成果/Result
- Development of a gliclazide ionic liquid and its mesoporous silica particles: An effective formulation strategy to improve oral absorption properties被引量：58收藏
- 作者：Zhou, Bijian Teng, Dan Li, Jinghui Zhang, Yanhong Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Shanghai Key Laboratory of New Drug Design; State Key Laboratory of Bioreactor Engineering
- 来源：RSC Advances 2022
- 关键词：Silica - Targeted drug delivery - Molecules - Controlled drug delivery - Encapsulation - Solubility - Positive ions - Mesoporous materials - Physicochemical properties - Supersaturation
- Insight into the effect of cocrystal polymorphism / stoichiomorphism on thermodynamic and photoluminescence properties: a case study被引量：45收藏
- 作者：Han, Xianyang Yin, Yu Zhu, Fan Yao, Yichen Hong, Minghuang Qi, Minghui Zhu, Bin Ren, Guobin
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2025
- 关键词：Crystal structure - Fluorescence - Fluorescence spectroscopy - Optical properties - Phase transitions - Photoluminescence - Polymorphism - Single crystals - Thermoanalysis - X ray diffraction
- Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point被引量：40收藏
- 作者：Yao, Yi-Chen Jin, Zhe Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology
- 来源：Crystal Growth and Design 2024
- 关键词：Melting point - Single crystals - Surface analysis - Thermoanalysis
- Slow-Release Drug-Drug Cocrystals of Oxaliplatin with Flavonoids: Delaying Hydrolysis and Reducing Toxicity被引量：31收藏
- 作者：Yin, He-Mei Wu, Nan Zhou, Bi-Jian Hong, Ming-Huang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Cancer cells - Controlled drug delivery - Fourier transform infrared spectroscopy - Dissolution - Targeted drug delivery - Cells - Flavonoids - X ray diffraction - Hydrogen bonds - Thermoanalysis - Toxicity - Cytology
- Development of gliclazide ionic liquid and the transdermal patches: An effective and noninvasive sustained release formulation to achieve hypoglycemic effects被引量：27收藏
- 作者：Zhou, Bijian Liu, Siyuan Yin, Hemei Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2021
- 关键词：Diabetes mellitus Gliclazide Ionic liquid Transdermal drug delivery Hypoglycemic effect
- Resurrecting the 'Disappearing Polymorph' of Rotigotine via Conformational Landscape Engineering被引量：25收藏
- 作者：Yi, Dongxu Qi, Minghui Xu, Shaohong Qi, Yonghua Xia, Ran Wu, Hao Ren, Guobin
- 机构： School of Pharmacy; School of Pharmacy; Children's Hospital Affiliated to Zhengzhou University; Henan Children’ s Hospital Zhengzhou Children’s Hospital; Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2025
- 关键词：Boltzmann equation - Conformations - Crystallization kinetics - Drug products - Engineering research - Molecular biology - Molecular physics - Polymorphism - Potential energy
- Cocrystals of Oxymatrine: Reducing Hygroscopicity and Affecting the Dissolution Rate被引量：25收藏
- 作者：Qi, Ming-Hui Li, Heng Zhu, Bin Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Dissolution - Hydrogen bonds - Metabolism
- Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy被引量：23收藏
- 作者：Chen, Wenhua Guo, Ne Qi, Minghui Dai, Haiying Hong, Minghuang Guan, Longfei Huan, Xiajuan Song, Shanshan He, Jinxue Wang, Yingqing Xi, Yong Yang, Xinying Shen, Yanyan Su, Yi Sun, Yiming Gao, Yinglei Chen, Yi Ding, Jian Tang, Yun Ren, Guobin Miao, Zehong Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Univ Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017
- 关键词：Antitumor drug BRCA1/2 PARP inhibitors Molecular docking
- Estimating Thermodynamic Stability Relationship of Polymorphs of Sofosbuvir被引量：22收藏
- 作者：Qi, Ming-Hui Hong, Ming-Huang Liu, Yan Wang, En-Fu Ren, Fu-Zheng Ren, Guo-Bin
