成果/Result
- Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs被引量：249收藏
- 作者：Chen, Xianjun Zhang, Dasheng Su, Ni Bao, Bingkun Xie, Xin Zuo, Fangting Yang, Lipeng Wang, Hui Jiang, Li Lin, Qiuning Fang, Mengyue Li, Ningfeng Hua, Xin Chen, Zhengda Bao, Chunyan Xu, Jinjin Du, Wenli Zhang, Lixin Zhao, Yuzheng Zhu, Linyong Loscalzo, Joseph Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NATURE BIOTECHNOLOGY 2019
- 关键词：cells - Enzyme kinetics - Fluorescence - Mammals - Cytology
- Lighting Up Live-cell and in Vivo central Carbon Metabolism with Genetically Encoded Fluorescent Sensors被引量：98收藏
- 作者：Zhang, Zhuo Cheng, Xiawei Zhao, Yuzheng Yang, Yi
- 机构： Optogenetics and Synthetic Biology Interdisciplinary Research Center; Shanghai Key Laboratory of New Drug Design; CAS Center for Excellence in Brain Science
- 来源：Annual Review of Analytical Chemistry 2020
- 关键词：Metabolism - Cytology - Carbon - Fluorescence imaging - Biomolecules - cells
- Lactate regulates major zygotic genome activation by H3K18 lactylation in mammals被引量：67收藏
- 作者：Li, Jingyu Hou, Weibo Zhao, Qi Han, Wei Cui, Hongdi Xiao, Songling Zhu, Ling Qu, Jiadan Liu, Xiaoyu Cong, Weitao Shen, Jingling Zhao, Yuzheng Gao, Shaorong Huang, Guoning Kong, Qingran
- 机构：Chongqing Med Univ;Wenzhou Med Univ;Tongji Univ;Wenzhou Med Univ;Wenzhou Univ
- 来源：NATIONAL SCIENCE REVIEW 2024
- 关键词：mammalian prEImplantation development lactate epigenetic remodeling histone lactylation zygotic genome activation
- Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding protEIns被引量：60收藏
- 作者：Liu, Renmei Yang, Jing Yao, Jing Zhao, Zhou He, Wei Su, Ni Zhang, Zeyi Zhang, Chenxia Zhang, Zhuo Cai, Haibo Zhu, Linyong Zhao, Yuzheng Quan, Shu Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE BIOTECHNOLOGY 2022
- 关键词：ProtEIns - cell culture
- Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia被引量：42收藏
- 作者：Chen, Chiqi Hao, Xiaoxin Lai, Xiaoyun Liu, Ligen Zhu, Jun Shao, Hongfang Huang, Dan Gu, Hao Zhang, Tinghua Yu, Zhuo Xie, Li Zhang, Xiaocui Yang, Yi Xu, Jun Zhao, Yuzheng Lu, Zhigang Zheng, Junke
- 机构：Shanghai Jiao Tong Univ;Shanghai Zhaxin Hosp;Shanghai Sixth Peoples Hosp;East China Univ Sci & Technol;Tongji Univ
- 来源：SCIENCE ADVANCES 2021
- 关键词：Diseases - Phosphorylation - Chemotherapy - Metabolism - Electric resistance - cells - Cytology
- Profiling metabolic states with genetically encoded fluorescent biosensors for NADH被引量：38收藏
- 作者：Zhao, Yuzheng Yang, Yi
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2015
- 关键词：Metabolism
- Glucose monitoring in living cells with single fluorescent protEIn-based sensors被引量：36收藏
- 作者：Hu, Hanyang Wei, Yufeng Wang, Daocheng Su, Ni Chen, Xianjun Zhao, Yuzheng Liu, Guixia Yang, Yi
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：RSC ADVANCES 2018
- 关键词：ProtEIns - Escherichia coli - cells - Cytology - Fluorescence - Metabolism - Glucose sensors
