- Metaproteomics: A strategy to study the taxonomy and functionality of the gut microbiota被引量：63收藏
- 作者：Wang, Yuqiu Zhou, Yanting Xiao, Xiao Zheng, Jing Zhou, Hu
- 机构：Chinese Acad Sci;Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF PROTEOMICS 2020
- 关键词：Metaproteomics Gut microbiota Metagenomics Metatranscriptomics Metabolomics Multi-omics
- 质疑
- Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs被引量：53收藏
- 作者：Feng, Ying Liu, Siyuan Mo, Qiqin Liu, Pengpeng Xiao, Xiao Ma, Hanhui
- 机构：East China Univ Sci & Technol;ShanghaiTech Univ;Univ Massachusetts
- 来源：PROTEIN & CELL 2023
- 质疑
- Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism被引量：17收藏
- 作者：Wang, Yuqiu Yang, Chen Hu, Hanyang Chen, Chen Yan, Mengdi Ling, Feixiang Wang, Kathy Cheng Wang, Xintao Deng, Zhe Zhou, Xinyue Zhang, Feixu Lin, Sen Du, Zengmin Zhao, Kai Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;NYU;Army Med Univ
- 来源：MOLECULAR THERAPY NUCLEIC ACIDS 2022
- 质疑
- Quantitative proteomic analysis uncovers inhibition of melanin synthesis by silk fibroin via MITF/tyrosinase axis in B16 melanoma cells被引量：15收藏
- 作者：Wang, Yuqiu Duan, Tianbi Hong, Minhua Zhou, Yanting Huang, Hui Xiao, Xiao Zheng, Jing Zhou, Hu Lu, Zhi
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Inoherb Co Ltd;East China Univ Sci & Technol;Univ Chinese Acad Sci
- 来源：LIFE SCIENCES 2021
- 关键词：Silk fibroin Quantitative proteomics Melanin Microphthalmia-associated transcription factor Tyrosinase
- 质疑
- Repeated Systemic Dosing of Adeno-Associated Virus Vectors in Immunocompetent Mice After Blockade of T Cell Costimulatory Pathways被引量：13收藏
- 作者：Zhong, Chen Jiang, Wei Wang, Yefan Sun, Junjiang Wu, Xia Zhuang, Yingping Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ N Carolina;Univ N Carolina
- 来源：HUMAN GENE THERAPY 2022
- 关键词：CTLA4-Ig CD40-Ig AAV multiple systemic administration immune tolerance
- 质疑
- Construction of the Isocopalane Skeleton: Application of a Desulfinylative 1,7-Hydrogen Atom Transfer Strategy被引量：12收藏
- 作者：Xiao, Xiong Xu, ZhongYu Zeng, Qian-Ding Chen, Xi-Bo Ji, Wen-Hao Han, Ying Wu, PeiYing Ren, Jiangmeng Zeng, Bu-Bing
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Shanghai Univ Tradit Chinese Med;Yangzhou Univ
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2015
- 关键词：hydrogen transfer natural products persulfates synthons terpenoids
- 质疑
- A Translational Study of TNF-Alpha Antagonists as an Adjunctive Therapy for Preventing Hemophilic Arthropathy被引量：11收藏
- 作者：Zhang, Feixu Xu, Mengyang Yang, Qin Hua, Baolai Xia, Binglan Lin, Zhenyang Xiao, Xiao Monahan, Paul E. Sun, Junjiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Yangzhou Univ;Univ N Carolina;Univ N Carolina
- 来源：JOURNAL OF CLINICAL MEDICINE 2020
- 关键词：hemophilia hemarthrosis hemophilic arthropathy TNF alpha anti-TNF alpha
- 质疑
- Treatment of experimental autoimmune encephalomyelitis using AAV gene therapy by blocking T cell costimulatory pathways被引量：9收藏
- 作者：Zhong, Chen Chen, Zifeng Xia, Yong Wu, Jun Zhang, Feixu Cheng, Cheng Wu, Xia Zhuang, Yingping Xiao, Xiao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ N Carolina
- 来源：MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT 2022
- 质疑
- A Facile Diethylene Glycol Reduction Method for the Synthesis of Ultrafine Pd/C Electrocatalyst with High Electrocatalytic Activity for Methanol Oxidation被引量：8收藏
- 作者：Zhai, Y. N. He, S. Xiao, X. Wu, Z. Q. Li, S. N. Lee, J. M.
