成果/Result
- Functionalization of single-walled carbon nanotubes enables efficient intracellular delivery of siRNA targeting MDM2 to inhibit breast cancer cells growth被引量：61收藏
- 作者：Chen, Hailong Ma, Xingyuan Li, Zhi Shi, Qiaoyun Zheng, Wenyun Liu, Yang Wang, Ping
- 机构：E China Univ Sci & Technol;Natl Univ Singapore;E China Univ Sci & Technol
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2012
- 关键词：Functionalized SWNTs Delivery of siRNA MDM2 Breast cancer cells
- PEGylated-PLGA Nanoparticles Coated with pH-Responsive Tannic Acid-Fe(III) Complexes for Reduced Premature Doxorubicin Release and Enhanced Targeting in Breast Cancer被引量：38收藏
- 作者：Hu, Fabiao Zhang, Ruihuan Guo, Wei Yan, Ting He, Xiujuan Hu, Fengzhi Ren, Fuzheng Ma, Xingyuan Lei, Jiandu Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Beijing Forestry Univ
- 来源：MOLECULAR PHARMACEUTICS 2021
- 关键词：TPLGA NPs premature release effect inhibition chemotherapy drug delivery tumor tissue targeting
- Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment被引量：24收藏
- 作者：Chen, Shanshan Deng, Changping Zheng, Wenyun Li, Shihui Liu, Yuping Zhang, Tong Zhang, Chen Fu, Yunhui Miao, Hui Ren, Fuzheng Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PHARMACEUTICS 2021
- 关键词：cannabidiol (CBD) bladder cancer (BC) RNA sequencing PI3K Akt chitosan CBD-loaded PLGA
- A novel liposome-polymer hybrid nanoparticles delivering a multi-epitope self-replication DNA vaccine and its preliminary immune evaluation in experimental animals被引量：23收藏
- 作者：Zhao, Zhangting Ma, Xingyuan Zhang, Ruihuan Hu, Fabiao Zhang, Tong Liu, Yuping Han, Myong Hun You, Fang Yang, Yi Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;KIM IL SUNG Univ;Natl Univ Singapore;SinGENE Biotech Pte Ltd
- 来源：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2021
- 关键词：DNA vaccine Liposome-polymer hybrid nanoparticles Delivery Immune evaluation Infectious diseases
- Cascade enzymatic reactions for efficient carbon sequestration被引量：17收藏
- 作者：Xia, Shunxiang Zhao, Xueyan Frigo-Vaz, Benjamin Zheng, Wenyun Kim, Jungbae Wang, Ping
- 机构：Univ Minnesota;Univ Minnesota;E China Univ Sci & Technol;Korea Univ
- 来源：BIORESOURCE TECHNOLOGY 2015
- 关键词：Carbon capture and storage Isocitrate dehydrogenase Aconitase Carbon dioxide Biocatalysis
- Designing and constructing a phage display synthesized single domain antibodies library based on camel VHHs frame for screening and identifying humanized TNF-α-specific nanobody被引量：17收藏
- 作者：Nie, Jifan Ma, Xingyuan Hu, Fabiao Miao, Hui Feng, Xin Zhang, Peiwen Han, Myong Hun You, Fang Yang, Yi Zhang, Wenlian Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Kim Il Sung Univ;Natl Univ Singapore;SinGENE Biotech Pte Ltd
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2021
- 关键词：Single domain antibodies Phage display library Designing and constructing Humanized TNF-alpha-specific Nb Screening and identifyin
- Visual diagnostic of Helicobacter pylori based on a cascade amplification of PCR and G-quadruplex DNAzyme as a color label被引量：17收藏
- 作者：Liu, Zhanmin Yao, Chenhui Wang, Yanming Zheng, Wenyun
- 机构：Shanghai Univ;East China Univ Sci & Technol
- 来源：JOURNAL OF MICROBIOLOGICAL METHODS 2018
- 关键词：Visual diagnostic Helicobacter pylori G-quadruplex DNAzyme
- A CqFerritin protein inhibits white spot syndrome virus infection via regulating iron ions in red claw crayfish Cherax quadricarinatus被引量：15收藏
- 作者：Chen, Xiao-Xiao Li, Yan-Yao Chang, Xue-Jiao Xie, Xiao-Lu Liang, Yu-Ting Wang, Ke-Jian Zheng, Wen-Yun Liu, Hai-Peng
- 机构：East China Univ Sci & Technol;Fujian Collaborat Innovat Ctr Exploitat & Utiliza
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2018
- 关键词：Ferritin Iron White spot syndrome virus Cherax quadricarinatus
- Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin被引量：15收藏
- 作者：Liu, Di Guo, Hua Zheng, Wenyun Zhang, Na Wang, Tianwen Wang, Ping Ma, Xingyuan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2016
- 关键词：Heat-labile enterotoxin (LT) A2 domain Cell-penetrating Multi-endocytosis pathway Drugs delivery
- A cytokine receptor domeless promotes white spot syndrome virus infection via JAK/STAT signaling pathway in red claw crayfish Cherax quadricarinatus被引量：14收藏
- 作者：Liu, Ling-ke Chen, Xiao-xiao Gao, Rui-lin Wang, Ke-jian Zheng, Wen-yun Liu, Hai-peng
