成果/Result
- admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties被引量：1485收藏
- 作者：Cheng, Feixiong Li, Weihua Zhou, Yadi Shen, Jie Wu, Zengrui Liu, Guixia Lee, Philip W. Tang, Yun
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2012
- 关键词：Industrial chemicals - Classification (of information) - Regression analysis - Consumer products - Indicators (chemical) - Additives - Chemical contamination - Database systems
- Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference被引量：626收藏
- 作者：Cheng, Feixiong Liu, Chuang Jiang, Jing Lu, Weiqiang Li, Weihua Liu, Guixia Zhou, Weixing Huang, Jin Tang, Yun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：PLOS COMPUTATIONAL BIOLOGY 2012
- 关键词：Cell culture - Complex networks - Computation theory - Drug interactions - Tensors
- Recent Advances in the Chemical Synthesis of C-Glycosides被引量：551收藏
- 作者：Yang, You Yu, Biao
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：CHEMICAL REVIEWS 2017
- 关键词：Glycosylation - Synthesis (chemical) - Cycloaddition - Metal complexes - Transition metals - Transition metal compounds
- FRET-Based Mito-Specific Fluorescent Probe for Ratiometric Detection and Imaging of Endogenous Peroxynitrite: Dyad of Cy3 and Cy5被引量：316收藏
- 作者：Jia, Xiaotong Chen, Qiangqiang Yang, Yingfang Tang, Yao Wang, Rui Xu, Yufang Zhu, Weiping Qian, Xuhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2016
- 关键词：Fluorescence spectroscopy - Probes
- A dual-response BODIPY-based fluorescent probe for the discrimination of glutathione from cystEIn and homocystEIn被引量：264收藏
- 作者：Wang, Feiyi Zhou, Li Zhao, Chunchang Wang, Rui Fei, Qiang Luo, Sihang Guo, Zhiqian Tian, He Zhu, Wei-Hong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2015
- 关键词：Cyclization - Probes - Covalent bonds - Fluorescence imaging - Peptides - Sulfur compounds
- Target identification among known drugs by deep learning from heterogeneous networks被引量：244收藏
- 作者：Zeng, Xiangxiang Zhu, Siyi Lu, Weiqiang Liu, Zehui Huang, Jin Zhou, Yadi Fang, Jiansong Huang, Yin Guo, Huimin Li, Lang Trapp, Bruce D. Nussinov, Ruth Eng, Charis Loscalzo, Joseph Cheng, Feixiong
- 机构：Hunan Univ;Xiamen Univ;East China Normal Univ;East China Normal Univ;East China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2020
- 关键词：Network embeddings - Deep learning - Genome
- Enhancing the Enrichment of Pharmacophore-Based Target Prediction for the Polypharmacological Profiles of Drugs被引量：236收藏
- 作者：Wang, Xia Pan, Chenxu Gong, Jiayu Liu, Xiaofeng Li, Honglin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2016
- 关键词：Drug interactions - Probability distributions - Query processing - Forecasting
- Graphene quantum dots/gold electrode and its application in living cell H2O2 detection被引量：236收藏
- 作者：Zhang, Yan Wu, Congyu Zhou, Xuejiao Wu, Xiaochen Yang, Yongqiang Wu, Haixia Guo, Shouwu Zhang, Jingyan
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：NANOSCALE 2013
- 关键词：Graphene - Semiconductor quantum dots - Gold compounds - Nanocrystals
- Insight into the Cellular Internalization and Cytotoxicity of Graphene Quantum Dots被引量：185收藏
- 作者：Wu, Congyu Wang, Chong Han, Ting Zhou, Xuejiao Guo, Shouwu Zhang, Jingyan
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：ADVANCED HEALTHCARE MATERIALS 2013
- 关键词：cellular internalization cytotoxicity distribution graphene quantum dots
- Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian-Cancer-Specific γ-Glutamyltranspeptidase被引量：184收藏
- 作者：Wang, Feiyi Zhu, Ying Zhou, Li Pan, Liang Cui, Zhifen Fei, Qiang Luo, Sihang Pan, Dun Huang, Qing Wang, Rui Zhao, Chunchang Tian, He Fan, Chunhai
