李剑 收藏
( 任职于 药学院)
教授、博士生导师。 【研究方向】 1、老药(化药和中草药)二次研发 2、抗耐药微生物(细菌和疟疾)感染新靶标确证和创新药物研发 3、抗衰老和AD新靶标确证和创新药物研发 【获奖成果】 荣获教育部自然科学一等奖（第一/2019，第一/2022）、上海市科技进步二等奖（第二/2020）、华夏医学科技二等奖（第二/2017）等奖项。领导研究团队率先提出老药（化药和中草药）二次研发理念，分别在主编的专著和参编的规划教材中以专章阐述，自行或与他人合作发现了60余种老药新用途，以部分老药为先导设计合成3000余个新结构衍生物，系统开展新靶标确证和候选新药研发。作为项... 详细>>
- admetSAR 2.0: web-service for prediction and optimization of chemical ADMET properties被引量：915收藏
- 作者：Yang, Hongbin Lou, Chaofeng Sun, Lixia Li, Jie Cai, Yingchun Wang, Zhuang Li, Weihua Liu, Guixia Tang, Yun
- 机构：East China Univ Sci & Technol
- 来源：BIOINFORMATICS 2019
- 质疑
- Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents被引量：173收藏
- 作者：Wang, Shengzheng Fang, Kun Dong, Guoqiang Chen, Shuqiang Liu, Na Miao, Zhenyuan Yao, Jianzhong Li, Jian Zhang, Wannian Sheng, Chunquan
- 机构：Second Mil Med Univ;Fourth Mil Med Univ;E China Univ Sci & Technol
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2015
- 质疑
- Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis被引量：155收藏
- 作者：Jiang, Kai Xu, Yue Wang, Dandan Chen, Feng Tu, Zizhuo Qian, Jie Xu, Sheng Xu, Yixiang Hwa, John Li, Jian Shang, Hongcai Xiang, Yaozu
- 机构：Tongji Univ;East China Univ Sci & Technol;Yale Univ;Beijing Univ Chinese Med
- 来源：PROTEIN & CELL 2022
- 关键词：myocardial infarction SGLT2 inhibitors empagliflozin cardioprotection NHE1 autosis
- 质疑
- Organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions被引量：140收藏
- 作者：Zhang, Shi-Lei Xie, He-Xin Zhu, Jin Li, Hao Zhang, Xin-Shuai Li, Jian Wang, Wei
- 机构：Chinese Acad Sci;Univ New Mexico;E China Univ Sci & Technol
- 来源：NATURE COMMUNICATIONS 2011
- 质疑
- Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence被引量：129收藏
- 作者：Chen, Feifei Di, Hongxia Wang, Youxin Cao, Qiao Xu, Bin Zhang, Xue Yang, Nana Liu, Guijie Yang, Cai-Guang Xu, Yong Jiang, Hualiang Lian, Fulin Zhang, Naixia Li, Jian Lan, Lefu
- 机构：Chinese Acad Sci;E China Univ Sci & Technol;Humanwell Healthcare Grp Co Ltd;Chinese Acad Sci
- 来源：NATURE CHEMICAL BIOLOGY 2016
- 质疑
- Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging被引量：121收藏
- 作者：Li, Jin Dong, Yan Wei, Ruwei Jiang, Guanyu Yao, Cheng Lv, Meng Wu, Yuyang Gardner, Sarah H. Zhang, Feng Lucero, Melissa Y. Huang, Jian Chen, Hao Ge, Guangbo Chan, Jefferson Chen, Jinquan Sun, Haitao Luo, Xiao Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Normal Univ;Chinese Acad Sci;Univ Illinois
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2022
- 关键词：Biocompatibility - Chlorine compounds - Fluorophores - Infrared devices - Medical applications - Photobleaching - Scaffolds - Scaffolds (biology)
- 质疑
- A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes被引量：109收藏
- 作者：Luo, Xiao Li, Jin Zhao, Jie Gu, Luyan Qian, Xuhong Yang, Youjun
- 机构：East China Normal Univ;East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2019
- 关键词：Near infrared Polymethine cyanine Fluorescence Steric protection Rigidity
- 质疑
- Two-Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence被引量：109收藏
- 作者：Gao, Ying Hu, Yulu Liu, Qimeng Li, Xiaokang Li, Xinming Kim, Chu-Young James, Tony D. Li, Jian Chen, Xi Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Univ Texas El Paso;Univ Bath;Tongji Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2021
- 关键词：bioimaging fluorescent probes lysosomal pH senescence β -galactosidase
- 质疑
- Divergent Cascade Construction of Skeletally Diverse "Privileged" Pyrazole-Derived Molecular Architectures被引量：103收藏
- 作者：Zhang, Yongqiang Wu, Shanchao Wang, Shengzheng Fang, Kun Dong, Guoqiang Liu, Na Miao, Zhenyuan Yao, Jianzhong Li, Jian Zhang, Wannian Sheng, Chunquan Wang, Wei
- 机构：Second Mil Med Univ;E China Univ Sci & Technol;Univ New Mexico
- 来源：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2015
- 关键词：Organocatalysis Divergent synthesis Molecular diversity Nitrogen heterocycles Spiro compounds Drug design
- 质疑