- 机构：Shaanxi Normal Univ;East China Univ Sci & Technol;Nanyang Technol Univ
- 来源：FUEL CELLS 2016
- 关键词：Diethylene Glycol Reduction Dispersion Electrocatalysis Methanol Oxidation Reaction Pd Nanoparticles
- 质疑
- Exploring the Potential Feasibility of Intra-articular Adeno-Associated Virus-Mediated Gene Therapy for Hemophilia Arthropathy被引量：8收藏
- 作者：Zhang, Feixu Yan, Xiaobo Li, Min Hua, Baolai Xiao, Xiao Monahan, Paul E. Sun, Junjiang
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Yangzhou Univ;Univ N Carolina;Univ N Carolina
- 来源：HUMAN GENE THERAPY 2020
- 关键词：hemophilia arthropathy intraarticular recombinant human factor VIII adeno-associated virus neutralizing antibody
- 质疑
- Integrated proteome and phosphoproteome analysis of interscapular brown adipose and subcutaneous white adipose tissues upon high fat diet feeding in mouse被引量：6收藏
- 作者：Wang, Yuqiu Li, Junmin Lu, Dayun Meng, Qian Song, Nixue Zhou, Hu Xiao, Xiao Sun, Liming Zhu, Hongwen
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Fudan Univ;Univ Chinese Acad Sci
- 来源：JOURNAL OF PROTEOMICS 2022
- 关键词：Brown adipose tissue Subcutaneous white adipose tissue High fat diet Proteomics Phosphoproteomics Metabolism
- 质疑
- Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models被引量：6收藏
- 作者：Zhou, Kaiyi Yuan, Meng Sun, Jiabao Zhang, Feixu Li, Xinting Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：GENE THERAPY 2025
- 质疑
- CuI-catalyzed intramolecular cyclization of 3-(2-aminophenyl)-2-bromoacrylate: synthesis of 2-carboxyindoles被引量：6收藏
- 作者：Xiao, Xiong Chen, Tian-Qi Ren, Jiangmeng Chen, Wei-Dong Zeng, Bu-Bing
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;E China Univ Sci & Technol
- 来源：TETRAHEDRON LETTERS 2014
- 关键词：Indoles CuI-catalyzed Intramolecular coupling 2-Bromo-3-phenylacrylate
- 质疑
- Concise synthesis of (+)-subersic acid from (-)-Sclareol被引量：5收藏
- 作者：Wang, Peiqiang Li, Jue Yu, Chen-Lin Xiao, Xiong Wu, Pei-Ying Zeng, Bu-Bing
- 机构：E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Chinese Acad Sci
- 来源：TETRAHEDRON 2015
- 关键词：(+)-Subersic acid [3,3]-Claisen rearrangement Mitsunobu reaction (-)-Sclareol
- 质疑
- BDNF gene therapy rescues neuronal function via unique and common transcriptional responses in Aβ and tau-driven Alzheimer's disease mouse models被引量：4收藏
- 作者：Tang, Siqi Luo, Wenshu Cheng, Cheng Shen, Leshan Wu, Xia Xiao, Xiao
- 机构：East China Univ Sci & Technol;Belief Biomed Inc;East China Univ Sci & Technol;Shanghai Belief Biomed Inc
- 来源：BIOCHEMISTRY AND BIOPHYSICS REPORTS 2025
- 关键词：BDNF Gene therapy Alzheimer's disease RNA-Seq analysis rTg4510 APP/PS1
