou, Komi Wei, Liujing Cao, Jingjing Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2013
- 关键词：Escherichia coli Glucose-6-phosphate dehydrogenase Lycopene MEP pathway
- Synthesis, characterization, fluorescence labeling and cellular internalization of novel amine-functionalized poly(ethylene glycol)-block-poly(ε-caprolactone) amphiphilic block copolymers被引量：37收藏
- 作者：Yan, Jinliang Ye, Zhaoyang Luo, Houyong Chen, Min Zhou, Yan Tan, Wensong Xiao, Yan Zhang, Yan Lang, Meidong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：POLYMER CHEMISTRY 2011
- Fabrication of three-dimensional poly(ε-caprolactone) scaffolds with hierarchical pore structures for tissue engineering被引量：36收藏
- 作者：Zhang, Qingchun Luo, Houyong Zhang, Yan Zhou, Yan Ye, Zhaoyang Tan, Wensong Lang, Meidong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2013
- 关键词：Poly(epsilon-caprolactone) Scaffolds Pore size Fibroblasts
- Identification of multiple sources of the acidic charge variants in an IgG1 monoclonal antibody被引量：35收藏
- 作者：Miao, Shiwei Xie, Panpan Zou, Mao Fan, Li Liu, Xuping Zhou, Yan Zhao, Liang Ding, Ding Wang, Haibin Tan, Wen-Song
- 机构：East China Univ Sci & Technol;Hisun Pharmaceut Hangzhou Co Ltd
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2017
- 关键词：mAb IgG1 Acidic charge heterogeneity Deamidation Galactosylation Disulfide bond reduction
- Hypoxia alleviates dexamethasone-induced inhibition of angiogenesis in cocultures of HUVECs and rBMSCs via HIF-1α被引量：35收藏
- 作者：Chai, Miaomiao Gu, Ce Shen, Qihua Liu, Jiaxing Zhou, Yi Jin, Ziyang Xiong, Wanli Zhou, Yan Tan, Wensong
- 机构：East China Univ Sci & Technol
- 来源：STEM CELL RESEARCH & THERAPY 2020
- 关键词：Mesenchymal stem cell Human umbilical vein endothelial cell Angiogenesis Dexamethasone Hypoxia
- Influence of lactic acid on the proliferation, metabolism, and differentiation of rabbit mesenchymal stem cells被引量：34收藏
- 作者：Chen, Ting Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：CELL BIOLOGY AND TOXICOLOGY 2009
- 关键词：Colony-forming units assays Differentiation Lactic acid Mesenchymal stem cells Metabolism Proliferation
- Elucidating the effects of pH shift on IgG1 monoclonal antibody acidic charge variant levels in Chinese hamster ovary cell cultures被引量：33收藏
- 作者：Xie, Panpan Niu, Huijie Chen, Xinning Zhang, Xintao Miao, Shiwei Deng, Xiancun Liu, Xuping Tan, Wen-Song Zhou, Yan Fan, Li
- 机构：East China Univ Sci & Technol;Hisun Pharmaceut Hangzhou Co Ltd
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2016
- 关键词：Acidic charge variants IgG1 monoclonal antibody Disulfide bond reduction Galactosylation Deamination Liquid chromatography mass spectrometry
- Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes被引量：33收藏
- 作者：Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui
- 机构：Department of Hepatobiliary Surgery;State Key Laboratory of Cell Biology;School of Life Science and Technology;Center for Drug Safety Evahtation and Research;State Key Laboratory of Bioreactor Engineering
- 来源：细胞研究（英文版） 2016
- 关键词：肝功能衰竭 人肝细胞 生物人工肝 急性 猪 植入 诱导 装置
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- 3D Dynamic Culture of Rabbit Articular Chondrocytes Encapsulated in Alginate Gel Beads Using Spinner Flasks for Cartilage Tissue Regeneration被引量：33收藏
- 作者：Xu, Feiyue Xu, Lei Wang, Qi Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：BIOMED RESEARCH INTERNATIONAL 2014
- The combined effect of sodium butyrate and low culture temperature on the production, sialylation, and biological activity of an antibody produced in CHO cells被引量：33收藏
- 作者：Chen, Fei Kou, Tianci Fan, Li Zhou, Yan Ye, Zhaoyang Zhao, Liang Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2011
- 关键词：CHO cells sodium butyrate low culture temperature sialylation N-glycolylneuraminic acid
- AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells被引量：32收藏
- 作者：Wu, Wei Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS 2011
- 关键词：AICAR Mesenchymal stem cells Differentiation Osteogenesis Small molecule
- Dipeptidyl peptidase IV inhibitory peptides from Chlorella vulgaris: in silico gastrointestinal hydrolysis and molecular mechanism被引量：31收藏
- 作者：Zhu, Qiaosha Chen, Xujun Wu, Junjie Zhou, Yan Qian, Yang Fang, Ming Xie, Jingli Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Fudan Univ;SCICB
- 来源：EUROPEAN FOOD RESEARCH AND TECHNOLOGY 2017
- 关键词：Chlorella vulgaris DPP-IV inhibitory peptides In silico hydrolysis Molecular docking
