成果/Result
- Estimation of ADME Properties with Substructure Pattern Recognition被引量：269收藏
- 作者：Shen, Jie Cheng, Feixiong Xu, You Li, Weihua Tang, Yun
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2010
- 关键词：Support vector machines - Chemical analysis
- A Three-Channel Fluorescent Probe That Distinguishes Peroxynitrite from Hypochlorite被引量：167收藏
- 作者：Zhang, Quanjuan Zhu, Zhichuan Zheng, Yongli Cheng, Jiagao Zhang, Na Long, Yi-Tao Zheng, Jing Qian, Xuhong Yang, Youjun
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2012
- 关键词：Fluorescence - Probes
- Classification of Cytochrome P450 Inhibitors and Noninhibitors Using Combined Classifiers被引量：164收藏
- 作者：Cheng, Feixiong Yu, Yue Shen, Jie Yang, Lei Li, Weihua Liu, Guixia Lee, Philip W. Tang, Yun
- 机构：E China Univ Sci & Technol;Kyoto Univ;E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2011
- 关键词：Decision trees - Data mining - Nearest nEIghbor search - Classification (of information) - Drug interactions - Backpropagation - Forecasting
- Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors被引量：88收藏
- 作者：Chen, Yanzuo Song, Wantong Shen, Limei Qiu, Nasha Hu, Mengying Liu, Yun Liu, Qi Huang, Leaf
- 机构：Univ N Carolina;Univ N Carolina;East China Univ Sci & Technol;Chinese Acad Sci;Zhejiang Univ
- 来源：ACS NANO 2019
- 关键词：hydralazine nanoparticles tumor penetration desmoplastic tumor tumor microenvironment
- Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy被引量：68收藏
- 作者：Li, Yue Chen, Jia Xia, Qi Shang, Jing He, Yujie Li, Zhi Chen, Yingying Gao, Feng Yu, Xi Yuan, Zeting Yin, Peihao
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;Anhui Med Univ
- 来源：JOURNAL OF NANOBIOTECHNOLOGY 2024
- 关键词：Photothermal therapy Ferroptosis ICD Immunotherapy CRC
- Computational investigation of interactions between human H2 receptor and its agonists被引量：57收藏
- 作者：Sun, Xianqiang Li, Yaozong Li, Weihua Xu, Zhejun Tang, Yun
- 机构： Department of Pharmaceutical Sciences
- 来源：Journal of Molecular Graphics and Modelling 2011
- 关键词：Computational chemistry - Molecular modeling - Molecular dynamics - Diagnosis - Search engines - Pharmacodynamics
- Enantioselective Conjugate Addition of N-Heterocycles to α,β-Unsaturated Ketones Catalyzed by Chiral Primary Amines被引量：55收藏
- 作者：Luo, Guangshun Zhang, Shilei Duan, Wenhu Wang, Wei
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ New Mexico
- 来源：SYNTHESIS-STUTTGART 2009
- 关键词：primary amines N-heterocycles enones conjugate addition catalysis
- Insights into Molecular Basis of Cytochrome P450 Inhibitory Promiscuity of Compounds被引量：54收藏
- 作者：Cheng, Feixiong Yu, Yue Zhou, Yadi Shen, Zhonghua Xiao, Wen Liu, Guixia Li, Weihua Lee, Philip W. Tang, Yun
- 机构：E China Univ Sci & Technol;Kyoto Univ
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2011
- 关键词：Drug interactions - Economic and social effects
- Accuracy Assessment of ProtEIn-Based Docking Programs against RNA Targets被引量：50收藏
- 作者：Li, Yaozong Shen, Jie Sun, Xiangiang Li, Weihua Liu, Guixia Tang, Yun
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2010
- 关键词：Gold - Binding energy - ProtEIns
- Intravenous delivery of enzalutamide based on high drug loading multifunctional graphene oxide nanoparticles for castration-resistant prostate cancer therapy被引量：39收藏
- 作者：Jiang, Wenjun Chen, Jiyuan Gong, Chunai Wang, Yuanyuan Gao, Yuan Yuan, Yongfang
- 机构：Fudan Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Second Mil Med Univ
- 来源：JOURNAL OF NANOBIOTECHNOLOGY 2020
- 关键词：Redox-sensitive Enzalutamide Graphene quantum dot derivate Castration-resistant prostate cancer
