成果/Result
- Development of a gliclazide ionic liquid and its mesoporous silica particles: An effective formulation strategy to improve oral absorption properties被引量：58收藏
- 作者：Zhou, Bijian Teng, Dan Li, Jinghui Zhang, Yanhong Qi, Minghui Hong, Minghuang Ren, Guo-Bin
- 机构： Engineering Research Centre of Pharmaceutical Process Chemistry; Shanghai Key Laboratory of New Drug Design; State Key Laboratory of Bioreactor Engineering
- 来源：RSC Advances 2022
- 关键词：Silica - Targeted drug delivery - Molecules - Controlled drug delivery - Encapsulation - Solubility - Positive ions - Mesoporous materials - Physicochemical properties - Supersaturation
- Insight into the effect of cocrystal polymorphism / stoichiomorphism on thermodynamic and photoluminescence properties: a case study被引量：45收藏
- 作者：Han, Xianyang Yin, Yu Zhu, Fan Yao, Yichen Hong, Minghuang Qi, Minghui Zhu, Bin Ren, Guobin
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology; State Key Laboratory of Bioreactor Engineering
- 来源：SSRN 2025
- 关键词：Crystal structure - Fluorescence - Fluorescence spectroscopy - Optical properties - Phase transitions - Photoluminescence - Polymorphism - Single crystals - Thermoanalysis - X ray diffraction
- Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point被引量：40收藏
- 作者：Yao, Yi-Chen Jin, Zhe Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构： Laboratory of Pharmaceutical Crystal Engineering & Technology
- 来源：Crystal Growth and Design 2024
- 关键词：Melting point - Single crystals - Surface analysis - Thermoanalysis
- Slow-Release Drug-Drug Cocrystals of Oxaliplatin with Flavonoids: Delaying Hydrolysis and Reducing Toxicity被引量：31收藏
- 作者：Yin, He-Mei Wu, Nan Zhou, Bi-Jian Hong, Ming-Huang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Cancer cells - Controlled drug delivery - Fourier transform infrared spectroscopy - Dissolution - Targeted drug delivery - Cells - Flavonoids - X ray diffraction - Hydrogen bonds - Thermoanalysis - Toxicity - Cytology
- Resurrecting the 'Disappearing Polymorph' of Rotigotine via Conformational Landscape Engineering被引量：25收藏
- 作者：Yi, Dongxu Qi, Minghui Xu, Shaohong Qi, Yonghua Xia, Ran Wu, Hao Ren, Guobin
- 机构： School of Pharmacy; School of Pharmacy; Children's Hospital Affiliated to Zhengzhou University; Henan Children’ s Hospital Zhengzhou Children’s Hospital; Engineering Research Centre of Pharmaceutical Process Chemistry
- 来源：SSRN 2025
- 关键词：Boltzmann equation - Conformations - Crystallization kinetics - Drug products - Engineering research - Molecular biology - Molecular physics - Polymorphism - Potential energy
- Cocrystals of Oxymatrine: Reducing Hygroscopicity and Affecting the Dissolution Rate被引量：25收藏
- 作者：Qi, Ming-Hui Li, Heng Zhu, Bin Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Dissolution - Hydrogen bonds - Metabolism
- Estimating Thermodynamic Stability Relationship of Polymorphs of Sofosbuvir被引量：22收藏
- 作者：Qi, Ming-Hui Hong, Ming-Huang Liu, Yan Wang, En-Fu Ren, Fu-Zheng Ren, Guo-Bin
- 机构：E China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2015
- 关键词：Solubility - Thermoanalysis - X ray powder diffraction - Free energy - Melting
- Cocrystals of Lenvatinib with Sulfamerazine and Salicylic Acid: Crystal Structure, Equilibrium Solubility, Stability Study, and Anti-Hepatoma Activity被引量：20收藏
- 作者：Hong, Minghuang Li, Shijia Ji, Weijie Qi, Ming-Hui Ren, Guo-bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Single crystals - Surface analysis - Crystal structure - Nuclear magnetic resonance spectroscopy - Salicylic acid - Differential scanning calorimetry - Amino acids - Fourier transform infrared spectroscopy - Thermogravimetric analysis - Hydrogen bonds - Drug delivery - Spectrometers - X ray diffraction
