成果/Result
- Influence of High Solid Concentration on Enzymatic Hydrolysis and Fermentation of Steam-Exploded Corn Stover Biomass被引量：148收藏
- 作者：Lu, Yifeng Wang, Yonghong Xu, Guoqian Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2010
- 关键词：Bioethanol Corn stover High solid concentration Enzymatic hydrolysis Fermentation
- Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces被引量：143收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Chinese Acad Sci;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2020
- 关键词：Ketones - Metabolism - Biochemistry - Bacteria - Metabolites - Glycerol
- Optimization of cellulase mixture for efficient hydrolysis of steam-exploded corn stover by statistically designed experiments被引量：112收藏
- 作者：Zhou, Jin Wang, Yong-Hong Chu, Ju Luo, Ling-Zhi Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：E China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2009
- 关键词：Cellulase mixture Optimization Steam-exploded corn stover Statistically designed experiments Bioethanol
- Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment被引量：61收藏
- 作者：Xia, Jian-Ye Wang, Yong-Hong Zhang, Si-Liang Chen, Ning Yin, Peng Zhuang, Ying-Ping Chu, Ju
- 机构：E China Univ Chem Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2009
- 关键词：Dissolved oxygen Fluid mechanics Gas-liquid mass transfer Mixing Mycelia fermentation Shear environment
- Flow Pattern, Mixing, Gas Hold-Up and Mass Transfer Coefficient of Triple-Impeller Configurations in Stirred Tank Bioreactors被引量：60收藏
- 作者：Xie, Minghui Xia, Jianye Zhou, Zhen Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2014
- 关键词：Gases - Liquids - Mixing - Pumps - Turbine components - Flow patterns - Mass transfer - Turbomachine blades - Velocity
- Screening endogenous signal peptides and protEIn folding factors to promote the secretory expression of heterologous protEIns in Pichia pastoris被引量：59收藏
- 作者：Duan, Guangdong Ding, Lumei Wei, Dongsheng Zhou, Hangcheng Chu, Ju Zhang, Siliang Qian, Jiangchao
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2019
- 关键词：Signal peptides Folding factors Pichia pastoris Heterologous protEIn Secretory expression
- Progress in the research of S-adenosyl-L-methionine production被引量：59收藏
- 作者：Chu, Ju Qian, Jiangchao Zhuang, Yingping Zhang, Siliang Li, Yourong
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2013
- 关键词：S-adenosyl-L-methionine L-Methionine ATP L-Methionine adenosyltransferase Pichia pastoris
- Industrial bioprocess control and optimization in the context of systems biotechnology被引量：56收藏
- 作者：Wang, Yong Chu, Ju Zhuang, Yingping Wang, Yonghong Xia, Jianye Zhang, Siliang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology Advances 2009
- Enhancement of phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5 using a novel strategy - shaking and extra-light supplementation approach被引量：52收藏
- 作者：Li, Xu Wang, Yong-Hong Zhang, Si-Liang Chu, Ju Zhang, Ming Huang, Ming-Zhi Zhuang, Ying-Ping
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：International Journal of Hydrogen Energy 2009
- 关键词：Image enhancement - Production efficiency
- Application of Euler-Lagrange CFD for quantitative evaluating the effect of shear force on Carthamus tinctorius L. cell in a stirred tank bioreactor被引量：49收藏
- 作者：Liu, Yu Wang, Ze-Jian Xia, Jian-Ye Haringa, Cees Liu, Ya-Ping Chu, Ju Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：East China Univ Sci & Technol;Dalian Pract Biotechnol Co Ltd;Delft Univ Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2016
- 关键词：Plant cell culture Fluid mechanics Agitation Power consumption C tinctorius L. cell Stress thresholds
- CFD analysis of the turbulent flow in baffled shake flasks被引量：49收藏
- 作者：Li, Chao Xia, Jian-Ye Chu, Ju Wang, Yong-Hong Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：E China Univ Sci & Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2013
- 关键词：Shake flask Hydrodynamics Mass transfer Mixing Shear force Power consumption