- 机构：Xiamen Univ;East China Univ Sci & Technol
- 来源：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2020
- 关键词：Domeless White spot syndrome virus JAK/STAT pathway Cherax quadricarinatus Phosphorylation
- Design and screening of a chimeric survivin-specific nanobody and its anticancer activities in vitro被引量：13收藏
- 作者：Zhang, Na Guo, Hua Zheng, Wenyun Wang, Tianwen Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANTI-CANCER DRUGS 2016
- 关键词：antibody engineering anticancers phage display survivin nanobody
- Improving the physicochemical properties of bicalutamide by complex formation with bovine serum albumin被引量：12收藏
- 作者：Yang, Congbin Di, Peiwen Fu, JinPing Xiong, Hui Jing, Qiufang Ren, Guobin Tang, Yun Zheng, Wenyun Liu, Guixia Ren, Fuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2017
- 关键词：Bovine serum albumin Bicalutamide Anti-solvent precipitation Interaction Molecular docking
- Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9被引量：12收藏
- 作者：Wang, Wenpeng Zheng, Wenyun Hu, Fengzhi He, Xiujuan Wu, Dong Zhang, Wenliang Liu, Haipeng Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ North Carolina Greensboro;Xiamen Univ
- 来源：ACS SYNTHETIC BIOLOGY 2018
- 关键词：CHO-K1 mammalian cell ER microenvironment antiapoptotic ability genome editing by CRISPR-Cas9 high quality protein production
- Split-Cas9-based targeted gene editing and nanobody-mediated proteolysis-targeting chimeras optogenetically coordinated regulation of Survivin to control the fate of cancer cells被引量：11收藏
- 作者：Deng, Changping Li, Shihui Liu, Yuping Bao, Wen Xu, Chengnan Zheng, Wenyun Wang, Meiyan Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Normal Univ;East China Normal Univ;East China Univ Sci & Technol
- 来源：CLINICAL AND TRANSLATIONAL MEDICINE 2023
- 关键词：Coordinated regulating to Survivin Fate of cancer cells Nanobody targeted degradation Photoactivatable proteolysis and editing
- Highly Efficient Folding of Multi-Disulfide Proteins in Superoxidizing Escherichia coli Cytoplasm被引量：10收藏
- 作者：Zhang, Wenyao Zheng, Wenyun Mao, Miaowei Yang, Yi
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2014
- 关键词：redox potential disulfide formation oxidative protein folding superoxidizing cells
- Enhancing the Antibody Production Efficiency of Chinese Hamster Ovary Cells through Improvement of Disulfide Bond Folding Ability and Apoptosis Resistance被引量：10收藏
- 作者：Zhang, Chen Fu, Yunhui Zheng, Wenyun Chang, Feng Shen, Yue Niu, Jinping Wang, Yangmin Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CELLS 2024
- 关键词：CHO cells antibody production efficiency disulfide bond folding apoptotic resistance unfolded protein response
- Corosolic acid-modified lipid nanoparticles as delivery carriers for DNA vaccines against avian influenza被引量：10收藏
- 作者：Guo, Ziyan Jing, Qiufang Xu, Zhongyu Zhang, Dahe Zheng, Wenyun Ren, Fuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Suzhou Womei Biol Co Ltd;East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2023
- 关键词：Lipid nanoparticles Cholesterol Corosolic acid Avian influenza vaccine Immune responses
- Immuno-Enhancing Effect of Ginsenoside Rh2 Liposomes on Foot-and-Mouth Disease Vaccine被引量：10收藏
- 作者：Miao, Saiya Jing, Qiufang Wang, Xuanyu Zheng, Wenyun Liu, Hui Tang, Liusiqi Wang, Xinzhu Ren, Fuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Baoshan Ctr Dis Control & Prevent;East China Univ Sci & Technol
- 来源：MOLECULAR PHARMACEUTICS 2023
- 关键词：ginsenoside Rh2 liposomes W/O/W emulsion foot-and-mouth disease vaccine immune adjuvant
- Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin被引量：9收藏
- 作者：Xu, Yuxin Zheng, Wenyun Wang, Tianwen Wang, Ping Zhu, Ling Ma, Xingyuan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Jiangnan Univ
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2012
- 关键词：Genetic protein TmSm(T34A) Enhancing sensitivity Chemotherapeutic agent Breast cell lines
- Structure-function analysis of human protein Ero1-Lα被引量：9收藏
- 作者：Chu, Yanyan Yang, Charles Chen, Xianjun Zheng, Wenyun Yang, Yi Tang, Yun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009
- 关键词：Disulfide bond Ero1-L alpha Thioredoxin Homology modeling Structure-function analysis
- Multiple targeting strategies achieve novel protein drug delivery into proapoptosis lung cancer cells by precisely inhibiting survivin被引量：8收藏
