成果/Result
- Extensive translation of circular RNAs driven by N6-methyladenosine被引量：1514收藏
- 作者：Yang, Yun Fan, Xiaojuan Mao, Miaowei Song, Xiaowei Wu, Ping Zhang, Yang Jin, Yongfeng Yang, Yi Chen, Ling-Ling Wang, Yang Wong, Catherine C. L. Xiao, Xinshu Wang, Zefeng
- 机构：Zhejiang Univ;Chinese Acad Sci;UCLA;Univ Calif Los Angeles;Univ North Carolina Chapel Hill
- 来源：CELL RESEARCH 2017
- 关键词：N-6-methyladenosine circular RNA cap-independent translation eIF4G2
- Spatiotemporal control of gene expression by a light-switchable transgene system被引量：406收藏
- 作者：Wang, Xue Chen, Xianjun Yang, Yi
- 机构：E China Univ Sci & Technol
- 来源：NATURE METHODS 2012
- SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents被引量：321收藏
- 作者：Zhao, Yuzheng Hu, Qingxun Cheng, Feixiong Su, Ni Wang, Aoxue Zou, Yejun Hu, Hanyang Chen, Xianjun Zhou, Hai-Meng Huang, Xinzhi Yang, Kai Zhu, Qian Wang, Xue Yi, Jing Zhu, Linyong Qian, Xuhong Chen, Lixin Tang, Yun Loscalzo, Joseph Yang, Yi
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Tsinghua Univ
- 来源：CELL METABOLISM 2015
- Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress被引量：277收藏
- 作者：Oldham, William M. Clish, Clary B. Yang, Yi Loscalzo, Joseph
- 机构：Brigham & Womens Hosp;Harvard Univ;Broad Inst Massachusetts Inst Technol & Harvard U;E China Univ Sci & Technol;Brigham & Womens Hosp
- 来源：CELL METABOLISM 2015
- Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism被引量：269收藏
- 作者：Tao, Rongkun Zhao, Yuzheng Chu, Huanyu Wang, Aoxue Zhu, Jiahuan Chen, Xianjun Zou, Yejun Shi, Mei Liu, Renmei Su, Ni Du, Jiulin Zhou, Hai-Meng Zhu, Linyong Qian, Xuhong Liu, Haiyan Loscalzo, Joseph Yang, Yi
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Univ Sci & Technol China;Tsinghua Univ
- 来源：NATURE METHODS 2017
- Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress被引量：257收藏
- 作者：Wang, Yi-Ping Zhou, Li-Sha Zhao, Yu-Zheng Wang, Shi-Wen Chen, Lei-Lei Liu, Li-Xia Ling, Zhi-Qiang Hu, Fu-Jun Sun, Yi-Ping Zhang, Jing-Ye Yang, Chen Yang, Yi Xiong, Yue Guan, Kun-Liang Ye, Dan
- 机构：Fudan Univ;Fudan Univ;E China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：EMBO JOURNAL 2014
- 关键词：acetylation G6PD nicotinamide adenine dinucleotide phosphate reactive oxygen species SIRT2
- Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs被引量：249收藏
- 作者：Chen, Xianjun Zhang, Dasheng Su, Ni Bao, Bingkun Xie, Xin Zuo, Fangting Yang, Lipeng Wang, Hui Jiang, Li Lin, Qiuning Fang, Mengyue Li, Ningfeng Hua, Xin Chen, Zhengda Bao, Chunyan Xu, Jinjin Du, Wenli Zhang, Lixin Zhao, Yuzheng Zhu, Linyong Loscalzo, Joseph Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NATURE BIOTECHNOLOGY 2019
- 关键词：Cells - Enzyme kinetics - Fluorescence - Mammals - Cytology
- Genetically Encoded Fluorescent Sensors for Intracellular NADH Detection被引量：238收藏
- 作者：Zhao, Yuzheng Jin, Jing Hu, Qingxun Zhou, Hai-Meng Yi, Jing Yu, Zhenhang Xu, Lei Wang, Xue Yang, Yi Loscalzo, Joseph
