成果/Result
- Functionalization of single-walled carbon nanotubes enables efficient intracellular delivery of siRNA targeting MDM2 to inhibit breast cancer cells growth被引量：61收藏
- 作者：Chen, Hailong Ma, Xingyuan Li, Zhi Shi, Qiaoyun Zheng, Wenyun Liu, Yang Wang, Ping
- 机构：E China Univ Sci & Technol;Natl Univ Singapore;E China Univ Sci & Technol
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2012
- 关键词：Functionalized SWNTs Delivery of siRNA MDM2 Breast cancer cells
- PEGylated-PLGA Nanoparticles Coated with pH-Responsive Tannic Acid-Fe(III) Complexes for Reduced Premature Doxorubicin Release and Enhanced Targeting in Breast Cancer被引量：38收藏
- 作者：Hu, Fabiao Zhang, Ruihuan Guo, Wei Yan, Ting He, Xiujuan Hu, Fengzhi Ren, Fuzheng Ma, Xingyuan Lei, Jiandu Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Beijing Forestry Univ
- 来源：MOLECULAR PHARMACEUTICS 2021
- 关键词：TPLGA NPs premature release effect inhibition chemotherapy drug delivery tumor tissue targeting
- Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment被引量：24收藏
- 作者：Chen, Shanshan Deng, Changping Zheng, Wenyun Li, Shihui Liu, Yuping Zhang, Tong Zhang, Chen Fu, Yunhui Miao, Hui Ren, Fuzheng Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PHARMACEUTICS 2021
- 关键词：cannabidiol (CBD) bladder cancer (BC) RNA sequencing PI3K Akt chitosan CBD-loaded PLGA
- A novel liposome-polymer hybrid nanoparticles delivering a multi-epitope self-replication DNA vaccine and its preliminary immune evaluation in experimental animals被引量：23收藏
- 作者：Zhao, Zhangting Ma, Xingyuan Zhang, Ruihuan Hu, Fabiao Zhang, Tong Liu, Yuping Han, Myong Hun You, Fang Yang, Yi Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;KIM IL SUNG Univ;Natl Univ Singapore;SinGENE Biotech Pte Ltd
- 来源：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2021
- 关键词：DNA vaccine Liposome-polymer hybrid nanoparticles Delivery Immune evaluation Infectious diseases
- Cascade enzymatic reactions for efficient carbon sequestration被引量：17收藏
- 作者：Xia, Shunxiang Zhao, Xueyan Frigo-Vaz, Benjamin Zheng, Wenyun Kim, Jungbae Wang, Ping
- 机构：Univ Minnesota;Univ Minnesota;E China Univ Sci & Technol;Korea Univ
- 来源：BIORESOURCE TECHNOLOGY 2015
- 关键词：Carbon capture and storage Isocitrate dehydrogenase Aconitase Carbon dioxide Biocatalysis
- Designing and constructing a phage display synthesized single domain antibodies library based on camel VHHs frame for screening and identifying humanized TNF-α-specific nanobody被引量：17收藏
- 作者：Nie, Jifan Ma, Xingyuan Hu, Fabiao Miao, Hui Feng, Xin Zhang, Peiwen Han, Myong Hun You, Fang Yang, Yi Zhang, Wenlian Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Kim Il Sung Univ;Natl Univ Singapore;SinGENE Biotech Pte Ltd
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2021
- 关键词：Single domain antibodies Phage display library Designing and constructing Humanized TNF-alpha-specific Nb Screening and identifyin
- Visual diagnostic of Helicobacter pylori based on a cascade amplification of PCR and G-quadruplex DNAzyme as a color label被引量：17收藏
- 作者：Liu, Zhanmin Yao, Chenhui Wang, Yanming Zheng, Wenyun
- 机构：Shanghai Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF MICROBIOLOGICAL METHODS 2018
- 关键词：Visual diagnostic Helicobacter pylori G-quadruplex DNAzyme
- A CqFerritin protein inhibits white spot syndrome virus infection via regulating iron ions in red claw crayfish Cherax quadricarinatus被引量：15收藏
- 作者：Chen, Xiao-Xiao Li, Yan-Yao Chang, Xue-Jiao Xie, Xiao-Lu Liang, Yu-Ting Wang, Ke-Jian Zheng, Wen-Yun Liu, Hai-Peng
- 机构：East China Univ Sci & Technol;Fujian Collaborat Innovat Ctr Exploitat & Utiliza
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2018
- 关键词：Ferritin Iron White spot syndrome virus Cherax quadricarinatus
- Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin被引量：15收藏
- 作者：Liu, Di Guo, Hua Zheng, Wenyun Zhang, Na Wang, Tianwen Wang, Ping Ma, Xingyuan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2016
- 关键词：Heat-labile enterotoxin (LT) A2 domain Cell-penetrating Multi-endocytosis pathway Drugs delivery
