成果/Result
- Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism被引量：191收藏
- 作者：Zhang, Jing Ma, Xiaoyu Lin, Dan Shi, Hengsong Yuan, Yuan Tang, Wei Zhou, Huanjun Guo, Han Qian, Jiangchao Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2015
- 关键词：Magnesium/calcium phosphate cements Cell adhesion Osteogenic differentiation Fibronectin Integrin
- A dual-delivery system of pH-responsive chitosan-functionalized mesoporous silica nanoparticles bearing BMP-2 and dexamethasone for enhanced bone regeneration被引量：122收藏
- 作者：Gan, Qi Zhu, Jiaoyang Yuan, Yuan Liu, Honglai Qian, Jiangchao Li, Yongsheng Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2015
- 关键词：Bone - Targeted drug delivery - Sol-gels - Sol-gel process - Silica nanoparticles - Mesoporous materials - ProtEIns - Controlled drug delivery
- Mitochondria-Targeted Hydroxyapatite Nanoparticles for Selective Growth Inhibition of Lung Cancer in Vitro and in Vivo被引量：106收藏
- 作者：Sun, Yi Chen, Yaying Ma, Xiaoyu Yuan, Yuan Liu, Changsheng Kohn, Joachim Qian, Jiangchao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Rutgers State Univ
- 来源：ACS APPLIED MATERIALS & INTERFACES 2016
- 关键词：hydroxyapatite nanoparticles lung cancer mitochondrion-targeted cytotoxicity uptake
- Effect of size on the cellular endocytosis and controlled release of mesoporous silica nanoparticles for intracellular delivery被引量：76收藏
- 作者：Gan, Qi Dai, Danwei Yuan, Yuan Qian, Jiangchao Sha, Sha Shi, Jianlin Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMEDICAL MICRODEVICES 2012
- 关键词：Size-dependent Mesoporous silica nanoparticles Intracellular delivery Controlled release
- Preferential tumor accumulation and desirable interstitial penetration of poly(lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly(D,L-lactic acid)被引量：70收藏
- 作者：Wang, Guoying Chen, Yaying Wang, Peng Wang, Yifeng Hong, Hua Li, Yulin Qian, Jiangchao Yuan, Yuan Yu, Bo Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Hangzhou Push Kang Biotechnol Co Ltd
- 来源：ACTA BIOMATERIALIA 2016
- 关键词：Polymeric nanoparticles Dual coating Chitosan oligosaccharide Poly (ethylene glycol)-poly (D,L-lactic acid) (PEG-PDLLA) Tumor accumulation Interstitial penetration
- Synergistic Combination of Bioactive Hydroxyapatite Nanoparticles and the Chemotherapeutic Doxorubicin to Overcome Tumor Multidrug Resistance被引量：62收藏
- 作者：Dong, Xiulin Sun, Yi Li, Yuanyuan Ma, Xiaoyu Zhang, Shuiquan Yuan, Yuan Kohn, Joachim Liu, Changsheng Qian, Jiangchao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Rutgers State Univ
- 来源：SMALL 2021
- 关键词：anti‐ tumor activity bioactivity hydroxyapatite nanoparticles mitochondrial Ca (2+) overload multidrug resistance reversal
- Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations被引量：60收藏
- 作者：Ma, Chao Li, Bo Zhang, Jinrui Sun, Yao Li, Jingjing Zhou, Hangcheng Shen, Jianlei Gu, Rui Qian, Jiangchao Fan, Chunhai Zhang, Hongjie Liu, Kai
- 机构：Tsinghua Univ;Chinese Acad Sci;Harvard Univ;Jilin Univ;East China Univ Sci & Technol
- 来源：ADVANCED MATERIALS 2021
- 关键词：biomaterials protEIn engineering nanomedicine rheumatoid arthritis nanoformulations
- Progress in the research of S-adenosyl-L-methionine production被引量：59收藏
- 作者：Chu, Ju Qian, Jiangchao Zhuang, Yingping Zhang, Siliang Li, Yourong
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2013
- 关键词：S-adenosyl-L-methionine L-Methionine ATP L-Methionine adenosyltransferase Pichia pastoris
- Screening endogenous signal peptides and protEIn folding factors to promote the secretory expression of heterologous protEIns in Pichia pastoris被引量：59收藏
- 作者：Duan, Guangdong Ding, Lumei Wei, Dongsheng Zhou, Hangcheng Chu, Ju Zhang, Siliang Qian, Jiangchao
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2019
- 关键词：Signal peptides Folding factors Pichia pastoris Heterologous protEIn Secretory expression
- Endosomal pH-activatable magnetic nanoparticle-capped mesoporous silica for intracellular controlled release被引量：54收藏
- 作者：Gan, Qi Lu, Xunyu Dong, Wenjie Yuan, Yuan Qian, Jiangchao Li, Yongsheng Shi, Jianlin Liu, Changsheng
- 机构：E China Univ Chem Technol;E China Univ Chem Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY 2012