- Coordination modes of bridge carboxylates in dinuclear manganese compounds determine thEIr catalase-like activities被引量：31收藏
- 作者：Jiang, Xiaojun Liu, Hui Zheng, Bing Zhang, Jingyan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：DALTON TRANSACTIONS 2009
- 关键词：Catalyst activity - Carboxylation - Manganese compounds - Ions - Electron spin resonance spectroscopy - Deprotonation - X ray diffraction
- In silico prediction of Tetrahymena pyriformis toxicity for diverse industrial chemicals with substructure pattern recognition and machine learning methods被引量：31收藏
- 作者：Cheng, Feixiong Shen, Jie Yu, Yue Li, Weihua Liu, Guixia Lee, Philip W. Tang, Yun
- 机构： Department of Pharmaceutical Sciences; Graduate School of Agriculture
- 来源：Chemosphere 2011
- 关键词：Support vector machines - Accident prevention - Industrial chemicals - Pattern recognition - Radial basis function networks - Organic chemicals - Decision trees - Nearest nEIghbor search
- A novel urinary oxalate determination method via a catalase model compound with oxalate oxidase被引量：29收藏
- 作者：Zuo, Guanke Jiang, Xiaojun Liu, Hui Zhang, Jingyan
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Pharmaceutical Sciences
- 来源：Analytical Methods 2010
- 关键词：Assays - Carbon dioxide - Propionic acid - Oxalic acid
- Spatiotemporally controllable diphtheria toxin expression using a light-switchable transgene system combining multifunctional nanoparticle delivery system for targeted melanoma therapy被引量：28收藏
- 作者：He, Muye Wang, Yan Chen, Xianjun Zhao, Yuzheng Lou, Kaiyan Wang, Yujie Huang, Lei Hou, Xinyu Xu, Jiajun Cai, Xiaoran Cheng, Yi Lan, Minbo Yang, Yi Gao, Feng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF CONTROLLED RELEASE 2020
- 关键词：Light-switchable gene expression Diphtheria toxin Melanoma Nanoparticle delivery system
- Formaldehyde rEInforces pro-inflammatory responses of macrophages through induction of glycolysis被引量：28收藏
- 作者：Ma, Huijuan Lin, Jinxuan Li, Linyi Ding, Zhaoqian Huang, Ping Song, Xiaodong Lou, Kaiyan Wang, Wei Xu, Huan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Univ Arizona;Univ Arizona
- 来源：CHEMOSPHERE 2021
- 关键词：Formaldehyde Macrophage Glycolysis Pro-inflammatory responses Lipopolysaccharide stimulation HIF-1 alpha
- Antioxidant and immunomodulatory activities of Polysaccharides from Moxa (Artemisia argyi) Leaf被引量：25收藏
- 作者：Lan, Min-Bo Zhang, Yan-Hong Zheng, Ying Yuan, Hui-Hui Zhao, Hong-Li Gao, Feng
- 机构： Shanghai Key Laboratory of Functional Materials Chemistry; Key Laboratory for Ultrafine Materials of Ministry of Education; Department of Pharmaceutics
- 来源：Food Science and Biotechnology 2010
- 关键词：Glucose - T-cells - Cell proliferation - Antioxidants
- Supramolecules-Guided Synthesis of Brightly Near-Infrared Au22 Nanoclusters with Aggregation-Induced Emission for Bioimaging被引量：20收藏
- 作者：Wei, Yifei Luan, Weiling Gao, Feng Hou, Xinyu
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 2019
- 关键词：bioimaging growth process near-infrared rapid synthesis supramolecules-guided assembly
- Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy被引量：16收藏
- 作者：Cheng, Yi Zou, Jiafeng He, Muye Hou, Xinyu Wang, Hongtao Xu, Jiajun Yuan, Zeting Lan, Minbo Yang, Yi Chen, Xianjun Gao, Feng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF CONTROLLED RELEASE 2024
- 关键词：Spatiotemporally controlled gene expression cancer -associated fibroblasts Multifunctional nanoparticles Pseudomonas exotoxin A Antimetastasis therapy Breast cancer
- Computational insights into the different catalytic activities of CYP2A13 and CYP2A6 on NNK被引量：15收藏