- A cytokine receptor domeless promotes white spot syndrome virus infection via JAK/STAT signaling pathway in red claw crayfish Cherax quadricarinatus被引量：14收藏
- 作者：Liu, Ling-ke Chen, Xiao-xiao Gao, Rui-lin Wang, Ke-jian Zheng, Wen-yun Liu, Hai-peng
- 机构：Xiamen Univ;East China Univ Sci & Technol
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2020
- 关键词：Domeless White spot syndrome virus JAK/STAT pathway Cherax quadricarinatus Phosphorylation
- Design and screening of a chimeric survivin-specific nanobody and its anticancer activities in vitro被引量：13收藏
- 作者：Zhang, Na Guo, Hua Zheng, Wenyun Wang, Tianwen Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANTI-CANCER DRUGS 2016
- 关键词：antibody engineering anticancers phage display survivin nanobody
- Improving the physicochemical properties of bicalutamide by complex formation with bovine serum albumin被引量：12收藏
- 作者：Yang, Congbin Di, Peiwen Fu, JinPing Xiong, Hui Jing, Qiufang Ren, Guobin Tang, Yun Zheng, Wenyun Liu, Guixia Ren, Fuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2017
- 关键词：Bovine serum albumin Bicalutamide Anti-solvent precipitation Interaction Molecular docking
- Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9被引量：12收藏
- 作者：Wang, Wenpeng Zheng, Wenyun Hu, Fengzhi He, Xiujuan Wu, Dong Zhang, Wenliang Liu, Haipeng Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ North Carolina Greensboro;Xiamen Univ
- 来源：ACS SYNTHETIC BIOLOGY 2018
- 关键词：CHO-K1 mammalian cell ER microenvironment antiapoptotic ability genome editing by CRISPR-Cas9 high quality protein production
- Split-Cas9-based targeted gene editing and nanobody-mediated proteolysis-targeting chimeras optogenetically coordinated regulation of Survivin to control the fate of cancer cells被引量：11收藏
- 作者：Deng, Changping Li, Shihui Liu, Yuping Bao, Wen Xu, Chengnan Zheng, Wenyun Wang, Meiyan Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Normal Univ;East China Normal Univ;East China Univ Sci & Technol
- 来源：CLINICAL AND TRANSLATIONAL MEDICINE 2023
- 关键词：Coordinated regulating to Survivin Fate of cancer cells Nanobody targeted degradation Photoactivatable proteolysis and editing
- Highly Efficient Folding of Multi-Disulfide Proteins in Superoxidizing Escherichia coli Cytoplasm被引量：10收藏
- 作者：Zhang, Wenyao Zheng, Wenyun Mao, Miaowei Yang, Yi
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2014
- 关键词：redox potential disulfide formation oxidative protein folding superoxidizing cells
- Enhancing the Antibody Production Efficiency of Chinese Hamster Ovary Cells through Improvement of Disulfide Bond Folding Ability and Apoptosis Resistance被引量：10收藏
- 作者：Zhang, Chen Fu, Yunhui Zheng, Wenyun Chang, Feng Shen, Yue Niu, Jinping Wang, Yangmin Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CELLS 2024
- 关键词：CHO cells antibody production efficiency disulfide bond folding apoptotic resistance unfolded protein response
- Corosolic acid-modified lipid nanoparticles as delivery carriers for DNA vaccines against avian influenza被引量：10收藏
- 作者：Guo, Ziyan Jing, Qiufang Xu, Zhongyu Zhang, Dahe Zheng, Wenyun Ren, Fuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Suzhou Womei Biol Co Ltd;East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2023
- 关键词：Lipid nanoparticles Cholesterol Corosolic acid Avian influenza vaccine Immune responses
- Immuno-Enhancing Effect of Ginsenoside Rh2 Liposomes on Foot-and-Mouth Disease Vaccine被引量：10收藏
- 作者：Miao, Saiya Jing, Qiufang Wang, Xuanyu Zheng, Wenyun Liu, Hui Tang, Liusiqi Wang, Xinzhu Ren, Fuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Baoshan Ctr Dis Control & Prevent;East China Univ Sci & Technol
- 来源：MOLECULAR PHARMACEUTICS 2023
- 关键词：ginsenoside Rh2 liposomes W/O/W emulsion foot-and-mouth disease vaccine immune adjuvant
- Targeting intracellular cancer proteins with tumor-microenvironment-responsive bispecific nanobody-PROTACs for enhanced therapeutic efficacy被引量：10收藏
- 作者：Deng, Changping Ma, Jiacheng Liu, Yuping Tong, Xikui Wang, Lei Dong, Jiayi Shi, Ping Wang, Meiyan Zheng, Wenyun Ma, Xingyuan
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Chinese Univ Hong Kong;East China Univ Sci & Technol;Shanghai Univ
