成果/Result
- Synergistic Combination of Bioactive Hydroxyapatite Nanoparticles and the Chemotherapeutic Doxorubicin to Overcome Tumor Multidrug Resistance被引量：62收藏
- 作者：Dong, Xiulin Sun, Yi Li, Yuanyuan Ma, Xiaoyu Zhang, Shuiquan Yuan, Yuan Kohn, Joachim Liu, Changsheng Qian, Jiangchao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Rutgers State Univ
- 来源：SMALL 2021
- 关键词：anti‐ tumor activity bioactivity hydroxyapatite nanoparticles mitochondrial Ca (2+) overload multidrug resistance reversal
- In Vivo Visualization of γ-Glutamyl Transpeptidase Activity with an Activatable Self-Immobilizing Near-Infrared Probe被引量：56收藏
- 作者：Li, Yuyao Xue, Chenghong Fang, Zhijun Xu, Weipan Xie, Hexin
- 机构：East China Univ Sci & Technol
- 来源：ANALYTICAL CHEMISTRY 2020
- 关键词：Mammals - Quinone - Enzyme activity - Probes - Cytology - Infrared devices
- A self-immobilizing near-infrared fluorogenic probe for sensitive imaging of extracellular enzyme activity in vivo被引量：54收藏
- 作者：Li, Yuyao Song, Heng Xue, Chenghong Fang, Zhijun Xiong, Liqin Xie, Hexin
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：CHEMICAL SCIENCE 2020
- 关键词：Infrared devices - Quinone - Enzyme activity - Probes
- High-yield porphyrin production through metabolic engineering and biocatalysis被引量：34收藏
- 作者：Chen, Haihong Wang, Yaohong Wang, Weishan Cao, Ting Zhang, Lu Wang, Zhengduo Chi, Xuran Shi, Tong Wang, Huangwei He, Xinwei Liang, Mindong Yang, Mengxue Jiang, Wenyi Lv, Dongyuan Yu, Jiaming Zhu, Guoliang Xie, Yongtao Gao, Bei Wang, Xinye Liu, Xueting Li, Youyuan Ouyang, Limin Zhang, Jingyu Liu, Huimin Li, Zilong Tong, Yaojun Xia, Xuekui Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Catalysis - Diagnosis - Fermentation - Medical applications - Metabolic engineering
- Enzyme-Activatable Near-Infrared Photosensitizer with High Enrichment in Tumor Cells Based on a Multi-Effect Design被引量：27收藏
- 作者：Li, Yuyao Zhang, Chaoying Wu, Qingyi Peng, Yan Ding, Yiru Zhang, Zhengwei Xu, Xiaoyong Xie, Hexin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024
- 关键词：Enzyme-Activatable Fluorescence Probe Photosensitizer Quinone Methide Tumor
- Genome-scale modeling forBacillus coagulansto understand the metabolic characteristics被引量：27收藏
- 作者：Chen, Yu Sun, Yan Liu, Zhihao Dong, Fengqing Li, Yuanyuan Wang, Yonghong
- 机构：East China Univ Sci & Technol;Chalmers Univ Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2020
- 关键词：Bacillus coagulans chemostat constraint-based model lactic acid fermentation metabolic switch
- Metabolic engineering Corynebacterium glutamicum to produce triacylglycerols被引量：25收藏
- 作者：Plassmeier, Jens Li, Youyuan Rueckert, Christian Sinskey, Anthony J.