- 机构：E China Univ Sci & Technol;Tsinghua Univ;Shanghai Jiao Tong Univ;China Natl Ctr Biotechnol Dev;Harvard Univ
- 来源：CELL METABOLISM 2011
- SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer被引量：226收藏
- 作者：Chen, Xiu-Fei Tian, Meng-Xin Sun, Ren-Qiang Zhang, Meng-Li Zhou, Li-Sha Jin, Lei Chen, Lei-Lei Zhou, Wen-Jie Duan, Kun-Long Chen, Yu-Jia Gao, Chao Cheng, Zhou-Li Wang, Fang Zhang, Jin-Ye Sun, Yi-Ping Yu, Hong-Xiu Zhao, Yu-Zheng Yang, Yi Liu, Wei-Ren Shi, Ying-Hong Xiong, Yue Guan, Kun-Liang Ye, Dan
- 机构：Shanghai Med Coll;Fudan Univ;Fudan Univ;Fudan Univ;Minist Educ
- 来源：EMBO REPORTS 2018
- 关键词：ACOX1 liver cancer oxidative stress SIRT5 succinylation
- An Artificial Molecular Shuttle Operates in Lipid Bilayers for Ion Transport被引量：182收藏
- 作者：Chen, Sujun Wang, Yichuan Nie, Ting Bao, Chunyan Wang, Chenxi Xu, Tianyi Lin, Qiuning Qu, Da-Hui Gong, Xueqing Yang, Yi Zhu, Linyong Tian, He
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2018
- 关键词：Molecular electronics - Ion exchange - Ions - Stochastic systems
- SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth被引量：167收藏
- 作者：Yang, Hui Zhou, Lisha Shi, Qian Zhao, Yuzheng Lin, Huaipeng Zhang, Mengli Zhao, Shimin Yang, Yi Ling, Zhi-Qiang Guan, Kun-Liang Xiong, Yue Ye, Dan
- 机构：Fudan Univ;E China Univ Sci & Technol;Zhejiang Prov Canc Hosp;Univ Calif San Diego;Univ Calif San Diego
- 来源：EMBO JOURNAL 2015
- 关键词：acetylation GOT2 malate-aspartate NADH shuttle pancreatic cancer
- Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces被引量：143收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Chinese Acad Sci;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2020
- 关键词：Ketones - Metabolism - Biochemistry - Bacteria - Metabolites - Glycerol
- A genome-wide positioning systems network algorithm for in silico drug repurposing被引量：136收藏
- 作者：Cheng, Feixiong Lu, Weiqiang Liu, Chuang Fang, Jiansong Hou, Yuan Handy, Diane E. Wang, Ruisheng Zhao, Yuzheng Yang, Yi Huang, Jin Hill, David E. Vidal, Marc Eng, Charis Loscalzo, Joseph
- 机构：Cleveland Clin;Case Western Reserve Univ;Case Western Reserve Univ;East China Normal Univ;East China Normal Univ
- 来源：NATURE COMMUNICATIONS 2019
- In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD+/NADH redox state被引量：136收藏
- 作者：Zhao, Yuzheng Wang, Aoxue Zou, Yejun Su, Ni Loscalzo, Joseph Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Harvard Med Sch
- 来源：NATURE PROTOCOLS 2016
- A redox mechanism underlying nucleolar stress sensing by nucleophosmin被引量：130收藏
- 作者：Yang, Kai Wang, Ming Zhao, Yuzheng Sun, Xuxu Yang, Yi Li, Xie Zhou, Aiwu Chu, Huilin Zhou, Hu Xu, Jianrong Wu, Mian Yang, Jie Yi, Jing
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Inst Mat Med;Shanghai Jiao Tong Univ
- 来源：NATURE COMMUNICATIONS 2016
- Charge-Reversal APTES-Modified Mesoporous Silica Nanoparticles with High Drug Loading and Release Controllability被引量：121收藏