- Insight into the Formation of Cocrystals of Flavonoids and 4,4′-Vinylenedipyridine: Heteromolecular Hydrogen Bonds, Molar Ratio, and Structural Analysis被引量：19收藏
- 作者：Zhang, Yanhong Zhu, Bin Ji, Wei-Jie Guo, Chun-Yang Hong, Minghuang Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2021
- 关键词：Hydrogen bonds - Single crystals - Molar ratio
- Analysis of the dissolution behavior and solubility of Rotigotine form II in different mono-solvents被引量：16收藏
- 作者：Yi, Dongxu Dong, Yuhang Wang, Qinglin Wu, Juan Qi, Minghui Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR LIQUIDS 2023
- 关键词：Rotigotine Hirshfeld surface Solubility Correlation Molecular simulation
- Cocrystals of flavonoids with 4,4′-ethylenebispyridine: Crystal structures analysis, dissolution behavior, and anti-tumor activity被引量：16收藏
- 作者：Zhang, Yanhong Yang, Rui Yin, He-Mei Zhou, Bijian Hong, Minghuang Zhu, Bin Qi, Ming-Hui Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2022
- 关键词：Tumors - Cancer cells - Single crystals - Dissolution
- Strategy to Tune the Performance of Two Drug Components: Drug-Drug Cocrystals of Lobaplatin with Flavonoids被引量：15收藏
- 作者：Yin, He-Mei Xie, Jun-Yi Jiang, Jun-Yi Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2022
- 关键词：Dissolution - Solubility
- Three solid forms of chlorantraniliprole: Structure, characterization, and phase transformation被引量：14收藏
- 作者：Du, Dan Liu, Peng-Jian Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2018
- 关键词：Chlorantraniliprole Solid forms Solvates Crystal structure Phase transformation
- Solubility correlation and thermodynamic analysis of two forms of Metaxalone in different pure solvents被引量：14收藏
- 作者：Hong, Minghuang Wu, Shiwang Qi, Minghui Ren, Guobin
- 机构：E China Univ Sci & Technol
- 来源：FLUID PHASE EQUILIBRIA 2016
- 关键词：Solubility Thermodynamic models Endothermic Entropy driven Nonspontaneous
- Preparation and characterization of several azoxystrobin channel solvates被引量：11收藏
- 作者：Du, Dan Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2019
- 关键词：Azoxystrobin Channel solvates Isostructurality Hirshfeld surface Pseudopolymorph Solvent-replacement method Porosity
- Structure properties of scoparone: Polymorphs and cocrystals被引量：10收藏
- 作者：Chen, Jin-yao Wang, Xiao-yu Hong, Ming-huang Yi, Dong-xu Qi, Ming-hui Ren, Guo-bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2019
- 关键词：Scoparone Polymorphs Cocrystals Crystal structure Powder dissolution study
- Design, screening, and properties of novel solvates of azoxystrobin based on isomorphism被引量：9收藏
- 作者：Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTENGCOMM 2020
- 关键词：Surface analysis - Single crystals - X ray diffraction - Set theory
- Colorful Prothionamide Salt Forms with Enhancement in Water Solubility and Dissolution Behavior被引量：9收藏
- 作者：Ji, Wei-Jie Jiang, Jun-Yi Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2023
- 关键词：Dissolution - Drug delivery - Free energy - Molecular orbitals - Naphthalene - Salts - Solubility
- Novel Salts of the Atypical Antipsychotic Drug Lurasidone with Improved Solubility and Bioavailability被引量：9收藏
- 作者：Guo, Chunyang Wang, Yuan Xie, Junyi Zhu, Bin Qi, Ming-Hui Hong, Minghuang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2023
- 关键词：Biochemistry - Drug delivery - Single crystals - Solubility - Thermoanalysis - X ray diffraction
- Solution-mediated polymorphic transformation of amorphous form to Form I of olmesartan medoxomil in methanol-water mixture solvents被引量：6收藏
- 作者：Qi, Ming-Hui Chen, Wan-Shang Zhou, Hui Chen, Jing-Yan Ren, Guo-Bin
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL RESEARCH AND TECHNOLOGY 2017
- 关键词：polymorph SMPT amorphous kinetics olmesartan medoxomil
