成果/Result
- MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17被引量：65收藏
- 作者：Xu, Ke Liang, Xin Shen, Ke Sun, Liyun Cui, Daling Zhao, Yuxia Tian, Jianhui Ni, Lei Liu, Jianwen
- 机构：Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：EXPERIMENTAL CELL RESEARCH 2012
- 关键词：Colorectal carcinoma Multidrug-resistance (MDR) MiR-222 ADAM-17 TGF-alpha EGFR
- Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression被引量：36收藏
- 作者：Shen, Ke Cui, Daling Sun, Liyun Lu, Yanhua Han, Mingquan Liu, Jianwen
- 机构：Tongji Univ;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF CELLULAR BIOCHEMISTRY 2012
- 关键词：INSULIN-LIKE GROWTH FACTOR TYPE I MULTIDRUG-RESISTANCE COLORECTAL CANCER RNA INTERFERENCE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2
- A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human He la cervix carcinoma cells被引量：28收藏
- 作者：Shen, Ke Sun, Liyun Zhang, Huanying Xu, Yufang Qian, Xuhong Lu, Yanhua Li, Qi Ni, Lei Liu, Jianwen
- 机构：E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Shanghai Jiao Tong Univ
- 来源：CANCER LETTERS 2013
- 关键词：Oxidative stress 7c Lysosomes Mitochondrion Apoptosis
- efficient degradation of sulfadiazine by photosynthetic cyanobacteria Synechocystis sp. PCC 6803 coupling with recombinant laccase strategy被引量：23收藏
- 作者：Wu, Ping Hu, Tianyouzi Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ;130 Meilong Rd
- 来源：CHEMICAL ENGINEERING JOURNAL 2023
- 关键词：Synechocystis Sulfadiazine Bioremediation Laccase Microalgae
- Recent advances in polysaccharide-dominated extracellular polymeric substances from microalgae: A review被引量：12收藏
- 作者：He, Yulong Ji, Liang Yuan, Yuchen Rui, Die Li, Jiaxin Cheng, Pengfei Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ;Ningbo Univ
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2025
- 关键词：Extracellular polymeric substances Polysaccharides Monosaccharide Secretion Bioactivity Microalgae
- Screening of microalgae strains for efficient biotransformation of small molecular organic acids from dark fermentation biohydrogen production wastewater被引量：11收藏
- 作者：Chen, Cheng Shi, Qianwen Tong, Akang Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ;130 Meilong Rd
- 来源：BIORESOURCE TECHNOLOGY 2023
- 关键词：Wastewater utilization Microalgae screening Biotransformation Butyric acid
- Hypericin-mediated photodynamic therapy enhances gemcitabine induced Capan-2 cell apoptosis via inhibiting NADPH level被引量：9收藏
- 作者：Sun, Liyun Shang, Huoli Wu, Yuzhen Xin, Xiujuan
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF PHARMACY AND PHARMACOLOGY 2022
- 关键词：hypericin gemcitabine Capan-2 apoptosis reactive oxygen species
- A Newly Authenticated Compound from Traditional Chinese Medicine Decoction Induces Melanogenesis in B16-F10 Cells by Increasing Tyrosinase Activity被引量：8收藏
- 作者：Xin, Xiu Juan Zou, Jiahong Zou, Tao Shang, Huoli Sun, Li Yun
- 机构：East China Univ Sci & Technol
- 来源：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2018
- Sustainable Biodegradation of Triclosan and Sulfamethoxazole with Cyanobacteria: Resistance Mechanism and Metabolic Transformation被引量：7收藏
- 作者：Wu, Ping Luo, Yeling Hu, Tianyouzi An, Xiongfang Xu, Xiaolin Sun, Liyun Tang, Tao Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Shihezi Univ
- 来源：ACS ES&T WATER 2025
- 关键词：
Synechocystis sp. PCC 6803 triclosan sulfamethoxazole biodegradation metabolicfate bioremediation