- 作者：Wang, Yifeng Sun, Yi Wang, Jine Yang, Yang Li, Yulin Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2016
- 关键词：mesoporous silica nanocarriers charge reversal doxorubicin drug delivery pH responsive
- Selective and Ratiometric Fluorescent Trapping and Quantification of Protein Vicinal Dithiols and in Situ Dynamic Tracing in Living Cells被引量：119收藏
- 作者：Huang, Chusen Jia, Ti Tang, Mengfang Yin, Qin Zhu, Weiping Zhang, Chao Yang, Yi Jia, Nengqin Xu, Yufang Qian, Xuhong
- 机构：E China Univ Sci & Technol;Shanghai Normal Univ;Shanghai Normal Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2014
- 关键词：Sulfur compounds - Cell membranes - Fluorescence imaging - Biosynthesis - Probes - Cytology
- In planta study of photosynthesis and photorespiration using NADPH and NADH/NAD+ fluorescent protein sensors被引量：109收藏
- 作者：Lim, Shey-Li Voon, Chia Pao Guan, Xiaoqian Yang, Yi Gardestrom, Per Lim, Boon Leong
- 机构：Univ Hong Kong;East China Univ Sci & Technol;Umea Univ;Chinese Univ Hong Kong;HKU Shenzhen Inst Res & Innovat
- 来源：NATURE COMMUNICATIONS 2020
- Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease被引量：106收藏
- 作者：Li, Xi Zhang, Yinan Xu, Lingya Wang, Aoxue Zou, Yejun Li, Ting Huang, Li Chen, Weicai Liu, Shuning Jiang, Kun Zhang, Xiuze Wang, Dongmei Zhang, Lijuan Zhang, Zhuo Zhang, Zeyi Chen, Xianjun Jia, Wei Zhao, Aihua Yan, Xinfeng Zhou, Haimeng Zhu, Linyong Ma, Xinran Ju, Zhenyu Jia, Weiping Wang, Congrong Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Chinese Acad Sci;Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6;East China Normal Univ
- 来源：CELL METABOLISM 2023
- Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor被引量：95收藏
- 作者：Zou, Yejun Wang, Aoxue Huang, Li Zhu, Xudong Hu, Qingxun Zhang, Yinan Chen, Xianjun Li, Fengwen Wang, Qiaohui Wang, Hu Liu, Renmei Zuo, Fangting Li, Ting Yao, Jing Qian, Yajin Shi, Mei Yue, Xiao Chen, Weicai Zhang, Zhuo Wang, Congrong Zhou, Yong Zhu, Linyong Ju, Zhenyu Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Hangzhou Normal Univ;Shanghai Jiao Tong Univ
- 来源：DEVELOPMENTAL CELL 2020
- Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors被引量：83收藏
- 作者：Zou, Yejun Wang, Aoxue Shi, Mei Chen, Xianjun Liu, Renmei Li, Ting Zhang, Chenxia Zhang, Zhuo Zhu, Linyong Ju, Zhenyu Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Jinan Univ;Harvard Med Sch
- 来源：NATURE PROTOCOLS 2018
- Structure-based investigation of fluorogenic Pepper aptamer被引量：78收藏
- 作者：Huang, Kaiyi Chen, Xianjun Li, Chunyan Song, Qianqian Li, Huiwen Zhu, Linyong Yang, Yi Ren, Aiming
- 机构：Zhejiang Univ;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE CHEMICAL BIOLOGY 2021
- Highly Selective Fluorescent Probe for Vicinal-Dithiol-Containing Proteins and In Situ Imaging in Living Cells被引量：73收藏
- 作者：Huang, Chusen Yin, Qin Zhu, Weiping Yang, Yi Wang, Xin Qian, Xuhong Xu, Yufang
- 机构：E China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2011