- Four solid forms of flibanserin: Insight into the crystal structures, properties, stability, and solid-state transition被引量：6收藏
- 作者：Qi, Ming-Hui Ye, Wen-Xin Ji, Wei-Jie Hong, Ming-Huang Ren, Guo-Bin
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2020
- 关键词：Flibanserin Solid form Crystal structure Solid-state transition Stability
- Crystal structure and physical stability of ginsenoside compound-K solvates被引量：6收藏
- 作者：Chen, Jinyao Zhu, Wenming Ji, Weijie Zhu, Bin Guo, Chunyang Qi, Minghui Ren, Guobin
- 机构：East China Univ Sci & Technol;Zhejiang Hisun Pharmaceut Co
- 来源：CRYSTENGCOMM 2019
- 关键词：Hydrogen bonds - X ray diffraction - Organic solvents - Thermogravimetric analysis - Single crystals - Stability - Differential scanning calorimetry - Molecules - Ethanol
- Enhancement of solubility and dissolution rate of dipyridamole by salifying: Preparation, characterization, and theoretical calculation被引量：5收藏
- 作者：Yi, Dongxu Dong, Yuhang Yao, Yichen Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2024
- 关键词：Dipyridamole Salt Solubility Fluorescence
- Conformation, virtual cocrystal screening, synthesis and determination of dipyridamole被引量：5收藏
- 作者：Yi, Dongxu Dong, Yuhang Qi, Minghui Hong, Minghung Zhu, Bin Ren, Guobin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2024
- 关键词：Dipyridamole Conformation Virtual cocrystal screening
- Multicomponent Pharmaceutical Adducts of Azoxystrobin: Physicochemical Properties, Thermodynamic, and Molecular Modeling Study被引量：3收藏
- 作者：Shi, Zhi-Ping Ren, Guo-Bin Qi, Ming-Hui Li, Zhong Xu, Xiao-Yong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CRYSTAL RESEARCH AND TECHNOLOGY 2021
- 关键词：azoxystrobin eutectics interaction energy molecular dynamics simulation solubility
- Insight into the Structure and Property Diversity of Four Nicorandil Oxalate Salt Polymorphs Based on Experiments and Quantum Chemistry Study被引量：3收藏
- 作者：Wang, Qinglin Guo, Chunyang Qi, Ming-Hui Zhu, Bin Ren, Guo-Bin Hong, Minghuang
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL GROWTH & DESIGN 2024
- 关键词：Binding energy - Crystal structure - Dissolution - Nickel compounds - Oxalic acid - Quantum chemistry - Single crystals - Solvents - Structural properties
- Solubility Measurement and Dynamic Simulation Analysis of the Brivaracetam Form A in 12 Pure Solvents被引量：3收藏
- 作者：Wu, Yue Shao, Jia-Hui Zhu, Bin Hong, Minghuang Ren, Guo-Bin Qi, Ming-Hui
- 机构：Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL AND ENGINEERING DATA 2025
- 关键词：Hydrogen bonds - Molecular dynamics - Solubility
- Preparation, characterization, and crystal structures of novel sophocarpine salts with improvements on stability and solubility被引量：2收藏
- 作者：Wang, Yuan Qian, Yi-Hui Hong, Ming-Huang Zhu, Bin Ren, Guo-Bin Qi, Ming -Hui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR STRUCTURE 2023
- 关键词：Crystal engineering Crystal structure Stability Thermal properties Sophocarpine
- Exploring New Solid Forms of Antirheumatic Drug Hydroxychloroquine: Novel Salts with Sustained-Release Performance被引量：1收藏
- 作者：Ji, Wei-Jie Wu, Yue Hong, Minghuang Zhu, Bin Ren, Guo-Bin Qi, Ming-Hui
- 机构：East China Univ Sci & Technol
- 来源：CRYSTAL RESEARCH AND TECHNOLOGY 2024
- 关键词：hydroxychloroquine hygroscopicity salification sustained-release
- A novel anion replaced gemini surfactant: Investigation on the primary interaction between gemini surfactant and BSA被引量：1收藏
- 作者：Jin, Yuhao Wu, Qi Yang, Ke Xu, Qianlin Bian, Yizhen Qi, Ming-Hui Zhu, Bin Ren, Guo-Bin Hong, Minghuang
- 机构：East China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2025
- 关键词：Gemini surfactant Bovine serum albumin Electrostatic interaction Hydrophobic interaction
