成果/Result
- Euler-Lagrange computational fluid dynamics for (bio)reactor scale down: An analysis of organism lifelines被引量：104收藏
- 作者：Haringa, Cees Tang, Wenjun Deshmukh, Amit T. Xia, Jianye Reuss, Matthias Heijnen, Joseph J. Mudde, Robert F. Noorman, Henk J.
- 机构：Delft Univ Technol;ECUST;DSM Biotechnol Ctr;Univ Stuttgart;Delft Univ Technol
- 来源：ENGINEERING IN LIFE SCIENCES 2016
- 关键词：CFD Euler-Lagrange Fermentation Industrial scale Scale down
- Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses被引量：81收藏
- 作者：Wang, Guan Tang, Wenjun Xia, Jianye Chu, Ju Noorman, Henk van Gulik, Walter M.
- 机构： State Key Laboratory of Bioreactor Engineering; DSM Biotechnology Center; Department of Biotechnology
- 来源：Engineering in Life Sciences 2020
- 关键词：Metabolism - Mass transfer - Mixing - Metabolic engineering - Batch data processing - Kinetics - Carbon dioxide
- Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment被引量：61收藏
- 作者：Xia, Jian-Ye Wang, Yong-Hong Zhang, Si-Liang Chen, Ning Yin, Peng Zhuang, Ying-Ping Chu, Ju
- 机构：E China Univ Chem Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2009
- 关键词：Dissolved oxygen Fluid mechanics Gas-liquid mass transfer Mixing Mycelia fermentation Shear environment
- The Impact of Systems Biology on Bioprocessing被引量：60收藏
- 作者：Campbell, Kate Xia, Jianye Nielsen, Jens
- 机构：Chalmers Univ Technol;East China Univ Sci & Technol;Tech Univ Denmark
- 来源：TRENDS IN BIOTECHNOLOGY 2017
- 关键词：Creep - Plant shutdowns - Computational methods - Fossil fuels - Data handling - Genes - Learning systems - Information analysis - Digital storage - Physiology
- Flow Pattern, Mixing, Gas Hold-Up and Mass Transfer Coefficient of Triple-Impeller Configurations in Stirred Tank Bioreactors被引量：60收藏
- 作者：Xie, Minghui Xia, Jianye Zhou, Zhen Chu, Ju Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2014
- 关键词：Gases - Liquids - Mixing - Pumps - Turbine components - Flow patterns - Mass transfer - Turbomachine blades - Velocity
- Industrial bioprocess control and optimization in the context of systems biotechnology被引量：56收藏
- 作者：Wang, Yong Chu, Ju Zhuang, Yingping Wang, Yonghong Xia, Jianye Zhang, Siliang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology Advances 2009
- CFD analysis of the turbulent flow in baffled shake flasks被引量：49收藏
- 作者：Li, Chao Xia, Jian-Ye Chu, Ju Wang, Yong-Hong Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：E China Univ Sci & Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2013
- 关键词：Shake flask Hydrodynamics Mass transfer Mixing Shear force Power consumption
- Application of Euler-Lagrange CFD for quantitative evaluating the effect of shear force on Carthamus tinctorius L. cell in a stirred tank bioreactor被引量：49收藏
- 作者：Liu, Yu Wang, Ze-Jian Xia, Jian-Ye Haringa, Cees Liu, Ya-Ping Chu, Ju Zhuang, Ying-Ping Zhang, Si-Liang
- 机构：East China Univ Sci & Technol;Dalian Pract Biotechnol Co Ltd;Delft Univ Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2016
- 关键词：Plant cell culture Fluid mechanics Agitation Power consumption C tinctorius L. cell Stress thresholds
- Power consumption, local and average volumetric mass transfer coefficient in multiple-impeller stirred bioreactors for xanthan gum solutions被引量：48收藏
- 作者：Xie, Ming-hui Xia, Jian-ye Zhou, Zhen Zhou, Guo-zhong Chu, Ju Zhuang, Ying-ping Zhang, Si-liang Noorman, Henk
- 机构：E China Univ Sci & Technol;Wenzhou Great Wall Mixer Design Inst;DSM Biotechnol Ctr
- 来源：CHEMICAL ENGINEERING SCIENCE 2014
- 关键词：Power Mass transfer Xanthan gum Non-Newtonian fluid Impeller combination
- Enzymatic Preparation of the Chiral (S)-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels被引量：45收藏
- 作者：Xu, Na Zhu, Jun Wu, Yin-Qi Zhang, Yan Xia, Jian-Ye Zhao, Qian Lin, Guo-Qiang Yu, Hui-Lei Xu, Jian-He
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Jiangsu Aosaikang Pharmaceut Co Ltd
- 来源：ORGANIC PROCESS RESEARCH & DEVELOPMENT 2020
- 关键词：prazole sulfide monooxygenase esomeprazole asymmetric oxidation oxygen mass transfer reaction regulation
- A 9-pool metabolic structured kinetic model describing days to seconds dynamics of growth and product formation by Penicillium chrysogenum被引量：45收藏
- 作者：Tang, Wenjun Deshmukh, Amit T. Haringa, Cees Wang, Guan van Gulik, Walter van Winden, Wouter Reuss, Matthias Heijnen, Joseph J. Xia, Jianye Chu, Ju Noorman, Henk J.