- 关键词：fluorescent probes in situ imaging protein labeling redox proteomics vicinal dithiols
- Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+redox被引量：73收藏
- 作者：Yang, Liang Lin, Xiaobing Tang, Haite Fan, Yuting Zeng, Sheng Jia, Lei Li, Yukun Shi, Yanan He, Shujing Wang, Hao Hu, Zhijuan Gong, Xiao Liang, Xiaoyan Yang, Yi Liu, Xingguo
- 机构：Guangzhou Med Univ;Chinese Acad Sci;Univ Chinese Acad Sci;Sun Yat Sen Univ;Chinese Acad Sci
- 来源：AGING CELL 2020
- 关键词：aging fertility mitochondria mitochondrial DNA nicotinamide mononucleotide
- A Light-Driven Molecular Machine Controls K+ Channel Transport and Induces Cancer Cell Apoptosis被引量：66收藏
- 作者：Yang, Huiting Yi, Jinhao Pang, Shihao Ye, Kai Ye, Zhicheng Duan, Qi Yan, Zexin Lian, Cheng Yang, Yi Zhu, Linyong Qu, Da-Hui Bao, Chunyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2022
- 关键词：Apoptosis Ion Channels K+ Transport Light-Triggered Rotation Molecular Motor
- A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3被引量：65收藏
- 作者：Liu, Kejia Guo, Chu Lao, Yimin Yangb, Jie Chen, Fei Zhao, Yuzheng Yang, Yi Yang, Jie Yi, Jing
- 机构：Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：AUTOPHAGY 2020
- 关键词：Autophagy BECN1 reactive oxygen species SENP3 SUMOylation
- Lighting Up Live-Cell and In Vivo Central Carbon Metabolism with Genetically Encoded Fluorescent Sensors被引量：63收藏
- 作者：Zhang, Zhuo Cheng, Xiawei Zhao, Yuzheng Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 13 2020
- 关键词：central carbon metabolism genetically encoded fluorescent sensors real-time monitoring fluorescence imaging
- Photosensitive Hydrogel Creates Favorable Biologic Niches to Promote Spinal Cord Injury Repair被引量：62收藏
- 作者：Cai, Zhengwei Gan, Yibo Bao, Chunyan Wu, Wanjiang Wang, Xuebin Zhang, Zetong Zhou, Qiang Lin, Qiuning Yang, Yi Zhu, Linyong
- 机构：East China Univ Sci & Technol;Army Med Univ;Army Med Univ;Army Med Univ;Army Med Univ
- 来源：ADVANCED HEALTHCARE MATERIALS 2019
- 关键词：hydrogels nerve guidance conduits photochemistry protein immobilization spinal cord injury repair
- Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity被引量：61收藏
- 作者：Zhu, Xudong Shen, Weiyan Yao, Ke Wang, Hu Liu, Bo Li, Tangliang Song, Lijuan Diao, Daojun Mao, Genxiang Huang, Ping Li, Chengtao Zhang, Hongbo Zou, Yejun Qiu, Yugang Zhao, Yuzheng Wang, Wengong Yang, Yi Hu, Zeping Auwerx, Johan Loscalzo, Joseph Zhou, Yong Ju, Zhenyu
- 机构：Hangzhou Normal Univ;Jinan Univ;Tsinghua Univ;Gannan Med Univ;Zhejiang Hosp
- 来源：CIRCULATION RESEARCH 2019
- 关键词：aging autophagy heart mitochondria telomerase
- Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins被引量：60收藏
- 作者：Liu, Renmei Yang, Jing Yao, Jing Zhao, Zhou He, Wei Su, Ni Zhang, Zeyi Zhang, Chenxia Zhang, Zhuo Cai, Haibo Zhu, Linyong Zhao, Yuzheng Quan, Shu Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE BIOTECHNOLOGY 2022
- 关键词：Proteins - Cell culture