- 机构：MIT;E China Univ Sci & Technol;MIT
- 来源：METABOLIC ENGINEERING 2016
- 关键词：Corynebacterium glutamicum Metabolic engineering TAG biosynthesis Triacylglycerol Microbial lipids
- Controlled synthesis and transformation of nano-hydroxyapatite with tailored morphologies for biomedical applications被引量：25收藏
- 作者：Ma, Xiaoyu Li, Yuanyuan Wang, Chengwei Sun, Yi Ma, Yifan Dong, Xiuling Qian, Jiangchao Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2017
- 关键词：Microemulsions - Hydroxyapatite - Nanocomposites - Medical applications
- Phosphorylation of uridine and cytidine by uridine-cytidine kinase被引量：23收藏
- 作者：Qian, Yahui Ding, Qingbao Li, Yanyu Zou, Zhi Yan, Bingkun Ou, Ling
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2014
- 关键词：Uridine 5 '-monophosphate Cytidine 5 '-monophosphate Uridine-cytidine kinase Acetate kinase GTP-regeneration
- Metabolic profiling and flux distributions reveal a key role of acetyl-CoA in sophorolipid synthesis by Candida bombicola被引量：21收藏
- 作者：Yang, Linbing Li, Youyuan Zhang, Xinkai Liu, Ting Chen, Jun Wei, Liujing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2019
- 关键词：Sophorolipid Metabolic flux Metabolic profile Acetyl-CoA Candida bombicola Biosurfactant
- Highly Efficient Multiple-Labeling Probes for the Visualization of Enzyme Activities被引量：17收藏
- 作者：Song, Heng Li, Yuyao Chen, Yefeng Xue, Chenghong Xie, Hexin
- 机构：East China Univ Sci & Technol
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2019
- 关键词：alkaline phosphatase enzyme activity imaging immobilization quinone methide
- The Impact of Heat-Moisture Treatment on Physicochemical Properties and Retrogradation Behavior of Sweet Potato Starch被引量：12收藏
- 作者：Li, Yaoyao Liu, Shaowei Liu, Xue Tang, Xiaozhi Zhang, Jian
- 机构：East China Univ Sci & Technol;China Agr Univ;Coll Food Sci & Engn;Chinese Acad Sci;Shandong Marine Resource & Environm Res Inst
- 来源：INTERNATIONAL JOURNAL OF FOOD ENGINEERING 2017
- 关键词：sweet potato starch heat-moisture treatment physicochemical properties digestibility retrogradation
- One-pot process of 2'-deoxyguanylic acid catalyzed by a multi-enzyme system被引量：12收藏
- 作者：Li, Yanyu Ding, Qingbao Ou, Ling Qian, Yahui Zhang, Jiao
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2015
- 关键词：2 '-deoxyguanylic acid N-deoxyribosyltransferase purine nucleoside phosphorylase deoxyguanosine kinase acetate kinase
- CRISPR/Cas9-based toolkit for rapid marker recycling and combinatorial libraries in Komagataella phaffii被引量：10收藏
- 作者：Zhou, Wei Li, Yuanyi Liu, Guosong Qin, Weichuang Wei, Dongzhi Wang, Fengqing Gao, Bei
- 机构：East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2024
- 关键词：Komagataella phaffii CRISPR/Cas9 Visual marker recycling Multi-fragment integration Large DNA fragment knockout Yeast assembled libraries
- The rational modification of the secretion pathway: The bidirectional grinding strategy on signal peptide and SecA in Bacillus subtilis被引量：9收藏
- 作者：Jiang, Zidong Zhang, Lujia Zhou, Wei Li, Hui Li, Yuanyi Qin, Weichuang Wang, Fengqing Wei, Dongzhi Gao, Bei
- 机构：East China Univ Sci & Technol;East China Normal Univ;East China Univ Sci & Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2023
- 关键词：Bacillus subtilis Embedded-Model Signal peptide Secretory component SecA
- Cellulase mediated stress triggers the mutations of oleaginous yeast Trichosporon cutaneum with super-large spindle morphology and high lipid accumulation被引量：8收藏
