成果/Result
- Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and the physicochemical and biological properties被引量：62收藏
- 作者：Wu, Hao Deng, Zhaizhu Zhou, Bijian Qi, Minghui Hong, Minghuang Ren, Guobin
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2019
- 关键词：Ibuprofen Ionic liquids Molecular interaction Skin permeability Cytotoxicity
- Development of a gliclazide ionic liquid and its mesoporous silica particles: An effective formulation strategy to improve oral absorption properties被引量：58收藏
- 作者：Zhou, Bijian Teng, Dan Li, Jinghui Zhang, Yanhong Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Shanghai Key Laboratory of New Drug Design; State Key Laboratory of Bioreactor Engineering
- 来源：RSC Advances 2022
- 关键词：Silica - Targeted drug delivery - Molecules - Controlled drug delivery - Encapsulation - Solubility - Positive ions - Mesoporous materials - Physicochemical properties - Supersaturation
- Insight into the effect of cocrystal polymorphism / stoichiomorphism on thermodynamic and photoluminescence properties: a case study被引量：45收藏
- 作者：Han, Xianyang Yin, Yu Zhu, Fan Yao, Yichen Hong, Minghuang Qi, Minghui Zhu, Bin Ren, Guobin
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2025
- 关键词：Crystal structure - Fluorescence - Fluorescence spectroscopy - Optical properties - Phase transitions - Photoluminescence - Polymorphism - Single crystals - Thermoanalysis - X ray diffraction
- Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point被引量：40收藏
- 作者：Yao, Yi-Chen Jin, Zhe Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology
- 来源：Crystal Growth and Design 2024
- 关键词：Melting point - Single crystals - Surface analysis - Thermoanalysis
- Ionic liquid form of donepezil: Preparation, characterization and formulation development被引量：31收藏
- 作者：Wu, Hao Fang, Fang Zheng, Lulu Ji, Weijie Qi, Minghui Hong, Minghuang Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2020
- 关键词：Ionic liquids Alzheimer's disease Donepezil Drug-in-adhesive patch Skin permeability
- Slow-Release Drug-Drug Cocrystals of Oxaliplatin with Flavonoids: Delaying Hydrolysis and Reducing Toxicity被引量：31收藏
- 作者：Yin, He-Mei Wu, Nan Zhou, Bi-Jian Hong, Ming-Huang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Cancer cells - Controlled drug delivery - Fourier transform infrared spectroscopy - Dissolution - Targeted drug delivery - Cells - Flavonoids - X ray diffraction - Hydrogen bonds - Thermoanalysis - Toxicity - Cytology
- Toward Understanding the Effect of Solvent Evaporation on the Morphology of PLGA Microspheres by Double Emulsion Method被引量：29收藏
- 作者：Si, Wei Yang, Qingqing Zong, Yuan Ren, Guobin Zhao, Ling Hong, Minghuang Xin, Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2021
- 关键词：Emulsification - Evaporation - Morphology - Microspheres - Diffusion
- Development of gliclazide ionic liquid and the transdermal patches: An effective and noninvasive sustained release formulation to achieve hypoglycemic effects被引量：27收藏
- 作者：Zhou, Bijian Liu, Siyuan Yin, Hemei Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2021
- 关键词：Diabetes mellitus Gliclazide Ionic liquid Transdermal drug delivery Hypoglycemic effect
- Cocrystals of Oxymatrine: Reducing Hygroscopicity and Affecting the Dissolution Rate被引量：25收藏
- 作者：Qi, Ming-Hui Li, Heng Zhu, Bin Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Dissolution - Hydrogen bonds - Metabolism
- Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy被引量：23收藏
