成果/Result
- Developmental ROS individualizes organismal stress resistance and lifespan被引量：194收藏
- 作者：Bazopoulou, Daphne Knoefler, Daniela Zheng, Yongxin Ulrich, Kathrin Oleson, Bryndon J. Xie, Lihan Kim, Minwook Kaufmann, Anke Lee, Young-Tae Dou, Yali Chen, Yong Quan, Shu Jakob, Ursula
- 机构：Univ Michigan;East China Univ Sci & Technol;SCICB;Michigan Med;Chinese Acad Sci
- 来源：NATURE 2019
- Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply被引量：82收藏
- 作者：Wang, Qin Quan, Shu Xiao, Han
- 机构：Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Terpenoid Mevalonate pathway 2-C-Methyl-D-erythritol 4-phosphate (MEP) Isopentenyl diphosphate (IPP) Dimethylallyl diphosphate (DMAPP) Biosynthesis
- Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins被引量：60收藏
- 作者：Liu, Renmei Yang, Jing Yao, Jing Zhao, Zhou He, Wei Su, Ni Zhang, Zeyi Zhang, Chenxia Zhang, Zhuo Cai, Haibo Zhu, Linyong Zhao, Yuzheng Quan, Shu Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE BIOTECHNOLOGY 2022
- 关键词：Proteins - Cell culture
- Visualizing chaperone-assisted protein folding被引量：51收藏
- 作者：Horowitz, Scott Salmon, Loic Koldewey, Philipp Ahlstrom, Logan S. Martin, Raoul Quan, Shu Afonine, Pavel V. van den Bedem, Henry Wang, Lili Xu, Qingping Trievel, Raymond C. Brooks, Charles L., III Bardwell, James C. A.
- 机构：Univ Michigan;Howard Hughes Med Inst;Univ Michigan;East China Univ Sci & Technol;Lawrence Berkeley Natl Lab
- 来源：NATURE STRUCTURAL & MOLECULAR BIOLOGY 2016
- An enzyme-based biosensor for monitoring and engineering protein stability in vivo被引量：30收藏
- 作者：Ren, Chang Wen, Xin Mencius, Jun Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2021
- 关键词：biosensor protein stability protein engineering deep mutational scanning
- Selection and screening strategies in directed evolution to improve protein stability被引量：27收藏
- 作者：Ren, Chang Wen, Xin Mencius, Jun Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Directed evolution Protein folding Protein stability Cell surface display Cell-free display Reporter protein Stability biosensor
- Advances in Biosynthesis of Natural Products from Marine Microorganisms被引量：25收藏
- 作者：Zhou, Quan Hotta, Kinya Deng, Yaming Yuan, Rui Quan, Shu Chen, Xi
- 机构：Northwest Univ;Genetech Biotechnol Pte Ltd;East China Univ Sci & Technol
- 来源：MICROORGANISMS 2021
- 关键词：marine natural products genomic screening heterologous expression combinatorial biosynthesis
- Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation被引量：24收藏
- 作者：Chen, Guochao Wang, Duo Wu, Bin Yan, Fuxiang Xue, Hongjuan Wang, Quanmeng Quan, Shu Chen, Yong
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;Chinese Acad Sci;Huazhong Agr Univ;East China Univ Sci & Technol
- 来源：NATURE COMMUNICATIONS 2020
- Chaperone Spy Protects Outer Membrane Proteins from Folding Stress via Dynamic Complex Formation被引量：21收藏
- 作者：He, Wei Yu, Gangjin Li, Tianpeng Bai, Ling Yang, Yuanyuan Xue, Zixiao Pang, Yonghao Reichmann, Dana Hiller, Sebastian He, Lichun Liu, Maili Quan, Shu
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Hebrew Univ Jerusalem;Univ Basel;Univ Chinese Acad Sci
- 来源：MBIO 2021
- 关键词：chaperone outer membrane protein biogenesis folding stress protein-protein interaction nuclear magnetic resonance spectroscopy
- Conversion of the molecular chaperone Spy into a novel fusion tag to enhance recombinant protein expression被引量：20收藏
- 作者：Ruan, Alessandro Ren, Chang Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2020
- 关键词：Protein expression Fusion tag Molecular chaperone Spy
- Novel T3SS effector EseK in Edwardsiella piSCIcida is chaperoned by EscH and EscS to express virulence被引量：19收藏
- 作者：Cao, Huifang Yang, Cuiting Quan, Shu Hu, Tianjian Zhang, Lingzhi Zhang, Yuanxing Yang, Dahai Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：CELLULAR MICROBIOLOGY 2018
- 关键词：chaperone Edwardsiella piSCIcida protein-protein interaction secretion translocation virulence factor
- The Edwardsiella piSCIcida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection被引量：19收藏
