成果/Result
- Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces被引量：143收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Chinese Acad Sci;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2020
- 关键词：Ketones - Metabolism - Biochemistry - Bacteria - Metabolites - Glycerol
- DNA Cleavage System of Nanosized Graphene Oxide Sheets and Copper Ions被引量：127收藏
- 作者：Ren, Hongliu Wang, Chong Zhang, Jiali Zhou, Xuejiao Xu, Dafeng Zheng, Jing Guo, Shouwu Zhang, Jingyan
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol
- 来源：ACS NANO 2010
- 关键词：graphene oxide DNA Intercalation DNA cleavage copper ion metal ions
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- Graphene quantum dots in photodynamic therapy被引量：49收藏
- 作者：Chen, Jiayi Wu, Wentian Zhang, Fangwei Zhang, Jiali Liu, Hui Zheng, Jing Guo, Shouwu Zhang, Jingyan
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：NANOSCALE ADVANCES 2020
- 关键词：Medical applications - Graphene - Irradiation - Photosensitizers - Nanocrystals - Semiconductor quantum dots - Aromatic compounds
- High-yield porphyrin production through metabolic engineering and biocatalysis被引量：34收藏
- 作者：Chen, Haihong Wang, Yaohong Wang, Weishan Cao, Ting Zhang, Lu Wang, Zhengduo Chi, Xuran Shi, Tong Wang, Huangwei He, Xinwei Liang, Mindong Yang, Mengxue Jiang, Wenyi Lv, Dongyuan Yu, Jiaming Zhu, Guoliang Xie, Yongtao Gao, Bei Wang, Xinye Liu, Xueting Li, Youyuan Ouyang, Limin Zhang, Jingyu Liu, Huimin Li, Zilong Tong, Yaojun Xia, Xuekui Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Catalysis - Diagnosis - Fermentation - Medical applications - Metabolic engineering
- Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：32收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Zhu, Guoliang Liu, Miaomiao Dai, Huanqin Hsiang, Tom Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;Chinese Acad Sci;East China Univ Sci & Technol;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Meroterpenoids Phytopathogenic fungus Bipolaris sorokiniana Genome-based mining Antimicrobial activity
- Coordination modes of bridge carboxylates in dinuclear manganese compounds determine thEIr catalase-like activities被引量：31收藏
- 作者：Jiang, Xiaojun Liu, Hui Zheng, Bing Zhang, Jingyan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：DALTON TRANSACTIONS 2009
- 关键词：Catalyst activity - Carboxylation - Manganese compounds - Ions - Electron spin resonance spectroscopy - Deprotonation - X ray diffraction
- A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137被引量：24收藏
- 作者：Zhang, Jingyu Li, Bixiao Qin, Yujie Karthik, Loganathan Zhu, Guoliang Hou, Chengjian Jiang, Lan Liu, Miaomiao Ye, Xin Liu, Mei Hsiang, Tom Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Sri Shakthi Inst Engn & Technol Autonomous;Griffith Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Abyssomicin Proximicin Marine-derived Verrucosispora sp OSMAC Anti-influenza A virus
- Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：23收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Liu, Miaomiao Hu, Jiansen Hou, Chengjian Zhu, Guoliang Jiang, Lan Xia, Xuekui Quinn, Ronald J. Feng, Yunjiang Zhang, Lixin Hsiang, Tom Liu, Xueting
- 机构：Chinese Acad Sci;Griffith Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Genome-based mining Halogenase Phytopathogenic fungus Bipolaris sorokiniana Antibacterial activity
- Recent advances in biotechnology for marine enzymes and molecules被引量：21收藏
- 作者：Zhang, Jingyu Jiang, Lan Chen, Xiangyin Lv, Kangjie Basiony, Mostafa Zhu, Guoliang Karthik, Loganathan Ouyang, Liming Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Synthetic biology - Ecosystems - Metabolic engineering - Marine applications - Molecules
- Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins被引量：18收藏
- 作者：Zhu, Guoliang Hou, Chengjian Yuan, Weize Wang, Zhenzhen Zhang, Jingyu Jiang, Lan Karthik, Loganathan Li, Bixiao Ren, Biao Lv, Kangjie Lu, Wanying Cong, Zhanren Dai, Huanqin Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd;Sichuan Univ;Sichuan Univ;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2020