- Multiple propionyl coenzyme a-supplying pathways for production of the bioplastic poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) in Haloferax mediterranEI被引量：49收藏
- 作者：Han, Jing Hou, Jing Zhang, Fan Ai, Guomin Li, Ming Cai, Shuangfeng Liu, Hailong Wang, Lei Wang, Zejian Zhang, Siliang Cai, Lei Zhao, Dahe Zhou, Jian Xiang, Hua
- 机构： State Key Laboratory of Microbial Resources; University of Chinese Academy of Sciences; Beijing Institute of Genomics; State Key Laboratory of Bioreactor Engineering; University of Massachusetts
- 来源：Applied and Environmental Microbiology 2013
- 关键词：Biochemistry - REInforced plastics - Coenzymes - Genes - Monomers
- Power consumption, local and average volumetric mass transfer coefficient in multiple-impeller stirred bioreactors for xanthan gum solutions被引量：48收藏
- 作者：Xie, Ming-hui Xia, Jian-ye Zhou, Zhen Zhou, Guo-zhong Chu, Ju Zhuang, Ying-ping Zhang, Si-liang Noorman, Henk
- 机构：E China Univ Sci & Technol;Wenzhou Great Wall Mixer Design Inst;DSM Biotechnol Ctr
- 来源：CHEMICAL ENGINEERING SCIENCE 2014
- 关键词：Power Mass transfer Xanthan gum Non-Newtonian fluid Impeller combination
- Understanding the effect of forEIgn gene dosage on the physiology of Pichia pastoris by transcriptional analysis of key genes被引量：47收藏
- 作者：Zhu, Taicheng Guo, Meijin Zhuang, Yingping Chu, Ju Zhang, Siliang
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2011
- 关键词：Gene dosage Pichia pastoris Methanol metabolism Cell physiology mRNA quantitative analysis
- Combined 13C-assisted metabolomics and metabolic flux analysis reveals the impacts of glutamate on the central metabolism of high β-galactosidase-producing Pichia pastoris被引量：45收藏
- 作者：Liu, Ping Huang, Mingzhi Guo, Menglei Qian, Jiangchao Lin, Weilu Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresources and Bioprocessing 2016
- 关键词：Gene expression - Physiology - Recombinant protEIns - Yeast
- GAP promoter library for fine-tuning of gene expression in Pichia pastoris被引量：45收藏
- 作者：Qin, Xiulin Qian, Jiangchao Yao, Gaofeng Zhuang, Yingping Zhang, Siliang Chu, Ju
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Applied and Environmental Microbiology 2011
- 关键词：Transcription - Amino acids - Fluorescence - Enzyme activity
- High efficient production of recombinant human consensus interferon mutant in high cell density culture of Pichia pastoris using two phases methanol control被引量：45收藏
- 作者：Wu, Dan Chu, Ju Hao, Yu-You Wang, Yong-Hong Zhuang, Ying-Ping Zhang, Si-Liang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Process Biochemistry 2011
- 关键词：Aggregates - Physiology - Methanol - Batch cell culture - Covalent bonds - Growth rate - Quality control - Cell proliferation - Sulfur compounds - Yeast - GlycoprotEIns - Recombinant protEIns
- Enhancement of phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5 using fed-batch operation based on ORP level被引量：44收藏
- 作者：Li, Xu Dai, Zhen-Zhen Wang, Yong-Hong Zhang, Si-Liang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：International Journal of Hydrogen Energy 2011
- 关键词：Efficiency - Redox reactions - Batch cell culture - Batch data processing - Photobioreactors - Feedback control - Fermentation - Image enhancement
- Optimization of l-methionine feeding strategy for improving S-adenosyl-l-methionine production by methionine adenosyltransferase overexpressed Pichia pastoris被引量：39收藏
- 作者：Hu, Hui Qian, Jiangchao Chu, Ju Wang, Yonghong Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2009
- 关键词：S-adenosyl-L-methionine Methionine adenosyltransferase L-methionine Pichia pastoris ATP
- Toward improvement of erythromycin a production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination被引量：39收藏
- 作者：Wu, Jiequn Zhang, Qinglin Deng, Wei Qian, Jiangchao Zhang, Siliang Liu, Wen
- 机构： State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Bioorganic and Natural Products Chemistry
- 来源：Applied and Environmental Microbiology 2011
- 关键词：DNA sequences - Antibiotics - Biochemistry - Oxygen supply