- 质疑
- Systemic effect of FHL1 on neuromuscular junction and myotube formation via insulin-like growth factor and myostatin signaling pathways被引量：3收藏
- 作者：Wu, Jiamei Zhao, Kai Du, Zengmin Chen, Ying Zhang, Feixu Jiang, Wei Zheng, Jing Wu, Xia Shen, Chengyong Xiao, Xiao
- 机构：East China Univ Sci & Technol;Zhejiang Univ
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2021
- 质疑
- Hippocampus-targeted BDNF gene therapy to rescue cognitive impairments of Alzheimer's disease in multiple mouse models被引量：3收藏
- 作者：Tang, Siqi Luo, Wenshu Wu, Shihao Yuan, Meng Wen, Jiashuo Zhong, Guoshen Shen, Leshan Jiang, Wei Cheng, Cheng Wu, Xia Xiao, Xiao
- 机构：East China Univ Sci & Technol;Belief Biomed Inc;Yunnan Univ;East China Univ Sci & Technol
- 来源：GENES & DISEASES 2026
- 关键词：AAVT42 Alzheime's disease Brain-derived neurotrophic factor Cognitive impairment Hippocampal RNA sequencing
- 质疑
- Prevalence of neutralizing antibodies against AAV8, AAV9, and AAV843 in a Chinese population被引量：3收藏
- 作者：Xu, Jingjing Zhang, Jingyu Xin, Lei Yang, Chen Zhang, Feixu Tang, Siqi Yao, Jie Wang, Hui Ning, Qinjie Yan, Mendi Li, Min Wu, Jiamei Chen, Ying Zhong, Chen Zhou, Kaiyi Du, Zengmin Jiang, Wei Wu, Xia Yang, Youjun Sun, Junjiang Xiao, Xiao Zheng, Jing
- 机构：East China Univ Sci & Technol;Harbin Med Univ
- 来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 2019
- 关键词：Neutralizing antibodies adeno-associated virus prevalence gene therapy
- 质疑
- AAV介导的TNFR关节内基因治疗对血友病性关节病预防和治疗的实验研究被引量：2收藏
- 作者：林振洋 王冶凡 张飞旭 周新月 宗晓莹 吴侠 华宝来 肖啸 孙君江
- 机构：华东理工大学药学院;华东理工大学生物工程学院;国家生物器反应工程重点实验室;徐州医科大学扬州临床学院;扬州大学临床医学院血液科
- 来源：《华东理工大学学报（自然科学版）》 2022
- 关键词：血友病性关节病 sTNFR 腺相关病毒(AAV) 关节内注射 基因治疗
- 摘要：血友病性关节病(HA)的发病机制与关节内炎性细胞因子过表达有关,肿瘤坏死因子α(TNFα)是最重要的炎性因子之一。可溶性肿瘤坏死因子受体(sTNFR)作为TNFα的受体可以特异性地与TNFα结合拮抗TNFα炎性效应。为探...
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- Methyl Group in Isocopalane Derivative Showed an Unusual Negative 1H NMR Chemical Shift被引量：2收藏
- 作者：Xiao, Xiong Chen, Tianqi Zhang, Fengfeng Cheng, Jiagao Wu, Peiying Ren, Jiangmeng Zeng, Bubing
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Shanghai Univ Tradit Chinese Med
- 来源：CHINESE JOURNAL OF CHEMISTRY 2015
- 关键词：shielding effect diterpenoid dihydropyrazole negative chemical shift computational study
- 质疑
- 来那度胺对血友病性关节炎的治疗作用研究被引量：2收藏
- 作者：王冶凡 林振洋 张飞旭 周新月 吴侠 肖啸 孙君江 华宝来
- 机构：华东理工大学药学院;华东理工大学生物反应器工程国家重点实验室;徐州医科大学扬州临床学院;扬州大学临床医学院血液科
- 来源：《中国实验血液学杂志》 2022
- 关键词：来那度胺 血友病性关节炎 人滑膜成纤维细胞 炎性因子 小鼠
- 摘要：目的:探讨来那度胺对人滑膜成纤维细胞(HFLS)增殖的影响以及对A型血友病小鼠血友病性关节炎(HA)的治疗效果。方法:以HFLS为模型细胞,在细胞培养基中添加柠檬酸铁和TNF-α重组蛋白,体外模拟炎性环境,加入不同浓度的...