- 关键词：Biochemistry - Chirality
- Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128被引量：18收藏
- 作者：Jiang, Lan Huang, Pei Ren, Biao Song, Zhijun Zhu, Guoliang He, Wenni Zhang, Jingyu Oyeleye, Ayokunmi Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Zunyi Med Univ;Sichuan Univ;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Marine-derived Actinomycete Candida albicans Polyene Cyclic peptides
- Study of Pharmacokinetics for Ivermectin B1a from Beagle Dogs被引量：17收藏
- 作者：Chen, Yuyang Huang, Xiaofang Guo, Zizheng Zhang, Jingyu Zhang, Lixin Dai, Renke
- 机构： School of Pharmacy; Guangdong Ruigu Biotech Corporation; State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Chromatographic Science 2025
- 关键词：Controlled drug delivery - Coronavirus - Pharmacokinetics - Pulmonary diseases
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi被引量：15收藏
- 作者：Jiang, Lan Zhu, Guoliang Han, Jianying Hou, Chengjian Zhang, Xue Wang, Zhixin Yuan, Weize Lv, Kangjie Cong, Zhanren Wang, Xinye Chen, Xiangyin Karthik, Loganathan Yang, Huanting Wang, Xuyuan Tan, Gaoyi Liu, Guang Zhao, Liya Xia, Xuekui Liu, Xiangyang Gao, Shushan Ma, Lei Liu, Mei Ren, Biao Dai, Huanqin Quinn, Ronald J. Hsiang, Tom Zhang, Jingyu Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Griffith Univ;Qilu Univ Technol;T3 Biosci LLC
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Fungi Bifunctional terpene synthases Terpenoids Anti-inflammatory
- OvoAMtht from Methyloversatilis thermotolerans ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities被引量：14收藏
- 作者：Cheng, Ronghai Weitz, Andrew C. Paris, Jared Tang, Yijie Zhang, Jingyu Song, Heng Naowarojna, Nathchar Li, Kelin Qiao, Lu Lopez, Juan Grinstaff, Mark W. Zhang, Lixin Guo, Yisong Elliott, Sean Liu, Pinghua
- 机构：Boston Univ;Carnegie Mellon Univ;East China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2022
- 关键词：Enzymes - Amino acids - Biochemistry - Electronic properties - Iron - Porphyrins
- Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert-isolated rare actinomycete Nocardia sp. XJ31被引量：12收藏
- 作者：Zhang, Li Zhang, Jingyu Ren, Biao Lu, Wanying Hou, Chengjian Wang, Jian Ma, Xiaolong Ma, Rong Liu, Mei Liu, Zhiheng Li, Jin-Ping Ding, Kan Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Boston Univ;Sichuan Univ;Sichuan Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Xinjiang desert Nocardiasp Anti-BCG Brasiliquinone Nocardimicin
- Separating graphene quantum dots by lateral size through gel column chromatography被引量：10收藏
- 作者：Wu, Wentian Cao, Jiamin Zhong, Min Wu, Haixia Zhang, Fangwei Zhang, Jingyan Guo, Shouwu
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：RSC ADVANCES 2019
- 关键词：Organic solar cells - Semiconductor quantum dots - Column chromatography - Graphene - Separation - Oxidation
- Direct evidence for the role of imidazole in disproportionation of hydrogen peroxide by a mononuclear manganese salen complex被引量：8收藏
- 作者：Li, Rong Tian, Jinlei Liu, Hui Yan, Shiping Guo, Shouwu Zhang, Jingyan
- 机构：E China Univ Sci & Technol;Nankai Univ;Shanghai Jiao Tong Univ
- 来源：TRANSITION METAL CHEMISTRY 2011
- 关键词：Ultraviolet visible spectroscopy - Synthesis (chemical) - Manganese compounds - Oxidation - Catalyst activity - Ligands - X ray diffraction
- Increased surface charge in the protEIn chaperone Spy enhances its anti-aggregation activity被引量：7收藏
- 作者：He, Wei Zhang, Jiayin Sachsenhauser, Veronika Wang, Lili Bardwell, James C. A. Quan, Shu
- 机构：East China Univ Sci & Technol;Univ Michigan
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2020
- 关键词：molecular chaperone Spy protEIn engineering protEIn aggregation electrostatic interaction hydrophobic interaction kinetics protEIn folding conformational change chaperone-substrate interaction