- 作者：Yang, Dahai Liu, Xiaohong Xu, Wenting Gu, Zhaoyan Yang, Cuiting Zhang, Lingzhi Tan, Jinchao Zheng, Xin Wang, Zhuang Quan, Shu Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Qingdao Natl Lab Marine Sci & Technol
- 来源：PLOS PATHOGENS 2019
- Structural basis for product specificities of MLL family methyltransferases被引量：16收藏
- 作者：Li, Yanjing Zhao, Lijie Zhang, Yuebin Wu, Ping Xu, Ying Mencius, Jun Zheng, Yongxin Wang, Xiaoman Xu, Wancheng Huang, Naizhe Ye, Xianwen Lei, Ming Shi, Pan Tian, Changlin Peng, Chao Li, Guohui Liu, Zhijun Quan, Shu Chen, Yong
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Univ Chinese Acad Sci;Chinese Acad Sci;Chinese Acad Sci
- 来源：MOLECULAR CELL 2022
- Exploring microbial degradation of polyamide 4 in soils: Unveiling degradation mechanisms, pathways, and the contribution of strain NR4被引量：16收藏
- 作者：Wang, Li Zhang, Ziwei Zhang, Di Qiu, Yongjun Wang, Yibing Quan, Shu Zhao, Liming
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI;East China Univ Sci & Technol
- 来源：JOURNAL OF CLEANER PRODUCTION 2023
- 关键词：Polyamide 4 Biodegradation Soil Enrichment and acclimation PA4 degrading mechanism
- Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes被引量：12收藏
- 作者：Zheng, Yongxin Huang, Yinping Mencius, Jun Li, Yanjing Zhao, Lijie Luo, Wanting Chen, Yong Quan, Shu
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;ShanghaiTech Univ
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2021
- 关键词：Alkylation - Enzymes - Kinetics - Amino acids - Gene expression - Catalysis - Molecular dynamics - Peptides
- Molecular Characterization of an Intrinsically Disordered Chaperone Reveals Net-Charge Regulation in Chaperone Action被引量：11收藏
- 作者：Ren, Chang Zheng, Yongxin Liu, Chunlan Mencius, Jun Wu, Zhili Quan, Shu
- 机构：East China Univ Sci & Technol;Shanghai Frontiers Sci Ctr Optogenet Tech Cell Me
- 来源：JOURNAL OF MOLECULAR BIOLOGY 2022
- 关键词：chaperone intrinsically disordered protein net-charge regulation protein aggregation stress response
- Insights into the client protein release mechanism of the ATP-independent chaperone Spy被引量：9收藏
- 作者：He, Wei Li, Xinming Xue, Hongjuan Yang, Yuanyuan Mencius, Jun Bai, Ling Zhang, Jiayin Xu, Jianhe Wu, Bin Xue, Yi Quan, Shu
- 机构：East China Univ Sci & Technol;Tsinghua Univ;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：NATURE COMMUNICATIONS 2022
- Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering被引量：9收藏
- 作者：Shang, Yue-Peng Chen, Qi Li, Ai-Tao Quan, Shu Xu, Jian-He Yu, Hui-Lei
- 机构：East China Univ Sci & Technol;Hubei Univ
- 来源：JOURNAL OF BIOTECHNOLOGY 2020
- 关键词：Haloketone reductase Substrate inhibition Protein engineering X-ray crystal structure Asymmetric reduction
- Increased surface charge in the protein chaperone Spy enhances its anti-aggregation activity被引量：7收藏
- 作者：He, Wei Zhang, Jiayin Sachsenhauser, Veronika Wang, Lili Bardwell, James C. A. Quan, Shu
- 机构：East China Univ Sci & Technol;Univ Michigan
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2020
- 关键词：molecular chaperone Spy protein engineering protein aggregation electrostatic interaction hydrophobic interaction kinetics protein folding conformational change chaperone-substrate interaction
- Simultaneous Improvement in the Thermostability and Catalytic Activity of Epoxidase Lsd18 for the Synthesis of Lasalocid A被引量：6收藏
- 作者：Liu, Ning Xiao, Hongli Zang, Yongjian Zhou, Longji Mencius, Jun Yang, Zhiwei Quan, Shu Chen, Xi
- 机构：Northwest Univ;Xi An Jiao Tong Univ;Yunnan Normal Univ;East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
- 关键词：natural product Lsd18 thermostability FoldX Rossetta-ddG catalytic activity
- Combinatorial metabolic engineering of Escherichia coli for de novo production of structurally defined and homogeneous Amino oligosaccharides被引量：6收藏
- 作者：Shi, Jinqi Deng, Chen Zhang, Chunyue Quan, Shu Fan, Liqiang Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Changzheng Hosp;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI;East China Univ Sci & Technol