- 作者：Xu, You Shen, Zhonghua Shen, Jie Liu, Guixia Li, Weihua Tang, Yun
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF MOLECULAR GRAPHICS & MODELLING 2011
- 关键词：CYP2A13 CYP2A6 NNK Molecular dynamics Molecular docking
- Photothermal therapy enhance the anti-mitochondrial metabolism effect of lonidamine to renal cell carcinoma in homologous-targeted nanosystem被引量：15收藏
- 作者：Chen, Jiyuan Ren, Fuzheng Cao, Wenfeng Wu, Zhengjie Ju, Guanqun Xiao, Chengwu Wu, Weijia Gao, Shen Xu, Chuanliang Gao, Yuan
- 机构：Fudan Univ;East China Univ Sci & Technol;Second Mil Med Univ
- 来源：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2021
- 关键词：Renal cell carcinoma Lonidamine Polydopamine Photothermal therapy Mitochondrial metabolism
- Tissue adhesive indocyanine green-locking granular gel-mediated photothermal therapy combined with checkpoint inhibitor for preventing postsurgical recurrence and metastasis of colorectal cancer被引量：12收藏
- 作者：Zeting, Yuan Shuli, Ma Yue, Li Haowei, Fang Jing, Shang Yueping, Zhan Jie, Wang Teng, Chen Wanli, Deng Zhang, Kunxi Peihao, Yin
- 机构：Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;Anhui Med Univ
- 来源：BIOENGINEERING & TRANSLATIONAL MEDICINE 2023
- 关键词：colorectal cancer granular hydrogel ICG immunotherapy photothermal therapy
- Computational Insights into Ligand Selectivity of Estrogen Receptors from Pharmacophore Modeling被引量：10收藏
- 作者：Fang, Jing Shen, Jie Cheng, Feixiong Xu, Zhejun Liu, Guixia Tang, Yun
- 机构：E China Univ Sci & Technol
- 来源：MOLECULAR INFORMATICS 2011
- 关键词：Estrogen receptor Ligand selectivity Molecular modeling Pharmacophore
- Organocatalytic enantioselective Michael addition reactions of fluoromalonates with α,β-unsaturated aldehydes被引量：9收藏
- 作者：Li Hao Ji YaFei Li Jian Zhang ShiLei Yu ChenGuang Wang Wei
- 机构：Univ New Mexico;E China Univ Sci & Technol
- 来源：SCIENCE CHINA-CHEMISTRY 2010
- 关键词：organocatalysis alpha,beta-unsaturated aldehydes chiral fluorinated compounds Michael addition
- Direct evidence for the role of imidazole in disproportionation of hydrogen peroxide by a mononuclear manganese salen complex被引量：8收藏
- 作者：Li, Rong Tian, Jinlei Liu, Hui Yan, Shiping Guo, Shouwu Zhang, Jingyan
- 机构：E China Univ Sci & Technol;Nankai Univ;Shanghai Jiao Tong Univ
- 来源：TRANSITION METAL CHEMISTRY 2011
- 关键词：Ultraviolet visible spectroscopy - Synthesis (chemical) - Manganese compounds - Oxidation - Catalyst activity - Ligands - X ray diffraction
- Kinetic study of the degradation of forskolin in aqueous systems by stability-indicating HPLC method and identification of its degradation products被引量：4收藏
- 作者：Wang, Yaqin Yin, Jiajun Weng, Weiyu Liu, Zhenjun Huang, Jianming
- 机构：Fudan Univ;E China Univ Sci & Technol
- 来源：JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES 2016
- 关键词：Degradation kinetics forskolin forskolin D HPLC isoforskolin stability
- Formaldehyde inhibits development of T lymphocytes in mice被引量：4收藏
- 作者：Ma, Huijuan Song, Xiaodong Zhang, Weiwei Ling, Xinyue Yang, Xiaoning Wu, Wenwei Lou, Kaiyan Xu, Huan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ
- 来源：TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY 2020
- 关键词：Formaldehyde selective inhibition CD8+T cells T cell development Runx3 ThPOK
- Comparative pharmacophore modeling of human adenosine receptor A1 and A3 antagonists被引量：0收藏
- 作者：Xu ZheJun Cheng FeiXiong Li Jie Zhou YaDi Su Ni Li WeiHua Liu GuiXia Tang Yun
- 机构：E China Univ Sci & Technol
- 来源：SCIENCE CHINA-CHEMISTRY 2012
- 关键词：pharmacophore modeling adenosine receptors antagonists enrichment factor simulated virtual screening