- 机构：E China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2015
- 关键词：Solubility - Thermoanalysis - X ray powder diffraction - Free energy - Melting
- Cocrystals of Lenvatinib with Sulfamerazine and Salicylic Acid: Crystal Structure, Equilibrium Solubility, Stability Study, and Anti-Hepatoma Activity被引量：20收藏
- 作者：Hong, Minghuang Li, Shijia Ji, Weijie Qi, Ming-Hui Ren, Guo-bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Surface analysis - Crystal structure - Nuclear magnetic resonance spectroscopy - Salicylic acid - Differential scanning calorimetry - Amino acids - Fourier transform infrared spectroscopy - Thermogravimetric analysis - Hydrogen bonds - Drug delivery - Spectrometers - X ray diffraction
- Insight into the Formation of Cocrystals of Flavonoids and 4,4′-Vinylenedipyridine: Heteromolecular Hydrogen Bonds, Molar Ratio, and Structural Analysis被引量：19收藏
- 作者：Zhang, Yanhong Zhu, Bin Ji, Wei-Jie Guo, Chun-Yang Hong, Minghuang Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Hydrogen bonds - Single crystals - Molar ratio
- Cocrystals of flavonoids with 4,4′-ethylenebispyridine: Crystal structures analysis, dissolution behavior, and anti-tumor activity被引量：16收藏
- 作者：Zhang, Yanhong Yang, Rui Yin, He-Mei Zhou, Bijian Hong, Minghuang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2022
- 关键词：Tumors - Cancer cells - Single crystals - Dissolution
- Analysis of the dissolution behavior and solubility of Rotigotine form II in different mono-solvents被引量：16收藏
- 作者：Yi, Dongxu Dong, Yuhang Wang, Qinglin Wu, Juan Qi, Minghui Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2023
- 关键词：Rotigotine Hirshfeld surface Solubility Correlation Molecular simulation
- Strategy to Tune the Performance of Two Drug Components: Drug-Drug Cocrystals of Lobaplatin with Flavonoids被引量：15收藏
- 作者：Yin, He-Mei Xie, Jun-Yi Jiang, Jun-Yi Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2022
- 关键词：Dissolution - Solubility
- Three solid forms of chlorantraniliprole: Structure, characterization, and phase transformation被引量：14收藏
- 作者：Du, Dan Liu, Peng-Jian Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2018
- 关键词：Chlorantraniliprole Solid forms Solvates Crystal structure Phase transformation
- Solubility correlation and thermodynamic analysis of two forms of Metaxalone in different pure solvents被引量：14收藏
- 作者：Hong, Minghuang Wu, Shiwang Qi, Minghui Ren, Guobin
- 机构：E China Univ Sci & Technol
- 来源：FLUID PHASE EQUILIBRIA 2016
- 关键词：Solubility Thermodynamic models Endothermic Entropy driven Nonspontaneous
- Solvent-Mediated Polymorphic Transformation of famoxadone from Form II to Form I in Several Mixed Solvent Systems被引量：14收藏
- 作者：Du, Dan Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol
- 来源：CRYSTALS 2019
- 关键词：famoxadone solvent-mediated polymorphic transformation hydrogen-bond-acceptance ability
- Preparation and characterization of several azoxystrobin channel solvates被引量：11收藏
- 作者：Du, Dan Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2019
- 关键词：Azoxystrobin Channel solvates Isostructurality Hirshfeld surface Pseudopolymorph Solvent-replacement method Porosity
- Structure properties of scoparone: Polymorphs and cocrystals被引量：10收藏
- 作者：Chen, Jin-yao Wang, Xiao-yu Hong, Ming-huang Yi, Dong-xu Qi, Ming-hui Ren, Guo-bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2019
- 关键词：Scoparone Polymorphs Cocrystals Crystal structure Powder dissolution study
- Design, screening, and properties of novel solvates of azoxystrobin based on isomorphism被引量：9收藏
- 作者：Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTENGCOMM 2020