- Regulation of the HMOX1 gene by the transcription factor AP-2δ with unique DNA binding site被引量：6收藏
- 作者：Sun, Liyun Zhao, Yuxia Gu, Shaohua Mao, Yumin Ji, Chaoneng Xin, Xiujuan
- 机构：E China Univ Sci & Technol;Fudan Univ
- 来源：MOLECULAR MEDICINE REPORTS 2014
- 关键词：AP-2 delta heme oxygenase-1 luciferase assay electromobility shift assays
- Transcriptomics reveal how circadian regulation contributes to starch hyperaccumulation in marine alga Tetraselmis helgolandica被引量：5收藏
- 作者：Shi, Qianwen Zhou, Zuodong Hong, Zhiwei Yang, Zhi Gao, Zhengquan Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Binzhou Med Univ;Shihezi Univ
- 来源：GLOBAL CHANGE BIOLOGY BIOENERGY 2023
- 关键词：circadian rhythm gene expression microalgae starch synthesis transcriptome
- 基于认知负荷理论和互证互补理论的遗传学理论与实验课程教学策略的探索被引量：3收藏
- 作者：孙丽云 姜曈 辛秀娟 张悦
- 机构：华东理工大学生物工程学院应用生物学系;华东理工大学生物工程学院;华东理工大学生物工程学院实验教学中心
- 来源：《高校生物学教学研究（电子版）》 2022
- 关键词：互证互补 认知负荷 生物科学 遗传学 综合课程
- 摘要：各高校的遗传学教学传统上分为理论课程和实验课程两部分,理论与实验分别开展教学,对概念和理论的讲授平面化,实验项目与书本脱节,缺乏理论联系实践的浸入式学习氛围。为解决此问题,本文基于对认知负荷理论和互证互补理论的认识和理解...
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- 金丝桃素联合紫杉醇通过上调胞内ROS水平抑制乳腺癌细胞生长被引量：3收藏
- 作者：任旺 冉鹏 叶蓓 孙丽云 辛秀娟
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《中国现代应用药学》 2021
- 关键词：乳腺癌 金丝桃素 紫杉醇 联合用药
- 摘要：目的研究紫杉醇联合金丝桃素对乳腺癌细胞增殖的影响。方法利用乳腺癌细胞株MCF-7和Bcap-37为研究对象,分别进行单药及联合用药,通过MTT法检测药物对肿瘤细胞增殖活性的影响;通过流式细胞技术检测药物对肿瘤细胞凋亡的影...
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- Mining marine dinoflagellate Amphidinium carterae for peridinin production by optimizing light conditions and mixotrophy strategy被引量：3收藏
- 作者：Hong, Zhiwei Qiu, Sheng E, Jiawei Zhang, Wenjun Yuan, Yuchen Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ
- 来源：BIORESOURCE TECHNOLOGY 2025
- 关键词：Microalgae Cultivation optimization Carotenoid Column photobioreactor Antioxidant activity
- Exploring Porphyridium purpureum and Porphyridium aerugineum as alternative resources for phycobiliprotein production被引量：3收藏
- 作者：Ji, Liang Zhao, Chenni He, Yulong Yuan, Yuchen Hong, Zhiwei Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ
- 来源：BIORESOURCE TECHNOLOGY 2025
- 关键词：Light quality Porphyridium purpureum Porphyridium aerugineum Phycoerythrin Phycocyanin Pigment
- Improving the bioactivity of rHirudin with boronophenylalanine site-specific modification被引量：3收藏
- 作者：Xin, Xiujuan Liu, Wenshe Sun, Liyun
- 机构：E China Univ Sci & Technol;Texas A&M Univ
- 来源：MOLECULAR MEDICINE REPORTS 2015
- 关键词：antithrombin activity boronophenylalanine proliferation inhibition recombinant Hirudin site-specific modification
- Identification of an Immune Cell Infiltration-Related Prognostic Model to Guide Immunotherapy in Endometrial Carcinoma被引量：2收藏
- 作者：Zhu, Haijun Luo, Fangjia He, Wanhong Zhang, Sufen Chen, Jing Sun, Liyun Ni, Xiaohua Wu, Qihan
- 机构：Shanghai Inst Biomed & Pharmaceut Technol;East China Univ Sci & Technol
- 来源：CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY 2023
- 关键词：uterine corpus endometrial carcinoma immune cell infiltration prognostic model immunotherapy
- 大肠杆菌L-阿拉伯糖异构酶的克隆表达及D-塔格糖的制备被引量：1收藏
- 作者：王栋 丁庆豹 欧伶 魏晓琨 许艳梅 孙丽云
- 机构：华东理工大学生物反应器工程国家重点实验室;上海斯贝生物科技有限公司
- 来源：《中国食品添加剂》 2010
- 关键词：大肠杆菌 L-阿拉伯糖异构酶 D-塔格糖 表达 转化
- 摘要：将大肠杆菌K-12中的L-阿拉伯糖异构酶基因araA克隆到载体pET-28a上,并转化入大肠杆菌BL21(DE3)中表达。通过SDS-PAGE分析发现,重组菌株能表达出大量可溶性酶蛋白。以重悬菌液为酶源、D-半乳糖为底物...