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2015
- 关键词：aromatic hydrocarbon transfer enzymes fluorescence photophysics tumor cells
- Direct Asymmetric Synthesis of β-Bis-Aryl-α-Amino Acid Esters via Enantioselective Copper-Catalyzed Addition of p-Quinone Methides被引量：170收藏
- 作者：He, Fu-Sheng Jin, Jing-Hai Yang, Zhong-Tao Yu, Xingxin Fossey, John S. Deng, Wei-Ping
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ Birmingham
- 来源：ACS CATALYSIS 2016
- 关键词：unnatural alpha-amino acids asymmetric catalysis copper conjugate addition para-quinone methides
- In silico Prediction of Chemical Ames Mutagenicity被引量：168收藏
- 作者：Xu, Congying Cheng, Feixiong Chen, Lei Du, Zheng Li, Weihua Liu, Guixia Lee, Philip W. Tang, Yun
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2012
- 关键词：Decision trees - Forecasting - Neural networks - Nearest nEIghbor search
- A Three-Channel Fluorescent Probe That Distinguishes Peroxynitrite from Hypochlorite被引量：167收藏
- 作者：Zhang, Quanjuan Zhu, Zhichuan Zheng, Yongli Cheng, Jiagao Zhang, Na Long, Yi-Tao Zheng, Jing Qian, Xuhong Yang, Youjun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2012
- 关键词：Fluorescence - Probes
- Network-Based Methods and ThEIr Applications in Drug Discovery被引量：166收藏
- 作者：Yu, Zhuohang Wu, Zengrui Wang, Ze Wang, Yimeng Zhou, Moran Li, Weihua Liu, Guixia Tang, Yun
- 机构： Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism
- 来源：Journal of Chemical Information and Modeling 2024
- Chemical biotechnology for plant protection被引量：157收藏
- 作者：Zhao, Zhenjiang Xu, Yufang Qian, Xuhong
- 机构： Shanghai Key Laboratory of New Drug Design; Shanghai Key Laboratory of Chemical Biology
- 来源：RSC Green Chemistry 2015
- Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis被引量：157收藏
- 作者：Sun, Lingna Fan, Mingrui Huang, Dong Li, Bingqin Xu, Ruoting Gao, Feng Chen, Yanzuo
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS 2021
- 关键词：Pulmonary fibrotic therapy Exosomes Liposomes Macrophages depletion Fibrosis penetration
- Dynamic Kinetic Resolution of Biaryl Lactones via a Chiral Bifunctional Amine Thiourea-Catalyzed Highly Atropoenantioselective Transesterification被引量：157收藏
- 作者：Yu, Chenguang Huang, He Li, Xiangmin Zhang, Yueteng Wang, Wei
- 机构：Univ New Mexico;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2016
- 关键词：Enantioselectivity - Transesterification - Esters
- In Silico Prediction of Chemical Acute Oral Toxicity Using MultiClassification Methods被引量：147收藏
- 作者：Li, Xiao Chen, Lei Cheng, Feixiong Wu, Zengrui Bian, Hanping Xu, Congying Li, Weihua Liu, Guixia Shen, Xu Tang, Yun
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2014
- 关键词：Risk assessment - Binary trees - Decision trees - Nearest nEIghbor search - Environmental Protection Agency - Barium compounds - Support vector machines
- Bright, Stable, and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near-Infrared Spectral Region被引量：142收藏
- 作者：Lei, Zuhai Li, Xinran Luo, Xiao He, Haihong Zheng, Jing Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2017
- 关键词：fluorophores imaging near-infrared
- The same oxygenation-state introduction of hypervalent sulfur under transition-metal-free conditions被引量：141收藏
- 作者：Zeng, Daming Wang, Ming Deng, Wei-Ping Jiang, Xuefeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Normal Univ
- 来源：ORGANIC CHEMISTRY FRONTIERS 2020
- 关键词：Fluorine compounds - Sulfur compounds - Oxygenation - Transition metals - Amides
- Direct Arylation of α-Amino C(sp3)-H Bonds by Convergent Paired Electrolysis被引量：132收藏
- 作者：Ma, Yueyue Yao, Xiantong Zhang, Lei Ni, Pufan Cheng, Ruihua Ye, Jinxing
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2019