- 关键词：Nanomagnetics - Cells - Nanoparticles - pH sensors - Silica - Magnetite - Targeted drug delivery - Cell culture - Molecular biology - Disease control - Physiological models
- Correlation of particle properties with cytotoxicity and cellular uptake of hydroxyapatite nanoparticles in human gastric cancer cells被引量：50收藏
- 作者：Cui, Xinhui Liang, Tong Liu, Changsheng Yuan, Yuan Qian, Jiangchao
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2016
- 关键词：Hydroxyapatite nanoparticles Particle properties Cancer cell Cytotoxicity Uptake Intracellular calcium concentration
- Controllable synthesis of spherical hydroxyapatite nanoparticles using inverse microemulsion method被引量：49收藏
- 作者：Ma, Xiaoyu Chen, Yaying Qian, Jiangchao Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：MATERIALS CHEMISTRY AND PHYSICS 2016
- 关键词：Microemulsion Hydroxyapatite Spherical nano particle
- Bioactive Core-Shell Hydroxyapatite Nanoplatform for Overcoming Multidrug Resistance in Cancer Therapy via Tumor-Specific Synergistic Calcium Overload被引量：48收藏
- 作者：Zhang, Shuiquan Shen, Tao Zhang, Wen Gong, Xue Yuan, Yuan Liu, Changsheng Qian, Jiangchao
- 机构： Key Laboratory for Ultrafine Materials of Ministry of Education; The State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2025
- 关键词：Bioactivity - Biocompatibility - Biomineralization - Calcification (biochemistry) - Calcium - Cell death - Chemical activation - Chemotherapy - Diseases - Microfluidics - Oncology - Platinum compounds - Targeted drug delivery - Tumors
- GAP promoter library for fine-tuning of gene expression in Pichia pastoris被引量：45收藏
- 作者：Qin, Xiulin Qian, Jiangchao Yao, Gaofeng Zhuang, Yingping Zhang, Siliang Chu, Ju
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Applied and Environmental Microbiology 2011
- 关键词：Transcription - Amino acids - Fluorescence - Enzyme activity
- Combined 13C-assisted metabolomics and metabolic flux analysis reveals the impacts of glutamate on the central metabolism of high β-galactosidase-producing Pichia pastoris被引量：45收藏
- 作者：Liu, Ping Huang, Mingzhi Guo, Menglei Qian, Jiangchao Lin, Weilu Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresources and Bioprocessing 2016
- 关键词：Gene expression - Physiology - Recombinant protEIns - Yeast
- Enhanced bioactivity of bone morphogenetic protEIn-2 with low dose of 2-N, 6-O-sulfated chitosan in vitro and in vivo被引量：43收藏
- 作者：Zhou, Huanjun Qian, Jiangchao Wang, Jing Yao, Wantong Liu, Changsheng Chen, Jianguo Cao, Xuehua
- 机构： The State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials; Engineering Research Center for Biomedical Materials
- 来源：Biomaterials 2009
- 关键词：Bone - Tissue engineering - Chitosan - Phosphatases - Sulfur compounds
- Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose被引量：42收藏
- 作者：Feng, Yao Tian, Xiwei Chen, Yang Wang, Zeyu Xia, Jianye Qian, Jiangchao Zhuang, Yingping Chu, Ju
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2021
- 关键词：Ethanol On-line Viable cell sensor Electronic nose
- A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica被引量：41收藏
- 作者：Gan, Qi Lu, Xunyu Yuan, Yuan Qian, Jiangchao Zhou, Huanjun Lu, Xun Shi, Jianlin Liu, Changsheng
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory for Ultrafine Materials of Ministry of Education; Engineering Research Center for Biomedical Materials of Ministry of Education
- 来源：Biomaterials 2011
- 关键词：Magnetite - Synthesis (chemical) - Controlled drug delivery - Nanomagnetics - Targeted drug delivery - Mesoporous materials - Silica nanoparticles
- Toward improvement of erythromycin a production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination被引量：39收藏
- 作者：Wu, Jiequn Zhang, Qinglin Deng, Wei Qian, Jiangchao Zhang, Siliang Liu, Wen
- 机构： State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Bioorganic and Natural Products Chemistry
- 来源：Applied and Environmental Microbiology 2011
- 关键词：DNA sequences - Antibiotics - Biochemistry - Oxygen supply
- Synthesis of mesoporous hydroxyapatite nanoparticles using a template-free sonochemistry-assisted microwave method被引量：39收藏
- 作者：Liang, Tong Qian, Jiangchao Yuan, Yuan Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS SCIENCE 2013