- Facile Creation of 3-Indolyl-3-hydroxy-2-oxindoles by an Organocatalytic Enantioselective Friedel-Crafts Reaction of Indoles with Isatins被引量：97收藏
- 作者：Deng, Jing Zhang, Shilei Ding, Peng Jiang, Hualiang Wang, Wei Li, Jian
- 机构：E China Univ Sci & Technol;Univ New Mexico;Chinese Acad Sci
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2010
- 关键词：asymmetric Friedel-Crafts reaction indoles isatins organocatalysis
- 质疑
- Prediction of chemical-protein interactions: multitarget-QSAR versus computational chemogenomic methods被引量：94收藏
- 作者：Cheng, Feixiong Zhou, Yadi Li, Jie Li, Weihua Liu, Guixia Tang, Yun
- 机构：E China Univ Sci & Technol
- 来源：MOLECULAR BIOSYSTEMS 2012
- 质疑
- Rigid and Photostable Shortwave Infrared Dye Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging被引量：90收藏
- 作者：Wei, Ruwei Dong, Yan Wang, Xueli Li, Jin Lei, Zuhai Hu, Zhubin Chen, Jinquan Sun, Haitao Chen, Hao Luo, Xiao Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;East China Normal Univ;Fudan Univ;Chinese Acad Sci;East China Normal Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Bioimaging - Chlorine compounds - Infrared radiation
- 质疑
- Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs被引量：90收藏
- 作者：Mao, Fei Ni, Wei Xu, Xiang Wang, Hui Wang, Jing Ji, Min Li, Jian
- 机构：E China Univ Sci & Technol
- 来源：MOLECULES 2016
- 关键词：drug-like property chemical structure-related criteria ring system functional group the heavy atoms proportion drug design
- 质疑
- Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration被引量：89收藏
- 作者：Jiang, Haiming Deng, Rong Yang, Xiuyan Shang, Jialin Lu, Shaoyong Zhao, Yanlong Song, Kun Liu, Xinyi Zhang, Qiufen Chen, Yu Chinn, Y. Eugene Wu, Geng Li, Jian Chen, Guoqiang Yu, Jianxiu Zhang, Jian
- 机构：Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Chinese Acad Sci;Chinese Acad Sci
- 来源：NATURE CHEMICAL BIOLOGY 2017
- 质疑
- Organocatalytic Enantioselective Direct Additions of Aldehydes to 4-Vinylpyridines and Electron-Deficient Vinylarenes and Their Synthetic Applications被引量：87收藏
- 作者：Wang, Sinan Li, Xiangmin Liu, Hongwei Xu, Li Zhuang, Jinchen Li, Jian Li, Hao Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2015
- 关键词：Ethers - Synthesis (chemical) - Catalysis - Enantioselectivity - Chemical activation - Pyridine
- 质疑
- A Direct Amine-Palladium Acetate Cocatalyzed Saegusa Oxidation Reaction of Unmodified Aldehydes to α,β-Unsaturated Aldehydes被引量：85收藏
- 作者：Zhu, Jin Liu, Jie Ma, Ruoqun Xie, Hexin Li, Jian Jiang, Hualiang Wang, Wei
- 机构：E China Univ Sci & Technol;Univ New Mexico;Chinese Acad Sci
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2009
- 关键词：aminocatalysis organocatalysis Saegusa reaction alpha,beta-unsaturated aldehydes
- 质疑
- Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents被引量：83收藏
- 作者：Li, Xiaokang Wang, Huan Lu, Zhengyu Zheng, Xinyu Ni, Wei Zhu, Jin Fu, Yan Lian, Fulin Zhang, Naixia Li, Jian Zhang, Haiyan Mao, Fei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2016
- 质疑
- Prediction of Polypharmacological Profiles of Drugs by the Integration of Chemical, Side Effect, and Therapeutic Space被引量：83收藏
- 作者：Cheng, Feixiong Li, Weihua Wu, Zengrui Wang, Xichuan Zhang, Chen Li, Jie Liu, Guixia Tang, Yun
- 机构：E China Univ Sci & Technol;Shanghai MCC Hosp
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2013
- 关键词：Proteins - Tensors - Association reactions - Drug interactions
- 质疑
- Discovering Potent Small Molecule Inhibitors of Cyclophilin A Using de Novo Drug Design Approach被引量：82收藏
- 作者：Ni, Shuaishuai Yuan, Yaxia Huang, Jin Mao, Xiaona Lv, Maosheng Zhu, Jin Shen, Xu Pei, Jianfeng Lai, Luhua Jiang, Hualiang Li, Jian
- 机构：Peking Univ;Peking Univ;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2009
- 质疑
- Photoactivatable senolysis with single-cell resolution delays aging被引量：78收藏
- 作者：Shi, Donglei Liu, Wenwen Gao, Ying Li, Xinming Huang, Yunyuan Li, Xiaokang James, Tony D. Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Hainan Univ;Univ Bath;Dali Univ