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- Chromosome-level genome provides novel insights into the starch metabolism regulation and evolutionary history of Tetraselmis helgolandica被引量：1收藏
- 作者：Zhou, Zuodong Jiawei, E. Shi, Qianwen Zhang, Wenjun Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ
- 来源：JOURNAL OF ADVANCED RESEARCH 2026
- 关键词：Genome assembly Comparative genomics Metabolism Circadian rhythm Starch synthesis Green algae
- Genome-wide hypermutation-engineered Synechocystis sp. PCC 6803 reveals membrane-mediated triclosan resistance被引量：0收藏
- 作者：Wu, Ping Wei, Kaixin Hu, Tianyouzi Chen, Jianfeng Luan, Guodong Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Shihezi Univ
- 来源：PLANT PHYSIOLOGY 2026
- Comparative analysis of two Porphyridium species for phycobiliprotein and polysaccharide production under different photoperiods被引量：0收藏
- 作者：Liang Ji Luxuan Xu Zhangzhen Chen Yulong He Artem Yurevich Manyakhin Pengfei Cheng Liyun Sun Jianhua Fan
- 机构：State Key Laboratory of Bioreactor Engineering;Department of Applied Biology;School of Chemistry and Chemical Engineering State Key Laboratory Incubation Base for Green Processing of Chemical Engineering;Far Eastern Branch;College of Food Science and Engineering
- 来源：生物资源与生物加工(英文) 2025
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- Heterologous assembly of red-type Rubisco and functional identification of chaperonin in Porphyridium purpureum被引量：0收藏
- 作者：Zhang, Wei Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ
- 来源：ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 2024
- 关键词：Red-type Rubisco Heterologous assembly Expression Chaperonin Red algae Diatom
- C/N ratio-directed two-stage mixotrophic cultivation of Isochrysis galbana for enhanced production of fucoxanthin and DHA被引量：0收藏
- 作者：Yuan, Yuchen Yang, Zhi Cao, Jiajun Sun, Liyun Ji, Liang Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ
- 来源：BIORESOURCE TECHNOLOGY 2026
- 关键词：Isochrysis galbana Fucoxanthin DHA C/N ratio Two-stage cultivation
- Comparative analysis of two Porphyridium species for phycobiliprotein and polysaccharide production under different photoperiods被引量：0收藏
- 作者：Ji, Liang Xu, Luxuan Chen, Zhangzhen He, Yulong Manyakhin, Artem Yurevich Cheng, Pengfei Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ;Russian Acad Sci;Ningbo Univ
- 来源：BIORESOURCES AND BIOPROCESSING 2025
- 关键词：
Porphyridium purpureum Porphyridium aerugineum Phycoerythrin Phycocyanin Polysaccharide
- Integrative network-level rewiring of photosynthetic metabolism boosts phycocyanin biosynthesis in cyanobacterial chassis被引量：0收藏
- 作者：Wei, Kaixin Rui, Die Yuan, Yuchen Chen, Jianfeng Cao, Jiajun Sun, Liyun Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ
- 来源：PLANT JOURNAL 2026
- 关键词：Synechocystis sp. PCC 6803 phycocyanin phycocyanobilin systems metabolic engineering photosynthetic cell factories
- Schizochytrium limacinum valorizes volatile fatty acid-rich dark fermentative effluent for docosahexaenoic acid production被引量：0收藏
- 作者：Zhang, Yingqiu Chen, Cheng Wei, Kaixin Sun, Liyun Tan, Gaoyi Zhang, Xu Fan, Jianhua
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shihezi Univ
- 来源：BIORESOURCE TECHNOLOGY 2025
- 关键词：Wastewater utilization Schizochytrium limacinum SR21 Butyric acid Biotransformation Fatty acid DHA