- 作者：Chen, Wenhua Guo, Ne Qi, Minghui Dai, Haiying Hong, Minghuang Guan, Longfei Huan, Xiajuan Song, Shanshan He, Jinxue Wang, Yingqing Xi, Yong Yang, Xinying Shen, Yanyan Su, Yi Sun, Yiming Gao, Yinglei Chen, Yi Ding, Jian Tang, Yun Ren, Guobin Miao, Zehong Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Univ Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017
- 关键词：Antitumor drug BRCA1/2 PARP inhibitors Molecular docking
- Strategy for Efficient Discovery of Cocrystals via a Network-Based Recommendation Model被引量：22收藏
- 作者：Zheng, Lulu Zhu, Bin Wu, Zengrui Fang, Xiaoxue Hong, Minghuang Liu, Guixia Li, Weihua Ren, Guobin Tang, Yun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2020
- Estimating Thermodynamic Stability Relationship of Polymorphs of Sofosbuvir被引量：22收藏
- 作者：Qi, Ming-Hui Hong, Ming-Huang Liu, Yan Wang, En-Fu Ren, Fu-Zheng Ren, Guo-Bin
- 机构：E China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2015
- 关键词：Solubility - Thermoanalysis - X ray powder diffraction - Free energy - Melting
- Cocrystals of Lenvatinib with Sulfamerazine and Salicylic Acid: Crystal Structure, Equilibrium Solubility, Stability Study, and Anti-Hepatoma Activity被引量：20收藏
- 作者：Hong, Minghuang Li, Shijia Ji, Weijie Qi, Ming-Hui Ren, Guo-bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Surface analysis - Crystal structure - Nuclear magnetic resonance spectroscopy - Salicylic acid - Differential scanning calorimetry - Amino acids - Fourier transform infrared spectroscopy - Thermogravimetric analysis - Hydrogen bonds - Drug delivery - Spectrometers - X ray diffraction
- Insight into the Formation of Cocrystals of Flavonoids and 4,4′-Vinylenedipyridine: Heteromolecular Hydrogen Bonds, Molar Ratio, and Structural Analysis被引量：19收藏
- 作者：Zhang, Yanhong Zhu, Bin Ji, Wei-Jie Guo, Chun-Yang Hong, Minghuang Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Hydrogen bonds - Single crystals - Molar ratio
- Cocrystals of flavonoids with 4,4′-ethylenebispyridine: Crystal structures analysis, dissolution behavior, and anti-tumor activity被引量：16收藏
- 作者：Zhang, Yanhong Yang, Rui Yin, He-Mei Zhou, Bijian Hong, Minghuang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2022
- 关键词：Tumors - Cancer cells - Single crystals - Dissolution
- Solubility correlation and thermodynamic analysis of two forms of Metaxalone in different pure solvents被引量：14收藏
- 作者：Hong, Minghuang Wu, Shiwang Qi, Minghui Ren, Guobin
- 机构：E China Univ Sci & Technol
- 来源：FLUID PHASE EQUILIBRIA 2016
- 关键词：Solubility Thermodynamic models Endothermic Entropy driven Nonspontaneous
- Study of Cycloxaprid Co-crystals: Characterization, Theory Calculation, Solubility, and Stability被引量：12收藏
- 作者：Li, Mengnan Wang, Jinling Xu, Xiaoyong Ren, Guobin Zhu, Bin Hong, Minghuang Li, Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2022
- 关键词：Chemical stability - Differential scanning calorimetry - Fourier transform infrared spectroscopy - Molecular orbitals - Nuclear magnetic resonance spectroscopy - Single crystals - Thermogravimetric analysis - X ray diffraction
- SMINBR: An Integrated Network and Chemoinformatics Tool Specialized for Prediction of Two-Component Crystal Formation被引量：11收藏
- 作者：Zheng, Lulu Zhu, Bin Wu, Zengrui Liang, Fang Hong, Minghuang Liu, Guixia Li, Weihua Ren, Guobin Tang, Yun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2021
- 关键词：Molecular interactions - Molecular structure - Crystals - Physicochemical properties
- Structure properties of scoparone: Polymorphs and cocrystals被引量：10收藏
- 作者：Chen, Jin-yao Wang, Xiao-yu Hong, Ming-huang Yi, Dong-xu Qi, Ming-hui Ren, Guo-bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2019
- 关键词：Scoparone Polymorphs Cocrystals Crystal structure Powder dissolution study