- Improved vitamin B12 production by step-wise reduction of oxygen uptake rate under dissolved oxygen limiting level during fermentation process被引量：38收藏
- 作者：Wang, Ze-Jian Wang, Hui-Yuan Li, Yong-Liang Chu, Ju Huang, Ming-Zhi Zhuang, Ying-Ping Zhang, Si-Liang
- 机构： State Key Laboratory of Bioreactor Engineering; Shijiazhuang Pharma
- 来源：Bioresource Technology 2010
- 关键词：Fermentation - Bacteria - Biosynthesis - Cell growth - Process control - Oxygen supply - Biochemistry - Growth kinetics
- In silico analysis and experimental improvement of taxadiene heterologous biosynthesis in Escherichia coli被引量：37收藏
- 作者：Meng, Hailin Wang, Yong Hua, Qiang Zhang, Siliang Wang, Xiaoning
- 机构： School of Bioscience and Bioengineering; Key Laboratory of Synthetic Biology; State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology and Bioprocess Engineering 2011
- 关键词：Thermodynamic properties - Chromosomes - Lipids - Escherichia coli - Biochemistry
- Enhancement of erythromycin A production with feeding available nitrogen sources in erythromycin biosynthesis phase被引量：36收藏
- 作者：Zou, Xiang Hang, Hai-feng Chu, Ju Zhuang, Ying-ping Zhang, Si-liang
- 机构：E China Univ Sci & Technol;Southwest Univ
- 来源：BIORESOURCE TECHNOLOGY 2009
- 关键词：Available nitrogen sources Biosynthesis phase Erythromycin A Industrial scale Scale up
- Effects of light/dark cycle, mixing pattern and partial pressure of H2 on biohydrogen production by Rhodobacter sphaeroides ZX-5被引量：35收藏
- 作者：Li, Xu Wang, Yonghong Zhang, Siliang Chu, Ju Zhang, Ming Huang, Mingzhi Zhuang, Yingping
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2011
- 关键词：Fermentation - Substrates - Mixing - Partial pressure - Image enhancement
- Molecular cloning and functional characterization of an ATP-binding cassette transporter OtrC from Streptomyces rimosus被引量：34收藏
- 作者：Yu, Lan Yan, Xiangyun Wang, Long Chu, Ju Zhuang, Yingping Zhang, Siliang Guo, Meijin
- 机构： State Key Laboratory of Bioreactor Engineering; School of Life and Science
- 来源：BMC Biotechnology 2012
- 关键词：Clone cells - Cloning - Escherichia coli
- 人工神经网络在红霉素发酵过程状态预估中的应用被引量：34收藏
- 作者：黄明志 杭海峰 储炬 叶勤 张嗣良
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《华东理工大学学报（自然科学版）》 2000
- 关键词：神经网络 BP网络 RBF网络 红霉素 发酵 状态预估
- 摘要：探索了动态 BP网络和 RBF网络在红霉素发酵过程状态预估中的应用 ,比较了它们的收敛速度和学习能力。结果表明 ,BP网络和 RBF网络都具有相当好的学习能力 ,但 RBF网络的收敛速度更快。训练好的神经网络 ,在红霉素...
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- Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation被引量：33收藏
- 作者：Chen, Yun Deng, Wei Wu, Jiequn Qian, Jiangchao Chu, Ju Zhuang, Yingping Zhang, Siliang Liu, Wen
- 机构： State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Bioorganic and Natural Product Chemistry; Shanghai Institute of Organic Chemistry
- 来源：Applied and Environmental Microbiology 2008
- 关键词：Biosynthesis - Fermentation - Microbiology
- DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-l-methionine production in Pichia pastoris被引量：32收藏
- 作者：Hu, Hui Qian, Jiangchao Chu, Ju Wang, Yong Zhuang, Yingping Zhang, Siliang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Biotechnology 2009
- 关键词：Escherichia coli - Yeast - Amino acids - Genes - Enzyme activity
- Production and purification of a novel thermostable phytase by Pichia pastoris FPHY34被引量：32收藏
- 作者：Guo, Mei-Jin Zhuang, Ying-Ping Chu, Ju Zhang, Si-Liang Xiong, Ai-Sheng Peng, Ri-He Yao, Quan-Hong
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Biotechnology; Research Centre for Agro-Biotechnology
- 来源：Process Biochemistry 2007
- 关键词：Cell growth - DNA - Fermenters - Genetic engineering - Methanol - Microfiltration - Thermodynamic stability
- Effects of vitamins on the lactic acid biosynthesis of Lactobacillus paracasEI NERCB 0401被引量：32收藏
- 作者：Xu, Guo-Qian Chu, Ju Zhuang, Ying-Ping Wang, Yong-Hong Zhang, Si-Liang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biochemical Engineering Journal 2008
- 关键词：Bacteria - Biosynthesis - Concentration (process) - Enzymes - Fermentation - Lactic acid - Surface analysis
