成果/Result
- Estimation of ADME Properties with Substructure Pattern Recognition被引量：269收藏
- 作者：Shen, Jie Cheng, Feixiong Xu, You Li, Weihua Tang, Yun
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2010
- 关键词：Support vector machines - Chemical analysis
- Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells被引量：262收藏
- 作者：Wang, Fen Gao, Feng Lan, Minbo Yuan, Huihui Huang, Yongping Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：TOXICOLOGY IN VITRO 2009
- 关键词：Silica nanoparticles Cytotoxicity Oxidative stress
- Pharos: Collating protein information to shed light on the druggable genome被引量：189收藏
- 作者：Dac-Trung Nguyen Mathias, Stephen Bologa, Cristian Brunak, Soren Fernandez, Nicolas Gaulton, Anna Hersey, Anne Holmes, Jayme Jensen, Lars Juhl Karlsson, Anneli Liu, Guixia Ma'ayan, Avi Mandava, Geetha Mani, Subramani Mehta, Saurabh Overington, John Patel, Juhee Rouillard, Andrew D. Schurer, Stephan Sheils, Timothy Simeonov, Anton Sklar, Larry A. Southall, Noel Ursu, Oleg Vidovic, Dusica Waller, Anna Yang, Jeremy Jadhav, Ajit Oprea, Tudor I. Guha, Rajarshi
- 机构：Natl Ctr Advancing Translat Sci;Icahn Sch Med Mt Sinai;Univ New Mexico;Univ New Mexico;Univ Miami
- 来源：NUCLEIC ACIDS RESEARCH 2017
- A Three-Channel Fluorescent Probe That Distinguishes Peroxynitrite from Hypochlorite被引量：167收藏
- 作者：Zhang, Quanjuan Zhu, Zhichuan Zheng, Yongli Cheng, Jiagao Zhang, Na Long, Yi-Tao Zheng, Jing Qian, Xuhong Yang, Youjun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2012
- 关键词：Fluorescence - Probes
- CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity被引量：165收藏
- 作者：Mansouri, Kamel Kleinstreuer, Nicole Abdelaziz, Ahmed M. Alberga, Domenico Alves, Vinicius M. Andersson, Patrik L. Andrade, Carolina H. Bai, Fang Balabin, Ilya Ballabio, Davide Benfenati, Emilio Bhhatarai, Barun Boyer, Scott Chen, Jingwen Consonni, Viviana Farag, Sherif Fourches, Denis Garcia-Sosa, Alfonso T. Gramatica, Paola Grisoni, Francesca Grulke, Chris M. Hong, Huixiao Horvath, Dragos Hu, Xin Huang, Ruili Jeliazkova, Nina Li, Jiazhong Li, Xuehua Liu, Huanxiang Manganelli, Serena Mangiatordi, Giuseppe F. Maran, Uko Marcou, Gilles Martin, Todd Muratov, Eugene Dac-Trung Nguyen Nicolotti, Orazio Nikolov, Nikolai G. Norinder, Ulf Papa, Ester Petitjean, Michel Piir, Geven Pogodin, Pavel Poroikov, Vladimir Qiao, Xianliang Richard, Ann M. Roncaglioni, Alessandra Ruiz, Patricia Rupakheti, Chetan Sakkiah, Sugunadevi Sangion, Alessandro Schramm, Karl-Werner Selvaraj, Chandrabose Shah, Imran Sild, Sulev Sun, Lixia Taboureau, Olivier Tang, Yun Tetko, Igor, V Todeschini, Roberto Tong, Weida Trisciuzzi, Daniela Tropsha, Alexander Van Den Driessche, George Varnek, Alexandre Wang, Zhongyu Wedebye, Eva B. Williams, Antony J. Xie, Hongbin Zakharov, Alexey, V Zheng, Ziye Judson, Richard S.
