成果/Result
- In Silico Prediction of Chemical Acute Oral Toxicity Using MultiClassification Methods被引量：147收藏
- 作者：Li, Xiao Chen, Lei Cheng, Feixiong Wu, Zengrui Bian, Hanping Xu, Congying Li, Weihua Liu, Guixia Shen, Xu Tang, Yun
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2014
- 关键词：Risk assessment - Binary trees - Decision trees - Nearest neighbor search - Environmental Protection Agency - Barium compounds - Support vector machines
- Bright, Stable, and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near-Infrared Spectral Region被引量：142收藏
- 作者：Lei, Zuhai Li, Xinran Luo, Xiao He, Haihong Zheng, Jing Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2017
- 关键词：fluorophores imaging near-infrared
- Association between cigarette smoking and Parkinson's disease: A meta-analysis被引量：134收藏
- 作者：Li, Xiao Li, Weihua Liu, Guixia Shen, Xu Tang, Yun
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：ARCHIVES OF GERONTOLOGY AND GERIATRICS 2015
- 关键词：Cigarette smoking Parkinson's disease Meta-analysis Pack-year
- A redox mechanism underlying nucleolar stress sensing by nucleophosmin被引量：130收藏
- 作者：Yang, Kai Wang, Ming Zhao, Yuzheng Sun, Xuxu Yang, Yi Li, Xie Zhou, Aiwu Chu, Huilin Zhou, Hu Xu, Jianrong Wu, Mian Yang, Jie Yi, Jing
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Inst Mat Med;Shanghai Jiao Tong Univ
- 来源：NATURE COMMUNICATIONS 2016
- Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease被引量：106收藏
- 作者：Li, Xi Zhang, Yinan Xu, Lingya Wang, Aoxue Zou, Yejun Li, Ting Huang, Li Chen, Weicai Liu, Shuning Jiang, Kun Zhang, Xiuze Wang, Dongmei Zhang, Lijuan Zhang, Zhuo Zhang, Zeyi Chen, Xianjun Jia, Wei Zhao, Aihua Yan, Xinfeng Zhou, Haimeng Zhu, Linyong Ma, Xinran Ju, Zhenyu Jia, Weiping Wang, Congrong Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Chinese Acad Sci;Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6;East China Normal Univ
- 来源：CELL METABOLISM 2023
- Asymmetric Intramolecular Oxa-Michael Reactions of Cyclohexadienones Catalyzed by a Primary Amine Salt被引量：106收藏
- 作者：Wu, Wenbin Li, Xin Huang, Huicai Yuan, Xiaoqian Lu, Junzhu Zhu, Kailong Ye, Jinxing
- 机构：E China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2013
- 关键词：asymmetric catalysis cyclohexadienones iminium activation Michael addition primary amine salt
- Diastereodivergent organocatalytic asymmetric vinylogous Michael reactions被引量：102收藏
- 作者：Li, Xin Lu, Min Dong, Yun Wu, Wenbin Qian, Qingqing Ye, Jinxing Dixon, Darren J.
- 机构：E China Univ Sci & Technol;Univ Oxford
- 来源：NATURE COMMUNICATIONS 2014
- PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21被引量：57收藏
- 作者：Liu, Xiaoye Zhang, Feifei Zhang, Yaping Li, Xie Chen, Chiqi Zhou, Meiyi Yu, Zhuo Liu, Yunxia Zhao, Yuzheng Hao, Xiaoxin Tang, Yabin Zhu, Liang Liu, Ligen Xie, Li Gu, Hao Shao, Hongfang Xia, Fangzhen Yin, Chunrong Tao, Minfang Xie, Jingjing Zhang, Cheng Cheng Yang, Yi Sun, Haipeng Chen, Guo-Qiang Zheng, Junke
- 机构：Shanghai Jiao Tong Univ;Chinese Acad Sci;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Shanghai Key Lab Orbital Dis & Ocular Oncol
- 来源：CELL REPORTS 2018
- Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models被引量：54收藏
- 作者：He, Xiaoxiao Wan, Jiangbo Yang, Xiaona Zhang, Xiuze Huang, Dan Li, Xie Zou, Yejun Chen, Chiqi Yu, Zhuo Xie, Li Zhang, Yaping Liu, Ligen Li, Shangang Zhao, Yuzheng Shao, Hongfang Yu, Ye Zheng, Junke
- 机构：Shanghai Ciao Tong Univ;Shanghai Pao Tong Univ;China Pharmaceut Univ;East China Univ Sci & Technol;Kunming Univ Sci & Technol
- 来源：JOURNAL OF CLINICAL INVESTIGATION 2021
- A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells被引量：52收藏
- 作者：Li, Xie Zhang, Changcheng Xu, Xiaopei Miao, Jun Yao, Jing Liu, Renmei Zhao, Yuzheng Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：NUCLEIC ACIDS RESEARCH 2020