- Study on Structure, Stability, and Phase Transformation of Dufulin Polymorphs被引量：9收藏
- 作者：Li, Mengnan Gong, Chengyu Ren, Guobin Xu, Xiaoyong Hong, Minghuang Li, Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Agriculture - Solubility - Density functional theory - Viruses - X ray diffraction - Antiviral agents - Crystalline materials - Phase transitions - Polymorphism - Stability - Thermoanalysis - Losses
- Colorful Prothionamide Salt Forms with Enhancement in Water Solubility and Dissolution Behavior被引量：9收藏
- 作者：Ji, Wei-Jie Jiang, Jun-Yi Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2023
- 关键词：Dissolution - Drug delivery - Free energy - Molecular orbitals - Naphthalene - Salts - Solubility
- Development of a gliclazide ionic liquid and its mesoporous silica particles: an effective formulation strategy to improve oral absorption properties被引量：9收藏
- 作者：Zhou, Bijian Teng, Dan Li, Jinghui Zhang, Yanhong Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：RSC ADVANCES 2021
- Novel Salts of the Atypical Antipsychotic Drug Lurasidone with Improved Solubility and Bioavailability被引量：9收藏
- 作者：Guo, Chunyang Wang, Yuan Xie, Junyi Zhu, Bin Qi, Ming-Hui Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2023
- 关键词：Biochemistry - Drug delivery - Single crystals - Solubility - Thermoanalysis - X ray diffraction
- Transdermal Delivery of Metformin Utilizing Ionic Liquid Technology: Insight Into the Relationship Between Counterion Structures and Properties被引量：6收藏
- 作者：Hong, Minghuang Wang, Qinglin Wang, Kai Li, Jinghui Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;Shanghai Frontier Sci Res Base Optogenet Tech Cel;Lab Pharmaceut Crystal Engn & Technol;East China Univ Sci & Technol
- 来源：PHARMACEUTICAL RESEARCH 2022
- 关键词：counterion structure delivery system ionic liquids metformin skin permeability transdermal drug
- Investigation of a solution-mediated phase transformation of pranlukast DMF solvate to hemihydrate被引量：6收藏
- 作者：Hong, Minghuang Chen, Jingyan Zhou, Hui Xu, Hao Ren, Guobin
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL RESEARCH AND TECHNOLOGY 2017
- 关键词：Pranlukast polymorphism solution-mediated phase transformation
- Four solid forms of flibanserin: Insight into the crystal structures, properties, stability, and solid-state transition被引量：6收藏
- 作者：Qi, Ming-Hui Ye, Wen-Xin Ji, Wei-Jie Hong, Ming-Huang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2020
- 关键词：Flibanserin Solid form Crystal structure Solid-state transition Stability
- Insight into the behavior regulation of drug transfer of nimodipine loaded PLGA microspheres by emulsion evaporation method被引量：5收藏
- 作者：Yang, Qingqing Bian, Yizhen Ren, Guobin Hong, Minghuang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 2023
- 关键词：Emulsion evaporation Drug transfer Solvent volatilization Crystallization Drug loading
- Enhancement of solubility and dissolution rate of dipyridamole by salifying: Preparation, characterization, and theoretical calculation被引量：5收藏
- 作者：Yi, Dongxu Dong, Yuhang Yao, Yichen Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2024
- 关键词：Dipyridamole Salt Solubility Fluorescence
- Conformation, virtual cocrystal screening, synthesis and determination of dipyridamole被引量：5收藏
- 作者：Yi, Dongxu Dong, Yuhang Qi, Minghui Hong, Minghung Zhu, Bin Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2024
- 关键词：Dipyridamole Conformation Virtual cocrystal screening
- Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z" with a Low Melting Point被引量：4收藏
- 作者：Yao, Yi-chen Jin, Zhe Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2023