- 机构：US EPA;ScitoVation LLC;Integrated Lab Syst Inc;Natl Inst Environm Hlth Sci;Tech Univ Munich
- 来源：ENVIRONMENTAL HEALTH PERSPECTIVES 2020
- Classification of Cytochrome P450 Inhibitors and Noninhibitors Using Combined Classifiers被引量：164收藏
- 作者：Cheng, Feixiong Yu, Yue Shen, Jie Yang, Lei Li, Weihua Liu, Guixia Lee, Philip W. Tang, Yun
- 机构：E China Univ Sci & Technol;Kyoto Univ;E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2011
- 关键词：Decision trees - Data mining - Nearest neighbor search - Classification (of information) - Drug interactions - Backpropagation - Forecasting
- ASD: a comprehensive database of allosteric proteins and modulators被引量：145收藏
- 作者：Huang, Zhimin Zhu, Liang Cao, Yan Wu, Geng Liu, Xinyi Chen, Yingyi Wang, Qi Shi, Ting Zhao, Yaxue Wang, Yuefei Li, Weihua Li, Yixue Chen, Haifeng Chen, Guoqiang Zhang, Jian
- 机构：Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Punan Hosp;Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：NUCLEIC ACIDS RESEARCH 2011
- Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain被引量：136收藏
- 作者：Wang, Suqing Wang, Rui Chen, Lang Bennett, David A. Dickson, Dennis W. Wang, Deng-Shun
- 机构：Univ Wisconsin;Wuhan Univ;E China Univ Sci & Technol;Rush Univ;Mayo Clin
- 来源：JOURNAL OF NEUROCHEMISTRY 2010
- 关键词：Alzheimer's disease Alzheimer's disease brain amyloid-degrading enzymes degradation endothelin-converting enzyme insulin-degrading enzyme neprilysin beta-amyloid
- Chitosan-graft-β-cyclodextrin nanoparticles as a carrier for controlled drug release被引量：135收藏
- 作者：Yuan, Zeting Ye, Yajing Gao, Feng Yuan, Huihui Lan, Minbo Lou, Kaiyan Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2013
- 关键词：Chitosan Cyclodextrin Ionic gelation Nano-drug delivery system
- Photodynamic therapy synergizes with PD-L1 checkpoint blockade for immunotherapy of CRC by multifunctional nanoparticles被引量：120收藏
- 作者：Yuan, Zeting Fan, Guohua Wu, Honglei Liu, Chaolian Zhan, Yueping Qiu, Yanyan Shou, Chenting Gao, Feng Zhang, Jun Yin, Peihao Xu, Ke
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;Anhui Med Univ
- 来源：MOLECULAR THERAPY 2021
- Pluronic-based functional polymeric mixed micelles for co-delivery of doxorubicin and paclitaxel to multidrug resistant tumor被引量：116收藏
- 作者：Chen, Yanzuo Zhang, Wei Huang, Yukun Gao, Feng Sha, Xianyi Fang, Xiaoling
- 机构：E China Univ Sci & Technol;Fudan Univ;Fudan Univ;Eastern Virginia Med Sch
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2015
- 关键词：Doxorubicin Paclitaxel Codelivery Polymeric micelle Anti-cancer efficacy Multidrug resistance
- Combined Cancer Chemo-Photodynamic and Photothermal Therapy Based on ICG/PDA/TPZ-Loaded Nanoparticles被引量：108收藏
- 作者：Huang, Xiaqin Wu, Junru He, Muye Hou, Xinyu Wang, Yan Cai, Xiaoran Xin, Hongliang Gao, Feng Chen, Yanzuo
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Nanjing Med Univ
- 来源：MOLECULAR PHARMACEUTICS 2019
- 关键词：nanoparticle chemo-photodynamic therapy photothermal therapy polydopamine indocyanine green tirapazamine Tumor
- Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones被引量：94收藏
- 作者：Mei, Kui Jin, Mei Zhang, Shilei Li, Ping Liu, Wenjing Chen, Xiaobei Xue, Fei Duan, Wenhu Wang, Wei
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ New Mexico