- Spatiotemporally controllable diphtheria toxin expression using a light-switchable transgene system combining multifunctional nanoparticle delivery system for targeted melanoma therapy被引量：28收藏
- 作者：He, Muye Wang, Yan Chen, Xianjun Zhao, Yuzheng Lou, Kaiyan Wang, Yujie Huang, Lei Hou, Xinyu Xu, Jiajun Cai, Xiaoran Cheng, Yi Lan, Minbo Yang, Yi Gao, Feng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF CONTROLLED RELEASE 2020
- 关键词：Light-switchable gene expression Diphtheria toxin Melanoma Nanoparticle delivery system
- Materiobiomodulated ROS Therapy for De Novo Hair Growth被引量：23收藏
- 作者：Bai, Long Wang, Yifei Wang, Kun Chen, Xiaoqian Zhao, Yuzheng Liu, Changsheng Qu, Xue
- 机构：East China Univ Sci & Technol;Shanghai Univ;East China Univ Sci & Technol;Shanghai Univ
- 来源：ADVANCED MATERIALS 2024
- 关键词：hair growth in situ intracellular delivery microneedles polydopamine reactive oxygen species
- Ultrafast internal conversion dynamics of bilirubin bound to UnaG and its N57A mutant被引量：20收藏
- 作者：Cao, Xiaodan Zhang, Changcheng Gao, Ziheng Liu, Yangyi Zhao, Yuzheng Yang, Yi Chen, Jinquan Jimenez, Ralph Xu, Jianhua
- 机构：East China Normal Univ;NIST;Univ Colorado;Univ Colorado;East China Univ Sci & Technol
- 来源：PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2019
- 关键词：Hydrogen bonds - Crystal structure - Chromophores - ProtEIns - Excited states
- Imaging intracellular metabolite and protEIn changes in live mammalian cells with bright fluorescent RNA-based genetically encoded sensors被引量：17收藏
- 作者：Fang, Mengyue Li, Huiwen Xie, Xin Wang, Hui Jiang, Ying Li, Tianyu Zhang, Bibi Jiang, Xin Cao, Yueyang Zhang, Rui Zhang, Dasheng Zhao, Yuzheng Zhu, Linyong Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：BIOSENSORS & BIOELECTRONICS 2023
- 关键词：Genetically encoded sensor Fluorogenic RNA aptamer Pepper Metabolite and protEIn dynamics
- Tofacitinib Citrate Coordination-Based Dual-Responsive/Scavenge Nanoplatform Toward Regulate Colonic Inflammatory Microenvironment for Relieving Colitis被引量：16收藏
- 作者：Zou, Jiafeng Jiang, Kun Chen, You Ma, Ying Xia, Chuanhe Ding, Wenxing Yao, Min Lin, Yiting Chen, Yanzuo Zhao, Yuzheng Gao, Feng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Med Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED HEALTHCARE MATERIALS 2024
- 关键词：colitis colonic inflammatory microenvironment coordination nanoplatform dual-responsive dual-scavenge tofacitinib citrate
- Succinate antagonizes α-ketoglutarate biosynthesis governing myeloid differentiation in normal hematopoiesis and myelodysplastic syndromes被引量：14收藏
- 作者：Zhang, Lingling Liu, Leiming Wang, Yue Wang, Aoxue Tang, Weitao Song, Yike Zhang, Zhuo Chen, Yaqiong Liao, Dandan Liang, Huixian Yang, Fan Liu, Yiming Zhou, Jiaying Xuan, Yan Yao, Ke Hu, Zeping Sun, Leimin Chen, Dan He, Ruikun Zhang, Yihan Zou, Yejun Yang, Hui Yang, Yi Li, Xie Zhao, Yuzheng Ju, Zhenyu