- 关键词：Surface analysis - Single crystals - X ray diffraction - Set theory
- Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy被引量：9收藏
- 作者：Chen, Wen-hua Song, Shan-shan Qi, Ming-hui Huan, Xia-juan Wang, Ying-qing Jiang, Hualiang Ding, Jian Ren, Guo-bin Miao, Ze-hong Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACTA PHARMACOLOGICA SINICA 2017
- 关键词：PARP-1 inhibitor olaparib breast cancer BRCA-deficient tumors
- Colorful Prothionamide Salt Forms with Enhancement in Water Solubility and Dissolution Behavior被引量：9收藏
- 作者：Ji, Wei-Jie Jiang, Jun-Yi Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2023
- 关键词：Dissolution - Drug delivery - Free energy - Molecular orbitals - Naphthalene - Salts - Solubility
- Development of a gliclazide ionic liquid and its mesoporous silica particles: an effective formulation strategy to improve oral absorption properties被引量：9收藏
- 作者：Zhou, Bijian Teng, Dan Li, Jinghui Zhang, Yanhong Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：RSC ADVANCES 2021
- Novel Salts of the Atypical Antipsychotic Drug Lurasidone with Improved Solubility and Bioavailability被引量：9收藏
- 作者：Guo, Chunyang Wang, Yuan Xie, Junyi Zhu, Bin Qi, Ming-Hui Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2023
- 关键词：Biochemistry - Drug delivery - Single crystals - Solubility - Thermoanalysis - X ray diffraction
- Four solid forms of filgotinib hydrochloride: Insight into the crystal structures, properties, stability, and solid-state transitions被引量：7收藏
- 作者：Qi, Ming-Hui Zhang, Qiao-Dan Liu, Yang Ren, Fu-Zheng Ren, Guo-Bin
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2019
- 关键词：Filgotinib hydrochloride Solid forms Solvates Crystal structure Solid-state transition
- Crystal structure and physical stability of ginsenoside compound-K solvates被引量：6收藏
- 作者：Chen, Jinyao Zhu, Wenming Ji, Weijie Zhu, Bin Guo, Chunyang Qi, Minghui Ren, Guobin
- 机构：East China Univ Sci & Technol;Zhejiang Hisun Pharmaceut Co
- 来源：CRYSTENGCOMM 2019
- 关键词：Hydrogen bonds - X ray diffraction - Organic solvents - Thermogravimetric analysis - Single crystals - Stability - Differential scanning calorimetry - Molecules - Ethanol
- Four solid forms of flibanserin: Insight into the crystal structures, properties, stability, and solid-state transition被引量：6收藏
- 作者：Qi, Ming-Hui Ye, Wen-Xin Ji, Wei-Jie Hong, Ming-Huang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2020
- 关键词：Flibanserin Solid form Crystal structure Solid-state transition Stability
- Transdermal Delivery of Metformin Utilizing Ionic Liquid Technology: Insight Into the Relationship Between Counterion Structures and Properties被引量：6收藏
- 作者：Hong, Minghuang Wang, Qinglin Wang, Kai Li, Jinghui Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;Shanghai Frontier Sci Res Base Optogenet Tech Cel;Lab Pharmaceut Crystal Engn & Technol;East China Univ Sci & Technol
- 来源：PHARMACEUTICAL RESEARCH 2022
- 关键词：counterion structure delivery system ionic liquids metformin skin permeability transdermal drug
- Solution-mediated polymorphic transformation of amorphous form to Form I of olmesartan medoxomil in methanol-water mixture solvents被引量：6收藏
- 作者：Qi, Ming-Hui Chen, Wan-Shang Zhou, Hui Chen, Jing-Yan Ren, Guo-Bin
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL RESEARCH AND TECHNOLOGY 2017
- 关键词：polymorph SMPT amorphous kinetics olmesartan medoxomil
- Enhancement of solubility and dissolution rate of dipyridamole by salifying: Preparation, characterization, and theoretical calculation被引量：5收藏
- 作者：Yi, Dongxu Dong, Yuhang Yao, Yichen Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2024
- 关键词：Dipyridamole Salt Solubility Fluorescence