- In Silico Estimation of Chemical Carcinogenicity with Binary and Ternary Classification Methods被引量：45收藏
- 作者：Li, Xiao Du, Zheng Wang, Jie Wu, Zengrui Li, Weihua Liu, Guixia Shen, Xu Tang, Yun
- 机构：E China Univ Sci & Technol;Shanghai Tobacco Grp Co Ltd;Chinese Acad Sci
- 来源：MOLECULAR INFORMATICS 2015
- 关键词：Binary classification Ternary classification Chemical carcinogenicity Machine learning methods Tobacco smoke
- Discovery of Potent Ligands for Estrogen Receptor β by Structure-Based Virtual Screening被引量：44收藏
- 作者：Shen, Jie Tan, Chengfang Zhang, Yanyan Li, Xi Li, Weihua Huang, Jin Shen, Xu Tang, Yun
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2010
- Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent被引量：43收藏
- 作者：Huang, Huang Lu, Weiqiang Li, Xi Cong, Xiaoli Ma, Hongmei Liu, Xiaofeng Zhang, Yu Che, Peng Ma, Ruoqun Li, Honglin Shen, Xu Jiang, Hualiang Huang, Jin Zhu, Jin
- 机构：E China Univ Sci & Technol;Minsheng Pharma;Chinese Acad Sci
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2012
- 关键词：Falcipain-2 Dihydrofolate reductase Dual inhibitor Antimalarial drug SAR Molecular docking
- Natural products as a gold mine for selective matrix metalloproteinases inhibitors被引量：40收藏
- 作者：Wang, Liyan Li, Xi Zhang, Shoude Lu, Weiqiang Liao, Sha Liu, Xiaofeng Shan, Lei Shen, Xu Jiang, Hualiang Zhang, Weidong Huang, Jin Li, Honglin
- 机构：Shanghai Jiao Tong Univ;E China Univ Sci & Technol;Second Mil Med Univ
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2012
- 关键词：Matrix metalloproteinases Virtual screening Natural product Anticancer agent
- In silico prediction of serious eye irritation or corrosion potential of chemicals被引量：40收藏
- 作者：Wang, Qin Li, Xiao Yang, Hongbin Cai, Yingchun Wang, Yinyin Wang, Zhuang Li, Weihua Tang, Yun Liu, Guixia
- 机构：East China Univ Sci & Technol
- 来源：RSC ADVANCES 2017
- 关键词：Health hazards - Chemical hazards - Synthetic aperture radar - Forecasting - Learning systems
- Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes被引量：39收藏
- 作者：Luo, Xiaoyan Zhou, Zhiqiang Li, Xin Liang, Xinmiao Ye, Jinxing
- 机构：E China Univ Sci & Technol
- 来源：RSC ADVANCES 2011
- 关键词：Aldehydes - addition reactions - Phosphorus compounds
- Discovery of Inhibitors To Block Interactions of HIV-1 Integrase with Human LEDGF/p75 via Structure-Based Virtual Screening and Bioassays被引量：37收藏
- 作者：Hu, Guoping Li, Xi Zhang, Xuan Li, Yaozong Ma, Lei Yang, Liu-Meng Liu, Guixia Li, Weihua Huang, Jin Shen, Xu Hu, Lihong Zheng, Yong-Tang Tang, Yun
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2012
- A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice被引量：34收藏
- 作者：Li, Ting Chen, Xianjun Qian, Yajie Shao, Jiawei Li, Xie Liu, Shuning Zhu, Linyong Zhao, Yuzheng Ye, Haifeng Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Normal Univ;East China Normal Univ
- 来源：NATURE COMMUNICATIONS 2021
- Asymmetric organocatalytic Michael/α-alkylation reaction of α,β-unsaturated aldehyde with chloroacetophenone被引量：30收藏
- 作者：Li, Wenjun Li, Xin Ye, Tingting Wu, Wenbin Liang, Xinmiao Ye, Jinxing
- 机构：E China Univ Sci & Technol
- 来源：TETRAHEDRON LETTERS 2011
- 关键词：Asymmetric catalysis alpha,beta-Unsaturated aldehyde Tandem reaction Organocatalysis Enantioselective
- Asymmetric Organocatalytic Michael addition of α,β-Unsaturated Ketone with 1,2,4-Triazole被引量：30收藏
- 作者：Zhou, Yufeng Li, Xin Li, Wenjun Wu, Chunlin Liang, Xinmiao Ye, Jinxing
- 机构：E China Univ Sci & Technol
- 来源：SYNLETT 2010
- 关键词：asymmetric catalysis 1,2,4-triazole Michael addition enone
- Hydrogen sulfide responsive nanoplatforms: Novel gas responsive drug delivery carriers for biomedical applications被引量：29收藏