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2024
- 关键词：Amino oligosaccharides Chitin oligosaccharides Metabolic engineering Fed-batch cultivation bioproduction
- Online bioinformatics teaching practice: Comparison of popular docking programs using SARS-CoV-2 spike RBD-ACE2 complex as a benchmark被引量：5收藏
- 作者：Fan, Wenxuan Mencius, Jun Du, Wenjing Fan, Huangyunxian Zhu, Hongjin Wei, Dongzhi Zhou, Mian Quan, Shu
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION 2021
- 关键词：COVID-19 molecular docking protein complex SARS-CoV-2
- Chaperone-substrate interactions monitored via a robust TEM-1 β-lactamase fragment complementation assay被引量：5收藏
- 作者：Bai, Ling He, Wei Li, Tianpeng Yang, Cuiting Zhuang, Yingping Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2017
- 关键词：Cell envelope Chaperone Protein fragment complementation assay Protein-protein interaction Stress TEM-1 beta-lactamase
- FADS-Based Directed Evolution of a Robust Bst DNA Polymerase Adapting High-Temperature Loop-Mediated Isothermal Amplification (HT-LAMP)被引量：4收藏
- 作者：Li, Xiao Tang, Qiongwei Jiang, Jingjie Shang, Yuepeng Lu, Zelin Chen, Mingli He, Jiajia Liu, Feng Zhu, Sisi Zhang, Zengping Han, Hui Yu, Xixi Li, Qiuxian Xiu, Yuansong Yang, Yuhong Gui, Ping Wang, Xuefeng Lu, Feng Jing, Wei Xu, Langping Lin, Yanna Wang, Xinglong Quan, Shu Liu, Xiang Yin, Huancai Ma, Fuqiang
- 机构：Chinese Acad Sci;Yeasen Biotechnol Shanghai Co Ltd;Molefuture Biotechnol Shanghai Co Ltd;Shandong Lab Adv Biomat & Med Devices Weihai;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2025
- 关键词：FADS Bst DNA polymerase HT-LAMP strand displacement index hydrophobic blade
- DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates被引量：4收藏
- 作者：Zhao, Lijie Huang, Naizhe Mencius, Jun Li, Yanjing Xu, Ying Zheng, Yongxin He, Wei Li, Na Zheng, Jun Zhuang, Min Quan, Shu Chen, Yong
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Sci;ShanghaiTech Univ
- 来源：ISCIENCE 2022
- Phase separation of a bacterial disordered chaperone mediated by electrostatic interactions被引量：1收藏
- 作者：Wu, Zhili Feng, Weiye Xu, Yicheng Zheng, Yongxin Quan, Shu
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：PROTEIN SCIENCE 2025
- 关键词：Asr bacteria electrostatic interactions LLPS molecular chaperone
- Reply to 'Misreading chaperone-substrate complexes from random noise'被引量：1收藏
- 作者：Horowitz, Scott Salmon, Loic Koldewey, Philipp Ahlstrom, Logan S. Martin, Raoul Quan, Shu Afonine, Pavel V. van den Bedem, Henry Wang, Lili Xu, Qingping Trievel, Raymond C. Brooks, Charles L., III Bardwell, James C. A.
- 机构：Univ Michigan;Howard Hughes Med Inst;East China Univ Sci & Technol;Lawrence Berkeley Natl Lab;Stanford Univ
- 来源：NATURE STRUCTURAL & MOLECULAR BIOLOGY 2018
- Bridging the biochemistry lecture and laboratory courses: Construction and application of the "Innovative Experimental Design" module被引量：1收藏
- 作者：Li, Pengfei Zhang, Boya He, Shuaifei Lu, Yuqing Jiang, Wenli Zhong, Qingsong Quan, Shu Wu, Haizhen Zhou, Mian
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION 2024
- 关键词：biochemistry course development laboratory course microbial fuel cells
- Revisiting the functions of periplasmic chaperones in the quality control of the autotransporter Ag43 using a phenotypically homogeneous Escherichia coli strain被引量：1收藏
- 作者：Xue, Zixiao Pang, Yonghao Quan, Shu
- 机构：East China Univ Sci & Technol;Shanghai Frontiers Sci Ctr Optogenet Tech Cell Me
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2022
- 关键词：Autotransporter Ag43 Phase variation Molecular chaperone Protein quality control SurA OsmY
- Sensing Cellular Damages Induced by Food Safety Hazards Using Bacterial Stress-Responsive Biosensors被引量：0收藏
- 作者：Li, Ruiqi Lou, Manzhuan He, Wei Quan, Shu
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Chinese Acad Sci
- 来源：BIOSENSORS-BASEL 2025
- 关键词：whole-cell biosensor cellular damage detection food safety hazards stress-responsive biosensors