- 来源：NATURE AGING 2023
- 质疑
- A Quinine-Squaramide Catalyzed Enantioselective Aza-Friedel-Crafts Reaction of Cyclic Trifluoromethyl Ketimines with Naphthols and Electron-Rich Phenols被引量：78收藏
- 作者：Zhou, Ding Huang, Zheng Yu, Xueting Wang, Youxin Li, Jian Wang, Wei Xie, Hexin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：ORGANIC LETTERS 2015
- 质疑
- A facile fluorescent probe with a large Stokes shift for sequentially detecting copper and sulfide in 100% aqueous solution and imaging them in living cells被引量：76收藏
- 作者：Wang, Huan Shi, Dong-Lei Li, Jin Tang, Hao-Yang Li, Jian Guo, Yuan
- 机构：Northwest Univ;Xian Univ Posts & Telecommun;East China Univ Sci & Technol
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2018
- 关键词：Copper ions Hydrogen sulfide Fluorescent imaging Large Stokes shift Pure water system
- 质疑
- First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase被引量：76收藏
- 作者：Li, Xiaokang Qiu, Wenjing Li, Jinwen Chen, Xi Hu, Yulu Gao, Ying Shi, Donglei Li, Xinming Lin, Huiling Hu, Zelan Dong, Guoqiang Sheng, Chunquan Jiang, Bei Xia, Conglong Kim, Chu-Young Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Second Mil Med Univ;Dali Univ;Univ Texas El Paso
- 来源：CHEMICAL SCIENCE 2020
- 关键词：Probes - Fluorescence imaging - Enzymes - Fluorescence spectroscopy - Mammals
- 质疑
- Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease被引量：75收藏
- 作者：Xu, Yi-xiang Wang, Huan Li, Xiao-kang Dong, Sheng-nan Liu, Wen-wen Gong, Qi Wang, Tian-duan-yi Tang, Yun Zhu, Jin Li, Jian Zhang, Hai-yan Mao, Fei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
- 关键词：Multifunctional agents AChE inhibitors MAO-B inhibitors Metal chelating agents Alzheimer's disease
- 质疑
- Network-based identification of microRNAs as potential pharmacogenomic biomarkers for anticancer drugs被引量：74收藏
- 作者：Li, Jie Lei, Kecheng Wu, Zengrui Li, Weihua Liu, Guixia Liu, Jianwen Cheng, Feixiong Tang, Yun
- 机构：East China Univ Sci & Technol;Sichuan Univ;Harvard Med Sch;Northeastern Univ
- 来源：ONCOTARGET 2016
- 关键词：pharmacogenomics miRNA network-based inference metformin breast cancer
- 质疑
- Cyclophilin A Associates with Enterovirus-71 Virus Capsid and Plays an Essential Role in Viral Infection as an Uncoating Regulator被引量：74收藏
- 作者：Qing, Jie Wang, Yaxin Sun, Yuna Huang, Jiaoyan Yan, Wenzhong Wang, Jinglan Su, Dan Ni, Cheng Li, Jian Rao, Zihe Liu, Lei Lou, Zhiyong
- 机构：Tsinghua Univ;Tsinghua Univ;Chinese Acad Sci;E China Univ Sci & Technol;Sichuan Univ
- 来源：PLOS PATHOGENS 2014
- 质疑
- In Silico Prediction of Compounds Binding to Human Plasma Proteins by QSAR Models被引量：72收藏
- 作者：Sun, Lixia Yang, Hongbin Li, Jie Wang, Tianduanyi Li, Weihua Liu, Guixia Tang, Yun
- 机构：East China Univ Sci & Technol
- 来源：CHEMMEDCHEM 2018
- 关键词：machine learning plasma protein binding QSAR pharmacokinetics consensus modeling
- 质疑
- JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification被引量：71收藏
- 作者：Sun, Wenyi Xie, Zuoquan Liu, Yifu Zhao, Dan Wu, Zhixiang Zhang, Dadong Lv, Hao Tang, Shuai Jin, Nan Jiang, Hualiang Tan, Minjia Ding, Jian Luo, Cheng Li, Jian Huang, Min Geng, Meiyu
- 机构：Chinese Acad Sci;E China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：CANCER RESEARCH 2015
- 质疑
- Development of the First Generation of Disulfide-Based Subtype Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors被引量：71收藏
- 作者：Liu, Yifu Xie, Zuoquan Zhao, Dan Zhu, Jin Mao, Fei Tang, Shuai Xu, Hui Luo, Cheng Geng, Meiyu Huang, Min Li, Jian
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2017
- 质疑
- In silico prediction of chemical mechanism of action via an improved network-based inference method被引量：68收藏
- 作者：Wu, Zengrui Lu, Weiqiang Wu, Dang Luo, Anqi Bian, Hanping Li, Jie Li, Weihua Liu, Guixia Huang, Jin Cheng, Feixiong Tang, Yun
- 机构：East China Univ Sci & Technol;East China Normal Univ;East China Normal Univ;Sichuan Univ;Harvard Med Sch
- 来源：BRITISH JOURNAL OF PHARMACOLOGY 2016
- 质疑