- 来源：ORGANIC LETTERS 2009
- Synthesis of Chiral 3-Substituted Phthalides by a Sequential Organocatalytic Enantioselective Aldol-Lactonization Reaction. Three-Step Synthesis of (S)-(-)-3-Butylphthalide被引量：90收藏
- 作者：Zhang, Haoyi Zhang, Shilei Liu, Lu Luo, Guangshun Duan, Wenhu Wang, Wei
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ New Mexico
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2010
- Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors被引量：88收藏
- 作者：Chen, Yanzuo Song, Wantong Shen, Limei Qiu, Nasha Hu, Mengying Liu, Yun Liu, Qi Huang, Leaf
- 机构：Univ N Carolina;Univ N Carolina;East China Univ Sci & Technol;Chinese Acad Sci;Zhejiang Univ
- 来源：ACS NANO 2019
- 关键词：hydralazine nanoparticles tumor penetration desmoplastic tumor tumor microenvironment
- Exploring coumarin egress channels in human cytochrome P450 2A6 by random acceleration and steered molecular dynamics simulations被引量：79收藏
- 作者：Li, Weihua Shen, Jie Liu, Guixia Tang, Yun Hoshino, Tyuji
- 机构：E China Univ Sci & Technol;Chiba Univ
- 来源：PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 2011
- 关键词：P450 2A6 coumarin egress channel molecular dynamics channel selectivity
- A Novel Bifunctional Sulfonamide Primary Amine-Catalyzed Enantioselective Conjugate Addition of Ketones to Nitroolefins被引量：77收藏
- 作者：Xue, Fei Zhang, Shilei Duan, Wenhu Wang, Wei
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ New Mexico
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2008
- 关键词：conjugate addition ketones nitroolefins organocatalysis sulfonamide primary amine
- In silico prediction of Tetrahymena pyriformis toxicity for diverse industrial chemicals with substructure pattern recognition and machine learning methods被引量：77收藏
- 作者：Cheng, Feixiong Shen, Jie Yu, Yue Li, Weihua Liu, Guixia Lee, Philip W. Tang, Yun
- 机构：E China Univ Sci & Technol;Kyoto Univ
- 来源：CHEMOSPHERE 2011
- 关键词：Tetrahymena pyriformis toxicity Quantitative structure-toxicity relationship Substructure pattern recognition Support vector machine Machine learning Information gain
- EpCAM Aptamer-Functionalized Cationic Liposome-Based Nanoparticles Loaded with miR-139-5p for Targeted Therapy in Colorectal Cancer被引量：74收藏
- 作者：Zhao, Yuyu Xu, Jiajun Van Minh Le Gong, Qianyi Li, Shaoyu Gao, Feng Ni, Lei Liu, Jianwen Liang, Xin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Natl Inst Med Mat;Xinjiang Med Univ
- 来源：MOLECULAR PHARMACEUTICS 2019
- 关键词：nanoparticle CRC targeted therapy miR-139-5p
- Preparation, characterization and pharmacokinetic studies of tacrolimus-dimethyl-β-cyclodextrin inclusion complex-loaded albumin nanoparticles被引量：70收藏
- 作者：Gao, Shanshan Sun, Jun Fu, Dongjun Zhao, Hongli Lan, Minbo Gao, Feng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2012
- 关键词：FK506/DM-beta-CD inclusion complex BSA nanoparticle Sustained-release
- Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy被引量：68收藏
- 作者：Li, Yue Chen, Jia Xia, Qi Shang, Jing He, Yujie Li, Zhi Chen, Yingying Gao, Feng Yu, Xi Yuan, Zeting Yin, Peihao
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;Anhui Med Univ
- 来源：JOURNAL OF NANOBIOTECHNOLOGY 2024
- 关键词：Photothermal therapy Ferroptosis ICD Immunotherapy CRC
- An efficient method for demethylation of aryl methyl ethers被引量：64收藏
