成果/Result
- Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species被引量：68收藏
- 作者：Zou, Jinglin Jiang, Cong Hu, Qiangsheng Jia, Xinlin Wang, Shuqi Wan, Shiyue Mao, Yuanqing Zhang, Dapeng Zhang, Peng Dai, Bin Li, Yongsheng
- 机构：East China Univ Sci & Technol;Tongji Univ;Shanghai Jiao Tong Univ;Shihezi Univ
- 来源：NATURE COMMUNICATIONS 2025
- Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration被引量：46收藏
- 作者：Liu, Shi Han, Zhengzhe Zhang, Dapeng Li, Xianglong Cao, Yuanyuan Huang, Jinghuan Li, Yongsheng
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Shihezi Univ
- 来源：BIOACTIVE MATERIALS 2023
- 关键词：Parathyroid hormone Dual -mode release Thermosensitive hydrogel Angiogenesis Bone regeneration
- Ferroptosis and Pyroptosis Co-Activated Nanomodulator for "Cold" Tumor Immunotherapy and Lung Metastasis Inhibition被引量：43收藏
- 作者：Jiang, Cong Li, Xianglong Pan, Fen Zhang, Lele Yu, Huansha Zhang, Jing Zou, Jinglin Zhong, Tianyu Zhang, Dapeng Yang, Yang Li, Yongsheng Zhang, Peng
- 机构：Tongji Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：ADVANCED FUNCTIONAL MATERIALS 2023
- 关键词：anti-PD-L1 ferroptosis immunosuppressive tumor microenvironment immunotherapy pyroptosis
- Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers被引量：29收藏
- 作者：Meshanni, Jaclynn A. Stevenson, Emily R. Zhang, Dapeng Sun, Rachel Ona, Nathan A. Reagan, Erin K. Abramova, Elena Guo, Chang-Jiang Wilkinson, Melissa Baboo, Ishana Yang, Yuzi Pan, Liuyan Maurya, Devendra S. Percec, Virgil Li, Yongsheng Gow, Andrew Weissman, Drew Atochina-Vasserman, Elena N.
- 机构：Univ Penn;Univ Penn;Rutgers State Univ;East China Univ Sci & Technol;Univ Penn
- 来源：NATURE COMMUNICATIONS 2025
- Tissue Engineering of JAK Inhibitor-Loaded Hierarchically Biomimetic Nanostructural Scaffold Targeting Cellular Senescence for Aged Bone Defect Repair and Bone Remolding被引量：26收藏
- 作者：Liu, Shi Jia, Xinlin Hao, Jina Zhang, Dapeng Yang, Shengchao Dai, Bin Mao, Yuanqing Li, Yongsheng
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shihezi Univ
- 来源：ADVANCED HEALTHCARE MATERIALS 2023
- 关键词：age-related bone repair JAK inhibitor osteoblast activity SASP senescence
- Copper-Doped Polydopamine Nanoparticles-Mediated GSH/GPX4-Depleted Ferroptosis and Cuproptosis Sensitizes Lung Tumor to Checkpoint Blockade Immunotherapy被引量：24收藏
- 作者：Jiang, Cong Li, Xianglong Wan, Shiyue Ji, Shuyu Wang, Qinghua Hu, Shiqi Chen, Pengcheng Wang, Bo Ge, Tao Zhang, Jing Cao, Yuanyuan Yang, Yang Zhang, Dapeng Li, Yongsheng Zhang, Peng
- 机构：Tongji Univ;East China Univ Sci & Technol;Jiangxi Sci & Technol Normal Univ;Wenzhou Med Univ;Chinese Acad Sci
- 来源：SMALL 2025
- 关键词：cuproptosis ferroptosis glutathione response hybrid nanoparticles immune checkpoint immunotherapy
- Self-Assembly of Glycerol-Amphiphilic Janus Dendrimers Amplifies and Indicates Principles for the Selection of Stereochemistry by Biological Membranes被引量：22收藏
- 作者：Zhang, Dapeng Xiao, Qi Rahimzadeh, Mehrnoush Liu, Matthew Rodriguez-Emmenegger, Cesar Miyazaki, Yusuke Shinoda, Wataru Percec, Virgil
- 机构：Univ Penn;East China Univ Sci & Technol;Temple Univ;ET Healthcare Inc;Gator Bio
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Biological membranes - Cytology - Enantiomers - Glycerol - Molecular dynamics - Phospholipids - Self assembly - Stereoselectivity
- Leap-Type Response of Redox/Photo-Active Lanthanide-Based Metal-Organic Frameworks for Early and Accurate Screening of Prostate Cancer被引量：19收藏
- 作者：Ge, Kaiming Chen, Guoli Zhang, Dapeng Hao, Ji-Na Li, Yongsheng
- 机构：East China Univ Sci & Technol;Shihezi Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024
- 关键词：Luminescent Biosensors Lanthanide Metal-Organic Frameworks Defects Leap-Type Response Tumor Markers
- One-Component Ionizable Amphiphilic Janus Dendrimers for Targeted mRNA Delivery被引量：12收藏
- 作者：Zhu, Pengyu Li, Yongsheng Zhang, Dapeng
- 机构：East China Univ Sci & Technol;Shihezi Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2025
- 关键词：Dendrimersome nanoparticles Ionizable amphiphilic Janus dendrimers mRNA delivery One component Organ-targeted delivery
- Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration被引量：7收藏
- 作者：Shi Liu Zhengzhe Han Ji-Na Hao Dapeng Zhang Xianglong Li Yuanyuan Cao Jinghuan Huang Yongsheng Li