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr;Delft Univ Technol;Univ Stuttgart
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2017
- 关键词：structured model black box model feast-famine kinetics Penicillium chrysogenum
- Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose被引量：42收藏
- 作者：Feng, Yao Tian, Xiwei Chen, Yang Wang, Zeyu Xia, Jianye Qian, Jiangchao Zhuang, Yingping Chu, Ju
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2021
- 关键词：Ethanol On-line Viable cell sensor Electronic nose
- Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains被引量：40收藏
- 作者：Xia, Jianye Wang, Guan Fan, Meng Chen, Min Wang, Zeyu Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF CHEMICAL ENGINEERING 2021
- 关键词：Fermentation Scale-up Bioreactors Gas-liquid flow Kinetics
- Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor被引量：30收藏
- 作者：Xia, Jian-Ye Wang, Si-Jing Zhang, Si-Liang Zhong, Jian-Jiang
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2008
- 关键词：CFD centrifugal impeller velocity profile shear force fluid circulation circulation time distribution
- Comprehensive reconstruction and in silico analysis of Aspergillus niger genome-scale metabolic network model that accounts for 1210 ORFs被引量：28收藏
- 作者：Lu, Hongzhong Cao, Weiqiang Ouyang, Liming Xia, Jianye Huang, Mingzhi Chu, Ju Zhuang, Yingping Zhang, Siliang Noorman, Henk
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2017
- 关键词：Aspergillus niger genome-scale metabolic model multi-omics glucoamylase
- Effects of flow field on the metabolic characteristics of Streptomyces lincolnensis in the industrial fermentation of lincomycin被引量：28收藏
- 作者：Li, Xiao Zhang, Jiang Tan, Ya-Li Li, Zhi-Hong Yu, Xue-Feng Xia, Jian-Ye Chu, Ju Ge, You-Qun
- 机构： College of Chemistry and Biology Science; Hubei Province Key Lab. of Yeast Function; State Key Laboratory of Bioreactor Engineering; Jiangxi GuoYao Pharmaceutical Limited Liability Company
- 来源：Journal of Bioscience and Bioengineering 2013
- 关键词：Axial flow - Bacteria - Dissolved oxygen - Fermentation - Fermenters - Flow fields - Impellers - Kinetic energy - Kinetics - Mass transfer - Metabolism - Radial flow - Shear flow - Volumetric analysis
- Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter被引量：27收藏
- 作者：Zou, Xiang Xia, Jian-Ye Chu, Ju Zhuang, Ying-Ping Zhang, Si-Liang
- 机构： State Key Laboratory of Bioreactor Engineering; College of Pharmaceutical Sciences
- 来源：Bioprocess and Biosystems Engineering 2012
- 关键词：Physiological models - Physiology - Rheology - Antibiotics - Oxygen - Biochemistry - Flow measurement - Biosynthesis - Non Newtonian flow - Non Newtonian liquids - Viscous flow
- Quantitative evaluation of the shear threshold on Carthamus tinctorius L. cell growth with computational fluid dynamics in shaken flask bioreactors被引量：26收藏
- 作者：Liu, Yu Wang, Ze-Jian Zhang, JianWen Xia, Jian-ye Chu, Ju Zhang, Si-Liang Zhuang, Ying-Ping
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Delft Univ Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2016
- 关键词：Fluid mechanics Power consumption Aggregation Plant cell bioreactors C. tinctorius L. cell Stress thresholds
- A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production被引量：25收藏
- 作者：Yang, Yiming Xia, Jianye Li, Jianhua Chu, Ju Li, Liang Wang, Yonghong Zhuang, Yingping Zhang, Siliang
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2012
- 关键词：Impeller configuration Cephalosporin C Morphology Computational fluid dynamics
- Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer被引量：22收藏
- 作者：Tang, Wenjun Pan, Ao Lu, Hongzhong Xia, Jianye Zhuang, Yingping Zhang, Siliang Chu, Ju Noorman, Henk
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2015
- 关键词：Glucoamylase Impeller type Aspergillus niger Morphology analysis CFD
- Novel scale-up strategy based on three-dimensional shear space for animal cell culture被引量：22收藏
- 作者：Li, Chao Teng, Xiaonuo Peng, Huadong Yi, Xiaoping Zhuang, Yingping Zhang, Siliang Xia, Jianye
- 机构：East China Univ Sci & Technol;Imperial Coll London;Imperial Coll London
- 来源：CHEMICAL ENGINEERING SCIENCE 2020
- 关键词：Shear rate Animal cell culture Scale-up Computational fluid dynamics Stirred tank bioreactor
- Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels被引量：18收藏
- 作者：Wang, Guan Wu, Baofeng Zhao, Junfei Haringa, Cees Xia, Jianye Chu, Ju Zhuang, Yingping Zhang, Siliang Heijnen, Joseph J. van Gulik, Walter Deshmukh, Amit T. Noorman, Henk J.