- 作者：Zuo, Li Yao, Shanyan Wang, Wei Duan, Wenhu
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ New Mexico
- 来源：TETRAHEDRON LETTERS 2008
- 关键词：demethylation aryl methyl ether iodocyclohexane hydrogen iodide
- (S)-Pyrrolidine sulfonamide catalyzed asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes被引量：59收藏
- 作者：Mei, Kui Zhang, Shilel He, Songtao Li, Ping Jin, Mel Xue, Fei Luo, Guangshun Zhang, Haoyi Song, Lirong Duan, Wenhu Wang, Wei
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ New Mexico
- 来源：TETRAHEDRON LETTERS 2008
- 关键词：aldol reaction aryl alkyl ketones pyrrolidine sulfonamide
- A novel lactoferrin-modified β-cyclodextrin nanocarrier for brain-targeting drug delivery被引量：57收藏
- 作者：Ye, Yajing Sun, Yi Zhao, Hongli Lan, Minbo Gao, Feng Song, Chao Lou, Kaiyan Li, Hao Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2013
- 关键词：beta-cyclodextrin derivatives Lactoferrin Transferrin Brain-targeting Nano-drug delivery system
- The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes被引量：57收藏
- 作者：Ye, Ya-Jing Wang, Yun Lou, Kai-Yan Chen, Yan-Zuo Chen, Rongjun Gao, Feng
- 机构：E China Univ Sci & Technol;Univ London Imperial Coll Sci Technol & Med;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF NANOMEDICINE 2015
- 关键词：dimethyl-beta-cyclodextrin inclusion complex chitosan nanoparticles drug delivery sustained release paclitaxel
- Computational investigation of interactions between human H2 receptor and its agonists被引量：57收藏
- 作者：Sun, Xianqiang Li, Yaozong Li, Weihua Xu, Zhejun Tang, Yun
- 机构： Department of Pharmaceutical Sciences
- 来源：Journal of Molecular Graphics and Modelling 2011
- 关键词：Computational chemistry - Molecular modeling - Molecular dynamics - Diagnosis - Search engines - Pharmacodynamics
- Enantioselective Conjugate Addition of N-Heterocycles to α,β-Unsaturated Ketones Catalyzed by Chiral Primary Amines被引量：55收藏
- 作者：Luo, Guangshun Zhang, Shilei Duan, Wenhu Wang, Wei
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ New Mexico
- 来源：SYNTHESIS-STUTTGART 2009
- 关键词：primary amines N-heterocycles enones conjugate addition catalysis
- Insights into Molecular Basis of Cytochrome P450 Inhibitory Promiscuity of Compounds被引量：54收藏
- 作者：Cheng, Feixiong Yu, Yue Zhou, Yadi Shen, Zhonghua Xiao, Wen Liu, Guixia Li, Weihua Lee, Philip W. Tang, Yun
- 机构：E China Univ Sci & Technol;Kyoto Univ
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2011
- 关键词：Drug interactions - Economic and social effects
- Colon-targeted delivery of tacrolimus using pH-responsive polymeric nanoparticles for murine colitis therapy被引量：53收藏
- 作者：Cai, Xiaoran Wang, Xiaolei He, Muye Wang, Yan Lan, Minbo Zhao, Yuzheng Gao, Feng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2021
- 关键词：Oral nanoparticle delivery system pH-responsive Targeted drug delivery Tacrolimus Inflammatory bowel diseases
- Activation of the cyclin D2 and cdk6 genes through NF-κB is critical for cell-cycle progression induced by HTLV-I Tax被引量：50收藏
- 作者：Iwanaga, R. Ozono, E. Fujisawa, J. Ikeda, M. A. Okamura, N. Huang, Y. Ohtani, K.
- 机构：Tokyo Med & Dent Univ;Tokyo Med & Dent Univ;Tokyo Med & Dent Univ;Kansai Med Univ;E China Univ Sci & Technol
- 来源：ONCOGENE 2008
- 关键词：HTLV-I Tax cell cycle E2F cyclin D2 cdk6