- 机构： Department of Hematology; Key Laboratory of Artificial Organs and Computational Medicine; Optogenetics & Synthetic Biology Interdisciplinary Research Center; Research Unit of New Techniques for Live-cell Metabolic Imaging; Key Laboratory of Regenerative Medicine of Ministry of Education
- 来源：Science Bulletin 2026
- Understanding the effect of temperature downshift on CHO cell growth, antibody titer and product quality by intracellular metabolite profiling and in vivo monitoring of redox state被引量：14收藏
- 作者：Zhu, Ziyu Chen, Xiaoqian Li, Wenhao Zhuang, Yingping Zhao, Yuzheng Wang, Guan
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;East China Univ Sci & Technol;Chinese Acad Med Sci;East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY PROGRESS 2023
- 关键词：antibody CHO cell culture intracellular sensor metabolomics NAD(+)/NADH ratio NADPH redox state temperature downshift
- Imaging the Redox States of Live cells with the Time-Resolved Fluorescence of Genetically Encoded Biosensors被引量：12收藏
- 作者：Li, Lei Zhang, Changcheng Wang, Peng Wang, Aoxue Zhou, Jiasheng Chen, Guoqing Xu, Jianhua Yang, Yi Zhao, Yuzheng Zhang, Sanjun Tian, Yang
- 机构：East China Normal Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Jiangnan Univ;Chinese Acad Sci
- 来源：ANALYTICAL CHEMISTRY 2019
- 关键词：cells - Fluorescence - Cytology - Bioimaging
- Discovery of Natural Products Targeting NQO1 via an Approach Combining Network-Based Inference and Identification of Privileged Substructures被引量：10收藏
- 作者：Wu, Zengrui Wang, Qiaohui Yang, Hongbin Wang, Jiye Li, Weihua Liu, Guixia Yang, Yi Zhao, Yuzheng Tang, Yun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2021
- 关键词：Neurodegenerative diseases - Quinone
- Sensitive detection via the time-resolved fluorescence of circularly permuted yellow fluorescent protEIn biosensors被引量：8收藏
- 作者：Li, Lei Cheng, Yuchi Shen, Shiyu Zhou, Jiasheng Wang, Aoxue Chen, Guoqing Xu, Jianhua Yang, Yi Zhao, Yuzheng Zhang, Sanjun Tian, Yang
- 机构：East China Normal Univ;East China Univ Sci & Technol;Jiangnan Univ;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2020
- 关键词：Circularly permuted fluorescent protEIns Time-resolved fluorescence Biosensor Fluorescent lifetime imaging
- Spatiotemporally controllable diphtherin transgene system and neoantigen immunotherapy被引量：7收藏
- 作者：He, Muye Sun, Yuji Cheng, Yi Wang, Jie Zhang, Miao Sun, Rui Hou, Xinyu Xu, Jiajun He, Hai Wang, Hongtao Yuan, Zeting Lan, Minbo Zhao, Yuzheng Yang, Yi Chen, Xianjun Gao, Feng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol;Chinese Acad Med Sci
- 来源：JOURNAL OF CONTROLLED RELEASE 2023
- 关键词：Light-switchable diphtherin gene expression Melanoma Immunotherapy Neoantigen Nanoparticle delivery system
- Bright and Stable Cyan Fluorescent RNA Enables Multicolor RNA Imaging in Live Escherichia coli被引量：3收藏
- 作者：Jiang, Li Zuo, Fangting Pan, Yuanyuan Li, Ruilong Shi, Yajie Huang, Xinyi Zhang, Dasheng Zhuang, Yingping Zhao, Yuzheng Lin, Qiuning Yang, Yi Zhu, Linyong Chen, Xianjun
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Med Sci