- 作者：Liu, Qi Li, Yuanyuan Hou, Weiliang Zhang, Bin Bao, Jie
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY JOURNAL 2023
- 关键词：cell size cell wall structure cellulase microbial lipid oleaginous yeast
- HP-DO3A-based amphiphilic MRI contrast agents and relaxation enhancement through thEIr assembly with polyelectrolytes被引量：8收藏
- 作者：Zhu, Qin Yang, Heng Li, Yuanyuan Tian, Yu Wang, Wei Tang, Weijun Yuan, Yuan Hu, Aiguo
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2016
- 关键词：Self assembly - Gadolinium compounds - Light scattering - Mass spectrometry - Polyelectrolytes - Synthesis (chemical) - Salts - Solutions - Hydrophobicity
- Combination of protEIn engineering and metabolic engineering to enhance (+)-nootkatone production in Saccharomyces cerevisiae被引量：7收藏
- 作者：Guo, Jingyan Zhou, Wei Li, Yuanyi Qin, Weichuang Wei, Dongzhi Wang, Fengqing Gao, Bei
- 机构：East China Univ Sci & Technol
- 来源：FOOD BIOENGINEERING 2022
- 关键词：(+)-nootkatone (+)-valencene metabolic engineering protEIn engineering Saccharomyces cerevisiae
- Torulopsis glabrata 620在丙酮酸生物合成中的能荷变化和氧化-还原态趋势被引量：6收藏
- 作者：王翠华 李友元 陈长华 李啸
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《华东理工大学学报（自然科学版）》 2006
- 关键词：高效液相色谱法 丙酮酸 能荷 氧化-还原态
- 摘要：建立了用高效液相色谱法同时测定丙酮酸产生菌Toru lop sis g labrata 620中的ATP、ADP、AM P、NAD+和NADH的方法,从而描绘了在整个发酵过程中菌体的能荷变化和氧化-还原态趋势,指出菌体的...
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- Highly Sensitive In Vivo Imaging of Bacterial Infections with a Hydrophilicity-Switching, Self-Immobilizing, Near-Infrared Fluorogenic β-Lactamase Probe Enriched within Bacteria被引量：6收藏
- 作者：Chen, Fangfang Li, Yuyao Peng, Yan Zhu, Yifan He, Gao Zhang, Zhengwei Xie, Hexin
- 机构：East China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：ADVANCED SCIENCE 2025
- 关键词：beta-lactamases antibiotic resistance bacterial infections fluorescence probes in vivo imaging
- Arylamino-substituted Rhodamine as a Fluorogenic Molecular Rotor for the Wash-free Imaging of Non-catalytic ProtEIns in Live Cells被引量：2收藏
- 作者：Tang, Huiling Yuan, Xia Chen, Yefeng Li, Yuyao Xu, Xiaoyong Xie, Hexin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANALYSIS & SENSING 2024
- 关键词：live cell imaging molecular rotor protEIn integrin alpha(v)beta(3)
- Revealing the endogenous homoserine cycle for the effective methanol conversion in Pichia pastoris被引量：2收藏
- 作者：Li, Yuanyi Zhou, Wei Ling, Ruijing Hou, Shuting Zhang, Lujia Gao, Bei
- 机构：East China Univ Sci & Technol;East China Normal Univ
- 来源：PROCESS BIOCHEMISTRY 2024
- 关键词：Methanol Homoserine cycle Pichia pastoris beta-carotene
- Boosting ascomycin production by n-butanol addition in fermentation of Streptomyces hygroscopicus var. ascomyceticus ATCC 14891被引量：0收藏
- 作者：Meng, Jinyu Chen, Qi Li, Youyuan Gao, Shuhong Zhang, Daojing
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2025
- 关键词：Streptomyces hygroscopicus var. ascomyceticus Ascomycin n-butanol addition Reactive oxygen species FK520 biosynthesis precursors Gene transcriptional level
- fmpRPMF: A Web Implementation for ProtEIn Identification by Robust Peptide Mass Fingerprinting被引量：0收藏
- 作者：Li, Youyuan Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS 2018
- 关键词：Feature-matching pattern peptide mass fingerprinting protEIn identification support vector machines web service