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- Sildenafil increases AAV9 transduction after a systemic administration and enhances AAV9-dystrophin therapeutic effect in mdx mice被引量：1收藏
- 作者：Zhou, Kaiyi Yuan, Meng Sun, Jiabao Zhang, Feixu Zong, Xiaoying Li, Zhanao Tang, Dingyue Zhou, Lichen Zheng, Jing Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Gen Hosp Western Theater Command PLA;Belief BioMed;Univ N Carolina
- 来源：GENE THERAPY 2024
- 质疑
- 人体肝脏靶向性新型AAV血清型载体的研发被引量：1收藏
- 作者：宁秦洁 陈颖 闫梦迪 胡泽岚 吴侠 杜增民 郑静 肖啸
- 机构：华东理工大学药学院
- 来源：《华东理工大学学报（自然科学版）》 2020
- 关键词：腺相关病毒(AAV) 基因治疗 新型AAV血清型 DNA shuffling 靶向 肝脏细胞
- 摘要：通过DNA shuffling技术选择8种AAV(AAV1~AAV4,AAV6~AAV9)cap基因序列进行cap基因的DNA改组,获得AAV突变体基因库。将突变体基因库插入到含有AAV2Rep基因和ITR序列的质粒中,...
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- Activated factor X delivered by adeno-associated virus significantly inhibited bleeding and alleviated hemophilic synovitis in hemophilic mice被引量：1收藏
- 作者：Zhang, Feixu Zhou, Xinyue Hua, Baolai He, Xinyi Li, Zhanao Xiao, Xiao Wu, Xia
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Capital Med Univ
- 来源：GENE THERAPY 2024
- 质疑
- The local density of H3K9me3 dictates the stability of HP1a condensates-mediated genomic interactions被引量：1收藏
- 作者：Feng, Ying Guo, Li Yang, Chen Zheng, Hui Xiao, Xiao Ma, Hanhui
- 机构：East China Univ Sci & Technol;ShanghaiTech Univ;ShanghaiTech Univ
- 来源：JOURNAL OF GENETICS AND GENOMICS 2023
- 关键词：H3K9me3 HP1 alpha Chromatin dynamics Genomic interaction Epigenetic perturbation
- 质疑
- 基于AFP靶点的肝细胞癌的免疫治疗研究被引量：1收藏
- 作者：张洁 汤丁越 王成烨 高雅文 徐文青 刘思雅 肖啸 吴侠
- 机构：华东理工大学生物工程学院;华东理工大学药学院
- 来源：《华东理工大学学报(自然科学版)》 2025
- 关键词：肝细胞癌 AFP 免疫疗法 腺病毒 治疗性肿瘤疫苗
- 摘要：甲胎蛋白(AFP)在大约70%~80%的肝细胞癌患者中表达,可作为肝细胞癌免疫治疗的靶点。目前大多以AFP为靶点的肿瘤疫苗的临床实验效果欠佳,因此急需开发一种更有效的、基于AFP抗原的治疗性肿瘤疫苗。以复制缺陷型腺病毒为...
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- 基于雌激素受体的全人源基因表达调控系统的构建与优化被引量：0收藏
- 作者：闫梦迪 陈颖 吴侠 肖啸
- 机构：华东理工大学药学院;内蒙古大学省部共建草原家畜生殖调控与繁育国家重点实验室
- 来源：《内蒙古大学学报（自然科学版）》 2020
- 关键词：人源化 诱导表达调控 基因治疗 基因开关 重组腺相关病毒
- 摘要：目前基因治疗已经成为精准医疗体系中重要组成部分。然而,靶标基因在体内表达量的不可控给基因治疗的安全性带来一定风险。本研究在雌激素受体诱导系统的基础上,优化构建了全人源基因调控系统,并通过绿色荧光(Green fluore...
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- Prophylaxis CTLA4-ig reduces anti-AAV neutralizing antibodies in AAV gene therapy for hemophilia被引量：0收藏
- 作者：Yu, Dandan Xu, Bingqi Liu, Wei Xue, Feng Chen, Yunfei Liu, Xiaofan Ju, Mankai Ting, Sun Dai, Xinyue Dong, Huan Gu, Wenjing Yang, Renchi Xiao, Xiao Wu, Xia Pei, Xiaolei Zhang, Lei
- 机构：Chinese Acad Med Sci;East China Univ Sci & Technol
- 来源：BLOOD 2025
- 质疑
- Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs (vol 14, pg 304, 2023)被引量：0收藏
- 作者：Feng, Ying Liu, Siyuan Mo, Qiqin Liu, Pengpeng Xiao, Xiao Ma, Hanhui
- 机构：ShanghaiTech Univ;East China Univ Sci & Technol;Univ Massachusetts
- 来源：PROTEIN & CELL 2024
- 质疑