- 来源：SMALL 2025
- 关键词：bioorthogonality cyan fluorescent RNA fluorophore RNA aptamer RNA imaging
- Simultaneous quantification of intracellular pH and lactate at the single-cell level using a genetically encoded fluorescence lifetime biosensor被引量：1收藏
- 作者：Zhou, Huangmei Zou, Yejun Song, Yike Zhang, Zhuo Chen, Kai Deng, Lunhua Li, Xie Zhang, Sanjun Zhao, Yuzheng
- 机构：East China Normal Univ;East China Univ Sci & Technol;Tongji Univ;Chinese Acad Med Sci;Shanxi Univ
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2025
- 关键词：Genetically encoded fluorescent biosensors Fluorescent protEIns Fluorescence lifetime imaging Lactate metabolism pH homeostasis
- Nitrogen-Boosted H2O2 Production of Arginine-Polyphenol Nanozyme Drives Oxidative Eustress for Hair Regeneration被引量：1收藏
- 作者：Wang, Yifei Yang, Yaojia Wang, Aoxue Shen, Chen Tan, Shenliang Liu, Changsheng Zhao, Yuzheng Qu, Xue
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Med Sci
- 来源：ADVANCED SCIENCE 2026
- 关键词：hair regeneration hydrogen peroxide nanoenzymes oxidative eustress polyphenol
- A GeneralStrategy for Developing Si-Rhodamine-BasedFluorogenic Dyes for Advanced Bioimaging and Biosensing被引量：0收藏
- 作者：Chen, Zhengda Shi, Yajie Jiang, Li Yin, Yuxin Yang, Lipeng Huang, Xinyi Jiang, Ling Guo, Wenjie Liu, Xiaoyu Fu, Rong Liu, Huining Bao, Bingkun Lin, Qiuning Zhao, Yuzheng Chen, Xianjun Yang, Yi Zhu, Linyong
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Frontiers Med Ctr
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2026
- 关键词：Bioimaging - Dyes - Fluorescence imaging - Silicon compounds - Stimulated emission
- 基于遗传编码荧光探针的精氨酸实时监测新技术被引量：0收藏
- 作者：李婷 黄瑾 张卓 赵玉政
- 机构：华东理工大学药学院;中国医学科学院细胞代谢监测成像新技术创新单元
- 来源：《科学通报》 2025
- 关键词：尿素 瓜氨酸 精氨酸 一氧化氮 代谢 鸟氨酸
- 摘要：精氨酸是氨基酸中的“多面手”,除了作为蛋白质和多肽的组成部分外,精氨酸可代谢产生尿素、鸟氨酸、瓜氨酸、一氧化氮、肌酸、胍丁胺等重要分子,在调节人体氮代谢稳态、心血管生理活动、免疫反应、生长繁殖等重要过程中发挥着关键作用[...
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- Type 2 Inflammatory Diseases: The Crossroads of Immunity and Metabolism被引量：0收藏
- 作者：Chen, Lin Pan, Zhou-Xian Ma, Zi-Qi Jin, Yu-Xuan Ru, Yi Gao, Pei-Song Yang, Cheng Zhao, Shi-Su Zhang, Jing Li, Ji-Han Chang, Christopher Zhao, Yu-Zheng Sun, Jin-Lyu
- 机构：Chinese Acad Med Sci & Peking Union Med Coll;East China Univ Sci & Technol;Chinese Acad Med Sci;Johns Hopkins Univ;Joe DiMaggio Childrens Hosp
- 来源：RESEARCH 2026
- 关键词：Diagnosis - Diseases - Metabolism - Pathology - Physiology - Signaling - Thorium compounds - Tissue - Tissue homeostasis
- Hydroxyl-radical-specific cascade photogeneration for oxygen-chain photocatalytic therapy被引量：0收藏
- 作者：Liu, Qiang Yan, Chenxu Li, Xie Huang, Haiyang Fan, Zheyu Zhang, Jizhan Zhang, Weiwei Shi, Ping Zhao, Yuzheng Guo, Zhiqian Zhu, Wei-Hong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2026
- 关键词：Chains - Mammals - Molecular oxygen - Photocatalytic activity - Photodynamic therapy - Reaction intermediates - Reactive oxygen species - Scaffolds - Scaffolds (biology)