- 关键词：arylation cross-coupling C-H activation electrocatalysis tertiary amines
- Predicting physical stability of solid dispersions by machine learning techniques被引量：128收藏
- 作者：Han, Run Xiong, Hui Ye, Zhuyifan Yang, Yilong Huang, Tianhe Jing, Qiufang Lu, Jiahong Pan, Hao Ren, Fuzheng Ouyang, Defang
- 机构：Univ Macau;East China Univ Sci & Technol;Liaoning Univ
- 来源：JOURNAL OF CONTROLLED RELEASE 2019
- 关键词：Solid dispersion Physical stability Machine learning Molecular modeling
- Visible-Light-Promoted Nickel- and Organic-Dye-Cocatalyzed Formylation Reaction of Aryl Halides and Triflates and Vinyl Bromides with Diethoxyacetic Acid as a Formyl Equivalent被引量：126收藏
- 作者：Huang, He Li, Xiangmin Yu, Chenguang Zhang, Yueteng Mariano, Patrick S. Wang, Wei
- 机构：Univ New Mexico;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2017
- 关键词：flow chemistry formylation nickel catalysis photoredox catalysis synthetic methods
- Chemical bioengineering in plant cell culture被引量：121收藏
- 作者：Hu, Fengxian Xu, Yufang Zhao, Zhenjiang
- 机构： School of Biotechnology; Shanghai Key Laboratory of New Drug Design
- 来源：RSC Green Chemistry 2015
- Chemo- and Regioselective Organo-Photoredox Catalyzed Hydroformylation of Styrenes via a Radical Pathway被引量：119收藏
- 作者：Huang, He Yu, Chenguang Zhang, Yueteng Zhang, Yongqiang Mariano, Patrick S. Wang, Wei
- 机构：Univ New Mexico;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2017
- 关键词：Carboxylation - Catalysis - Regioselectivity - Hydroformylation - Free radicals - Styrene
- Surface Modified with a Host Defense Peptide-Mimicking β-Peptide Polymer Kills Bacteria on Contact with High Efficacy被引量：118收藏
- 作者：Qian, Yuxin Qi, Fan Chen, Qi Zhang, Qiang Qiao, Zhongqian Zhang, Si Wei, Ting Yu, Qian Yu, Shan Mao, Zhengwei Gao, Changyou Ding, Yiru Cheng, Yanyong Jin, Chenyu Xie, Hexin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2018
- 关键词：beta-peptide polymer graft to antimicrobial surface divalent ion membrane destabilization biocompatible surface antimicrobial resistance MRSA
- Eu(OTf)3-Catalyzed Formal Dipolar [4π+2σ] Cycloaddition of Bicyclo-[1.1.0]butanes with Nitrones: Access to Polysubstituted 2-Oxa-3-azabicyclo[3.1.1]heptanes被引量：113收藏
- 作者：Zhang, Jian Su, Jia-Yi Zheng, Hanliang Li, Hao Deng, Wei-Ping
- 机构：Zhejiang Normal Univ;East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024
- 关键词：Bicyclic Compounds Bioisosteres Dipolar Cycloaddition Bicyclo[1.1.0]butanes Strained Molecules
- Palladium-Catalyzed Asymmetric [4+3] Cyclization of Trimethylenemethane: Regio-, Diastereo-, and Enantioselective Construction of Benzofuro[3,2-b]azepine Skeletons被引量：113收藏
- 作者：Liu, Yang-Zi Wang, Zhongao Huang, Zesheng Zheng, Xing Yang, Wu-Lin Deng, Wei-Ping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2020
- 关键词：[4+3] cyclization asymmetric catalysis chiral azepines cycloaddition palladium
- Effect of Lateral Size of Graphene Quantum Dots on ThEIr Properties and Application被引量：111收藏
- 作者：Zhang, Fangwei Liu, Fei Wang, Chong Xin, Xiaozhen Liu, Jingyuan Guo, Shouwu Zhang, Jingyan
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2016
- 关键词：graphene quantum dot gel electrophoresis lateral size photoluminescence
- Two-Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence被引量：109收藏
- 作者：Gao, Ying Hu, Yulu Liu, Qimeng Li, Xiaokang Li, Xinming Kim, Chu-Young James, Tony D. Li, Jian Chen, Xi Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Univ Texas El Paso;Univ Bath;Tongji Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2021
- 关键词：bioimaging fluorescent probes lysosomal pH senescence β -galactosidase