- 机构：ECUST;Delft Univ Technol;Delft Univ Technol;DSM Biotechnol Ctr;Delft Univ Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2018
- 关键词：degeneration glucose transport power input redox energy metabolism scale down
- Dependence of fungal characteristics on seed morphology and shear stress in bioreactors被引量：18收藏
- 作者：Lu, Hongzhong Li, Chao Tang, Wenjun Wang, Zejian Xia, Jianye Zhang, Siliang Zhuang, Yingping Chu, Ju Noorman, Henk
- 机构：E China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2015
- 关键词：Aspergillus niger Morphological control Stirred tank Mass transfer Rheology Hydrodynamics
- Dynamic response of Aspergillus niger to single pulses of glucose with high and low concentrations被引量：16收藏
- 作者：Wang, Shuai Liu, Peng Shu, Wei Li, Chao Li, Huan Liu, Shanshan Xia, Jianye Noorman, Henk
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Aspergillus niger Substrate pulse Glucose excess Rapid sampling Dynamic responses Intracellular metabolites
- Dynamic metabolic response of Aspergillus niger to glucose perturbation: evidence of regulatory mechanism for reduced glucoamylase production被引量：13收藏
- 作者：Li, Chao Shu, Wei Wang, Shuai Liu, Peng Zhuang, Yingpping Zhang, Siliang Xia, Jianye
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2018
- 关键词：Aspergillus niger Glucose stimulus Dynamic metabolic response Glucoamylase In vivo kinetics
- CFD Simulation of Average and Local Gas-Liquid Flow Properties in Stirred Tank Reactors with Multiple Rushton Impellers被引量：12收藏
- 作者：Pan, Ao Xie, Minghui Li, Chao Xia, Jianye Chu, Ju Zhuang, Yingping
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 2017
- 关键词：Gas-Liquid Stirred Tank Hydrodynamics Population Balance Model Inter-Phase Forces
- Polyphenol oxidase inhibition by Saccharomyces cerevisiae extracts: A promising approach to prevent enzymatic browning被引量：12收藏
- 作者：Liu, Zebo Ding, Hui Martuscelli, Maria Sajid, Saria Hang, Haifeng Mohsin, Ali Zhu, Xiaofeng Sun, Huijie Xia, Jianye Yin, Zhongping Zhuang, Yingping Guo, Meijin Wang, Zejian
- 机构：East China Univ Sci & Technol;Univ Teramo;Riphah Int Univ;Jiangxi Agr Univ;East China Univ Sci & Technol
- 来源：LWT-FOOD SCIENCE AND TECHNOLOGY 2024
- 关键词：Polyphenol oxidase inhibitor Saccharomyces cerevisiae extracts Reduced glutathione Anti-browning Molecular docking and dynamics simulation
- Dynamic response of Aspergillus niger to periodical glucose pulse stimuli in chemostat cultures被引量：12收藏
- 作者：Liu, Peng Wang, Shuai Li, Chao Zhuang, Yingping Xia, Jianye Noorman, Henk
- 机构：East China Univ Sci & Technol;DSM Biotechnol Ctr
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2021
- 关键词：Aspergillus niger central carbon metabolism dynamic response periodically repeating glucose pulse substrate fluctuation
- Hydrodynamic investigation of a novel shear-generating device for the measurement of anchorage-dependent cell adhesion intensity被引量：11收藏
- 作者：Wang, Han Xia, Jianye Zheng, Zhiming Zhuang, Ying-Ping Yi, Xiaoping Zhang, Dahe Wang, Peng
- 机构：Chinese Acad Sci;Univ Sci & Technol China;East China Univ Sci & Technol
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2018
- 关键词：Animal cell culture Adhesion force Energy dissipation rate Microcarriers Modeling
- γ-PGA Fermentation by Bacillus subtilis PG-001 with Glucose Feedback Control pH-stat Strategy被引量：11收藏
- 作者：Wang, Jia-Qi Zhao, Jie Xia, Jian-Ye
- 机构：East China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2022
- 关键词：gamma-PGA Fermentation Bacillus subtilis pH-stat Alkali consumption