- 作者：Zou, Jiafeng Yuan, Zeting Chen, Xiaojie Chen, You Yao, Min Chen, Yang Li, Xiang Chen, Yi Ding, Wenxing Xia, Chuanhe Zhao, Yuzheng Gao, Feng
- 机构：East China Univ Sci & Technol;Zhejiang Chinese Med Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 2024
- 关键词：Hydrogen sulfide Disease mechanisms Removal of hydrogen sulfide Responsive nanoplatforms Challenges Biomedical applications
- Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells被引量：28收藏
- 作者：Huang, Dan Zhang, Changcheng Xiao, Ming Li, Xie Chen, Weicai Jiang, Yu Yuan, Yamin Zhang, Yaping Zou, Yejun Deng, Lei Wang, Yang Sun, Yuying Dong, Wenping Zhang, Zhuo Xie, Li Yu, Zhuo Chen, Chiqi Liu, Ligen Wang, Jing Yang, Yi Yang, Jie Zhao, Yuzheng Zheng, Junke
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Chinese Acad Med Sci
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2023
- 关键词：redox metabolism AML leukemia-initiating cells drug resistance
- Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors被引量：27收藏
- 作者：Wang, Aoxue Zou, Yejun Liu, Shuning Zhang, Xiuze Li, Ting Zhang, Lijuan Wang, Ruwen Xia, Yale Li, Xie Zhang, Zhuo Liu, Tiemin Ju, Zhenyu Wang, Ru Loscalzo, Joseph Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Shanghai Univ Sport;Fudan Univ;Jinan Univ
- 来源：NATURE PROTOCOLS 2024
- In silico prediction of chemical aquatic toxicity with chemical category approaches and substructural alerts被引量：26收藏
- 作者：Sun, Lu Zhang, Chen Chen, Yingjie Li, Xiao Zhuang, Shulin Li, Weihua Liu, Guixia Lee, Philip W. Tang, Yun
- 机构：E China Univ Sci & Technol;Zhejiang Univ
- 来源：TOXICOLOGY RESEARCH 2015
- Lighting up arginine metabolism reveals itsfunctional diversity in physiology and pathology被引量：21收藏
- 作者：Li, Rui Li, Yan Jiang, Kun Zhang, Lijuan Li, Ting Zhao, Aihua Zhang, Zhuo Xia, Yale Ge, Kun Chen, Yaqiong Wang, Chengnuo Tang, Weitao Liu, Shuning Lin, Xiaoxi Song, Yuqin Mei, Jie Xiao, Chun Wang, Aoxue Zou, Yejun Li, Xie Chen, Xianjun Ju, Zhenyu Jia, Wei Loscalzo, Joseph Sun, Yu Fang, Wei Yang, Yi Zhao, Yuzheng
- 机构：East China Univ Sci & Technol;Chinese Acad Med Sci;Univ Chinese Acad Sci;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：CELL METABOLISM 2025
- Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA被引量：21收藏
- 作者：Lu, W. Cheng, F. Yan, W. Li, X. Yao, X. Song, W. Liu, M. Shen, X. Jiang, H. Chen, J. Li, J. Huang, J.
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Sichuan Univ;Collaborat Innovat Ctr Biotherapy
- 来源：ONCOGENE 2017
- Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking被引量：20收藏
- 作者：Hu, Guoping Li, Xi Sun, Xianqiang Lu, Weiqiang Liu, Guixia Huang, Jin Shen, Xu Tang, Yun
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MOLECULAR MODELING 2012
- 关键词：Drug repositioning HIV-1 Integrase Human LEDGF/p75 protein Molecular docking Protein-protein interaction
- Catalytic Asymmetric Formal Aza-Diels-Alder Reactions of α,β-Unsaturated Ketones and 3H-Indoles被引量：20收藏
- 作者：Hu, Haoxiang Meng, Chunna Dong, Yun Li, Xin Ye, Jinxing
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：ACS CATALYSIS 2015
- 关键词：asymmetric catalysis amine aza-Diels-Alder cycloaddition piperidinone bifunctional catalyst
- PIFA-Mediated Cross-Dehydrogenative Coupling of N-Heteroarenes with Cyclic Ethers: Ethanol as an Efficient Promoter被引量：20收藏
- 作者：Li, Xiang Liu, Chaoyang Guo, Shixun Wang, Wei Zhang, Yongqiang
- 机构：East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2021
- 关键词：Cross-dehydrogenative coupling Cyclic ethers Ethanol PIFA Visible Light
- In silico prediction of chemical subcellular localization via multi-classification methods被引量：17收藏
- 作者：Yang, Hongbin Li, Xiao Cai, Yingchun Wang, Qin Li, Weihua Liu, Guixia Tang, Yun
- 机构：East China Univ Sci & Technol
- 来源：MEDCHEMCOMM 2017