- Taming Highly Enolizable Aldehydes via Enzyme Catalysis for Enantiocomplementary Construction of β-Hydroxyphosphonates被引量：7收藏
- 作者：Li, Huangong Zhu, Zheng Wu, Dongqi Ju, Yongyuan Li, Dan Zou, Keke Zhu, Chaonan Zhang, Jingyu Zhu, Guoliang Zhang, Lixin Chi, Yonggui Robin Xie, Yongtao
- 机构：East China Univ Sci & Technol;Nanyang Technol Univ;Guizhou Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2025
- 关键词：Catalysis - Enantioselectivity
- Scalable secondary metabolite production in Streptomyces using a plug-and-play system被引量：5收藏
- 作者：Yang, Bowen Li, Zilong Zhang, Jingyu Qiu, Shiwen Liu, Xueting Liang, Zonglin Yan, Hao Zhang, Yanyan Liu, Lihong Xia, Bing Bao, Lianqun Li, Defeng Zhou, Shanshan Corre, Christophe Zhang, Chengyu Lu, Yinhua Tan, Gao-Yi Xia, Xuekui Li, Shanshan Zhang, Lixin Wang, Weishan
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Chinese Acad Sci;Beijing Key Lab Genet Element Biosourcing & Intell;Chinese Acad Agr Sci
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Biomolecules - Strain
- G2 Helix as the Plastic Region Modulating Diastereoselectivity of Cyclization in Fungal Bifunctional Sesterterpene Synthases被引量：2收藏
- 作者：Zhang, Weiyan Xu, Kangwei Lan, Keying Xu, Wujue Peng, Kaitong Lv, Kangjie Zhang, Yanye Zhang, Jingyu Nie, Shaoping Jiang, Yi Hsiang, Tom Zhang, Lixin Wu, Ruibo Liu, Xueting
- 机构：East China Univ Sci & Technol;Sun Yat Sen Univ;Nanchang Univ;Yunnan Univ;Univ Guelph
- 来源：ACS CATALYSIS 2025
- 关键词：G2 helix fungal sesterterpenesynthase diastereoselectivity mutagenesis conformational flexibility
- Rational spatial rewiring of key enzymes enhances α-santalene production in Saccharomyces cerevisiae被引量：2收藏
- 作者：Tan, Wenwen Tong, Shengkun Gao, Yaojie Wang, Jing Zhang, Jingyu Xie, Zhiping Dai, Huanqin Liang, Yu Tan, Gao-Yi Zhang, Lixin Tong, Yaojun
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：BIORESOURCE TECHNOLOGY 2025
- 关键词：Subcellular enzyme localization Spatial engineering alpha-Santalene Saccharomyces cerevisiae Metabolic engineering Synthetic biology
- Silk Sericin-inspired Poly-β-homoserine for ProtEIn Protection被引量：0收藏
- 作者：Zhang, Jun-Yu Cai, Jia-Yi Zhang, Dong-Hui Liu, Long-Qiang Zhi, Zhong-Hua Li, Bing Chen, Qi Liu, Run-Hui
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Fudan Univ
- 来源：CHINESE JOURNAL OF POLYMER SCIENCE 2026
- 关键词：Silk sericin Poly-
beta -homoserine ProtEIn protection Stabilizer Ring-opening polymerization
- DNA硫修饰结合蛋白识别序列的表征与拓展促进新型核酸检测技术发展被引量：0收藏
- 作者：帅玉婷 许安安 李甲乙 韩照晰 马蒂尼 段海容 王馨叶 蒋岚 张敬宇 谭高翼 刘雪婷 赵一雷 童垚俊 王申林 贺新义 邓子新 刘光 张立新
- 机构：East China Univ Sci & Technol ECUST;Shanghai Jiao Tong Univ
- 来源：《Science Bulletin》 2023
- 关键词：核酸检测技术 限制性核酸内切酶 SBD 序列模式 识别序列 防御系统 硫原子 抗氧化应激
- 摘要：DNA硫修饰是一种DNA磷酸骨架上的非桥接氧原子被硫原子所取代的修饰,属于原核生物表观遗传标志物之一,它对细菌防御系统、抗氧化应激和基因调控等生命过程具有重要影响.DNA硫修饰可以被硫修饰依赖限制性核酸内切酶的硫结合域S...
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- Reprogramming ThDP Enzymes for Z-Alkenes: Overriding Thermodynamic Preference via Noncovalent Controls被引量：0收藏
- 作者：Li, Huangong Yang, Tairan Zhao, Yilong Pan, Rui Peng, Jinmin Lai, Yinhong Zhang, Jingyu Liu, Xueting Zhu, Guoliang Zhang, Lixin Chi, Yonggui Robin Xie, Yongtao
- 机构：East China Univ Sci & Technol;Nanyang Technol Univ;Guizhou Univ;Chinese Acad Sci
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2026
- 关键词：C (programming language) - Chelation - Chemical bonds - Complexation - Dehalogenation - Enzymes - Ligands - Plants (botany) - Scaffolds - Stereochemistry - Thermodynamics
- Publisher Correction: Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces (Nature Biotechnology, (2020), 38, 1, (76-83), 10.1038/s41587-019-0335-4)被引量：-1收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构： State Key Laboratory of Microbial Resources; State Key Laboratory of Bioreactor Engineering; State Key Laboratory for Biology of Plant Diseases and Insect Pests; State Key Laboratory of Molecular Developmental Biology; Key Biosensor Laboratory of Shandong Province
- 来源：Nature Biotechnology 2020