- 机构：Lab of Low-Dimensional Materials Chemistry;Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities;Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan
- 来源：生物活性材料（英文） 2023
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- Redox-responsive engineered hybrid nanomedicine for gallbladder cancer therapy via hyaluronic acid depletion被引量：2收藏
- 作者：Zou, Jinglin Jiang, Cong Li, Xianglong Zhong, Tianyu Wang, Shuqi Wang, Bo Zhang, Dapeng Hao, Ji-Na Cao, Yuanyuan Guan, Mengjia Zhang, Peng Dai, Bin Li, Yongsheng
- 机构：East China Univ Sci & Technol;Tongji Univ;Shihezi Univ;Shanghai Jiao Tong Univ
- 来源：APPLIED MATERIALS TODAY 2023
- 关键词：Gallbladder cancer Extracellular matrix Hyaluronidase Nanocarrier Redox-responsive
- One-component ionizable amphiphilic Janus dendrimers as a delivery platform for efficient mRNA vaccine development被引量：0收藏
- 作者：Ona, Nathan A. Zhang, Dapeng Lindesmith, Lisa C. Park, Wook-Jin Meshanni, Jaclynn A. Berkihiser, Sydni Vasserman, Jessica A. Toshtzar, Sepideh Moore, Nathanael C. Williams, Blair Nakagawa, Benjamin Baboo, Ishana Pan, Liuyan Cheng, Wanting Mercado-Lopez, Xiomara Bonilla-Acosta, Wendy Brewer-Jensen, Paul D. Zweigart, Mark R. Reyes, Yaoska I. Mallory, Michael L. May, Samantha R. Zhou, Yongfeng Percec, Virgil Baric, Ralph S. Li, Yongsheng Weissman, Drew Atochina-Vasserman, Elena N.
- 机构：Univ Penn;Univ Penn;East China Univ Sci & Technol;Univ North Carolina Chapel Hill;Shanghai Jiao Tong Univ
- 来源：SCIENCE ADVANCES 2026
- 关键词：Cell membranes - Cost effectiveness - Diseases - RNA
- Inhalable Mucus-Penetrating Engineered Hybrid Nanomedicine for Enhanced Treatment of Idiopathic Pulmonary Fibrosis被引量：0收藏
- 作者：Zou, Jinglin Jiang, Cong Zhang, Jing Wan, Shiyue Yang, Yuzi Leng, Yuheng Wang, Shuqi Jia, Xinlin Mao, Yuanqing Zhang, Dapeng Li, Yongsheng
- 机构：East China Univ Sci & Technol;Tongji Univ;Shanghai Jiao Tong Univ
- 来源：NANO LETTERS 2025
- 关键词：hybrid nanoparticle pulmonary drug delivery inhalable nanomedicine idiopathic pulmonary fibrosis mucus penetration
- Ionizable mesoporous silica nanoparticle-mediated siAURKB delivery for colorectal cancer therapy被引量：0收藏
- 作者：Yao, Yuhao Leng, Yuheng Li, Xilong Chen, Pengcheng Zou, Jinglin Shi, Lei Zhang, Dapeng Li, Yongsheng
- 机构：East China Univ Sci & Technol;Shanghai Univ Chinese Tradit Med
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2026
- 关键词：Cell death - Controlled drug delivery - Diseases - Mammals - Medical nanotechnology - Nanoparticles - Oncology - RNA - Silica - Surface treatment - Targeted drug delivery - Tumors
- Hemiaminal hydrogel-manganese nanoparticle hybrids boost healing of penetrating orocutaneous fistulas through microenvironmental regulation被引量：0收藏
- 作者：Yang, Yuzi Wang, Jing Pan, Fen Li, Ya Wang, Shuqi Ma, Chunyue Wang, Ruohua Pan, Xueyan Cao, Yuanyuan Zhang, Dapeng Li, Yongsheng
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Hainan Western Cent Hosp;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：BIOMATERIALS 2027
- 关键词：Organic-inorganic hybrid hydrogel ROS-Responsive degradation Penetrating orocutaneous fistulas Immune microenvironment modulation
- Machine Learning-guided Prediction of Ionizable Amphiphilic Janus Dendrimers for mRNA Nanomedicine被引量：0收藏
- 作者：Cheng, Wan-Ting Zheng, Heng-Li Zhu, Peng-Yu Hao, Ji-Na Zhang, Da-Peng Li, Yong-Sheng
- 机构：East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF POLYMER SCIENCE 2026
- 关键词：Janus dendrimer Machine learning mRNA delivery Molecular modeling
- Silica-based nanoplatforms for nucleic acid delivery: Emerging strategies and biomedical applications被引量：0收藏
- 作者：Li, Xilong Bai, Yacheng Zhang, Dapeng Li, Yongsheng
- 机构：East China Univ Sci & Technol
- 来源：NANO TODAY 2026
- 关键词：Nucleic acid delivery Silica nanocarriers Loading strategies Responsive mechanisms Biological applications
- Semiclosed Cyclic Hemiaminal-Based Multistimuli- Responsive Hydrogels for Advanced Wound Dressings被引量：0收藏
- 作者：Yang, Yuzi Pan, Fen Jiang, Cong Li, Xilong Fan, Xiaoxuan Sun, Zhaolong Zhang, Yan Wan, Shiyue Chen, Pengcheng Zhong, Zhengrong Zhang, Peng Zhang, Dapeng Li, Yongsheng
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Tongji Univ;Jiangsu Univ
- 来源：BIOMACROMOLECULES 2026
- 关键词：Bacteria - Biochemistry - Bioelectric phenomena - Ethylene