- 作者：Hu, Fabiao Yan, Ting Guo, Wei Liu, Qiuli Han, Myong Hun Liu, Chang Liu, Yuping Zheng, Wenyun You, Fang Yang, Yi Zhang, Wenliang Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;KIM IL SUNG Univ;Natl Univ Singapore;SinGENE Biotech Pte Ltd
- 来源：NANOSCALE 2020
- 关键词：Cancer cells - Tumors - Cell death - Mammals - Diseases - Targeted drug delivery - Biocompatibility - Controlled drug delivery - Recombinant proteins
- A recombinant protein TmSm(T34A) can inhibit proliferation and proapoptosis to breast cancer stem cells(BCSCs) by down-regulating the expression of Cyclin D1被引量：8收藏
- 作者：Ma, Xingyuan Zhang, Yi Kang, Yanyan Li, Linfeng Zheng, Wenyun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2016
- 关键词：TmSm(T34A) BCSCs Proliferation Proapoptosis Cyclin D1
- Crucial effect of the first CXXC motif of human QSOX 1b on the activity to different substrates被引量：8收藏
- 作者：Zheng, Wenyun Chu, Yanyan Yin, Qin Xu, Lei Yang, Charles Zhang, Wenyao Tang, Yun Yang, Yi
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF BIOCHEMISTRY 2011
- 关键词：electron transfer molecular modelling QSOX site-directed mutagenesis thiol oxidation
- A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells被引量：8收藏
- 作者：Lin, Nanjing Zheng, Wenyun Li, Linfeng Liu, Hui Wang, Tianwen Wang, Ping Ma, Xingyuan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：TARGETED ONCOLOGY 2014
- 关键词：Tat-INF7-ubiquitin (TIU) system Cytosolic delivery Bak BH3 Inducing apoptosis
- Elucidating respective functions of two domains BIR and C-helix of human IAP survivin for precise targeted regulating mitotic cycle, apoptosis and autophagy of cancer cells被引量：8收藏
- 作者：Hu, Fabiao Pan, Daxia Zheng, Wenyun Yan, Ting He, Xiujuan Ren, Fuzheng Lu, Yiming Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Second Mil Med Univ
- 来源：ONCOTARGET 2017
- 关键词：BIR and CC domains survivin cell cycle apoptosis and autophagy breast cancer cells
- Exploring the Smallest Active Fragment of HsQSOX1b and Finding a Highly Efficient Oxidative Engine被引量：7收藏
- 作者：Zheng, Wenyun Zhang, Wenyao Hu, Wei Zhang, Chao Yang, Yi
- 机构：E China Univ Sci & Technol
- 来源：PLOS ONE 2012
- Development of a synthetic library of humanized nanobodies for targeted IL-6 inhibition被引量：6收藏
- 作者：Wang, Lei Dong, Jiayi Wu, Chenlu Yan, Chenyue Bi, Chong Xu, Chengnan Wu, Yiling Zheng, Wenyun Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2024
- 关键词：nanobody humanization stability synthetic library phage display interleukin-6 blocking antibody
- The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance被引量：6收藏
- 作者：Deng, Changping Hu, Fabiao Zhao, Zhangting Zhou, Yiwen Liu, Yuping Zhang, Tong Li, Shihui Zheng, Wenyun Zhang, Wenliang Wang, Tianwen Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ N Carolina;Xinyang Normal Univ
- 来源：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2022
- 关键词：survivin P-Glycoprotein CRISPR Cas9-based Tet-off system PI3K Akt mTOR pathway MCF-7 cells multi-drug resistance
- A nanobody-based molecular toolkit for ubiquitin-proteasome system explores the main role of survivin subcellular localization被引量：6收藏
- 作者：Miao, Hui Liu, Chang Ouyang, Hao Zhang, Peiwen Liu, Yuping Zhang, Chen Deng, Changping Fu, Yunhui Niu, Jinping Zheng, Wenyun You, Fang Yang, Yi Ma, Xingyuan
- 机构：East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;Natl Univ Singapore
- 来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2023
- 关键词：survivin subcellular function nanobody targeted TRIM21 apoptosis and cell cycle anti-cancer
- Development of an oral gut-targeted rabies virus-like particles (RVLPs) vaccine with mucosal immune adjuvant LTB via delivering of localized-release microparticles被引量：6收藏
- 作者：Niu, Jinping Zhao, Zhangting Zhang, Tong Liu, Qingwei Huang, Liyao Li, Shipo Liu, Haipeng Yu, Shaowen Li, Linfeng Jia, Hao Zheng, Wenyun Yang, Feng Ma, Xingyuan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Xiamen Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：EMERGING MICROBES & INFECTIONS 2025
- 关键词：Oral gut-targeted rabies virus-like particles (RVLPs) mucosal immune vaccines localized-release microparticles LTB B subunit of heat-labile toxin (LTB) PLGA/Eudradit microparticle (EPLGA MPs)
