成果/Result
- Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease被引量：12收藏
- 作者：Hongjuan Tong Kaiyan Lou Wei Wang
- 机构：Shanghai Key Laboratory of Chemical Biology;Department of Chemistry and Chemical Biology
- 来源：药学学报（英文版） 2015
- 关键词：Alzheimer's disease Blood-brain barrier Fluorescence probe Near-infrared fluorescence Optical imaging Amyloid-β plagues
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- 不对称水溶性菁染料的简便制备与纯化方法被引量：11收藏
- 作者：楼开炎 钱旭红 宋恭华
- 机构：华东理工大学药物化工研究所
- 来源：《华东理工大学学报（自然科学版）》 2002
- 关键词：水溶性菁染料 合成 纯化 制备薄层色谱
- 摘要：以对肼基苯磺酸为起始原料 ,经 6步反应合成了 2个可用于 DNA荧光标记的不对称水溶性菁染料。采用三元展开剂体系 ,用制备薄层色谱方法分离提纯各中间体和产物 。
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- Recent developments in multimodality fluorescence imaging probes被引量：10收藏
- 作者：Jianhong Zhao Junwei Chen Shengnan Ma Qianqian Liu Lixian Huang Xiani Chen Kaiyan Lou Wei Wang
- 机构：Shanghai Key Laboratory of Chemical Biology;Department of Chemistry and Chemical Biology
- 来源：药学学报（英文版） 2018
- 关键词：Optical imaging Fluorescence Multimodality Near-infrared fluorescence Nanoprobe Computed tomography Magnetic resonance imaging Positron emission tomo graphy Single-photon emission computed tomography Photoacoustic imaging
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- New small-molecule drug design strategies for fighting resistant influenza A被引量：8收藏
- 作者：Zuyuan Shen Kaiyan Lou Wei Wang
- 机构：Shanghai Key Laboratory of Chemical Biology;Department of Chemistry and Chemical Biology
- 来源：药学学报（英文版） 2015
- 关键词：Influenza A virus Drug discovery Resistance M2 ion channel Neuraminidase
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- A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions被引量：2收藏
- 作者：Junwei Chen Na Wang Hongjuan Tong Chao Song Huijuan Ma Yajun Zhang Feng Gao Huan Xu Wei Wang Kaiyan Lou
- 机构：State Key Laboratory of Bioengineering Reactor.Shanghai Key Laboratory of New Drug Design;School of Pharmacy;Department of Pharmacology and Toxicology and BIO5 Institute
- 来源：中国化学快报（英文版） 2021
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- 基于mPEG-β-环糊精和喜树碱前药的还原敏感自组装胶束作为药物释放载体被引量：1收藏
- 作者：Yiben Lu Miao Zhang Yongjun Zheng Xinyu Hou Muye He Kaiyan Lou Feng Gao
- 机构：Shanghai Key Laboratory of Functional Materials Chemistry;Shanghai Key Laboratory of New Drug Design;Department of Pharmaceutics
- 来源：中国药学（英文版） 2021
- 关键词：mPEG-β-环糊精 喜树碱前药 自组装胶束 还原响应 超分子
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- A pinacol boronate caged NIAD-4 derivative as a near-infrared fluorescent probe for fast and selective detection of hypochlorous acid被引量：1收藏
- 作者：Hongjuan Tong Yajun Zhang ShengnanMa Minghao Zhang Na Wang Rui Wang Kaiyan Lou Wei Wang
- 机构：Shanghai Key Laboratory of New Drug Design;Department of Chemistry and Chemical Biology
- 来源：中国化学快报（英文版） 2018
- 关键词：Fluorescent probeHypochlorous acidBoronateReactive oxygen species （ROS）Near-infrared （NIR） imaging
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- Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by a-cyclodextrin被引量：1收藏
- 作者：Lei Huang Jiaojiao Chen Muye He Xinyu Hou Yiben Lu Kaiyan Lou Feng Gao
- 机构：Department of Pharmaceutics;Shanghai Key Laboratory of New Drug Design;Shanghai Key Laboratory of Functional Materials Chemistry
- 来源：中国化学快报（英文版） 2019
- 关键词：α-Cyclodextrin mPEG Grafted chitosan Self-assembly Nanoparticle Drug delivery
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- (±)-N-叔丁氧羰基-3-乙基-戊氨酸的合成被引量：0收藏
- 作者：庄金臣 沈祖源 楼开炎 王卫
- 机构：华东理工大学药学院
- 来源：《合成化学》 2016
- 关键词：非天然氨基酸 3-戊酮 N-叔丁氧羰基-3-乙基-戊氨酸 合成
- 摘要：在最优反应条件[海因2 mmol,n(3-戊酮)∶n(海因)=1.5,乙醇胺为碱,p H 4,于55℃反应6 h]下制得5-(1-乙基亚丙基)海因(4);4用5%Pd/C催化加氢制得5-(3-戊基)海因(5);5先在碱性...
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