- 来源：MEDCOMM 2025
- 关键词：nanobody PD-L1 and Survivin proteolysis targeting chimeras (PROTACs) targeted degradation tumor microenvironment
- Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin被引量：9收藏
- 作者：Xu, Yuxin Zheng, Wenyun Wang, Tianwen Wang, Ping Zhu, Ling Ma, Xingyuan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Jiangnan Univ
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2012
- 关键词：Genetic protein TmSm(T34A) Enhancing sensitivity Chemotherapeutic agent Breast cell lines
- Structure-function analysis of human protein Ero1-Lα被引量：9收藏
- 作者：Chu, Yanyan Yang, Charles Chen, Xianjun Zheng, Wenyun Yang, Yi Tang, Yun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009
- 关键词：Disulfide bond Ero1-L alpha Thioredoxin Homology modeling Structure-function analysis
- Multiple targeting strategies achieve novel protein drug delivery into proapoptosis lung cancer cells by precisely inhibiting survivin被引量：8收藏
- 作者：Hu, Fabiao Yan, Ting Guo, Wei Liu, Qiuli Han, Myong Hun Liu, Chang Liu, Yuping Zheng, Wenyun You, Fang Yang, Yi Zhang, Wenliang Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;KIM IL SUNG Univ;Natl Univ Singapore;SinGENE Biotech Pte Ltd
- 来源：NANOSCALE 2020
- 关键词：Cancer cells - Tumors - Cell death - Mammals - Diseases - Targeted drug delivery - Biocompatibility - Controlled drug delivery - Recombinant proteins
- A recombinant protein TmSm(T34A) can inhibit proliferation and proapoptosis to breast cancer stem cells(BCSCs) by down-regulating the expression of Cyclin D1被引量：8收藏
- 作者：Ma, Xingyuan Zhang, Yi Kang, Yanyan Li, Linfeng Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2016
- 关键词：TmSm(T34A) BCSCs Proliferation Proapoptosis Cyclin D1
- Crucial effect of the first CXXC motif of human QSOX 1b on the activity to different substrates被引量：8收藏
- 作者：Zheng, Wenyun Chu, Yanyan Yin, Qin Xu, Lei Yang, Charles Zhang, Wenyao Tang, Yun Yang, Yi
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF BIOCHEMISTRY 2011
- 关键词：electron transfer molecular modelling QSOX site-directed mutagenesis thiol oxidation
- Levels of effectiveness of gene therapies targeting survivin and its splice variants in human breast cancer cells被引量：8收藏
- 作者：Zheng, Wenyun Kang, Yanyan Li, Linfeng Xu, Yuxin Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：DRUG DISCOVERIES AND THERAPEUTICS 2011
- 关键词：Survivin splice variant growth inhibition apoptosis breast cancer
- A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells被引量：8收藏
- 作者：Lin, Nanjing Zheng, Wenyun Li, Linfeng Liu, Hui Wang, Tianwen Wang, Ping Ma, Xingyuan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：TARGETED ONCOLOGY 2014
- 关键词：Tat-INF7-ubiquitin (TIU) system Cytosolic delivery Bak BH3 Inducing apoptosis
- Elucidating respective functions of two domains BIR and C-helix of human IAP survivin for precise targeted regulating mitotic cycle, apoptosis and autophagy of cancer cells被引量：8收藏
- 作者：Hu, Fabiao Pan, Daxia Zheng, Wenyun Yan, Ting He, Xiujuan Ren, Fuzheng Lu, Yiming Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Second Mil Med Univ
- 来源：ONCOTARGET 2017
- 关键词：BIR and CC domains survivin cell cycle apoptosis and autophagy breast cancer cells
- Exploring the Smallest Active Fragment of HsQSOX1b and Finding a Highly Efficient Oxidative Engine被引量：7收藏
- 作者：Zheng, Wenyun Zhang, Wenyao Hu, Wei Zhang, Chao Yang, Yi
- 机构：E China Univ Sci & Technol
- 来源：PLOS ONE 2012
- 新形势下药学专业认知实习新要求和新模式探索被引量：7收藏
- 作者：郑文云 任福正 李剑 邓卫平 唐赟
- 机构：华东理工大学药学院药物科学系
- 来源：《化工高等教育》 2016
- 关键词：认知实习 药学专业 新模式 实践探索
- 摘要：为了提高药学类专业本科生在制药企业进行认知实习的效果,建立学校—药企互联互通的人才培养新模式,本文结合新形势下药学专业认知实习的新要求,对我校奉贤校区现阶段药学专业认知实习过程中遇到的实际问题进行了系统的分析和总结,提出...
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- Development of a synthetic library of humanized nanobodies for targeted IL-6 inhibition被引量：6收藏
- 作者：Wang, Lei Dong, Jiayi Wu, Chenlu Yan, Chenyue Bi, Chong Xu, Chengnan Wu, Yiling Zheng, Wenyun Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2024
- 关键词：nanobody humanization stability synthetic library phage display interleukin-6 blocking antibody