- 关键词：Hydroxyapatite - Microwave irradiation - Fourier transform infrared spectroscopy - High resolution transmission electron microscopy - Sintering - Mesoporous materials - Nanoparticles - Pore size - Synthesis (chemical) - Desorption - Sonochemistry - Specific surface area
- Optimization of l-methionine feeding strategy for improving S-adenosyl-l-methionine production by methionine adenosyltransferase overexpressed Pichia pastoris被引量：39收藏
- 作者：Hu, Hui Qian, Jiangchao Chu, Ju Wang, Yonghong Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2009
- 关键词：S-adenosyl-L-methionine Methionine adenosyltransferase L-methionine Pichia pastoris ATP
- Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation被引量：33收藏
- 作者：Chen, Yun Deng, Wei Wu, Jiequn Qian, Jiangchao Chu, Ju Zhuang, Yingping Zhang, Siliang Liu, Wen
- 机构： State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Bioorganic and Natural Product Chemistry; Shanghai Institute of Organic Chemistry
- 来源：Applied and Environmental Microbiology 2008
- 关键词：Biosynthesis - Fermentation - Microbiology
- In vitro osteoblast-like and endothelial cells' response to calcium silicate/calcium phosphate cement被引量：33收藏
- 作者：Zhao, Qinghui Qian, Jiangchao Zhou, Huanjun Yuan, Yuan Mao, Yuhao Liu, Changsheng
- 机构： State Key Laboratory of Bioreactor Engineering; Engineering Research Center for Biomedical Materials; Key Laboratory for Ultrafine Materials
- 来源：Biomedical Materials 2010
- 关键词：Biocompatibility - Cell adhesion - Cements - Phosphatases - Endothelial cells - Silicates - Cell proliferation
- Engineering Pichia pastoris to improve S-adenosyl- l-methionine production using systems metabolic strategies被引量：32收藏
- 作者：Qin, Xiulin Lu, Junjie Zhang, Yin Wu, Xiaole Qiao, Xuefeng Wang, Zhipeng Chu, Ju Qian, Jiangchao
- 机构：East China Univ Sci & Technol;Guangxi Univ
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2020
- 关键词：metabolic engineering Pichia pastoris promoter library S-adenosyl-L-methionine transcriptome profiling
- DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-l-methionine production in Pichia pastoris被引量：32收藏
- 作者：Hu, Hui Qian, Jiangchao Chu, Ju Wang, Yong Zhuang, Yingping Zhang, Siliang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Biotechnology 2009
- 关键词：Escherichia coli - Yeast - Amino acids - Genes - Enzyme activity
- Impacts of high β-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via 13C metabolic flux analysis被引量：31收藏
- 作者：Nie, Yongsheng Huang, Mingzhi Lu, Junjie Qian, Jiangchao Lin, Weilu Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2014
- 关键词：P. pastoris C-13 metabolic flux analysis Central metabolism Heterologous protEIn expression
- Production and distribution of β-glucosidase in a mutant strain Trichoderma viride T 100-14被引量：31收藏
- 作者：Wang, Yong-Hong Zhou, Jin Chu, Ju Qian, Jiang-Chao Zhang, Si-Liang Zhuang, Ying-Ping
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：New Biotechnology 2009
- 关键词：Fermentation
- Polyglutamic acid-coordinated assembly of hydroxyapatite nanoparticles for synergistic tumor-specific therapy被引量：28收藏
- 作者：Ma Xiaoyu Dong Xiuling Zang Chunyu Sun Yi Qian Jiangchao Yuan Yuan Liu Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NANOSCALE 2019
- 关键词：Hydroxyapatite - Targeted drug delivery - Calcium - Hybrid systems - Mitochondria - Nanoparticles - Controlled drug delivery - Nanoclusters - Chemotherapy - Crystallinity - Toxicity
- A novel strategy for tumor therapy: targeted, PAA-functionalized nano-hydroxyapatite nanomedicine被引量：26收藏
- 作者：Zhang, Shuiquan Ma, Xiaoyu Sha, Dongyong Qian, Jiangchao Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2020
- 关键词：Cells - Medical nanotechnology - Hydroxyapatite - Nanocomposites - Tumors - Cytology - Organic acids - Diseases
- Cytotoxicity and Cellular Uptake of Amorphous Silica Nanoparticles in Human Cancer Cells被引量：26收藏
- 作者：Wu, Yuequn Tang, Wei Wang, Peng Liu, Changsheng Yuan, Yuan Qian, Jiangchao
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 2015
- 关键词：Cytotoxicity - Diseases - Cancer cells - Silica nanoparticles - Lanthanum compounds - Molecular biology
